Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders

Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis

(2017) Sandro Altamura et al.   JOURNAL OF ALZHEIMERS DISEASE

Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells

(2013) Wen Guo et al.   AGING CELL

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys

(2013) F. Schwoebel et al.   BLOOD

Regulation of erythropoiesis by hypoxia-inducible factors

(2013) Volker H. Haase   BLOOD REVIEWS

Hepcidin-25: Measurement by LC–MS/MS in serum and urine, reference ranges and urinary fractional excretion

(2013) Fleur Wolff et al.   CLINICA CHIMICA ACTA

Fine-tuned shuttles for bone morphogenetic proteins

(2013) Kristi A Wharton et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Regulation of systemic iron homeostasis

(2013) Karin E. Finberg   CURRENT OPINION IN HEMATOLOGY

Iron deficiency: From diagnosis to treatment

(2013) Vanessa Polin et al.   DIGESTIVE AND LIVER DISEASE

Dynamics of Anemia in Relation to Parasitic Infections, Micronutrient Status, and Increasing Age in South-Central Côte d'Ivoire

(2013) Aurélie A. Righetti et al.   JOURNAL OF INFECTIOUS DISEASES

Mammalian iron transporters: Families SLC11 and SLC40

(2013) Nicolas Montalbetti et al.   MOLECULAR ASPECTS OF MEDICINE

Challenges for malaria elimination in Zanzibar: pyrethroid resistance in malaria vectors and poor performance of long-lasting insecticide nets

(2013) Khamis A Haji et al.   Parasites & Vectors

Anemia and mortality in acute coronary syndromes: A systematic review and meta-analysis

(2012) Patrick R. Lawler et al.   AMERICAN HEART JOURNAL

Myelodysplastic syndromes: 2012 update on diagnosis, risk-stratification, and management

(2012) Guillermo Garcia-Manero   AMERICAN JOURNAL OF HEMATOLOGY

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload

(2012) Maja Vujić Spasić et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region

(2012) Eva Maurer et al.   BIOLOGICAL CHEMISTRY

Beyond anemia: hepcidin, monocytes and inflammation

(2012) Xiaolan Zhang et al.   BIOLOGICAL CHEMISTRY

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

The porphyrias: advances in diagnosis and treatment

(2012) M. Balwani et al.   BLOOD

Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6

(2012) Pauline Lee et al.   BLOOD CELLS MOLECULES AND DISEASES

Iron overload in non-transfusion-dependent thalassemia: a clinical perspective

(2012) Khaled M. Musallam et al.   BLOOD REVIEWS

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

(2012) Sandra L. Ross et al.   Cell Metabolism

Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination

(2012) Bo Qiao et al.   Cell Metabolism

Regulation of iron homeostasis by microRNAs

(2012) Mirco Castoldi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Circulating Human Hepcidin-25 Concentrations Display a Diurnal Rhythm, Increase with Prolonged Fasting, and Are Reduced by Growth Hormone Administration

(2012) J. S. Troutt et al.   CLINICAL CHEMISTRY

Post-transfusional iron overload in the haemoglobinopathies

(2012) Isabelle Thuret   COMPTES RENDUS BIOLOGIES

Iron homeostasis in the Metabolic Syndrome

(2012) Christian Datz et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element

(2012) Yanli Hou et al.   GENE

The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice

(2012) G. Casanovas et al.   HAEMATOLOGICA

Late stage erythroid precursor production is impaired in mice with chronic inflammation

(2012) O. D. Prince et al.   HAEMATOLOGICA

Inhibition of hepcidin transcription by growth factors

(2012) Julia B. Goodnough et al.   HEPATOLOGY

Molecular Diagnostic and Pathogenesis of Hereditary Hemochromatosis

(2012) Paulo C. J. L. Santos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neogenin Interacts with Matriptase-2 to Facilitate Hemojuvelin Cleavage

(2012) Caroline A. Enns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

(2012) Qingdu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

(2012) Flavia D’Alessio et al.   JOURNAL OF HEPATOLOGY

Duodenal Reductase Activity and Spleen Iron Stores Are Reduced and Erythropoiesis Is Abnormal in Dcytb Knockout Mice Exposed to Hypoxic Conditions

(2012) Jeehyea Choi et al.   JOURNAL OF NUTRITION

Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations

(2012) Elmar Aigner et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Estrogen Regulates Hepcidin Expression via GPR30-BMP6-Dependent Signaling in Hepatocytes

(2012) Yasumasa Ikeda et al.   PLoS One

Increased Serum Hepcidin Levels in Subjects with the Metabolic Syndrome: A Population Study

(2012) Nicola Martinelli et al.   PLoS One

Hereditary hemochromatosis and transferrin receptor 2

(2011) Juxing Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis

(2011) W. Chen et al.   BLOOD

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

(2011) D. Meynard et al.   BLOOD

Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2

(2011) D. F. Wallace et al.   BLOOD

Regulation of hepcidin expression at high altitude

(2011) N. P. Talbot et al.   BLOOD

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

(2011) I. Theurl et al.   BLOOD

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria

(2011) M.-B. Troadec et al.   BLOOD

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

(2011) A. U. Steinbicker et al.   BLOOD

Hepcidin regulation by innate immune and infectious stimuli

(2011) A. E. Armitage et al.   BLOOD

A novel N491S mutation in the human SLC11A2 gene impairs protein trafficking and in association with the G212V mutation leads to microcytic anemia and liver iron overload

(2011) Edouard Bardou-Jacquet et al.   BLOOD CELLS MOLECULES AND DISEASES

Iron Regulation of Hepcidin Despite Attenuated Smad1,5,8 Signaling in Mice Without Transferrin Receptor 2 or Hfe

(2011) Elena Corradini et al.   GASTROENTEROLOGY

Iron Levels in Hepatocytes and Portal Tract Cells Predict Progression and Outcomes of Patients With Advanced Chronic Hepatitis C

(2011) Richard W. Lambrecht et al.   GASTROENTEROLOGY

Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo

(2011) I. Theurl et al.   HAEMATOLOGICA

Conditional disruption of mouse HFE2 gene: Maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin

(2011) Konstantinos Gkouvatsos et al.   HEPATOLOGY

BMPER Protein Is a Negative Regulator of Hepcidin and Is Up-regulated in Hypotransferrinemic Mice

(2011) Neeta Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

(2011) Mirco Castoldi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Molecular Pathogenesis of Hereditary Hemochromatosis

(2011) Jodie Babitt et al.   SEMINARS IN LIVER DISEASE

Anemia of Inflammation

(2011) C. N. Roy   Hematology-American Society of Hematology Education Program

Serum Hepcidin and Macrophage Iron Correlate With MCP-1 Release and Vascular Damage in Patients With Metabolic Syndrome Alterations

(2010) Luca Valenti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

(2010) B. J. Sasu et al.   BLOOD

Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project

(2010) A. Piperno et al.   BLOOD

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

(2010) A.-S. Zhang et al.   BLOOD

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

(2010) D. H. Lee et al.   BLOOD

Altered hepatic BMP signaling pathway in human HFE hemochromatosis

(2010) Giuliano Bolondi et al.   BLOOD CELLS MOLECULES AND DISEASES

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption

(2010) Liviu Vanoaica et al.   Cell Metabolism

Divalent metal transporter, iron and Parkinson's disease: A pathological relationship

(2010) Hyun-pil Lee et al.   CELL RESEARCH

Inherited disorders of iron metabolism

(2010) Clara Camaschella et al.   CURRENT OPINION IN PEDIATRICS

Hereditary Hemochromatosis: Pathogenesis, Diagnosis, and Treatment

(2010) Antonello Pietrangelo   GASTROENTEROLOGY

Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis

(2010) John D. Ryan et al.   HEPATOLOGY

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

(2010) James E. Nelson et al.   HEPATOLOGY

Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors

(2010) Samira Lakhal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

(2010) Hong Ye et al.   JOURNAL OF CLINICAL INVESTIGATION

Soybean ferritin: implications for iron status of vegetarians

(2009) Bo Lönnerdal   AMERICAN JOURNAL OF CLINICAL NUTRITION

Hepcidin, the hormone of iron metabolism, is bound specifically to  -2-macroglobulin in blood

(2009) G. Peslova et al.   BLOOD

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

(2009) T. Tanno et al.   BLOOD

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

(2009) K. Mleczko-Sanecka et al.   BLOOD

Polymorphisms and mutations of human TMPRSS6 in iron deficiency anemia

(2009) E. Beutler et al.   BLOOD CELLS MOLECULES AND DISEASES

Adipose Tissue Expression and Genetic Variants of the Bone Morphogenetic Protein Receptor 1A Gene (BMPR1A) Are Associated With Human Obesity

(2009) Y. Bottcher et al.   DIABETES

Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of Hemochromatosis

(2009) Elena Corradini et al.   GASTROENTEROLOGY

Abnormal glucose metabolism in heterozygous mutant mice for a type I receptor required for BMP signaling

(2009) Gregory J. Scott et al.   GENESIS

STAT3 signaling within hepatocytes is required for anemia of inflammation in vivo

(2009) Ryotaro Sakamori et al.   JOURNAL OF GASTROENTEROLOGY

Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin

(2009) Marc Ruivard et al.   JOURNAL OF HEPATOLOGY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Mutations in the Gene Encoding DMT1: Clinical Presentation and Treatment

(2009) Achille Iolascon et al.   SEMINARS IN HEMATOLOGY

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Lipopolysaccharide Induces a Significant Increase in Expression of Iron Regulatory Hormone Hepcidin in the Cortex and Substantia Nigra in Rat Brain

(2008) Qin Wang et al.   ENDOCRINOLOGY

2-Oxoglutarate-dependent oxygenases control hepcidin gene expression

(2008) Georgia G. Braliou et al.   JOURNAL OF HEPATOLOGY

Iron in NASH, chronic liver diseases and HCC: How much iron is too much?

(2008) Antonello Pietrangelo   JOURNAL OF HEPATOLOGY

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

(2008) Maria Vittoria Verga Falzacappa et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

Viral infection and iron metabolism

(2008) Hal Drakesmith et al.   NATURE REVIEWS MICROBIOLOGY

Iron Deficiency Anemia

(2008) Susan F. Clark   NUTRITION IN CLINICAL PRACTICE

Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle

(2008) A. K. Sendamarai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005

(2008) Erin McLean et al.   PUBLIC HEALTH NUTRITION