Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients

Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?

(2021) Varnica Bajaj et al.   Frontiers in Physiology

Divulging the Intricacies of Crosstalk Between NF-Kb and Nrf2-Keap1 Pathway in Neurological Complications of COVID-19

(2021) Ranjana Bhandari et al.   MOLECULAR NEUROBIOLOGY

Return-to-work, disabilities and occupational health in the age of COVID-19

(2021) Diane Godeau et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Can Resveratrol-Inhaled Formulations Be Considered Potential Adjunct Treatments for COVID-19?

(2021) Giovanni A. Rossi et al.   Frontiers in Immunology

Revisiting Pleiotropic Effects of Type I Interferons: Rationale for Its Prophylactic and Therapeutic Use Against SARS-CoV-2

(2021) Diana Garcia-del-Barco et al.   Frontiers in Immunology

Aging and Interferons: Impacts on Inflammation and Viral Disease Outcomes

(2021) Emily Feng et al.   Cells

Nephroprotective activity of natural products against chemical toxicants: The role of Nrf2/ARE signaling pathway

(2021) Emad Molaei et al.   Food Science & Nutrition

Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications?

(2021) Pedro Castro et al.   CARDIOVASCULAR DRUGS AND THERAPY

Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies

(2021) Tahereh Farkhondeh et al.   MOLECULES

Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury

(2021) Dan-Dan Zhu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays

(2021) Fulvio Perrella et al.   Biomolecules

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

(2021) Liyan Yang et al.   Biomedicines

Monocytes present age‐related changes in phospholipid concentration and decreased energy metabolism

(2020) Mario Saare et al.   AGING CELL

NRF2 as a Therapeutic Target in Neurodegenerative Diseases

(2020) Mikah S. Brandes et al.   ASN Neuro

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks

(2020) Hossam M. Ashour et al.   Pathogens

Why does COVID-19 disproportionately affect older people?

(2020) Amber L. Mueller et al.   Aging-US

Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series

(2020) Sigurd F. Lax et al.   ANNALS OF INTERNAL MEDICINE

Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19?

(2020) Ahmed S. Abouhashem et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection

(2020) Livan Delgado-Roche et al.   ARCHIVES OF MEDICAL RESEARCH

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

(2020) Meijuan Zheng et al.   Cellular & Molecular Immunology

Contrast enhanced ultrasonography (CEUS) to detect abdominal microcirculatory disorders in severe cases of COVID-19 infection: First experience

(2020) E.M. Jung et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

(2020) Hin Chu et al.   CLINICAL INFECTIOUS DISEASES

Surgical mask partition reduces the risk of non-contact transmission in a golden Syrian hamster model for Coronavirus Disease 2019 (COVID-19)

(2020) Jasper Fuk-Woo Chan et al.   CLINICAL INFECTIOUS DISEASES

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China

(2020) Mingkai Tan et al.   IMMUNOLOGY

Indomethacin and resveratrol as potential treatment adjuncts for SARS‐CoV‐2/COVID‐19

(2020) Mark A. Marinella   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Detection of SARS-CoV-2 in Different Types of Clinical Specimens

(2020) Wenling Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The many faces of the anti-COVID immune response

(2020) Santosha A. Vardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Covid-19 accelerates endothelial dysfunction and nitric oxide deficiency

(2020) Shawn J. Green   MICROBES AND INFECTION

Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution

(2020) Walter Gottlieb Land   Molecular Diagnosis & Therapy

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

(2020) Sin Fun Sia et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Covid-19, Angiogenesis, and ARDS Endotypes

(2020) Lida Hariri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors

(2020) Matthew Hackbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

(2020) Jianzhong Shi et al.   SCIENCE

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

(2020) Elisa d’Alessandro et al.   THROMBOSIS AND HAEMOSTASIS

D-dimer is Associated with Severity of Coronavirus Disease 2019: A Pooled Analysis

(2020) Giuseppe Lippi et al.   THROMBOSIS AND HAEMOSTASIS

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

(2020) Cynthia Magro et al.   Translational Research

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

(2020) Sharon E Fox et al.   Lancet Respiratory Medicine

Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease

(2020) Brendan T Freitas et al.   ACS Infectious Diseases

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease

(2020) Majd AlGhatrif et al.   JAMA Cardiology

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

(2020) Jing Liu et al.   EBioMedicine

SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes

(2020) Janko Nikolich-Zugich et al.   GeroScience

From causes of aging to death from COVID-19

(2020) Mikhail V. Blagosklonny   Aging-US

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2

(2020) Yu Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Atazanavir, alone or in combination with ritonavir, inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production

(2020) Natalia Fintelman-Rodrigues et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcription Factor Nrf2 as a Potential Therapeutic Target for Prevention of Cytokine Storm in COVID-19 Patients

(2020) R. A. Zinovkin et al.   BIOCHEMISTRY-MOSCOW

The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway

(2020) Tahereh Farkhondeh et al.   BIOMEDICINE & PHARMACOTHERAPY

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

COVID-19, acute respiratory distress syndrome (ARDS), and hyperbaric oxygen therapy (HBOT): what is the link?

(2020) Antonio De Maio et al.   CELL STRESS & CHAPERONES

COVID-19 and heme oxygenase: novel insight into the disease and potential therapies

(2020) Philip L. Hooper   CELL STRESS & CHAPERONES

Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients

(2020) Amr H. Sawalha et al.   CLINICAL IMMUNOLOGY

Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review

(2020) V. Montalvan et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

(2020) Gholam Hossein Meftahi et al.   INFLAMMATION RESEARCH

Clinical characteristics of 82 cases of death from COVID-19

(2020) Bicheng Zhang et al.   PLoS One

Predictors of COVID ‐19 severity: A literature review

(2020) Benjamin Gallo Marin et al.   REVIEWS IN MEDICAL VIROLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Type III interferons disrupt the lung epithelial barrier upon viral recognition

(2020) Achille Broggi et al.   SCIENCE

The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China

(2020) Jianhong Fu et al.   THROMBOSIS RESEARCH

COVID-19 Sepsis and Microcirculation Dysfunction

(2020) Antonio Colantuoni et al.   Frontiers in Physiology

Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation

(2020) Jie Liang et al.   Frontiers in Immunology

Targeting the NLRP3 Inflammasome in Severe COVID-19

(2020) Tracey L. Freeman et al.   Frontiers in Immunology

Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19

(2020) Joe M. McCord et al.   Antioxidants

Immune Phenotyping Based on the Neutrophil-to-Lymphocyte Ratio and IgG Level Predicts Disease Severity and Outcome for Patients With COVID-19

(2020) Bicheng Zhang et al.   Frontiers in Molecular Biosciences

Immunopathology of Hyperinflammation in COVID-19

(2020) Joshua N. Gustine et al.   AMERICAN JOURNAL OF PATHOLOGY

An aberrant STAT pathway is central to COVID-19

(2020) Toshifumi Matsuyama et al.   CELL DEATH AND DIFFERENTIATION

Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation

(2020) Lars Wallentin et al.   EUROPEAN HEART JOURNAL

T cell responses and therapies against SARS‐CoV‐2 infection

(2020) Salman M. Toor et al.   IMMUNOLOGY

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation

(2020) Yoojin Lee et al.   Journal of Innate Immunity

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

(2020) Rubens Cecchini et al.   MEDICAL HYPOTHESES

Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

(2020) Luca Perico et al.   Nature Reviews Nephrology

Nox2 activation in Covid-19

(2020) Francesco Violi et al.   Redox Biology

Aging in COVID-19: Vulnerability, immunity and intervention

(2020) Yiyin Chen et al.   AGEING RESEARCH REVIEWS

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

COVID‐19: Virology, biology and novel laboratory diagnosis

(2020) Malihe Mohamadian et al.   JOURNAL OF GENE MEDICINE

JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy

(2020) Sairaj Satarker et al.   POSTGRADUATE MEDICINE

The impact of ageing on monocytes and macrophages

(2020) Roel P.H. De Maeyer et al.   IMMUNOLOGY LETTERS

Pulmonary Endothelial Dysfunction and Thrombotic Complications in Patients with COVID-19

(2020) Cristina Rodríguez et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neutrophil Extracellular Traps in Arterial and Venous Thrombosis

(2019) Elodie Laridan et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

(2019) I-Yin Chen et al.   Frontiers in Microbiology

Oxidative-Inflammatory Stress in Immune Cells from Adult Mice with Premature Aging

(2019) Antonio Garrido et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting autophagy using natural compounds for cancer prevention and therapy

(2019) Shuo Deng et al.   CANCER

Health benefits of resveratrol administration

(2019) Sabina Galiniak et al.   ACTA BIOCHIMICA POLONICA

Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

Resveratrol and Vascular Function

(2019) Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation

(2019) Liselot Koelman et al.   Immunity & Ageing

The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance

(2019) Günther Schönrich et al.   Frontiers in Cellular and Infection Microbiology

What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity

(2019) Andrea Musumeci et al.   Frontiers in Immunology

Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes

(2019) Ye Zhang et al.   Annals of the New York Academy of Sciences

Vascular Endothelial Cell Biology: An Update

(2019) Krüger-Genge et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

(2019) Anna Aiello et al.   Frontiers in Immunology

Classical monocytes from older adults maintain capacity for metabolic compensation during glucose deprivation and lipopolysaccharide stimulation

(2019) Johnathan R. Yarbro et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury

(2018) Eun Nim Kim et al.   Aging-US

RIG-I and Other RNA Sensors in Antiviral Immunity

(2018) Kwan T. Chow et al.   Annual Review of Immunology

Altered monocyte phenotypes but not impaired peripheral T cell immunity may explain susceptibility of the elderly to develop tuberculosis

(2018) Russell Ault et al.   EXPERIMENTAL GERONTOLOGY

Aging impairs mitochondrial respiratory capacity in classical monocytes

(2018) Brandt D. Pence et al.   EXPERIMENTAL GERONTOLOGY

The role of oxidative stress in anxiety disorder: cause or consequence?

(2018) Alessandra das Graças Fedoce et al.   FREE RADICAL RESEARCH

An Interplay between Senescence, Apoptosis and Autophagy in Glioblastoma Multiforme—Role in Pathogenesis and Therapeutic Perspective

(2018) Elzbieta Pawlowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

How myeloid cells contribute to the pathogenesis of prominent emerging zoonotic diseases

(2018) Aroon Supramaniam et al.   JOURNAL OF GENERAL VIROLOGY

Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury

(2018) Wesley M. Raup-Konsavage et al.   KIDNEY INTERNATIONAL

Small Molecules as SIRT Modulators

(2018) Xinfa Bai et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant

(2018) Shun Kageyama et al.   MOLECULAR AND CELLULAR BIOLOGY

A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing

(2018) Pei-Hui Wang et al.   NUCLEIC ACIDS RESEARCH

Protective effects and immunomodulation on piglets infected with rotavirus following resveratrol supplementation

(2018) Qiankun Cui et al.   PLoS One

The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence

(2018) Siew-Min Ong et al.   Cell Death & Disease

Alleviation of Acute Lung Injury in Rats with Sepsis by Resveratrol via the Phosphatidylinositol 3-Kinase/Nuclear Factor-Erythroid 2 Related Factor 2/Heme Oxygenase-1 (PI3K/Nrf2/HO-1) Pathway

(2018) Yu Wang et al.   MEDICAL SCIENCE MONITOR

On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability

(2018) Lukas Diederich et al.   Frontiers in Physiology

Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus

(2018) Hong-Yan Guo et al.   Journal of Immunology Research

CD8 + T cells and NK cells: parallel and complementary soldiers of immunotherapy

(2018) Jillian Rosenberg et al.   Current Opinion in Chemical Engineering

Tetraspanins as Organizers of Antigen-Presenting Cell Function

(2018) Maria Laura Saiz et al.   Frontiers in Immunology

Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration

(2018) Jiatao Li et al.   Frontiers in Immunology

Resveratrol Modulates SIRT1 and DNMT Functions and Restores LINE-1 Methylation Levels in ARPE-19 Cells under Oxidative Stress and Inflammation

(2018) Andrea Maugeri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Antiviral Effect of Resveratrol in Piglets Infected with Virulent Pseudorabies Virus

(2018) Xinghong Zhao et al.   Viruses-Basel

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

(2018) David Olagnier et al.   Nature Communications

cGAS and STING: At the intersection of DNA and RNA virus-sensing networks

(2018) Guoxin Ni et al.   PLoS Pathogens

Physiology in Perspective: Understanding the Aging Process

(2018) Gary C. Sieck   PHYSIOLOGY

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

(2018) Chaker El Kalamouni et al.   Viruses-Basel

Vitamin D: Nutrient, Hormone, and Immunomodulator

(2018) Francesca Sassi et al.   Nutrients

Successful and Maladaptive T Cell Aging

(2017) Jörg J. Goronzy et al.   IMMUNITY

Anti-inflammatory effects of H2S during acute bacterial infection: a review

(2017) Francesca Benedetti et al.   Journal of Translational Medicine

Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults

(2017) Leticia Elizondo-Montemayor et al.   MEDIATORS OF INFLAMMATION

Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis

(2017) Yulong Wei et al.   Molecular Medicine Reports

Induction of Heme Oxygenase-1 Attenuates the Severity of Sepsis in a Non-Surgical Preterm Mouse Model

(2017) Kazumichi Fujioka et al.   SHOCK

RIG-1 and MDA-5 signaling pathways contribute to IFN-β production and viral replication in porcine circovirus virus type 2-infected PK-15 cells in vitro

(2017) Bei Huang et al.   VETERINARY MICROBIOLOGY

Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis

(2017) Áislan de Carvalho Vivarini et al.   Frontiers in Immunology

Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis

(2016) Govinda Bhattarai et al.   Acta Biomaterialia

Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity

(2016) Franck J. Barrat et al.   Annual Review of Medicine

Antiviral effect of resveratrol in ducklings infected with virulent duck enteritis virus

(2016) Xinghong Zhao et al.   ANTIVIRAL RESEARCH

Resveratrol and Lifespan in Model Organisms

(2016) Kathrin Pallauf et al.   CURRENT MEDICINAL CHEMISTRY

Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation

(2016) Payel Sil et al.   INFLAMMATION RESEARCH

Macrophages and Neutrophils: Regulation of the Inflammatory Microenvironment in Autoimmunity and Cancer

(2016) Michal A. Rahat et al.   MEDIATORS OF INFLAMMATION

The effect of vitamin D on lower respiratory tract infections in children

(2016) Tugba Sismanlar et al.   TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS

Effect of vitamin D3 on maturation and antigen-presenting function of dendritic cells treated with Mycobacterium tuberculosis

(2016) Chun-Yu Liu et al.   Asian Pacific Journal of Tropical Medicine

SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway

(2016) Shih-Wein Li et al.   Scientific Reports

An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment

(2016) Shijin Xia et al.   Journal of Immunology Research

Neutrophil Extracellular Traps Go Viral

(2016) Günther Schönrich et al.   Frontiers in Immunology

Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation

(2015) Norbert Latruffe et al.   Annals of the New York Academy of Sciences

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Attenuation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway byPorphyromonas gingivalisGingipains RgpA, RgpB, and Kgp

(2015) Masaaki Nakayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

(2015) Hin Chu et al.   JOURNAL OF INFECTIOUS DISEASES

Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension

(2015) J. Rincón et al.   LIFE SCIENCES

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Resveratrol Ameliorates Renal Damage, Increases Expression of Heme Oxygenase-1, and Has Anti-Complement, Anti-Oxidative, and Anti-Apoptotic Effects in a Murine Model of Membranous Nephropathy

(2015) Chia-Chao Wu et al.   PLoS One

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Regulatory T cell identity: formation and maintenance

(2015) Xudong Li et al.   TRENDS IN IMMUNOLOGY

Foxp3 + CD4 + T Cells Improve Healing After Myocardial Infarction by Modulating Monocyte/Macrophage Differentiation

(2014) Johannes Weirather et al.   CIRCULATION RESEARCH

Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model

(2014) Naofumi Tamaki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration

(2014) Yvonne Samstag et al.   IMMUNOLOGICAL REVIEWS

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA

(2014) A. Agrawal et al.   JOURNAL OF IMMUNOLOGY

Sulfur compounds block MCP-1 production by Mycoplasma fermentans-infected macrophages through NF-κB inhibition

(2014) Francesca Benedetti et al.   Journal of Translational Medicine

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Inflammasomes in cancer: a double-edged sword

(2014) Ryan Kolb et al.   Protein & Cell

Vitamin D in inflammatory diseases

(2014) Thea K. Wöbke et al.   Frontiers in Physiology

Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging

(2014) Joy G. Mohanty et al.   Frontiers in Physiology

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

(2013) Rafał Kozieł et al.   BIOCHEMICAL JOURNAL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The Th17/Treg balance is disturbed during aging

(2013) Vanessa Schmitt et al.   EXPERIMENTAL GERONTOLOGY

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy

(2013) Veera Ganesh Yerra et al.   Redox Biology

The role of the T cell in age-related inflammation

(2012) Richard Macaulay et al.   AGE

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18

(2012) Anthony J. Valente et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin II and Oxidative Stress in the Failing Heart

(2012) Daniela Zablocki et al.   ANTIOXIDANTS & REDOX SIGNALING

Angiotensin II-Induced Production of Mitochondrial Reactive Oxygen Species: Potential Mechanisms and Relevance for Cardiovascular Disease

(2012) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Loss of stress response as a consequence of viral infection: implications for disease and therapy

(2012) Philip L. Hooper et al.   CELL STRESS & CHAPERONES

Neutrophil – CD4+CD25+ T regulatory cell interactions: A possible new mechanism of infectious tolerance

(2012) Natalia Lewkowicz et al.   IMMUNOBIOLOGY

Age-Associated Proinflammatory Secretory Phenotype in Vascular Smooth Muscle Cells From the Non-human Primate Macaca mulatta: Reversal by Resveratrol Treatment

(2012) A. Csiszar et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resveratrol and apoptosis

(2011) Hung-Yun Lin et al.   Annals of the New York Academy of Sciences

Macrophages and Tissue Injury: Agents of Defense or Destruction?

(2011) Debra L. Laskin et al.   Annual Review of Pharmacology and Toxicology

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

CD103+pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen

(2011) A. Nicole Desch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

(2011) Venizelos Papayannopoulos et al.   PLoS One

The Nrf2-ARE Pathway

(2010) Jeffrey A. Johnson et al.   Annals of the New York Academy of Sciences

Aging and Immune Function: Molecular Mechanisms to Interventions

(2010) Subramaniam Ponnappan et al.   ANTIOXIDANTS & REDOX SIGNALING

Antiviral activity of resveratrol: Table 1

(2010) Michela Campagna et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults

(2010) Sebastian Seidler et al.   BMC IMMUNOLOGY

Vitamin D: modulator of the immune system

(2010) Femke Baeke et al.   CURRENT OPINION IN PHARMACOLOGY

ACE2–angiotensin-(1–7)–Mas axis and oxidative stress in cardiovascular disease

(2010) Luiza A Rabelo et al.   HYPERTENSION RESEARCH

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Impaired Functions of Peripheral Blood Monocyte Subpopulations in Aged Humans

(2010) Joseph Nyugen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool

(2010) P. J. E. J. van de Berg et al.   JOURNAL OF IMMUNOLOGY

Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

(2010) Alexander Panda et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial translocation of oxidized cofilin induces caspase-independent necrotic-like programmed cell death of T cells

(2010) G H Wabnitz et al.   Cell Death & Disease

Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

(2010) Saskia L. Smits et al.   PLoS Pathogens

Candidate Genes Associated with Susceptibility for SARS-Coronavirus

(2009) Ying-Hen Hsieh et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Hyperbaric oxygen induces a cytoprotective and angiogenic response in human microvascular endothelial cells

(2009) Cassandra A. Godman et al.   CELL STRESS & CHAPERONES

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury

(2009) Franco R. D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

Telomere Diseases

(2009) Rodrigo T. Calado et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

Dysregulation of TLR3 Impairs the Innate Immune Response to West Nile Virus in the Elderly

(2008) K.-F. Kong et al.   JOURNAL OF VIROLOGY

Mechanisms of Severe Acute Respiratory Syndrome Pathogenesis and Innate Immunomodulation

(2008) M. Frieman et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Vitamin D: a D-Lightful health perspective

(2008) Michael F Holick   NUTRITION REVIEWS

Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression

(2008) Eva-K. Pauli et al.   PLoS Pathogens

The immune system in extreme longevity

(2007) P. Sansoni et al.   EXPERIMENTAL GERONTOLOGY