What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity

Integrative single-cell analysis

(2019) Tim Stuart et al.   NATURE REVIEWS GENETICS

Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation

(2018) Jason D. Buenrostro et al.   CELL

Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection

(2018) Monica Macal et al.   IMMUNITY

Homeostatic control of dendritic cell numbers and differentiation

(2018) Regine J Dress et al.   IMMUNOLOGY AND CELL BIOLOGY

Clonal analysis of lineage fate in native haematopoiesis

(2018) Alejo E. Rodriguez-Fraticelli et al.   NATURE

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

(2018) Amir Giladi et al.   NATURE CELL BIOLOGY

Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells

(2018) Patrick Fernandes Rodrigues et al.   NATURE IMMUNOLOGY

FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data

(2018) Josip S Herman et al.   NATURE METHODS

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

(2018) Marie Dominique Ah Kioon et al.   Science Translational Medicine

DiSNE Movie Visualization and Assessment of Clonal Kinetics Reveal Multiple Trajectories of Dendritic Cell Development

(2018) Dawn S. Lin et al.   Cell Reports

Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo

(2018) Johanna Salvermoser et al.   Frontiers in Immunology

Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells

(2018) Colleen M. Lau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification

(2017) Lucja T. Grajkowska et al.   IMMUNITY

CD8 + T Cells Orchestrate pDC-XCR1 + Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming

(2017) Anna Brewitz et al.   IMMUNITY

Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments

(2017) Nobuyuki Onai et al.   INTERNATIONAL IMMUNOLOGY

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo

(2017) Weike Pei et al.   NATURE

A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes

(2017) Hong Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the human DC lineage through the integration of high-dimensional techniques

(2017) Peter See et al.   SCIENCE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Dendritic cell subsets

(2017) Christophe Macri et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Transcriptional Control of Dendritic Cell Development

(2016) Theresa L. Murphy et al.   Annual Review of Immunology

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

(2016) Diego Adhemar Jaitin et al.   CELL

IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively

(2016) Dorine Sichien et al.   IMMUNITY

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

(2016) Martin Guilliams et al.   IMMUNITY

A CD2 high-expressing stress-resistant human plasmacytoid dendritic-cell subset

(2016) Christian Bryant et al.   IMMUNOLOGY AND CELL BIOLOGY

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

(2016) Charlotte L. Scott et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c + or CD141 + DCs

(2016) Gaëlle Breton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IFN-β Expression in the Spleen Is Restricted to a Subpopulation of Plasmacytoid Dendritic Cells Exhibiting a Specific Immune Modulatory Transcriptome Signature

(2016) Jens Bauer et al.   JOURNAL OF IMMUNOLOGY

Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences

(2016) Gael Auray et al.   JOURNAL OF IMMUNOLOGY

Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate

(2016) Xiaodi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Continuous single cell imaging reveals sequential steps of plasmacytoid dendritic cell development from common dendritic cell progenitors

(2016) Ezgi Dursun et al.   Scientific Reports

The Branching Point in Erythro-Myeloid Differentiation

(2015) Leïla Perié et al.   CELL

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2015) Franziska Paul et al.   CELL

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor

(2015) Gary E Grajales-Reyes et al.   NATURE IMMUNOLOGY

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow

(2015) Andreas Schlitzer et al.   NATURE IMMUNOLOGY

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

(2014) Sarah L. Rowland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

(2014) Vanja Sisirak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2

(2014) Hiyaa S. Ghosh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell technologies sharpen up mammalian stem cell research

(2014) Philipp S. Hoppe et al.   NATURE CELL BIOLOGY

Dendritic cell fate is determined by BCL11A

(2014) G. C. Ippolito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

(2013) G. Nizzoli et al.   BLOOD

Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage

(2013) Barbara U. Schraml et al.   CELL

Sca-1 expression defines developmental stages of mouse pDCs that show functional heterogeneity in the endosomal but not lysosomal TLR9 response

(2013) Marina Niederquell et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Clonogenic Progenitor with Prominent Plasmacytoid Dendritic Cell Developmental Potential

(2013) Nobuyuki Onai et al.   IMMUNITY

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Cross-presentation by human dendritic cell subsets

(2013) Elodie Segura et al.   IMMUNOLOGY LETTERS

A type I IFN–Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors

(2013) Yi-Ling Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diverse and heritable lineage imprinting of early haematopoietic progenitors

(2013) Shalin H. Naik et al.   NATURE

Neonatal Plasmacytoid Dendritic Cells (pDCs) Display Subset Variation but Can Elicit Potent Anti-Viral Innate Responses

(2013) Xiaoming Zhang et al.   PLoS One

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation

(2013) Jesse W. Williams et al.   Nature Communications

Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells

(2012) P. Sathe et al.   BLOOD

Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor

(2012) A. Schlitzer et al.   BLOOD

Plasmacytoid Dendritic Cells Transport Peripheral Antigens to the Thymus to Promote Central Tolerance

(2012) Husein Hadeiba et al.   IMMUNITY

Zbtb46expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages

(2012) Ansuman T. Satpathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Identification of CCR9- murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs

(2011) A. Schlitzer et al.   BLOOD

Antigen Targeting to Plasmacytoid Dendritic Cells via Siglec-H Inhibits Th Cell-Dependent Autoimmunity

(2011) J. Loschko et al.   JOURNAL OF IMMUNOLOGY

Continuous Expression of the Transcription Factor E2-2 Maintains the Cell Fate of Mature Plasmacytoid Dendritic Cells

(2010) Hiyaa S. Ghosh et al.   IMMUNITY

Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual

(2010) Melissa Swiecki et al.   IMMUNITY

The CD8+dendritic cell subset

(2010) Ken Shortman et al.   IMMUNOLOGICAL REVIEWS

MHC class II–restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell–mediated autoimmunity

(2010) Magali Irla et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD2 Distinguishes Two Subsets of Human Plasmacytoid Dendritic Cells with Distinct Phenotype and Functions

(2009) T. Matsui et al.   JOURNAL OF IMMUNOLOGY

Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development

(2008) Babacar Cisse et al.   CELL