Journal
VIRUSES-BASEL
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/v11010002
Keywords
antiviral; heme-oxygenase 1; Zika virus; viral replication
Categories
Funding
- Federation BioST from Reunion Island University
- ZIKAlliance project (European Union-Horizon 2020 program) [735548]
- ZIKAlert project (European Union-Region Reunion program) [SYNERGY: RE0001902]
- Regional Council of Reunion Island (European Union-Region Reunion program) [SYNERGY: RE0012406]
- Regional Council of Reunion Island [DIRED 20131515]
- La Reunion Island University - French ministry MEESR
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Heme oxygenase-1 (HO-1), a rate-limiting enzyme involved in the degradation of heme, is induced in response to a wide range of stress conditions. HO-1 exerts antiviral activity against a broad range of viruses, including the Hepatitis C virus, the human immunodeficiency virus, and the dengue virus by inhibiting viral growth. It has been reported that HO-1 displays antiviral activity against the Zika virus (ZIKV) but the mechanisms of viral inhibition remain largely unknown. Using a ZIKV RNA replicon with the Green Fluorescent Protein (GFP) as a reporter protein, we were able to show that HO-1 expression resulted in the inhibition of viral RNA replication. Conversely, we observed a decrease in HO-1 expression in cells replicating the ZIKV RNA replicon. The study of human cells infected with ZIKV showed that the HO-1 expression level was significantly lower once viral replication was established, thereby limiting the antiviral effect of HO-1. Our work highlights the capacity of ZIKV to thwart the anti-replicative activity of HO-1 in human cells. Therefore, the modulation of HO-1 as a novel therapeutic strategy against ZIKV infection may display limited effect.
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