4.5 Article

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2


Volume 368, Issue 6494, Pages 1016-+


DOI: 10.1126/science.abb7015




  1. National Key RAMP
  2. D Program of China [2020YFC0846500, 2018YFC1200601, 2016YFD0500301]

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Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19 (coronavirus disease 2019), which was first reported in Wuhan, China, in December 2019. Despite extensive efforts to control the disease, COVID-19 has now spread to more than 100 countries and caused a global pandemic. SARS-CoV-2 is thought to have originated in bats; however, the intermediate animal sources of the virus are unknown. In this study, we investigated the susceptibility of ferrets and animals in close contact with humans to SARS-CoV-2. We found that SARS-CoV-2 replicates poorly in dogs, pigs, chickens, and ducks, but ferrets and cats are permissive to infection. Additionally, cats are susceptible to airborne transmission. Our study provides insights into the animal models for SARS-CoV-2 and animal management for COVID-19 control.


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Harwinder Sidhu
Interesting article! According to this paper pigs chickens and ducks are not susceptible to covid. However a recent Canada-US study done by University of Iowa found pigs to be susceptible to covid19.
Amy Case
How widespread or significant did this turn out to be?
Zachery Wolfe
The unknown mechanism that prevents replication of covid in the lower respiratory tract of ferrets could have huge implications for human health. I am excited to see if the researchers follow up!


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