Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

(2020) Camillo Sargiacomo et al.   Aging-US

Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review

(2020) Jaume Alijotas-Reig et al.   AUTOIMMUNITY REVIEWS

COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome?

(2020) Serena Colafrancesco et al.   AUTOIMMUNITY REVIEWS

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Withanone and withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells

(2020) Vipul Kumar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

SARS-CoV-2: a storm is raging

(2020) Savannah F. Pedersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

(2020) Jing Liu et al.   EBioMedicine

Redox regulation by NRF2 in aging and disease

(2019) Cody J. Schmidlin et al.   FREE RADICAL BIOLOGY AND MEDICINE

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner

(2019) Dong-Dong Huang et al.   EXPERIMENTAL GERONTOLOGY

HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression

(2019) Tianjing Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program

(2019) Emanuel Wyler et al.   Nature Communications

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines

(2019) Paola Pontecorvi et al.   Journal of Neuroinflammation

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

(2018) Moataz Abdalkader et al.   Frontiers in Neuroscience

Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells

(2018) Lulu Zhou et al.   Redox Biology

RA-839, a selective agonist of Nrf2/ARE pathway, exerts potent anti-rotaviral efficacy in vitro

(2018) Upayan Patra et al.   ANTIVIRAL RESEARCH

Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway

(2018) Choongho Lee   Oxidative Medicine and Cellular Longevity

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

(2018) Chaker El Kalamouni et al.   Viruses-Basel

Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein ‐ ring finger protein 4 dependent pathway

(2017) Narayana Komaravelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

HIV-1 decreases Nrf2/ARE activity and phagocytic function in alveolar macrophages

(2017) Bashar S. Staitieh et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Frailty Is Associated With Lower Expression of Genes Involved in Cellular Response to Stress: Results From the Toledo Study for Healthy Aging

(2017) Mariam El Assar et al.   Journal of the American Medical Directors Association

Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay

(2016) Mizuki Yamamoto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis

(2016) Gaia Skibinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA Regulation of Human Genes Essential for Influenza A (H7N9) Replication

(2016) Stefan Wolf et al.   PLoS One

A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation

(2015) Meike Dittmann et al.   CELL

Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2

(2015) Narayana Komaravelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression

(2015) Violetta Krajka-Kuźniak et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection

(2014) Robert F Foronjy et al.   BMC IMMUNOLOGY

Comparison of Varicella-Zoster Virus RNA Sequences in Human Neurons and Fibroblasts

(2014) N. L. Baird et al.   JOURNAL OF VIROLOGY

TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice

(2014) C. Tarnow et al.   JOURNAL OF VIROLOGY

Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking

(2014) A Sato et al.   LEUKEMIA

Whole Blood Transcriptional Profiling Reveals Deregulation of Oxidative and Antioxidative Defence Genes in Myelofibrosis and Related Neoplasms. Potential Implications of Downregulation of Nrf2 for Genomic Instability and Disease Progression

(2014) Hans Carl Hasselbalch et al.   PLoS One

Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells

(2014) David Olagnier et al.   PLoS Pathogens

Differential Response of Primary Alveolar Type I and Type II Cells to LPS Stimulation

(2013) Mandi H. Wong et al.   PLoS One

Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice

(2013) Bastian Hatesuer et al.   PLoS Pathogens

Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry

(2012) M. Kawase et al.   JOURNAL OF VIROLOGY

Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells

(2011) Matthew J. Kesic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

(2011) Yumiko Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Nrf2 in Host Defense against Influenza Virus in Cigarette Smoke-Exposed Mice

(2011) Y. Yageta et al.   JOURNAL OF VIROLOGY

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

(2011) Brooks M. Hybertson et al.   MOLECULAR ASPECTS OF MEDICINE

Fast and SNP-tolerant detection of complex variants and splicing in short reads

(2010) T. D. Wu et al.   BIOINFORMATICS

Differential Cellular Responses to Protein Adducts of Naphthoquinone and Monocrotaline Pyrrole

(2010) Lynn S. Nakayama Wong et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity

(2010) K. N. Lewis et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Effects of Positive Iron Status at a Cellular Level

(2010) Joe M. McCord   NUTRITION REVIEWS

Identification of three novel plasminogen (PLG) gene mutations in a series of 23 patients with low PLG activity

(2010) Jürgen Klammt et al.   THROMBOSIS AND HAEMOSTASIS

Antiviral Activity of Nrf2 in a Murine Model of Respiratory Syncytial Virus Disease

(2008) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE