Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

Microbe- and danger-induced inflammation

(2015) Achille Broggi et al.   MOLECULAR IMMUNOLOGY

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

(2014) Madalina V. Nastase et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Interaction of S100A13 with C2 domain of receptor for advanced glycation end products (RAGE)

(2014) Sandhya G. Rani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mitochondrial damage-associated molecular patterns and vascular function

(2014) C. F. Wenceslau et al.   EUROPEAN HEART JOURNAL

Soluble biglycan as a biomarker of inflammatory renal diseases

(2014) Louise Tzung-Harn Hsieh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

S100A4 and Uric Acid Promote Mesenchymal Stromal Cell Induction of IL-10+/IDO+ Lymphocytes

(2014) J. L. Eisenbacher et al.   JOURNAL OF IMMUNOLOGY

Blood transfusion products contain mitochondrial DNA damage-associated molecular patterns: a potential effector of transfusion-related acute lung injury

(2014) Yann-Leei Lee et al.   JOURNAL OF SURGICAL RESEARCH

Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis

(2014) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury

(2014) Kristin Moreth et al.   MATRIX BIOLOGY

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

(2014) Jonathan P. Little et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondrial DAMPs Induce Endotoxin Tolerance in Human Monocytes: An Observation in Patients with Myocardial Infarction

(2014) Irene Fernández-Ruiz et al.   PLoS One

Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4

(2014) Katharine J. Goodall et al.   PLoS One

The Expression of HMGB1 on Microparticles from Jurkat and HL-60 Cells Undergoing Apoptosisin vitro

(2014) D. M. Spencer et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals

(2014) A Maeda et al.   Cell Death & Disease

DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway

(2014) Su-Yu Tsai et al.   PLoS Pathogens

Syndecans as Modulators and Potential Pharmacological Targets in Cancer Progression

(2014) Despoina Barbouri et al.   Frontiers in Oncology

The Translocation of Nuclear Molecules During Inflammation and Cell Death

(2013) David S. Pisetsky   ANTIOXIDANTS & REDOX SIGNALING

DAMPs and autophagy

(2013) Qiuhong Zhang et al.   Autophagy

Cellular signalling of the receptor for advanced glycation end products (RAGE)

(2013) Jianling Xie et al.   CELLULAR SIGNALLING

Histones trigger sterile inflammation by activating the NLRP3 inflammasome

(2013) Ramanjaneyulu Allam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Biological interplay between proteoglycans and their innate immune receptors in inflammation

(2013) Helena Frey et al.   FEBS Journal

The interplay between pathogen-associated and danger-associated molecular patterns: an inflammatory code in cancer?

(2013) Monica Escamilla-Tilch et al.   IMMUNOLOGY AND CELL BIOLOGY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Versatile role of heparanase in inflammation

(2013) Rachel Goldberg et al.   MATRIX BIOLOGY

Strange attractors: DAMPs and autophagy link tumor cell death and immunity

(2013) W Hou et al.   Cell Death & Disease

ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner

(2012) Claudio Marcelo Fader et al.   Autophagy

Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation

(2012) T. V. Brennan et al.   BLOOD

Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation

(2012) Kristin Moreth et al.   CELL CYCLE

Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation

(2012) Liliana Schaefer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death

(2012) Christian Beyer et al.   Innate Immunity

Biglycan

(2012) Madalina V. Nastase et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Unknown

(2012) Huan Yang et al.   MOLECULAR MEDICINE

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

ATP Release from Dying Autophagic Cells and Their Phagocytosis Are Crucial for Inflammasome Activation in Macrophages

(2012) Gizem Ayna et al.   PLoS One

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification

(2012) M. Oldenburg et al.   SCIENCE

A Comparative Study of Fibronectin Cleavage by MMP-1, -3, -13, and -14

(2012) Xiaorong Zhang et al.   Cartilage

Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications

(2011) Ravichandran Ramasamy et al.   Annals of the New York Academy of Sciences

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages

(2011) Wei Li et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus

(2011) V. Urbonaviciute et al.   JOURNAL OF INTERNAL MEDICINE

Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease

(2011) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21

(2011) R. Merline et al.   Science Signaling

The Structural Biology of Toll-like Receptors

(2011) Istvan Botos et al.   STRUCTURE

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

The Danger Signal S100B Integrates Pathogen– and Danger–Sensing Pathways to Restrain Inflammation

(2011) Guglielmo Sorci et al.   PLoS Pathogens

The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

(2010) Kristin Moreth et al.   JOURNAL OF CLINICAL INVESTIGATION

Uric acid promotes an acute inflammatory response to sterile cell death in mice

(2010) Hajime Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

IL-1β Processing in Host Defense: Beyond the Inflammasomes

(2010) Mihai G. Netea et al.   PLoS Pathogens

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

(2009) Pamela Gasse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

CD14 but not MD2 transmit signals from DAMP

(2009) Kyung-Hee Chun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

(2009) Kenshi Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

NETs: a new strategy for using old weapons

(2009) Venizelos Papayannopoulos et al.   TRENDS IN IMMUNOLOGY

The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis

(2008) Trinh T. Tran et al.   BIOMARKERS

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die

(2008) J Thorburn et al.   CELL DEATH AND DIFFERENTIATION

A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS

(2008) S. Lehnardt et al.   JOURNAL OF NEUROSCIENCE