Alzheimer’s Disease Genetics: A Dampened Microglial Response?

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia

(2021) Andy P. Tsai et al.   NEUROBIOLOGY OF DISEASE

Interpretation of risk loci from genome-wide association studies of Alzheimer's disease

(2020) Shea J Andrews et al.   LANCET NEUROLOGY

Human Herpesvirus 6 Detection in Alzheimer’s Disease Cases and Controls across Multiple Cohorts

(2020) Mary Alice Allnutt et al.   NEURON

Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1

(2020) Julia Minderjahn et al.   Nature Communications

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

(2020) Kai Schlepckow et al.   EMBO Molecular Medicine

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

(2020) Shoutang Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

(2020) Benjamin J. Andreone et al.   NATURE NEUROSCIENCE

Attenuated immune control of Epstein Barr virus in humanized mice is associated with the multiple sclerosis risk factor HLA‐DR15

(2020) Hana Zdimerova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

(2020) Mari Takalo et al.   Molecular Neurodegeneration

Association of blood-based transcriptional risk scores with biomarkers for Alzheimer disease

(2020) Young Ho Park et al.   Neurology-Genetics

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

(2020) Marta Olah et al.   Nature Communications

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

(2019) Lorenza Magno et al.   Alzheimers Research & Therapy

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Evaluation of CD33 as a genetic risk factor for Alzheimer’s disease

(2019) Steven Estus et al.   ACTA NEUROPATHOLOGICA

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

(2019) Sven J. van der Lee et al.   ACTA NEUROPATHOLOGICA

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

(2019) Ana Griciuc et al.   NEURON

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

Mapping microglia states in the human brain through the integration of high-dimensional techniques

(2019) Roman Sankowski et al.   NATURE NEUROSCIENCE

Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

(2019) Hailan Yao et al.   Frontiers in Cellular Neuroscience

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

B-cell Therapy for Multiple Sclerosis: Entering an era

(2018) Ariele L. Greenfield et al.   ANNALS OF NEUROLOGY

A story of birth and death: Insights into the formation and dynamics of the microglial population

(2018) Katharine Askew et al.   BRAIN BEHAVIOR AND IMMUNITY

Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis

(2018) Maneesh K. Misra et al.   GENES AND IMMUNITY

Molecular basis for the loss-of-function effects of the Alzheimer’s disease–associated R47H variant of the immune receptor TREM2

(2018) Athena Sudom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain

(2018) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

(2018) Mario Merlini et al.   Neurodegenerative Diseases

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

(2018) C.Y. Daniel Lee et al.   NEURON

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

(2018) Ben Readhead et al.   NEURON

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

GWAS on family history of Alzheimer’s disease

(2018) Riccardo E. Marioni et al.   Translational Psychiatry

The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response

(2018) Liqian Zhu et al.   Journal of Immunology Research

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

(2018) Justin Rustenhoven et al.   Molecular Neurodegeneration

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

(2018) Faten A. Sayed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases

(2018) Hiroyuki Konishi et al.   Frontiers in Cellular Neuroscience

Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

(2018) Sonja Rakic et al.   Acta Neuropathologica Communications

Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2

(2018) Christel Claes et al.   Alzheimers & Dementia

Microglia and the Brain: Complementary Partners in Development and Disease

(2018) Timothy R. Hammond et al.   Annual Review of Cell and Developmental Biology

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

(2018) Nisha Rathore et al.   PLoS Genetics

Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis

(2018) Hongmei Li et al.   Translational Neurodegeneration

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

(2017) Kuan-lin Huang et al.   NATURE NEUROSCIENCE

Location, Location, Location: Microglia Are Where They Live

(2017) Margaret M. McCarthy   NEURON

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia

(2017) Douglas G. Walker et al.   Frontiers in Aging Neuroscience

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study

(2017) Natasha Z. R. Steele et al.   PLOS MEDICINE

Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?

(2017) Shyam Sushama Jose et al.   Frontiers in Immunology

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

(2016) Laura Piccio et al.   ACTA NEUROPATHOLOGICA

TREM1 facilitates microglial phagocytosis of amyloid beta

(2016) Teng Jiang et al.   ACTA NEUROPATHOLOGICA

Why NAD + Declines during Aging: It’s Destroyed

(2016) Michael B. Schultz et al.   Cell Metabolism

Repression of telomere-associated genes by microglia activation in neuropsychiatric disease

(2016) Golo Kronenberg et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

(2016) Taylor R. Jay et al.   JOURNAL OF NEUROSCIENCE

The silent war of CMV in aging and HIV infection

(2016) Rita B. Effros   MECHANISMS OF AGEING AND DEVELOPMENT

Assessment of the genetic variance of late-onset Alzheimer's disease

(2016) Perry G. Ridge et al.   NEUROBIOLOGY OF AGING

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes

(2016) Kambis Sadeghi et al.   PLoS One

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

(2015) Christina M. Lill et al.   Alzheimers & Dementia

ATREM1variant alters the accumulation of Alzheimer-related amyloid pathology

(2015) Joseph M. Replogle et al.   ANNALS OF NEUROLOGY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

CD33 modulates TREM2: convergence of Alzheimer loci

(2015) Gail Chan et al.   NATURE NEUROSCIENCE

Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex

(2015) Douglas G. Walker et al.   NEUROBIOLOGY OF AGING

Human-specific derived alleles ofCD33and other genes protect against postreproductive cognitive decline

(2015) Flavio Schwarz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brief Report: Connecting Two Pathways Through Ca2+Signaling: NLRP3 Inflammasome Activation Induced by a HypermorphicPLCG2Mutation

(2015) Jae Jin Chae et al.   Arthritis & Rheumatology

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Chronic Inflammatory Disorders and Risk of Type 2 Diabetes Mellitus, Coronary Heart Disease, and Stroke

(2014) Alex Dregan et al.   CIRCULATION

CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility

(2014) T. Raj et al.   HUMAN MOLECULAR GENETICS

Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1)-mediated Bcl-2 Induction Prolongs Macrophage Survival

(2014) Zhihong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative Regulation of Toll-like Receptor-4 Signaling through the Binding of Glycosylphosphatidylinositol-anchored Glycoprotein, CD14, with the Sialic Acid-binding Lectin, CD33

(2014) Akiko Ishida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide

(2014) K. Dower et al.   JOURNAL OF IMMUNOLOGY

Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia

(2014) Tijmen J Hommes et al.   JOURNAL OF PATHOLOGY

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

(2014) Mitchell R. White et al.   PLoS One

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

Homeostatic and injury-induced microglia behavior in the aging brain

(2013) Jasmin K. Hefendehl et al.   AGING CELL

Association of Parkinson Disease with Structural and Regulatory Variants in the HLA Region

(2013) William T. Wissemann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Activation of Triggering Receptor Expressed on Myeloid Cells-1 Protects Monocyte from Apoptosis through Regulation of Myeloid Cell Leukemia-1

(2013) MeiTing Cai et al.   ANESTHESIOLOGY

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Complexities in the Relationship Between Infection and Autoimmunity

(2013) Robert Root-Bernstein et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Can Infections Cause Alzheimer's Disease?

(2013) F. Mawanda et al.   EPIDEMIOLOGIC REVIEWS

Induction of myelodysplasia by myeloid-derived suppressor cells

(2013) Xianghong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

(2013) Jian Luo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing

(2013) M. Malik et al.   JOURNAL OF NEUROSCIENCE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Attenuated Inflammatory Response in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Knock-Out Mice following Stroke

(2013) Matthias W. Sieber et al.   PLoS One

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Evidence for impaired amyloid β clearance in Alzheimer's disease

(2013) Kristin R Wildsmith et al.   Alzheimers Research & Therapy

A Hypermorphic Missense Mutation in PLCG2 , Encoding Phospholipase Cγ2, Causes a Dominantly Inherited Autoinflammatory Disease with Immunodeficiency

(2012) Qing Zhou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease

(2012) Sang-Sun Yoon et al.   Biomolecules & Therapeutics

Autoimmune heart disease: role of sex hormones and autoantibodies in disease pathogenesis

(2012) DeLisa Fairweather et al.   Expert Review of Clinical Immunology

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors

(2012) R. J. W. Arts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

TGF-β induced by interleukin-34-stimulated microglia regulates microglial proliferation and attenuates oligomeric amyloid β neurotoxicity

(2012) Di Ma et al.   NEUROSCIENCE LETTERS

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Herpesvirus Exploitation of Host Immune Inhibitory Pathways

(2012) Gabrielle Stack et al.   Viruses-Basel

National estimates of the prevalence of Alzheimer’s disease in the United States

(2011) Ron Brookmeyer et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Interleukin-34 Selectively Enhances the Neuroprotective Effects of Microglia to Attenuate Oligomeric Amyloid-β Neurotoxicity

(2011) Tetsuya Mizuno et al.   AMERICAN JOURNAL OF PATHOLOGY

Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells

(2011) A. B. Perez-Oliva et al.   GLYCOBIOLOGY

Phospholipase Cγ-2 and Intracellular Calcium Are Required for Lipopolysaccharide-induced Toll-like Receptor 4 (TLR4) Endocytosis and Interferon Regulatory Factor 3 (IRF3) Activation

(2011) Chih-Yuan Chiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Age-related alterations in the dynamic behavior of microglia

(2010) Mausam R. Damani et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways

(2010) P Prieto et al.   CELL DEATH AND DIFFERENTIATION

Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

(2010) Huan Cao et al.   IMMUNOLOGY

Alzheimer's disease genetics: current knowledge and future challenges

(2010) Paul Hollingworth et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

(2010) Suwen Wei et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy

(2009) Justin Zaghi et al.   ACTA NEUROPATHOLOGICA

Immune blood biomarkers of Alzheimer disease patients

(2009) Hripsime Avagyan et al.   JOURNAL OF NEUROIMMUNOLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Siglecs as positive and negative regulators of the immune system: Figure 1

(2008) Paul R. Crocker et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B

(2008) Takeshi Satoh et al.   CELL

From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

(2008) Omar Sharif et al.   IMMUNOBIOLOGY

DAP10- and DAP12-associated receptors in innate immunity

(2008) Lewis L. Lanier   IMMUNOLOGICAL REVIEWS

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE