Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

(2018) Pablo Garcia-Reitboeck et al.   Cell Reports

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior

(2017) Y R Yang et al.   MOLECULAR PSYCHIATRY

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

(2017) Erika Castillo et al.   Scientific Reports

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

(2016) Bosiljka Tasic et al.   NATURE NEUROSCIENCE

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

(2016) Mariet Allen et al.   Scientific Data

Convergent genetic and expression data implicate immunity in Alzheimer's disease

(2015) Lesley Jones et al.   Alzheimers & Dementia

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis

(2015) Xuehua Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Protective alleles and modifier variants in human health and disease

(2015) Andrew R. Harper et al.   NATURE REVIEWS GENETICS

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

(2015) Mar Matarin et al.   Cell Reports

Brief Report: Connecting Two Pathways Through Ca2+Signaling: NLRP3 Inflammasome Activation Induced by a HypermorphicPLCG2Mutation

(2015) Jae Jin Chae et al.   Arthritis & Rheumatology

PLCG1 mutations in cutaneous T-cell lymphomas

(2014) José P. Vaqué et al.   BLOOD

Dysfunction of phospholipase Cγ in immune disorders and cancer

(2014) Hans Koss et al.   TRENDS IN BIOCHEMICAL SCIENCES

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

DCC Expression by Neurons Regulates Synaptic Plasticity in the Adult Brain

(2013) Katherine E. Horn et al.   Cell Reports

A Hypermorphic Missense Mutation in PLCG2 , Encoding Phospholipase Cγ2, Causes a Dominantly Inherited Autoinflammatory Disease with Immunodeficiency

(2012) Qing Zhou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cold Urticaria, Immunodeficiency, and Autoimmunity Related toPLCG2Deletions

(2012) Michael J. Ombrello et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

(2011) Koichiro Abe et al.   ARTHRITIS AND RHEUMATISM

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

The Germinal Zones of the Basal Ganglia But Not the Septum Generate GABAergic Interneurons for the Cortex

(2010) A. N. Rubin et al.   JOURNAL OF NEUROSCIENCE

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

TREM and TREM-like receptors in inflammation and disease

(2009) Jill W Ford et al.   CURRENT OPINION IN IMMUNOLOGY

Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations

(2009) Katy L. Everett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY