Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?
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Title
Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?
Authors
Keywords
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Journal
IMMUNOLOGY
Volume 132, Issue 1, Pages 18-26
Publisher
Wiley
Online
2010-11-11
DOI
10.1111/j.1365-2567.2010.03368.x
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Note: Only part of the references are listed.- CD22 x Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and Develop Systemic Autoimmunity
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- Comparative genomics indicates the mammalian CD33rSiglec locus evolved by an ancient large-scale inverse duplication and suggests all Siglecs share a common ancestral region
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- SIGLEC16encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpartSIGLEC11and has functional and non-functional alleles in humans
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