Herpesvirus Exploitation of Host Immune Inhibitory Pathways

Cutting Edge: Programmed Death-1 Up-Regulation Is Involved in the Attrition of Cytomegalovirus-Specific CD8+ T Cells in Acute Self-Limited Hepatitis B Virus Infection

(2014) J.-Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell Programming by Cytomegalovirus Stunts Naive T Cell Responses via the PD-L1/PD-1 Pathway

(2014) C. A. Benedict et al.   JOURNAL OF IMMUNOLOGY

Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis

(2014) M. Lafon et al.   JOURNAL OF IMMUNOLOGY

IL-10 and Natural Regulatory T Cells: Two Independent Anti-Inflammatory Mechanisms in Herpes Simplex Virus-Induced Ocular Immunopathology

(2014) Pranita P. Sarangi et al.   JOURNAL OF IMMUNOLOGY

PDL-1 Blockade Impedes T Cell Expansion and Protective Immunity Primed by Attenuated Listeria monocytogenes

(2014) J. H. Rowe et al.   JOURNAL OF IMMUNOLOGY

IL-10: The Master Regulator of Immunity to Infection

(2014) Kevin N. Couper et al.   JOURNAL OF IMMUNOLOGY

Constitutive AP-1 Activity and EBV Infection Induce PD-L1 in Hodgkin Lymphomas and Posttransplant Lymphoproliferative Disorders: Implications for Targeted Therapy

(2012) M. R. Green et al.   CLINICAL CANCER RESEARCH

Suppression of Antigen-Specific T Cell Responses by the Kaposi's Sarcoma-Associated Herpesvirus Viral OX2 Protein and Its Cellular Orthologue, CD200

(2012) K. Misstear et al.   JOURNAL OF VIROLOGY

IL-10 Regulates Viral Lung Immunopathology during Acute Respiratory Syncytial Virus Infection in Mice

(2012) Jens Loebbermann et al.   PLoS One

Host Immune Responses to a Viral Immune Modulating Protein: Immunogenicity of Viral Interleukin-10 in Rhesus Cytomegalovirus-Infected Rhesus Macaques

(2012) Meghan K. Eberhardt et al.   PLoS One

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

CD200 receptor and macrophage function in the intestine

(2011) Calum C. Bain et al.   IMMUNOBIOLOGY

IL-10 Restricts Activation-Induced Death of NK Cells during Acute Murine Cytomegalovirus Infection

(2011) M. A. Stacey et al.   JOURNAL OF IMMUNOLOGY

B and T Lymphocyte Attenuator Restricts the Protective Immune Response against Experimental Malaria

(2011) Guido Adler et al.   JOURNAL OF IMMUNOLOGY

Suppressive CD8+ T Cells Arise in the Absence of CD4 Help and Compromise Control of Persistent Virus

(2011) M. J. Molloy et al.   JOURNAL OF IMMUNOLOGY

Cytomegalovirus e127 Protein Interacts with the Inhibitory CD200 Receptor

(2011) M. Foster-Cuevas et al.   JOURNAL OF VIROLOGY

PD-L2 is expressed on activated human T cells and regulates their function

(2011) Nassima Messal et al.   MOLECULAR IMMUNOLOGY

DNA Viruses (CMV, EBV, and the Herpesviruses)

(2011) Martin Zamora   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Autocrine Regulation of Pulmonary Inflammation by Effector T-Cell Derived IL-10 during Infection with Respiratory Syncytial Virus

(2011) Jie Sun et al.   PLoS Pathogens

Exhausted Cytotoxic Control of Epstein-Barr Virus in Human Lupus

(2011) Martin Larsen et al.   PLoS Pathogens

Absence of Cross-Presenting Cells in the Salivary Gland and Viral Immune Evasion Confine Cytomegalovirus Immune Control to Effector CD4 T Cells

(2011) Senta M. Walton et al.   PLoS Pathogens

Salivary Gland NK Cells Are Phenotypically and Functionally Unique

(2011) Marlowe S. Tessmer et al.   PLoS Pathogens

Slow Down and Survive: Enigmatic Immunoregulation by BTLA and HVEM

(2010) Theresa L. Murphy et al.   Annual Review of Immunology

Immune Inhibitory Ligand CD200 Induction by TLRs and NLRs Limits Macrophage Activation to Protect the Host from Meningococcal Septicemia

(2010) Subhankar Mukhopadhyay et al.   Cell Host & Microbe

Role of PD-1 in regulating acute infections

(2010) Keturah E Brown et al.   CURRENT OPINION IN IMMUNOLOGY

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

B and T Lymphocyte Attenuator Is Highly Expressed on CMV-Specific T Cells during Infection and Regulates Their Function

(2010) N.-E. Serriari et al.   JOURNAL OF IMMUNOLOGY

IL-10 Restricts Memory T Cell Inflation during Cytomegalovirus Infection

(2010) M. Jones et al.   JOURNAL OF IMMUNOLOGY

Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signaling

(2010) J.-W. Shui et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD4 T-Cell Help Programs a Change in CD8 T-Cell Function Enabling Effective Long-Term Control of Murine Gammaherpesvirus 68: Role of PD-1-PD-L1 Interactions

(2010) P. Dias et al.   JOURNAL OF VIROLOGY

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Programmed Death-1 Expression on Epstein Barr Virus Specific CD8+ T Cells Varies by Stage of Infection, Epitope Specificity, and T-Cell Receptor Usage

(2010) Thomas C. Greenough et al.   PLoS One

Attenuation of innate immunity by cytomegalovirus IL-10 establishes a long-term deficit of adaptive antiviral immunity

(2010) W. L. W. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

(2010) E. Lazar-Molnar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency

(2009) A. K. L. Cheung et al.   BLOOD

Heterogeneity in the CD200R paired receptor family

(2009) Munir Akkaya et al.   IMMUNOGENETICS

vOX2 glycoprotein of human herpesvirus 8 modulates human primary macrophages activity

(2009) Cristiano Salata et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection

(2009) Seung-Hwan Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-10 Deficiency Unleashes an Influenza-Specific Th17 Response and Enhances Survival against High-Dose Challenge

(2009) K. K. McKinstry et al.   JOURNAL OF IMMUNOLOGY

Essential Roles for Dok2 and RasGAP in CD200 Receptor-Mediated Regulation of Human Myeloid Cells

(2009) R. Mihrshahi et al.   JOURNAL OF IMMUNOLOGY

B and T Lymphocyte Attenuator Tempers Early Infection Immunity

(2009) Y. Sun et al.   JOURNAL OF IMMUNOLOGY

Reduced lymphocyte infiltration during cytomegalovirus brain infection of interleukin-10–deficient mice

(2009) Maxim C-J Cheeran et al.   JOURNAL OF NEUROVIROLOGY

Virus-Encoded Homologs of Cellular Interleukin-10 and Their Control of Host Immune Function

(2009) B. Slobedman et al.   JOURNAL OF VIROLOGY

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

(2009) Jie Sun et al.   NATURE MEDICINE

B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation

(2009) Oezcan Talay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unconventional ligand activation of herpesvirus entry mediator signals cell survival

(2009) T. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced monocyte Fc phagocytosis by a homologue of interleukin-10 encoded by human cytomegalovirus

(2009) Anthony Jaworowski et al.   VIROLOGY

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

(2008) T. Azuma et al.   BLOOD

Control of viral immunoinflammatory lesions by manipulating CD200:CD200 receptor interaction

(2008) Pranita P. Sarangi et al.   CLINICAL IMMUNOLOGY

Strategies for use of IL-10 or its antagonists in human disease

(2008) Anne O'Garra et al.   IMMUNOLOGICAL REVIEWS

Laboratory Strains of Murine Cytomegalovirus Are Genetically Similar to but Phenotypically Distinct from Wild Strains of Virus

(2008) L. M. Smith et al.   JOURNAL OF VIROLOGY

Immunomodulatory Properties of a Viral Homolog of Human Interleukin-10 Expressed by Human Cytomegalovirus during the Latent Phase of Infection

(2008) C. Jenkins et al.   JOURNAL OF VIROLOGY

The salivary glands as a privileged site of cytomegalovirus immune evasion and persistence

(2008) Ann E. Campbell et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

(2008) Robert J Snelgrove et al.   NATURE IMMUNOLOGY

The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes

(2007) Eva S.K. Rijkers et al.   MOLECULAR IMMUNOLOGY