Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

Titers of Herpes Simplex Virus Type 1 Antibodies Positively Correlate with Grey Matter Volumes in Alzheimer's Disease

(2018) Roberta Mancuso et al.   JOURNAL OF ALZHEIMERS DISEASE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

(2017) Katie J. Ryan et al.   Science Translational Medicine

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

(2017) Rahul S. Desikan et al.   PLOS MEDICINE

High avidity HSV-1 antibodies correlate with absence of amnestic Mild Cognitive Impairment conversion to Alzheimer’s disease

(2016) Simone Agostini et al.   BRAIN BEHAVIOR AND IMMUNITY

Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα

(2016) Masako Kohyama et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques

(2016) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

Distribution of cellular HSV-1 receptor expression in human brain

(2016) Richard Lathe et al.   JOURNAL OF NEUROVIROLOGY

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

Relation of genomic variants for Alzheimer disease dementia to common neuropathologies

(2016) Jose M. Farfel et al.   NEUROLOGY

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

(2016) Karpagam Srinivasan et al.   Nature Communications

Alzheimer’s Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci

(2016) Celeste M. Karch et al.   PLoS One

Herpes simplex infection and the risk of Alzheimer's disease: A nested case-control study

(2015) Hugo Lövheim et al.   Alzheimers & Dementia

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

(2015) Stacy Steinberg et al.   NATURE GENETICS

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

PILRα Negatively Regulates Mouse Inflammatory Arthritis

(2014) Yonglian Sun et al.   JOURNAL OF IMMUNOLOGY

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

PILR  and PILR  have a siglec fold and provide the basis of binding to sialic acid

(2014) Q. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILR 

(2014) K. Kuroki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Evolutionarily Conserved Paired Immunoglobulin-like Receptor α (PILRα) Domain Mediates Its Interaction with Diverse Sialylated Ligands

(2012) Yonglian Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LC–MS/MS Characterization of O-Glycosylation Sites and Glycan Structures of Human Cerebrospinal Fluid Glycoproteins

(2012) Adnan Halim et al.   JOURNAL OF PROTEOME RESEARCH

Herpes Simplex Encephalitis Affecting the Entire Limbic System

(2012) Arseny A. Sokolov et al.   MAYO CLINIC PROCEEDINGS

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation

(2012) Jing Wang et al.   NATURE IMMUNOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rare Variants in APP, PSEN1 and PSEN2 Increase Risk for AD in Late-Onset Alzheimer's Disease Families

(2012) Carlos Cruchaga et al.   PLoS One

PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues

(2011) Amane Kogure et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

(2011) E Genin et al.   MOLECULAR PSYCHIATRY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

HSV-1 promotes Ca2+-mediated APP phosphorylation and Aβ accumulation in rat cortical neurons

(2010) Roberto Piacentini et al.   NEUROBIOLOGY OF AGING

APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle

(2010) C.J. Carter   NEUROSCIENCE LETTERS

APP Processing Induced by Herpes Simplex Virus Type 1 (HSV-1) Yields Several APP Fragments in Human and Rat Neuronal Cells

(2010) Giovanna De Chiara et al.   PLoS One

Binding of Herpes Simplex Virus Glycoprotein B (gB) to Paired Immunoglobulin-Like Type 2 Receptor   Depends on Specific Sialylated O-Linked Glycans on gB

(2009) J. Wang et al.   JOURNAL OF VIROLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B

(2008) Takeshi Satoh et al.   CELL

Biophysical Characterization ofO-Glycosylated CD99 Recognition by Paired Ig-like Type 2 Receptors

(2008) Shigekazu Tabata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study

(2008) Luc Letenneur et al.   PLoS One