A1/A2 astrocytes in central nervous system injuries and diseases: Angels or devils?
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Title
A1/A2 astrocytes in central nervous system injuries and diseases: Angels or devils?
Authors
Keywords
Reactive astrocytes, Phenotypic conversion, Neurovascular unit, Neuroinflammation, Neurological disorders
Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 148, Issue -, Pages 105080
Publisher
Elsevier BV
Online
2021-05-26
DOI
10.1016/j.neuint.2021.105080
References
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Note: Only part of the references are listed.- Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy
- (2021) Lin Shao et al. FASEB JOURNAL
- Astrocyte subtype-specific approach to Alzheimer's disease treatment
- (2021) Sukanya Sarkar et al. NEUROCHEMISTRY INTERNATIONAL
- The Neurovascular Unit Dysfunction in Alzheimer’s Disease
- (2021) Luis O. Soto-Rojas et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination
- (2021) Jingwei Zheng et al. Journal of Neuroinflammation
- Reactive astrocyte nomenclature, definitions, and future directions
- (2021) Carole Escartin et al. NATURE NEUROSCIENCE
- Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission
- (2021) Nanshan Song et al. Frontiers in Pharmacology
- Contribution of astrocytes to neuropathology of neurodegenerative diseases
- (2021) Cigdem Acioglu et al. BRAIN RESEARCH
- An engineered neurovascular unit for modeling neuroinflammation
- (2021) Suyeong Seo et al. Biofabrication
- Mesenchymal Stem Cell Derived Extracellular Vesicles for Repairing the Neurovascular Unit after Ischemic Stroke
- (2021) Courtney Davis et al. Cells
- Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas
- (2021) Francesco Girolamo et al. Fluids and Barriers of the CNS
- The effects of A1/A2 astrocytes on oligodendrocyte linage cells against white matter injury under prolonged cerebral hypoperfusion
- (2020) Nobukazu Miyamoto et al. GLIA
- Oxylipin Profiles as Functional Characteristics of Acute Inflammatory Responses in Astrocytes Pre-Treated with IL-4, IL-10, or LPS
- (2020) Dmitry V. Chistyakov et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Early Reactive A1 Astrocytes Induction by the Neurotoxin 3-Nitropropionic Acid in Rat Brain
- (2020) Carmen Lopez-Sanchez et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition
- (2020) Dongliang Li et al. Journal of Neuroinflammation
- High-frequency repetitive transcranial magnetic stimulation improves functional recovery by inhibiting neurotoxic polarization of astrocytes in ischemic rats
- (2020) Ye Hong et al. Journal of Neuroinflammation
- Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype
- (2020) Baohua Hou et al. Cell Death & Disease
- A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment
- (2020) He-Yang Zhang et al. Journal of Neuroinflammation
- Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats
- (2020) Ferdinand Althammer et al. Journal of Neuroinflammation
- Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain
- (2020) Ting Li et al. Journal of Neuroinflammation
- Roles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced Early Brain Injury via Regulation of Phenotype Polarization in Astrocytes
- (2020) Mian Ma et al. MOLECULAR NEUROBIOLOGY
- NF-κB signaling in astrocytes modulates brain inflammation and neuronal injury following sequential exposure to manganese and MPTP during development and aging
- (2020) Sean L Hammond et al. TOXICOLOGICAL SCIENCES
- Rising Stars: Astrocytes as a Therapeutic Target for ALS Disease
- (2020) Michal Izrael et al. Frontiers in Neuroscience
- Interaction of Microglia and Astrocytes in the Neurovascular Unit
- (2020) Li-rong Liu et al. Frontiers in Immunology
- The Increased Densities, But Different Distributions, of Both C3 and S100A10 Immunopositive Astrocyte-Like Cells in Alzheimer’s Disease Brains Suggest Possible Roles for Both A1 and A2 Astrocytes in the Disease Pathogenesis
- (2020) Andrew King et al. Brain Sciences
- Fasudil inhibits the activation of microglia and astrocytes of transgenic Alzheimer's disease mice via the downregulation of TLR4/Myd88/NF-κB pathway
- (2020) Min-fang Guo et al. JOURNAL OF NEUROIMMUNOLOGY
- Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte
- (2020) Min Liu et al. Journal of Neuroinflammation
- Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?
- (2020) Shane A. Liddelow et al. TRENDS IN IMMUNOLOGY
- Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination
- (2020) Álvaro Moreno-García et al. Biomolecules
- Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra
- (2020) Claudia Luna-Herrera et al. Journal of Immunology Research
- Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
- (2020) Hyuk Sung Kwon et al. Translational Neurodegeneration
- Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model
- (2019) Nicole Reichenbach et al. EMBO Molecular Medicine
- Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial–Astrocytic Crosstalk
- (2019) David P. Q. Clark et al. NEUROCHEMICAL RESEARCH
- Effects of FGF2/FGFR1 Pathway on Expression of A1 Astrocytes After Infrasound Exposure
- (2019) Lin-Hui Zou et al. Frontiers in Neuroscience
- Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia
- (2019) Kristin Hartmann et al. Acta Neuropathologica Communications
- Silencing miR-21 induces polarization of astrocytes to the A2 phenotype and improves the formation of synapses by targeting glypican 6 via the signal transducer and activator of transcription-3 pathway after acute ischemic spinal cord injury
- (2019) Yanlin Su et al. FASEB JOURNAL
- Cerebral inducible nitric oxide synthase protein expression in microglia, astrocytes and neurons in Trypanosoma brucei brucei-infected rats
- (2019) Raymond Cespuglio et al. PLoS One
- Blocking Notch signal pathway suppresses the activation of neurotoxic A1 astrocytes after spinal cord injury
- (2019) Dingfei Qian et al. CELL CYCLE
- Interleukin-6 Expression by Hypothalamic Microglia in Multiple Inflammatory Contexts: A Systematic Review
- (2019) Vanessa C. D. Bobbo et al. Biomed Research International
- Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/β‐catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide
- (2019) Peixian Huang et al. BRAIN PATHOLOGY
- Glial Scar—a Promising Target for Improving Outcomes After CNS Injury
- (2019) Yuanyuan He et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease
- (2019) Darrick T. Balu et al. NEUROBIOLOGY OF DISEASE
- HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0
- (2019) Niko Hensel et al. Journal of Neuroinflammation
- High complement levels in astrocyte-derived exosomes of Alzheimer disease
- (2018) Edward J. Goetzl et al. ANNALS OF NEUROLOGY
- Astrocytes in primary cultures express serine racemase, synthesize d -serine and acquire A1 reactive astrocyte features
- (2018) Suyan Li et al. BIOCHEMICAL PHARMACOLOGY
- Complement Component C3 Promotes Cerebral Ischemia/Reperfusion Injury Mediated by TLR2/NFκB Activation in Diabetic Mice
- (2018) Zheng Lin et al. NEUROCHEMICAL RESEARCH
- Effects of long-term rapamycin treatment on glial scar formation after cryogenic traumatic brain injury in mice
- (2018) Yan-Ying Fan et al. NEUROSCIENCE LETTERS
- Normal aging induces A1-like astrocyte reactivity
- (2018) Laura E. Clarke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes
- (2018) Matthew Neal et al. GLIA
- MFG-E8 reverses microglial-induced neurotoxic astrocyte (A1) via NF-κB and PI3K-Akt pathways
- (2018) Xiaotian Xu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model
- (2018) Atsushi Fujita et al. Journal of Neuroinflammation
- Inhibitive Effects of FGF2/FGFR1 Pathway on Astrocyte-Mediated Inflammation in vivo and in vitro After Infrasound Exposure
- (2018) Ya-Jun Shi et al. Frontiers in Neuroscience
- Stroke target identification guided by astrocyte transcriptome analysis
- (2018) Cordula Rakers et al. GLIA
- Pentraxin 3 promotes long-term cerebral blood flow recovery, angiogenesis, and neuronal survival after stroke
- (2018) Ivana Rajkovic et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- A new function for Prokineticin 2: Recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury
- (2018) Mayara Vieira Mundim et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
- (2018) Alexandra Litvinchuk et al. NEURON
- Astrocyte Heterogeneity in the Adult Central Nervous System
- (2018) Sean J. Miller Frontiers in Cellular Neuroscience
- Connexin 30 Deficiency Attenuates Chronic but Not Acute Phases of Experimental Autoimmune Encephalomyelitis Through Induction of Neuroprotective Microglia
- (2018) Mei Fang et al. Frontiers in Immunology
- Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury
- (2017) Lawrence R. Shiow et al. GLIA
- Reactive Astrocytes: Production, Function, and Therapeutic Potential
- (2017) Shane A. Liddelow et al. IMMUNITY
- Regulation of RhoA by STAT3 coordinates glial scar formation
- (2017) Francois Renault-Mihara et al. JOURNAL OF CELL BIOLOGY
- Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury
- (2017) Enmanuel J. Perez et al. JOURNAL OF CLINICAL INVESTIGATION
- Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity
- (2017) Eva Czirr et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury
- (2017) Masamitsu Hara et al. NATURE MEDICINE
- The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
- (2017) Costantino Iadecola NEURON
- Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
- (2017) Qiaoqiao Shi et al. Science Translational Medicine
- Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia
- (2016) Anna Stokowska et al. BRAIN
- Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease
- (2016) H. Lian et al. JOURNAL OF NEUROSCIENCE
- Astrocyte scar formation aids central nervous system axon regeneration
- (2016) Mark A. Anderson et al. NATURE
- Schizophrenia risk from complex variation of complement component 4
- (2016) Aswin Sekar et al. NATURE
- The complex STATes of astrocyte reactivity: How are they controlled by the JAK–STAT3 pathway?
- (2016) Kelly Ceyzériat et al. NEUROSCIENCE
- An Interplay of S-Nitrosylation and Metal Ion Binding for Astrocytic S100B Protein
- (2016) Małgorzata Bajor et al. PLoS One
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
- (2016) Richard Gordon et al. Nature Communications
- Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10
- (2015) Beatriz Almolda et al. BRAIN BEHAVIOR AND IMMUNITY
- Astrocyte-targeted production of IL-10 induces changes in microglial reactivity and reduces motor neuron death after facial nerve axotomy
- (2015) Nàdia Villacampa et al. GLIA
- Pentraxin 3 mediates neurogenesis and angiogenesis after cerebral ischaemia
- (2015) Beatriz Rodriguez-Grande et al. Journal of Neuroinflammation
- The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases
- (2015) L. Ben Haim et al. JOURNAL OF NEUROSCIENCE
- NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease
- (2015) Hong Lian et al. NEURON
- Astrocytes in Neurodegenerative Disease: Table 1.
- (2015) Hemali Phatnani et al. Cold Spring Harbor Perspectives in Biology
- Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration
- (2015) Ru-jia Liao et al. Scientific Reports
- Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity
- (2015) Cinzia Severini et al. Scientific Reports
- TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation
- (2014) Diana M. Norden et al. GLIA
- Astrocyte activation is suppressed in both normal and injured brain by FGF signaling
- (2014) W. Kang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Acute-Phase Protein PTX3 is an Essential Mediator of Glial Scar Formation and Resolution of Brain Edema after Ischemic Injury
- (2013) Beatriz Rodriguez-Grande et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Oligodendroglia: metabolic supporters of axons
- (2013) Brett M. Morrison et al. TRENDS IN CELL BIOLOGY
- The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease
- (2012) Alexander H. Stephan et al. Annual Review of Neuroscience
- Genomic Analysis of Reactive Astrogliosis
- (2012) J. L. Zamanian et al. JOURNAL OF NEUROSCIENCE
- From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
- (2012) Jacques Banchereau et al. NATURE IMMUNOLOGY
- Complement Inhibition Promotes Endogenous Neurogenesis and Sustained Anti-Inflammatory Neuroprotection following Reperfused Stroke
- (2012) Andrew F. Ducruet et al. PLoS One
- Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation
- (2012) H. Qin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prokineticin 2 is an endangering mediator of cerebral ischemic injury
- (2012) M. Y. Cheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Signaling Pathways in Reactive Astrocytes, a Genetic Perspective
- (2011) Wenfei Kang et al. MOLECULAR NEUROBIOLOGY
- NF-κB is 25
- (2011) David Baltimore NATURE IMMUNOLOGY
- Role of Signal Transducer and Activator of Transcription-3 in Up-Regulation of GFAP After Epilepsy
- (2011) Zucai Xu et al. NEUROCHEMICAL RESEARCH
- Analysis of glial secretome: The long pentraxin PTX3 modulates phagocytic activity of microglia
- (2010) Hyejin Jeon et al. JOURNAL OF NEUROIMMUNOLOGY
- Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF- after Vascular Damage
- (2010) C. Schachtrup et al. JOURNAL OF NEUROSCIENCE
- Astrocytes: biology and pathology
- (2009) Michael V. Sofroniew et al. ACTA NEUROPATHOLOGICA
- The bright side of the glial scar in CNS repair
- (2009) Asya Rolls et al. NATURE REVIEWS NEUROSCIENCE
- The NF- B Family of Transcription Factors and Its Regulation
- (2009) A. Oeckinghaus et al. Cold Spring Harbor Perspectives in Biology
- The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin receptor-1
- (2008) Silvia Franchi et al. BMC IMMUNOLOGY
- STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury
- (2008) J. E. Herrmann et al. JOURNAL OF NEUROSCIENCE
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