Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype

NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology

(2019) Xiaolong He et al.   Cellular & Molecular Immunology

A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis

(2018) Xiao-Lu Yuan et al.   CNS Neuroscience & Therapeutics

Anticonvulsant agent DPP4 inhibitor sitagliptin downregulates CXCR3/RAGE pathway on seizure models

(2018) Yunli Liu et al.   EXPERIMENTAL NEUROLOGY

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

(2017) Jun Yin et al.   MOLECULAR NEUROBIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation

(2017) Youichi Shinozaki et al.   Cell Reports

An interferon-β-resistant and NLRP3 inflammasome–independent subtype of EAE with neuronal damage

(2016) Makoto Inoue et al.   NATURE NEUROSCIENCE

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Cognition and fatigue in patients with relapsing multiple sclerosis treated by subcutaneous interferon β-1a: an observational study SKORE

(2016) Yvonne Benešová et al.   Therapeutic Advances in Neurological Disorders

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

(2015) Samia Habbas et al.   CELL

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Hippocampal function is compromised in an animal model of multiple sclerosis

(2015) T. Novkovic et al.   NEUROSCIENCE

The role of inflammasome in Alzheimer's disease

(2014) Li Liu et al.   AGEING RESEARCH REVIEWS

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Altered cognitive-emotional behavior in early experimental autoimmune encephalitis – Cytokine and hormonal correlates

(2013) Shaona Acharjee et al.   BRAIN BEHAVIOR AND IMMUNITY

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

(2013) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

Interleukin-1  Alters Glutamate Transmission at Purkinje Cell Synapses in a Mouse Model of Multiple Sclerosis

(2013) G. Mandolesi et al.   JOURNAL OF NEUROSCIENCE

Effects of central and peripheral inflammation on hippocampal synaptic plasticity

(2013) Massimiliano Di Filippo et al.   NEUROBIOLOGY OF DISEASE

Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain

(2012) I. Carrero et al.   EXPERIMENTAL NEUROLOGY

Serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with multiple sclerosis

(2012) Ying-Chun Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor

(2012) Joana C d’Avila et al.   Journal of Neuroinflammation

Role of P2X7 Receptor-Mediated IL-18/IL-18R Signaling in Morphine Tolerance: Multiple Glial-Neuronal Dialogues in the Rat Spinal Cord

(2012) Meng-Ling Chen et al.   JOURNAL OF PAIN

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cognition in multiple sclerosis

(2011) Dawn W Langdon   CURRENT OPINION IN NEUROLOGY

Development of a Method for the Purification and Culture of Rodent Astrocytes

(2011) Lynette C. Foo et al.   NEURON

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

(2010) M. Faideau et al.   HUMAN MOLECULAR GENETICS

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

Interleukin 18 in the CNS

(2010) Silvia Alboni et al.   Journal of Neuroinflammation

Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE

(2010) Marina O Ziehn et al.   LABORATORY INVESTIGATION

Relevance of cognitive deterioration in early relapsing-remitting MS: a 3-year follow-up study

(2010) Maria P Amato et al.   Multiple Sclerosis Journal

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

(2009) Javier Palazuelos et al.   BRAIN

The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: The elevation of IL-1 receptor antagonist and IL-1 receptor type II after steroid therapy

(2009) Irena Dujmovic et al.   JOURNAL OF NEUROIMMUNOLOGY

A role for galanin in human and experimental inflammatory demyelination

(2009) D. C. Wraith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Japanese Encephalitis Virus infection induces IL-18 and IL-1β in microglia and astrocytes: Correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death

(2008) Sulagna Das et al.   JOURNAL OF NEUROIMMUNOLOGY

Interleukin-18-Mediated Microglia/Astrocyte Interaction in the Spinal Cord Enhances Neuropathic Pain Processing after Nerve Injury

(2008) K. Miyoshi et al.   JOURNAL OF NEUROSCIENCE

Cognitive impairment in multiple sclerosis

(2008) F Patti   Multiple Sclerosis Journal

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders

(2008) Massimiliano Di Filippo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES