Mesenchymal Stem Cell Derived Extracellular Vesicles for Repairing the Neurovascular Unit after Ischemic Stroke

Extracellular Vesicles in Viral Pathogenesis: A Case of Dr. Jekyll and Mr. Hyde

(2021) Lada Purvinsh et al.   Life-Basel

Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

(2021) Salim S. Virani et al.   CIRCULATION

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

(2020) Xing-Liang Fan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss of Capillary Pericytes and the Blood‐Brain Barrier in White Matter in Post‐Stroke and Vascular Dementias and Alzheimer’s Disease

(2020) Ren Ding et al.   BRAIN PATHOLOGY

Non-viral delivery systems of DNA into stem cells: promising and multifarious actions for regenerative medicine

(2020) Mahboob Morshed et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain

(2020) Ting Li et al.   Journal of Neuroinflammation

Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation

(2020) Min Han et al.   Drug Design Development and Therapy

Structural and Functional Remodeling of the Brain Vasculature Following Stroke

(2020) Moises Freitas-Andrade et al.   Frontiers in Physiology

Characterizing Extracellular Vesicles and Their Diverse RNA Contents

(2020) Eren M. Veziroglu et al.   Frontiers in Genetics

Therapeutic potential of extracellular vesicle‐associated long noncoding RNA

(2020) Louis J. Born et al.   Bioengineering & Translational Medicine

Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p

(2020) Danqing Xin et al.   Acta Biomaterialia

Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke

(2020) Abolfazl Rahmani et al.   AGEING RESEARCH REVIEWS

Deleterious Alteration of Glia in the Brain of Alzheimer’s Disease

(2020) Eunyoung Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2020) Theo Vos et al.   LANCET

Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization

(2020) Jiangmei Wang et al.   Stem Cell Research & Therapy

The Role of Extracellular Vesicles (EVs) in the Epigenetic Regulation of Bone Metabolism and Osteoporosis

(2020) Maurizio Muraca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain Injury

(2020) Nicole Kaminski et al.   Frontiers in Cellular Neuroscience

Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Recovery Following Spinal Cord Injury via Improvement of the Integrity of the Blood-Spinal Cord Barrier

(2019) Yanhui Lu et al.   Frontiers in Neuroscience

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Catherine Owens Johnson et al.   LANCET NEUROLOGY

Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

(2019) Jinxuan Zhao et al.   CARDIOVASCULAR RESEARCH

Comparative Analysis of Secretome of Human Umbilical Cord- and Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells

(2019) Yu. A. Romanov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Secretome analysis of human bone marrow derived mesenchymal stromal cells

(2019) Falk Baberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy

(2019) Zurab Nadareishvili et al.   CEREBROVASCULAR DISEASES

Propagermanium, a CCR2 inhibitor, attenuates cerebral ischemia/reperfusion injury through inhibiting inflammatory response induced by microglia

(2019) Shucheng He et al.   NEUROCHEMISTRY INTERNATIONAL

Hypoxic preconditioning improves the survival and neural effects of transplanted mesenchymal stem cells via CXCL12/CXCR4 signalling in a rat model of cerebral infarction

(2019) Yueqiang Hu et al.   CELL BIOCHEMISTRY AND FUNCTION

Mitophagy is a protective response against oxidative damage in bone marrow mesenchymal stem cells

(2019) Pan Fan et al.   LIFE SCIENCES

Blood vessels as a scaffold for neuronal migration

(2019) Teppei Fujioka et al.   NEUROCHEMISTRY INTERNATIONAL

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

Endothelial Targets in Stroke

(2019) Anuska V. Andjelkovic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Preclinical translation of exosomes derived from mesenchymal stem/stromal cells

(2019) Fanny M. Elahi et al.   STEM CELLS

MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing

(2019) Xiaoning He et al.   Stem Cells International

An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons

(2019) Scott G. Canfield et al.   Fluids and Barriers of the CNS

Mitochondria as a therapeutic target for ischemic stroke

(2019) Zhi He et al.   FREE RADICAL BIOLOGY AND MEDICINE

Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys

(2019) Veronica Go et al.   GeroScience

Hypoxia conditioning enhances neuroprotective effects of aged human bone marrow mesenchymal stem cell-derived conditioned medium against cerebral ischemia in vitro

(2019) Ying Zhang et al.   BRAIN RESEARCH

Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Metabolic Renovascular Disease in Swine

(2018) Alfonso Eirin et al.   CELL TRANSPLANTATION

Delivering CRISPR: a review of the challenges and approaches

(2018) Christopher A. Lino et al.   DRUG DELIVERY

Extracellular vesicles and their content in bioactive lipid mediators: more than a sack of microRNA

(2018) Eric Boilard   JOURNAL OF LIPID RESEARCH

Exosomes Secreted by Adipose-Derived Stem Cells Contribute to Angiogenesis of Brain Microvascular Endothelial Cells Following Oxygen–Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis

(2018) Yujia Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice

(2018) Zhuo Cheng et al.   Journal of Neuroinflammation

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

(2018) Mithilesh Kumar Jha et al.   NEUROSCIENTIST

Blood-brain barrier dysfunction and recovery after ischemic stroke

(2018) Xiaoyan Jiang et al.   PROGRESS IN NEUROBIOLOGY

Brief Reports: Protective Effects of Endothelial Progenitor Cell-Derived Extracellular Mitochondria in Brain Endothelium

(2018) Kazuhide Hayakawa et al.   STEM CELLS

RNA-dependent RNA targeting by CRISPR-Cas9

(2018) Steven C Strutt et al.   eLife

MicroRNA‐210 Promotes Accumulation of Neural Precursor Cells Around Ischemic Foci After Cerebral Ischemia by Regulating the SOCS1–STAT3–VEGF‐C Pathway

(2018) Zhao‐You Meng et al.   Journal of the American Heart Association

Hypoxia-inducible factor 1 signalling, metabolism and its therapeutic potential in cardiovascular disease

(2018) Maria da Luz Sousa Fialho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astrocyte-Derived Exosomes Treated With a Semaphorin 3A Inhibitor Enhance Stroke Recovery via Prostaglandin D 2 Synthase

(2018) Kenichiro Hira et al.   STROKE

May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells

(2018) Cesar V Borlongan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

(2018) Mohashin Pathan et al.   NUCLEIC ACIDS RESEARCH

Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs

(2018) Guanguan Qiu et al.   Stem Cell Research & Therapy

Application of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Stroke: Biodistribution and MicroRNA Study

(2018) Gyeong Joon Moon et al.   Translational Stroke Research

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury

(2017) Qingyi Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distinct Effects of miR-210 Reduction on Neurogenesis: Increased Neuronal Survival of Inflammation But Reduced Proliferation Associated with Mitochondrial Enhancement

(2017) Ludmila A. Voloboueva et al.   JOURNAL OF NEUROSCIENCE

Transplantation with hypoxia-preconditioned mesenchymal stem cells suppresses brain injury caused by cardiac arrest-induced global cerebral ischemia in rats

(2017) Ji-wen Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Proteomic analysis of the secretome of human bone marrow-derived mesenchymal stem cells primed by pro-inflammatory cytokines

(2017) Elisa Maffioli et al.   Journal of Proteomics

Vascular Endothelial Growth Factor Isoform-B Stimulates Neurovascular Repair After Ischemic Stroke by Promoting the Function of Pericytes via Vascular Endothelial Growth Factor Receptor-1

(2017) Noëmie Jean LeBlanc et al.   MOLECULAR NEUROBIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Platelet microvesicles in health and disease

(2017) Imene Melki et al.   PLATELETS

Cell-Penetrating Peptides: From Basic Research to Clinics

(2017) Giulia Guidotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Enhanced neuroprotective efficacy of bone marrow mesenchymal stem cells co-overexpressing BDNF and VEGF in a rat model of cardiac arrest-induced global cerebral ischemia

(2017) Lili Zhou et al.   Cell Death & Disease

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

(2017) Elena Redondo-Castro et al.   Stem Cell Research & Therapy

CRISPR-Mediated Integration of Large Gene Cassettes Using AAV Donor Vectors

(2017) Rasmus O. Bak et al.   Cell Reports

RNA in extracellular vesicles

(2017) Kyoung Mi Kim et al.   Wiley Interdisciplinary Reviews-RNA

Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility

(2017) Abiola A. Ayanlaja et al.   Frontiers in Molecular Neuroscience

ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes

(2017) Francesco Drago et al.   Frontiers in Pharmacology

The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer

(2017) Jie Yin et al.   Journal of Immunology Research

Mitochondrial composition and function under the control of hypoxia

(2017) Dominik C. Fuhrmann et al.   Redox Biology

Non-coding RNAs in Mesenchymal Stem Cell-Derived Extracellular Vesicles: Deciphering Regulatory Roles in Stem Cell Potency, Inflammatory Resolve, and Tissue Regeneration

(2017) Farah Fatima et al.   Frontiers in Genetics

Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke

(2017) Masataka Nakajima et al.   Molecular Therapy-Methods & Clinical Development

Pericytes from Mesenchymal Stem Cells as a model for the blood-brain barrier

(2017) Xiaohe Tian et al.   Scientific Reports

Membrane particles generated from mesenchymal stromal cells modulate immune responses by selective targeting of pro-inflammatory monocytes

(2017) Fabiany da C. Gonçalves et al.   Scientific Reports

Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity

(2016) Li-Hua Peng et al.   BIOMATERIALS

Electroacupuncture modulates stromal cell-derived factor-1α expression and mobilization of bone marrow endothelial progenitor cells in focal cerebral ischemia/reperfusion model rats

(2016) Chenchen Xie et al.   BRAIN RESEARCH

Stroke Serum Priming Modulates Characteristics of Mesenchymal Stromal Cells by Controlling the Expression miRNA-20a

(2016) Eun Hee Kim et al.   CELL TRANSPLANTATION

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Astrocyte-Derived CCL2 is Associated with M1 Activation and Recruitment of Cultured Microglial Cells

(2016) Mingfeng He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

(2016) Christopher S. von Bartheld et al.   JOURNAL OF COMPARATIVE NEUROLOGY

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia

(2016) Robert G. Underly et al.   JOURNAL OF NEUROSCIENCE

Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons

(2016) Yi Zhang et al.   MOLECULAR NEUROBIOLOGY

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Is Immunomodulation a Principal Mechanism Underlying How Cell-Based Therapies Enhance Stroke Recovery?

(2016) Nikunj Satani et al.   Neurotherapeutics

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling

(2016) Johnathon D. Anderson et al.   STEM CELLS

Mesenchymal Stem Cells and Pericytes: To What Extent Are They Related?

(2016) Lucas Eduardo Botelho de Souza et al.   STEM CELLS AND DEVELOPMENT

Identification of Reversible Disruption of the Human Blood–Brain Barrier Following Acute Ischemia

(2016) Alexis N. Simpkins et al.   STROKE

Thromboinflammation in Stroke Brain Damage

(2016) Simon F. De Meyer et al.   STROKE

Injury, inflammation and the emergence of human-specific genes

(2016) Andrew Baird et al.   WOUND REPAIR AND REGENERATION

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Priming Dental Pulp Stem Cells With Fibroblast Growth Factor-2 Increases Angiogenesis of Implanted Tissue-Engineered Constructs Through Hepatocyte Growth Factor and Vascular Endothelial Growth Factor Secretion

(2016) Caroline Gorin et al.   Stem Cells Translational Medicine

Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31

(2016) Ting Kang et al.   Stem Cells Translational Medicine

Spheroid Culture of Mesenchymal Stem Cells

(2016) Zoe Cesarz et al.   Stem Cells International

TRPM7 regulates vascular endothelial cell adhesion and tube formation

(2015) Zhao Zeng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

(2015) MikoŁaj P. Zaborowski et al.   BIOSCIENCE

High-resolution in vivo optical imaging of stroke injury and repair

(2015) Sava Sakadžić et al.   BRAIN RESEARCH

Intranasal Delivery of Bone Marrow Mesenchymal Stem Cells Improved Neurovascular Regeneration and Rescued Neuropsychiatric Deficits after Neonatal Stroke in Rats

(2015) Zheng Zachory Wei et al.   CELL TRANSPLANTATION

Perspective for Stroke and Brain Injury Research: Mechanisms and Potential Therapeutic Targets

(2015) Jun Chen et al.   CNS Neuroscience & Therapeutics

Angiogenesis-regulating microRNAs and Ischemic Stroke

(2015) Ke-Jie Yin et al.   Current Vascular Pharmacology

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Ultrastructural analysis of blood–brain barrier breakdown in the peri-infarct zone in young adult and aged mice

(2015) Patrick C Nahirney et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

(2015) Jie Pan et al.   Journal of Neuroinflammation

Human umbilical cord blood-derived mesenchymal stem cells improve functional recovery through thrombospondin1, pantraxin3, and vascular endothelial growth factor in the ischemic rat brain

(2015) Hyung Woo Park et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

(2015) Yanlu Zhang et al.   JOURNAL OF NEUROSURGERY

Cytokine-mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium

(2015) Keith D. Rochfort et al.   MICROVASCULAR RESEARCH

Mitochondrial transfer from Wharton's jelly-derived mesenchymal stem cells to mitochondria-defective cells recaptures impaired mitochondrial function

(2015) Hung-Yu Lin et al.   MITOCHONDRION

Inducible in vivo genome editing with CRISPR-Cas9

(2015) Lukas E Dow et al.   NATURE BIOTECHNOLOGY

Photoactivatable CRISPR-Cas9 for optogenetic genome editing

(2015) Yuta Nihongaki et al.   NATURE BIOTECHNOLOGY

A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

(2015) Lauren R Polstein et al.   Nature Chemical Biology

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Cobalt chloride induces neuronal differentiation of human mesenchymal stem cells through upregulation of microRNA-124a

(2014) Eun Su Jeon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro characterization of scaffold-free three-dimensional mesenchymal stem cell aggregates

(2014) Christina L. Rettinger et al.   CELL AND TISSUE RESEARCH

Microglial regulation of immunological and neuroprotective functions of astroglia

(2014) Shih-Heng Chen et al.   GLIA

Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment

(2014) Kae M. Pusic et al.   GLIA

bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusionvia activation of PI3K/Akt/ERK1/2 pathway

(2014) Zhouguang Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer

(2014) Kaiming Liu et al.   MICROVASCULAR RESEARCH

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Proangiogenic Compositions of Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells

(2014) Jianying Chen et al.   PLoS One

Interferon-Gamma Modification of Mesenchymal Stem Cells: Implications of Autologous and Allogeneic Mesenchymal Stem Cell Therapy in Allotransplantation

(2014) Kisha Nandini Sivanathan et al.   Stem Cell Reviews and Reports

Pretreatment Blood–Brain Barrier Damage and Post-Treatment Intracranial Hemorrhage in Patients Receiving Intravenous Tissue-Type Plasminogen Activator

(2014) Richard Leigh et al.   STROKE

Astrogliosis

(2014) Michael V. Sofroniew   Cold Spring Harbor Perspectives in Biology

Mesenchymal Stem Cell Delivery Routes and Fate

(2014) Andreas Kurtz   International Journal of Stem Cells

Mesenchymal stem cells: a new trend for cell therapy

(2013) Xin Wei et al.   ACTA PHARMACOLOGICA SINICA

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: Role of secretome and exosomes

(2013) Marie Maumus et al.   BIOCHIMIE

The stem cell secretome and its role in brain repair

(2013) Denise Drago et al.   BIOCHIMIE

MSC-based VEGF gene therapy in rat myocardial infarction model using facial amphipathic bile acid-conjugated polyethyleneimine

(2013) Hyung-Ho Moon et al.   BIOMATERIALS

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Delayed Intranasal Delivery of Hypoxic-Preconditioned Bone Marrow Mesenchymal Stem Cells Enhanced Cell Homing and Therapeutic Benefits after Ischemic Stroke in Mice

(2013) Ning Wei et al.   CELL TRANSPLANTATION

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain

(2013) L Zeng et al.   GENE THERAPY

A Novel Brain Neurovascular Unit Model with Neurons, Astrocytes and Microvascular Endothelial Cells of Rat

(2013) Qiang Xue et al.   International Journal of Biological Sciences

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Immune Players in the CNS: The Astrocyte

(2013) Cathy J. Jensen et al.   Journal of Neuroimmune Pharmacology

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Blood-Brain Barrier Breakdown after Embolic Stroke in Rats Occurs without Ultrastructural Evidence for Disrupting Tight Junctions

(2013) Martin Krueger et al.   PLoS One

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

Molecular Parallels between Neural and Vascular Development

(2013) A. Eichmann et al.   Cold Spring Harbor Perspectives in Medicine

Biodistribution of Mesenchymal Stem/Stromal Cells in a Preclinical Setting

(2013) Luc Sensebé et al.   Stem Cells International

Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture System

(2013) Christian Bucher et al.   Stem Cells International

Pericytes, Mesenchymal Stem Cells and the Wound Healing Process

(2013) Stuart Mills et al.   Cells

Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery

(2012) Xinglu Huang et al.   BIOMATERIALS

Hypoxic preconditioning enhances the therapeutic potential of the secretome from cultured human mesenchymal stem cells in experimental traumatic brain injury

(2012) Ching-Ping Chang et al.   CLINICAL SCIENCE

Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis

(2012) Soo Young Kim et al.   EPILEPSIA

Comparison of polarization properties of human adult microglia and blood-derived macrophages

(2012) Bryce A. Durafourt et al.   GLIA

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cell-penetrating peptide mimicking polymer-based combined delivery of paclitaxel and siRNA for enhanced tumor growth suppression

(2012) Yeon Lim Jang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Efficacy of mesoporous silica nanoparticles in delivering BMP-2 plasmid DNA forin vitroosteogenic stimulation of mesenchymal stem cells

(2012) Tae-Hyun Kim et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia

(2012) Yuan-Lei Lou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats

(2012) Ling Wei et al.   NEUROBIOLOGY OF DISEASE

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials

(2012) Manoj M. Lalu et al.   PLoS One

Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery

(2012) K. Hayakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Cell-penetrating peptides: breaking through to the other side

(2012) Erez Koren et al.   TRENDS IN MOLECULAR MEDICINE

PEI Conjugated Gold Nanoparticles: Efficient Gene Carriers with Visible Fluorescence

(2012) Huayu Tian et al.   Advanced Healthcare Materials

Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain

(2011) Congmin Wang et al.   CELL RESEARCH

Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling

(2011) Heng-Chao Yu et al.   HEPATOLOGY

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

(2011) J. V. Faustino et al.   JOURNAL OF NEUROSCIENCE

Human MSC Suppression Correlates With Cytokine Induction of Indoleamine 2,3-Dioxygenase and Bystander M2 Macrophage Differentiation

(2011) Moïra François et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

(2011) S. Gatti et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1α in MSCs

(2010) Hongbao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Low Molecular Weight Polyethylenimine Conjugated Gold Nanoparticles as Efficient Gene Vectors

(2010) Chu Hu et al.   BIOCONJUGATE CHEMISTRY

Microporation is a valuable transfection method for efficient gene delivery into human umbilical cord blood-derived mesenchymal stem cells

(2010) Jung Lim et al.   BMC BIOTECHNOLOGY

The neuroprotective effect of erythropoietin-transduced human mesenchymal stromal cells in an animal model of ischemic stroke

(2010) Goang-Won Cho et al.   BRAIN RESEARCH

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Intravenous Administration of 99mTc-HMPAO-Labeled Human Mesenchymal Stem Cells after Stroke: In Vivo Imaging and Biodistribution

(2010) Olivier Detante et al.   CELL TRANSPLANTATION

Protein Kinase C Activation Modulates Reversible Increase in Cortical Blood–Brain Barrier Permeability and Tight Junction Protein Expression during Hypoxia and Posthypoxic Reoxygenation

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Mammalian microRNAs predominantly act to decrease target mRNA levels

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