Connexin 30 Deficiency Attenuates Chronic but Not Acute Phases of Experimental Autoimmune Encephalomyelitis Through Induction of Neuroprotective Microglia

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis

(2018) Alazne Zabala et al.   EMBO Molecular Medicine

Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia

(2018) Sinead A. O'Sullivan et al.   JOURNAL OF NEUROCHEMISTRY

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

(2018) Ludwig Kappos et al.   LANCET

Novel disease-modifying anti-rheumatic drug iguratimod suppresses chronic experimental autoimmune encephalomyelitis by down-regulating activation of macrophages/microglia through an NF-κB pathway

(2018) Guangrui Li et al.   Scientific Reports

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Anti-inflammatory disease-modifying treatment and short-term disability progression in SPMS

(2017) Johannes Lorscheider et al.   NEUROLOGY

Microglia Morphological Categorization in a Rat Model of Neuroinflammation by Hierarchical Cluster and Principal Components Analysis

(2017) María del Mar Fernández-Arjona et al.   Frontiers in Cellular Neuroscience

Anti-inflammatory Microglia/Macrophages As a Potential Therapeutic Target in Brain Metastasis

(2017) Kleopatra E. Andreou et al.   Frontiers in Oncology

Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences

(2016) Silvia M. Tietz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation

(2016) Ryo Yamasaki et al.   JOURNAL OF NEUROSCIENCE

Safety and efficacy of the selective sphingosine 1-phosphate receptor modulator ozanimod in relapsing multiple sclerosis (RADIANCE): a randomised, placebo-controlled, phase 2 trial

(2016) Jeffrey A Cohen et al.   LANCET NEUROLOGY

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

(2016) Yuta Katayama et al.   NATURE

Excitatory and Inhibitory Neurons in the Hippocampus Exhibit Molecularly Distinct Large Dense Core Vesicles

(2016) José J. Ramírez-Franco et al.   Frontiers in Cellular Neuroscience

Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation

(2016) Mitsuru Watanabe et al.   Scientific Reports

Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV

(2015) Y. Grishchuk et al.   Disease Models & Mechanisms

Connexin43 and connexin47 alterations after neural precursor cells transplantation in experimental autoimmune encephalomyelitis

(2015) Paschalis Theotokis et al.   GLIA

Inhibition of SystemXc−Transporter Attenuates Autoimmune Inflammatory Demyelination

(2015) Kirsten S. Evonuk et al.   JOURNAL OF IMMUNOLOGY

Factors influencing long-term outcomes in relapsing–remitting multiple sclerosis: PRISMS-15

(2015) Ludwig Kappos et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives

(2015) Daniel Ontaneda et al.   LANCET NEUROLOGY

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Gap junction and hemichannel-independent actions of connexins on cell and tissue functions - An update

(2014) Jade Z. Zhou et al.   FEBS LETTERS

Distinct permeation profiles of the connexin 30 and 43 hemichannels

(2014) Daniel Bloch Hansen et al.   FEBS LETTERS

Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice

(2014) Egle Cekanaviciute et al.   GLIA

Astrocytic TGF-  Signaling Limits Inflammation and Reduces Neuronal Damage during Central Nervous System Toxoplasma Infection

(2014) E. Cekanaviciute et al.   JOURNAL OF IMMUNOLOGY

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

(2014) Ulrike Pannasch et al.   NATURE NEUROSCIENCE

Effects of neural progenitor cells on post-stroke neurological impairment—a detailed and comprehensive analysis of behavioral tests

(2014) Thorsten R. Doeppner et al.   Frontiers in Cellular Neuroscience

Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes

(2013) Luke M Healy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Onset of secondary progressive phase and long-term evolution of multiple sclerosis

(2013) A. Scalfari et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Connexin 43 Astrocytopathy Linked to Rapidly Progressive Multiple Sclerosis and Neuromyelitis Optica

(2013) Katsuhisa Masaki et al.   PLoS One

Extensive loss of connexins in Baló’s disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte–oligodendrocyte/myelin interaction

(2012) Katsuhisa Masaki et al.   ACTA NEUROPATHOLOGICA

Gap junction pathology in multiple sclerosis lesions and normal-appearing white matter

(2012) Kyriaki Markoullis et al.   ACTA NEUROPATHOLOGICA

Connexin-based intercellular communication and astrocyte heterogeneity

(2012) Martin Theis et al.   BRAIN RESEARCH

Gap-junction-mediated cell-to-cell communication

(2012) Jean-Claude Hervé et al.   CELL AND TISSUE RESEARCH

Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis

(2012) Kyriaki Markoullis et al.   GLIA

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury

(2012) Michael J. Chen et al.   GLIA

Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice

(2012) Sarah E. Lutz et al.   JOURNAL OF NEUROIMMUNOLOGY

Critical Role of Connexin 43 in Secondary Expansion of Traumatic Spinal Cord Injury

(2012) C. Huang et al.   JOURNAL OF NEUROSCIENCE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Interleukin-34 Selectively Enhances the Neuroprotective Effects of Microglia to Attenuate Oligomeric Amyloid-β Neurotoxicity

(2011) Tetsuya Mizuno et al.   AMERICAN JOURNAL OF PATHOLOGY

The S100A10-Annexin A2 Complex Provides a Novel Asymmetric Platform for Membrane Repair

(2011) Atoosa Rezvanpour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential expression of SOCS1 in macrophages in relapsing-remitting and chronic EAE and its role in disease severity

(2010) Jennifer L. Berard et al.   GLIA

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes

(2008) Annette Koulakoff et al.   GLIA

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury

(2008) Michael Cronin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Natural history of secondary-progressive multiple sclerosis

(2008) Helen Tremlett et al.   Multiple Sclerosis Journal