Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

Relationship Between the Gut Microbiome and Systemic Chemotherapy

(2020) Samantha M. Ervin et al.   DIGESTIVE DISEASES AND SCIENCES

Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer

(2020) Ching-Wei Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PT-112 in advanced metastatic castrate-resistant prostate cancer (mCRPC), as monotherapy or in combination with PD-L1 inhibitor avelumab: Findings from two phase I studies.

(2020) Alan Haruo Bryce et al.   JOURNAL OF CLINICAL ONCOLOGY

Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy

(2020) Guojun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

(2020) Isaure Vanmeerbeek et al.   OncoImmunology

PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models

(2020) Takahiro Yamazaki et al.   OncoImmunology

Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress

(2020) Juliette Humeau et al.   EMBO Molecular Medicine

Nivolumab (NIVO) + ipilimumab (IPI) + 2 cycles of platinum-doublet chemotherapy (chemo) vs 4 cycles chemo as first-line (1L) treatment (tx) for stage IV/recurrent non-small cell lung cancer (NSCLC): CheckMate 9LA.

(2020) Martin Reck et al.   JOURNAL OF CLINICAL ONCOLOGY

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Immunotherapy for the first-line treatment of patients with metastatic non-small cell lung cancer

(2019) Pablo Martinez et al.   CLINICAL CANCER RESEARCH

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells

(2019) Maxine Bauzon et al.   OncoImmunology

Next generation sequencing of PD-L1 for predicting response to immune checkpoint inhibitors

(2019) Jeffrey M. Conroy et al.   Journal for ImmunoTherapy of Cancer

Non‐Thermal Plasma as a Unique Delivery System of Short‐Lived Reactive Oxygen and Nitrogen Species for Immunogenic Cell Death in Melanoma Cells

(2019) Abraham Lin et al.   Advanced Science

The NKG2A immune checkpoint — a new direction in cancer immunotherapy

(2019) Benjamin C. Creelan et al.   Nature Reviews Clinical Oncology

Glucocorticoids promote breast cancer metastasis

(2019) Milan M. S. Obradović et al.   NATURE

Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?

(2019) Yoshihiro Ohue et al.   CANCER SCIENCE

TIM-3 dictates functional orientation of the immune infiltrate in ovarian cancer

(2019) Jitka Fucikova et al.   CLINICAL CANCER RESEARCH

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

(2019) Linda Hammerich et al.   NATURE MEDICINE

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

(2019) Leonie Voorwerk et al.   NATURE MEDICINE

Tumor lysis with LTX-401 creates anticancer immunity

(2019) Wei Xie et al.   OncoImmunology

Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma

(2019) Praveen K. Bommareddy et al.   OncoImmunology

The novel oncolytic compound LTX-401 induces antitumor immune responses in experimental hepatocellular carcinoma

(2019) Brynjar Mauseth et al.   Molecular Therapy-Oncolytics

Neoadjuvant Chemotherapy Increases PD-L1 Expression and CD8+ Tumor-infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma

(2019) EIJI FUKUOKA et al.   ANTICANCER RESEARCH

Process of immunogenic cell death caused by disulfiram as the anti-colorectal cancer candidate

(2019) Si-yuan You et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adjuvant Chemotherapy Increases Programmed Death-Ligand 1 (PD-L1) Expression in Non–small Cell Lung Cancer Recurrence

(2019) Max Lacour et al.   Clinical Lung Cancer

Beta blockade as adjunctive breast cancer therapy: A review

(2019) Sneha Phadke et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression

(2019) Cristina Segovia et al.   NATURE MEDICINE

ErtlFunctionalGroupsFinder: automated rule-based functional group detection with the Chemistry Development Kit (CDK)

(2019) Sebastian Fritsch et al.   Journal of Cheminformatics

Trial watch: dendritic cell vaccination for cancer immunotherapy

(2019) Jenny Sprooten et al.   OncoImmunology

Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients

(2019) Silvia C. Formenti et al.   Journal for ImmunoTherapy of Cancer

Pembrolizumab in relapsed or refractory Hodgkin lymphoma: 2-year follow-up of KEYNOTE-087

(2019) Robert Chen et al.   BLOOD

An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation

(2019) Luciano Castiello et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy

(2019) David A. Schaer et al.   CLINICAL CANCER RESEARCH

CD4 T cells target colorectal cancer antigens upregulated by oxaliplatin

(2019) Jeanne Galaine et al.   INTERNATIONAL JOURNAL OF CANCER

Nano-encapsulated tryptanthrin derivative for combined anticancer therapy via inhibiting indoleamine 2,3-dioxygenase and inducing immunogenic cell death

(2019) Canyu Yang et al.   Nanomedicine

Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity

(2019) Heng Yang et al.   NATURE MEDICINE

Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles

(2019) Claire Vanpouille-Box et al.   NATURE REVIEWS DRUG DISCOVERY

Cisplatin and oxaliplatin induce similar immunogenic changes in preclinical models of head and neck cancer

(2019) So-Jin Park et al.   ORAL ONCOLOGY

Extracorporeal photochemotherapy induces bona fide immunogenic cell death

(2019) Kazuki Tatsuno et al.   Cell Death & Disease

Cisplatin increases PD-L1 expression and optimizes immune check-point blockade in non-small cell lung cancer

(2019) Ludovic Fournel et al.   CANCER LETTERS

Pre-operative β-blockade with propranolol reduces biomarkers of metastasis in breast cancer: a Phase II randomized trial

(2019) Jonathan G Hiller et al.   CLINICAL CANCER RESEARCH

Calreticulin exposure on malignant blasts correlates with improved natural killer cell-mediated cytotoxicity in acute myeloid leukemia patients

(2019) Iva Truxova et al.   HAEMATOLOGICA

BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma

(2019) Miao Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

cGAS/STING axis mediates a topoisomerase II inhibitor–induced tumor immunogenicity

(2019) Zining Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunosuppression by Mutated Calreticulin Released from Malignant Cells

(2019) Peng Liu et al.   MOLECULAR CELL

Chemotherapy-induced neuroinflammation is associated with disrupted colonic and bacterial homeostasis in female mice

(2019) B. R. Loman et al.   Scientific Reports

Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer

(2019) Anne-Sophie Hamy et al.   OncoImmunology

Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients

(2019) Lenka Kasikova et al.   Journal for ImmunoTherapy of Cancer

Immune induction strategies to enhance responses to PD-1 blockade: lessons from the TONIC trial

(2019) Sandra Demaria et al.   Journal for ImmunoTherapy of Cancer

Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer Cells

(2019) Jinthe Van Loenhout et al.   Cancers

Sequencing Ipilimumab Immunotherapy Before or After Chemotherapy (Nab-Paclitaxel and Bevacizumab) for the Treatment of BRAFwt (BRAF Wild-Type) Metastatic Malignant Melanoma

(2019) Svetomir N. Markovic et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Medium dose intermittent cyclophosphamide induces immunogenic cell death and cancer cell autonomous type I interferon production in glioma models

(2019) Bin Du et al.   CANCER LETTERS

Unusual nature of long non-coding RNAs coding for “unusual peptides”

(2019) Angshuman Bagchi   GENE

Dominant Role of the Gut Microbiota in Chemotherapy Induced Neuropathic Pain

(2019) Chandran Ramakrishna et al.   Scientific Reports

Vinorelbine, cyclophosphamide and 5-FU effects on the circulating and intratumoural landscape of immune cells improve anti-PD-L1 efficacy in preclinical models of breast cancer and lymphoma

(2018) Stefania Orecchioni et al.   BRITISH JOURNAL OF CANCER

Cytosolic DNA Sensing in Organismal Tumor Control

(2018) Claire Vanpouille-Box et al.   CANCER CELL

Extracorporeal Photochemotherapy Drives Monocyte-to-Dendritic Cell Maturation to Induce Anticancer Immunity

(2018) Alessandra Ventura et al.   CANCER RESEARCH

eIF2α phosphorylation is pathognomonic for immunogenic cell death

(2018) Lucillia Bezu et al.   CELL DEATH AND DIFFERENTIATION

Impact of 5-Fu/oxaliplatin on mouse dendritic cells and synergetic effect with a colon cancer vaccine

(2018) Xinqiang Hong et al.   Chinese Journal of Cancer Research

Dinaciclib induces immunogenic cell death and enhances anti-PD1–mediated tumor suppression

(2018) Dewan Md Sakib Hossain et al.   JOURNAL OF CLINICAL INVESTIGATION

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

(2018) Franck Pagès et al.   LANCET

Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study

(2018) Marina Chiara Garassino et al.   LANCET ONCOLOGY

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

The promise and challenges of immune agonist antibody development in cancer

(2018) Patrick A. Mayes et al.   NATURE REVIEWS DRUG DISCOVERY

Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC

(2018) Mark A. Socinski et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combining chemotherapy with PD-1 blockade in NSCLC

(2018) Matthen Mathew et al.   PHARMACOLOGY & THERAPEUTICS

The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies

(2018) Laurence Zitvogel et al.   SCIENCE

PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer

(2018) Magalie Dosset et al.   OncoImmunology

Gemcitabine alters the proteasome composition and immunopeptidome of tumour cells

(2018) A. M. Gravett et al.   OncoImmunology

Targeting adenosine for cancer immunotherapy

(2018) Robert D. Leone et al.   Journal for ImmunoTherapy of Cancer

STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer

(2018) Abdi Ghaffari et al.   BRITISH JOURNAL OF CANCER

Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody

(2018) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC

(2018) Scott J. Antonia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

(2018) Lien Van Hoecke et al.   Nature Communications

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

Impact of cytotoxic chemotherapy on PD-L1 expression in patients with non–small cell lung cancer negative for EGFR mutation and ALK fusion

(2018) Hitomi Sakai et al.   LUNG CANCER

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

(2018) Silvia C. Formenti et al.   NATURE MEDICINE

Linking cellular stress responses to systemic homeostasis

(2018) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram

(2018) Dusana Majera et al.   PROSTATE

Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16

(2018) Sanjeev Kumar Sagwal et al.   Cell Death & Disease

Effect of Platinum-Based Chemotherapy on PD-L1 Expression on Tumor Cells in Non-small Cell Lung Cancer

(2018) Junghoon Shin et al.   Cancer Research and Treatment

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

(2018) Kathleen M. Kokolus et al.   OncoImmunology

Electrochemotherapy with cisplatin increases survival and induces immunogenic responses in murine models of lung cancer and colorectal cancer

(2018) Liam Friel Tremble et al.   CANCER LETTERS

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

(2017) Abhishek D. Garg et al.   IMMUNOLOGICAL REVIEWS

High hydrostatic pressure affects antigenic pool in tumor cells: Implication for dendritic cell-based cancer immunotherapy

(2017) Linda Urbanova et al.   IMMUNOLOGY LETTERS

Role of interferon regulatory factor 1 in governing Treg depletion, Th1 polarization, inflammasome activation and antitumor efficacy of cyclophosphamide

(2017) Carla Buccione et al.   INTERNATIONAL JOURNAL OF CANCER

Nanosecond-Pulsed DBD Plasma-Generated Reactive Oxygen Species Trigger Immunogenic Cell Death in A549 Lung Carcinoma Cells through Intracellular Oxidative Stress

(2017) Abraham Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase II Trial of Atezolizumab As First-Line or Subsequent Therapy for Patients With Programmed Death-Ligand 1–Selected Advanced Non–Small-Cell Lung Cancer (BIRCH)

(2017) Solange Peters et al.   JOURNAL OF CLINICAL ONCOLOGY

Carboplatin and programmed death-ligand 1 blockade synergistically produce a similar antitumor effect to carboplatin alone in murine ID8 ovarian cancer model

(2017) Xinxin Zhu et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

The immune contexture in cancer prognosis and treatment

(2017) Wolf H. Fridman et al.   Nature Reviews Clinical Oncology

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Gut microbiota modulation of chemotherapy efficacy and toxicity

(2017) James L. Alexander et al.   Nature Reviews Gastroenterology & Hepatology

Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer

(2017) Scott J. Antonia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

(2017) Moshe Sade-Feldman et al.   Nature Communications

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice

(2017) Romana Mikyskova et al.   OncoImmunology

Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune-environment

(2017) Chiara Riganti et al.   OncoImmunology

Pro-necrotic molecules impact local immunosurveillance in human breast cancer

(2017) Gautier Stoll et al.   OncoImmunology

Nano-Pulse Stimulation is a physical modality that can trigger immunogenic tumor cell death

(2017) Richard Nuccitelli et al.   Journal for ImmunoTherapy of Cancer

The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer

(2016) Sylvain Ladoire et al.   Autophagy

Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients

(2016) J. Fucikova et al.   BLOOD

Repeated cycles of 5-fluorouracil chemotherapy impaired anti-tumor functions of cytotoxic T cells in a CT26 tumor-bearing mouse model

(2016) Yanhong Wu et al.   BMC IMMUNOLOGY

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Calreticulin Expression in Human Non–Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis

(2016) Jitka Fucikova et al.   CANCER RESEARCH

Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells

(2016) E. Beyranvand Nejad et al.   CANCER RESEARCH

The Basis of Oncoimmunology

(2016) A. Karolina Palucka et al.   CELL

The oncolytic compound LTX-401 targets the Golgi apparatus

(2016) Heng Zhou et al.   CELL DEATH AND DIFFERENTIATION

The oncolytic peptide LTX-315 overcomes resistance of cancers to immunotherapy with CTLA4 checkpoint blockade

(2016) T Yamazaki et al.   CELL DEATH AND DIFFERENTIATION

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

(2016) Jonathan E Rosenberg et al.   LANCET

Irinotecan-Induced Gastrointestinal Dysfunction and Pain Are Mediated by Common TLR4-Dependent Mechanisms

(2016) Hannah R. Wardill et al.   MOLECULAR CANCER THERAPEUTICS

The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death

(2016) Chiara Pozzi et al.   NATURE MEDICINE

Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination

(2016) Celine Boutros et al.   Nature Reviews Clinical Oncology

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

(2016) Tania Løve Aaes et al.   Cell Reports

Immunogenicity of trivalent influenza vaccine in patients with lung cancer undergoing anticancer chemotherapy

(2016) Kei Nakashima et al.   Human Vaccines & Immunotherapeutics

PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction?

(2016) Claud Grigg et al.   Journal for ImmunoTherapy of Cancer

Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes

(2015) Daniel Yuan Qiang Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells

(2015) S. Martin et al.   BIOCHEMICAL PHARMACOLOGY

Docetaxel enhances CD3+ CD56+ cytokine-induced killer cells-mediated killing through inducing tumor cells phenotype modulation

(2015) WenJia Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface-Associated Calreticulin

(2015) A. M. Dudek-Peri  et al.   CANCER RESEARCH

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

(2015) Claire Vanpouille-Box et al.   CANCER RESEARCH

Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer

(2015) S. Takeuchi et al.   CANCER RESEARCH

Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor- B to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer

(2015) J. Peng et al.   CANCER RESEARCH

Reactive oxygen species involved in CT26 immunogenic cell death induced by Clostridium difficile toxin B

(2015) Chunli Sun et al.   IMMUNOLOGY LETTERS

Alkylating Agent Melphalan Augments the Efficacy of Adoptive Immunotherapy Using Tumor-Specific CD4+T Cells

(2015) Xiaoyun Lu et al.   JOURNAL OF IMMUNOLOGY

PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy

(2015) S. P. Patel et al.   MOLECULAR CANCER THERAPEUTICS

Natural and therapy-induced immunosurveillance in breast cancer

(2015) Guido Kroemer et al.   NATURE MEDICINE

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via CD91

(2015) Maria Saveria Gilardini Montani et al.   NUTRITION

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells

(2015) Liv-Marie Eike et al.   Oncotarget

Immunological data from cancer patients treated with Ad5/3 E2F Δ24 GMCSF suggests utility for tumor immunotherapy

(2015) Otto Hemminki et al.   Oncotarget

PD-1 Restrains Radiotherapy-Induced Abscopal Effect

(2015) S. S. Park et al.   Cancer Immunology Research

Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer

(2015) Jitka Fucikova et al.   Frontiers in Immunology

Chemotherapy Use, Performance Status, and Quality of Life at the End of Life

(2015) Holly G. Prigerson et al.   JAMA Oncology

Nanoelectroablation of Murine Tumors Triggers a CD8-Dependent Inhibition of Secondary Tumor Growth

(2015) Richard Nuccitelli et al.   PLoS One

Treatment of osteosarcoma with microwave thermal ablation to induce immunogenic cell death

(2015) Zhe Yu et al.   Oncotarget

Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma

(2015) Tiansuo Zhao et al.   Oncotarget

Immunosuppressive Myeloid Cells Induced by Chemotherapy Attenuate Antitumor CD4+ T-Cell Responses through the PD-1-PD-L1 Axis

(2014) Z.-C. Ding et al.   CANCER RESEARCH

Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state

(2014) Miki Tongu et al.   CANCER SCIENCE

Tumor-infiltrating dendritic cells exhibit defective cross-presentation of tumor antigens, but is reversed by chemotherapy

(2014) Alison M. McDonnell et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosis

(2014) Sarah Dimeloe et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

High hydrostatic pressure induces immunogenic cell death in human tumor cells

(2014) Jitka Fucikova et al.   INTERNATIONAL JOURNAL OF CANCER

Newcastle disease virotherapy induces long-term survival and tumor-specific immune memory in orthotopic glioma through the induction of immunogenic cell death

(2014) Carolien A. Koks et al.   INTERNATIONAL JOURNAL OF CANCER

The key role of calreticulin in immunomodulation induced by chemotherapeutic agents

(2014) Yoshiyuki Yamamura et al.   International Journal of Clinical Oncology

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy

(2014) D. Zamarin et al.   Science Translational Medicine

Screening of novel immunogenic cell death inducers within the NCI Mechanistic Diversity Set

(2014) Abdul Qader Sukkurwala et al.   OncoImmunology

LTX-315 (Oncopore™)

(2014) Ketil André Camilio et al.   OncoImmunology

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors

(2013) A. C. West et al.   CANCER RESEARCH

CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

(2013) Yuting Ma et al.   CANCER RESEARCH

Capsaicin as an inducer of damage-associated molecular patterns (DAMPs) of immunogenic cell death (ICD) in human bladder cancer cells

(2013) Donatella D’Eliseo et al.   CELL STRESS & CHAPERONES

LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma

(2013) J. T. Yeung et al.   CLINICAL CANCER RESEARCH

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Bleomycin Exerts Ambivalent Antitumor Immune Effect by Triggering Both Immunogenic Cell Death and Proliferation of Regulatory T Cells

(2013) Hélène Bugaut et al.   PLoS One

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

(2013) S. Viaud et al.   SCIENCE

Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo

(2012) Miki Tongu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine

(2012) Hui-Ming Chen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

(2012) I. Diaconu et al.   CANCER RESEARCH

Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma

(2012) S. Miyamoto et al.   CANCER RESEARCH

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Primary Effusion Lymphoma Cell Death Induced by Bortezomib and AG 490 Activates Dendritic Cells through CD91

(2012) Mara Cirone et al.   PLoS One

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

(2012) L. Senovilla et al.   SCIENCE

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

(2012) L. Menger et al.   Science Translational Medicine

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

(2011) Abhishek D. Garg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Involvement of damage-associated molecular patterns in tumor response to photodynamic therapy: surface expression of calreticulin and high-mobility group box-1 release

(2011) Mladen Korbelik et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response

(2011) J. Fucikova et al.   CANCER RESEARCH

Unraveling Cancer Chemoimmunotherapy Mechanisms by Gene and Protein Expression Profiling of Responses to Cyclophosphamide

(2011) F. Moschella et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Measles virus causes immunogenic cell death in human melanoma

(2011) O G Donnelly et al.   GENE THERAPY

Epothilone B enhances Class I HLA and HLA-A2 surface molecule expression in ovarian cancer cells

(2011) Ilenia Pellicciotta et al.   GYNECOLOGIC ONCOLOGY

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

(2011) Yuting Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of Immunogenic Apoptosis by Blockade of Epidermal Growth Factor Receptor Activation with a Specific Antibody

(2011) Greta Garrido et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas

(2011) Christoph Bergmann et al.   Journal of Translational Medicine

Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy

(2011) Ioannis Alagkiozidis et al.   Journal of Translational Medicine

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro

(2010) Jürgen Sonnemann et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cyclophosphamide Induces Differentiation of Th17 Cells in Cancer Patients

(2010) S. Viaud et al.   CANCER RESEARCH

Cyclophosphamide Synergizes with Type I Interferons through Systemic Dendritic Cell Reactivation and Induction of Immunogenic Tumor Apoptosis

(2010) G. Schiavoni et al.   CANCER RESEARCH

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell-Dependent Antitumor Immunity

(2010) J. Vincent et al.   CANCER RESEARCH

Consecutive low doses of cyclophosphamide preferentially target Tregs and potentiate T cell responses induced by DNA PLG microparticle immunization

(2010) Christine M. Barbon et al.   CELLULAR IMMUNOLOGY

A Novel Chemoimmunomodulating Property of Docetaxel: Suppression of Myeloid-Derived Suppressor Cells in Tumor Bearers

(2010) K. N. Kodumudi et al.   CLINICAL CANCER RESEARCH

Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages

(2010) Ilia N. Buhtoiarov et al.   IMMUNOLOGY

Metronomic chemotherapy: new rationale for new directions

(2010) Eddy Pasquier et al.   Nature Reviews Clinical Oncology

Classification of Chemotherapeutic Agents Based on Their Differential In vitro Effects on Dendritic Cells

(2009) H. Tanaka et al.   CANCER RESEARCH

Dual Therapeutic Efficacy of Vinblastine as a Unique Chemotherapeutic Agent Capable of Inducing Dendritic Cell Maturation

(2009) H. Tanaka et al.   CANCER RESEARCH

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice

(2009) Hanh K. Le et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3+ Regulatory T Cells

(2008) S. Ladoire et al.   CLINICAL CANCER RESEARCH

Post-apoptotic tumors are more palatable to dendritic cells and enhance their antigen cross-presentation activity

(2008) Davide Brusa et al.   VACCINE