Radiation causes tissue damage by dysregulating inflammasome–gasdermin D signaling in both host and transplanted cells

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Developmental origin, functional maintenance and genetic rescue of osteoclasts

(2019) Christian E. Jacome-Galarza et al.   NATURE

IRF2 transcriptionally induces GSDMD expression for pyroptosis

(2019) Nobuhiko Kayagaki et al.   Science Signaling

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Changes in trabecular bone score and bone mineral density following allogeneic hematopoietic stem cell transplantation

(2019) Yejee Lim et al.   BONE

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

(2019) Sheng Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gasdermin D activity in inflammation and host defense

(2019) Judy Lieberman et al.   Science Immunology

5-Androstenediol prevents radiation injury in mice by promoting NF-κB signaling and inhibiting AIM2 inflammasome activation

(2019) Tiancong Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

(2019) Jian Gao et al.   Cell Death & Disease

Total body irradiation in allogeneic bone marrow transplantation conditioning regimens: A review

(2018) Adrien Paix et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

(2018) Apurva Kanneganti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mortality After High-Energy Pelvic Fractures in Patients of Age 65 Years or Older

(2018) Dayley S. Keil et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice

(2018) Jianqiu Xiao et al.   PLOS BIOLOGY

Central nervous system complications after allogeneic hematopoietic stem cell transplantation

(2017) Ranjit Kumar Chaudhary et al.   Future Oncology

A noncanonical function of cGAMP in inflammasome priming and activation

(2017) Karen V. Swanson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

(2017) David Furman et al.   NATURE MEDICINE

NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages

(2017) Yan-gang Liu et al.   Cell Death & Disease

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells

(2017) Chun Wang et al.   Scientific Reports

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

(2017) Yael Alippe et al.   Scientific Reports

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

(2016) A. A. Basiorka et al.   BLOOD

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

(2016) Bo Hu et al.   SCIENCE

Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation

(2016) C Wang et al.   Cell Death & Disease

Unraveling the Pathogenesis of MDS: The NLRP3 Inflammasome and Pyroptosis Drive the MDS Phenotype

(2016) David A. Sallman et al.   Frontiers in Oncology

Management of Radiation-associated Fractures

(2016) Christopher P. Cannon et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms

(2015) Chao Qu et al.   FASEB JOURNAL

Single-Limb Irradiation Induces Local and Systemic Bone Loss in a Murine Model

(2015) Laura E Wright et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis

(2014) Z. Ding et al.   CARDIOVASCULAR RESEARCH

Radiation Exposure Induces Inflammasome Pathway Activation in Immune Cells

(2014) Veit M. Stoecklein et al.   JOURNAL OF IMMUNOLOGY

Periodontitis mainly increases osteoclast formation via enhancing the differentiation of quiescent osteoclast precursors into osteoclasts

(2014) D.-E. Lee et al.   JOURNAL OF PERIODONTAL RESEARCH

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(2014) Ben Lu et al.   MOLECULAR MEDICINE

The Nlrp3 inflammasome regulates acute graft-versus-host disease

(2013) Dragana Jankovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mortality after low trauma hip fracture: a prospective cohort study

(2012) Majid Valizadeh et al.   BMC MUSCULOSKELETAL DISORDERS

TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis

(2012) Sanna Nyström et al.   EMBO JOURNAL

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Molecular Basis of Requirement of Receptor Activator of Nuclear Factor κB Signaling for Interleukin 1-mediated Osteoclastogenesis

(2012) Joel Jules et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery

(2012) Christian E Jacome-Galarza et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target Genes

(2012) Süheda Erener et al.   MOLECULAR CELL

Radioimmunotherapy-based conditioning for hematopoietic cell transplantation in children with malignant and nonmalignant diseases

(2011) A. S. Schulz et al.   BLOOD

Bone density and structure in long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation

(2011) Sogol Mostoufi-Moab et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes

(2010) R. K. S. Malireddi et al.   JOURNAL OF IMMUNOLOGY

Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse

(2009) Hisataka Kondo et al.   JOURNAL OF APPLIED PHYSIOLOGY