Control of Apoptosis in Treatment and Biology of Pancreatic Cancer

Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells

(2014) Nameeta Mujumdar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the Death Receptor pathway

(2014) Zhiyu Chen et al.   CANCER LETTERS

Therapeutic potential of histone deacetylase inhibitors in pancreatic cancer

(2014) Wan Feng et al.   CANCER LETTERS

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

(2014) W. Zhang et al.   Science Signaling

Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation

(2013) Li Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Triptolide-induced Cell Death in Pancreatic Cancer Is Mediated byO-GlcNAc Modification of Transcription Factor Sp1

(2013) Sulagna Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Histone deacetylase inhibitors and pancreatic cancer: Are there any promising clinical trials?

(2013) Ioannis Koutsounas   WORLD JOURNAL OF GASTROENTEROLOGY

Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer

(2013) J S Carew et al.   Cell Death & Disease

Phase I Trial of AEG35156 an Antisense Oligonucleotide to XIAP Plus Gemcitabine in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

(2012) Daruka Mahadevan et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Role of Wnt/β-catenin Signaling in Drug Resistance of Pancreatic Cancer

(2012) Jiujie Cui et al.   CURRENT PHARMACEUTICAL DESIGN

NF-κB as a target for pancreatic cancer therapy

(2012) Carmine Carbone et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Triptolide Cooperates With Cisplatin to Induce Apoptosis in Gemcitabine-Resistant Pancreatic Cancer

(2012) Wenbo Zhu et al.   PANCREAS

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer

(2012) R. Chugh et al.   Science Translational Medicine

Immunotherapy updates in pancreatic cancer: are we there yet?

(2012) Krishna Soujanya Gunturu et al.   Therapeutic Advances in Medical Oncology

Lineage Tracing Evidence for Transdifferentiation of Acinar to Duct Cells and Plasticity of Human Pancreas

(2011) Isabelle Houbracken et al.   GASTROENTEROLOGY

Pancreatic ductal cells in development, regeneration, and neoplasia

(2011) Maximilian Reichert et al.   JOURNAL OF CLINICAL INVESTIGATION

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic Cancer Therapy

(2011) Ashiq Masood et al.   Cancers

Targeting apoptosis pathways in pancreatic cancer

(2010) Alexander Arlt et al.   CANCER LETTERS

Triptolide Induces Cell Death in Pancreatic Cancer Cells by Apoptotic and Autophagic Pathways

(2010) Nameeta Mujumdar et al.   GASTROENTEROLOGY

Advanced or Metastatic Pancreatic Cancer: Molecular Targeted Therapies

(2010) Soley Bayraktar et al.   MOUNT SINAI JOURNAL OF MEDICINE

Potentiation of the effect of gemcitabine by emodin in pancreatic cancer is associated with survivin inhibition

(2009) Qingqu Guo et al.   BIOCHEMICAL PHARMACOLOGY

Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells

(2009) Claudia Scholl et al.   CELL

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

(2009) Sandra J.M. Healy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy

(2009) Yong Lin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pancreatic cancer: molecular pathogenesis and new therapeutic targets

(2009) Han H. Wong et al.   Nature Reviews Gastroenterology & Hepatology

Wnt signaling in development and disease

(2009) Jennifer L. Freese et al.   NEUROBIOLOGY OF DISEASE

Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice

(2009) X Xu et al.   ONCOGENE

The Role of MMP7 and Its Cross-Talk with the FAS/FASL System during the Acquisition of Chemoresistance to Oxaliplatin

(2009) Vanessa Almendro et al.   PLoS One

Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas

(2009) M. Rovira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-Molecule Activators of a Proenzyme

(2009) D. W. Wolan et al.   SCIENCE

Gemcitabine Resistance in Pancreatic Cancer: Picking the Key Players

(2008) M. P. Kim et al.   CLINICAL CANCER RESEARCH

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

(2008) J. M. Bailey et al.   CLINICAL CANCER RESEARCH

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Oral mTOR Inhibitor Everolimus in Patients With Gemcitabine-Refractory Metastatic Pancreatic Cancer

(2008) Brian M. Wolpin et al.   JOURNAL OF CLINICAL ONCOLOGY

Apoptotic pathways in pancreatic ductal adenocarcinoma

(2008) Rainer Hamacher et al.   Molecular Cancer

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE