Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review
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Title
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 11, Pages 5801
Publisher
MDPI AG
Online
2021-05-28
DOI
10.3390/ijms22115801
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Note: Only part of the references are listed.- Natural Killer T Cells in Various Mouse Models of Hepatitis
- (2021) Jun Guan et al. Biomed Research International
- Hepatocellular carcinoma
- (2021) Josep M. Llovet et al. Nature Reviews Disease Primers
- Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3
- (2021) Zhengjun Zhou et al. Journal for ImmunoTherapy of Cancer
- “Complimenting the Complement”: Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma
- (2021) Astha Malik et al. Frontiers in Oncology
- Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma
- (2020) Bruno Sangro et al. JOURNAL OF HEPATOLOGY
- Angiogenesis Genotyping and Clinical Outcomes in Patients with Advanced Hepatocellular Carcinoma Receiving Sorafenib: The ALICE-2 Study
- (2020) Luca Faloppi et al. Targeted Oncology
- The future of cancer immunotherapy: microenvironment-targeting combinations
- (2020) Yonina R. Murciano-Goroff et al. CELL RESEARCH
- Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials
- (2020) Choudhary Harsha et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma
- (2020) Richard S. Finn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Scientific Rationale for Combined Immunotherapy with PD-1/PD-L1 Antibodies and VEGF Inhibitors in Advanced Hepatocellular Carcinoma
- (2020) Masatoshi Kudo Cancers
- Immune Checkpoint Inhibitors in Hepatocellular Cancer: Current Understanding on Mechanisms of Resistance and Biomarkers of Response to Treatment
- (2020) Amblessed E. Onuma et al. GENE EXPRESSION
- Phase Ib Study of Lenvatinib Plus Pembrolizumab in Patients With Unresectable Hepatocellular Carcinoma
- (2020) Richard S. Finn et al. JOURNAL OF CLINICAL ONCOLOGY
- T Cells in Fibrosis and Fibrotic Diseases
- (2020) Mengjuan Zhang et al. Frontiers in Immunology
- Effectiveness of nivolumab versus regorafenib in hepatocellular carcinoma patients who failed sorafenib treatment
- (2020) Cheol-Hyung Lee et al. Clinical and Molecular Hepatology
- Pattern Recognition Receptors: Significance of Expression in the Liver
- (2020) Jan Żeromski et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Dendritic Cell and T Cell Crosstalk in Liver Fibrogenesis and Hepatocarcinogenesis: Implications for Prevention and Therapy of Liver Cancer
- (2020) Isabella Lurje et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Activation of Nrf2/AREs-mediated antioxidant signalling, and suppression of profibrotic TGF-β1/Smad3 pathway: a promising therapeutic strategy for hepatic fibrosis — A review
- (2020) Yongfang Gong et al. LIFE SCIENCES
- The Role of Sinusoidal Endothelial Cells in the Axis of Inflammation and Cancer Within the Liver
- (2020) Alex L. Wilkinson et al. Frontiers in Physiology
- FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation
- (2020) Mirela Cioplea et al. Journal of Immunology Research
- Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib
- (2020) Thomas Yau et al. JAMA Oncology
- Immune exclusion-Wnt/CTNNB1 class predicts resistance to immunotherapies in HCC
- (2019) Roser Pinyol et al. CLINICAL CANCER RESEARCH
- Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial
- (2019) Andrew X Zhu et al. LANCET ONCOLOGY
- Immune Checkpoint Inhibitor-Induced Myositis: a Case Report and Literature Review
- (2019) Hiroko Kadota et al. Current Rheumatology Reports
- Molecular model linking Th2 polarized M2 tumour‐associated macrophages with deaminase‐mediated cancer progression mutation signatures
- (2019) Jared Mamrot et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy
- (2019) Anthony Tanoto Tan et al. GASTROENTEROLOGY
- Macrophage-derived CCL22 promotes an immunosuppressive tumor microenvironment via IL-8 in malignant pleural effusion
- (2019) Dong Wang et al. CANCER LETTERS
- Genome-wide copy number alteration and VEGFA amplification of circulating cell-free DNA as a biomarker in advanced hepatocellular carcinoma patients treated with Sorafenib
- (2019) Chung Ryul Oh et al. BMC CANCER
- RATIONALE 301 study: tislelizumab versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma
- (2019) Shukui Qin et al. Future Oncology
- Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma
- (2019) Man Liu et al. GUT
- A Positive Feedback Loop Between Cancer Stem‐Like Cells and Tumor‐Associated Neutrophils Controls Hepatocellular Carcinoma Progression
- (2019) Shao‐Lai Zhou et al. HEPATOLOGY
- The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice
- (2019) Junwen Qu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma
- (2019) Yohei Mano et al. JOURNAL OF GASTROENTEROLOGY
- Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials
- (2019) Yucai Wang et al. JAMA Oncology
- Tumor-Associated Neutrophils in Cancer: Going Pro
- (2019) Wu et al. Cancers
- The Tumor Microenvironment Innately Modulates Cancer Progression
- (2019) Dominique C. Hinshaw et al. CANCER RESEARCH
- Autoimmunity, checkpoint inhibitor therapy and immune-related adverse events: A review
- (2019) Shaheen Khan et al. SEMINARS IN CANCER BIOLOGY
- PD-1 inhibitors monotherapy in hepatocellular carcinoma: Meta-analysis and systematic review
- (2019) Ioannis A. Voutsadakis Hepatobiliary & Pancreatic Diseases International
- From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma
- (2019) Yaojie Fu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Bacterial infections in cirrhosis: Current treatment
- (2019) Godolfino Miranda-Zazueta et al. Annals of Hepatology
- LBA38_PRCheckMate 459: A randomized, multi-center phase III study of nivolumab (NIVO) vs sorafenib (SOR) as first-line (1L) treatment in patients (pts) with advanced hepatocellular carcinoma (aHCC)
- (2019) T Yau et al. ANNALS OF ONCOLOGY
- Predictive and Prognostic Factors in HCC Patients Treated with Sorafenib
- (2019) Oronzo Brunetti et al. Medicina-Lithuania
- Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response
- (2019) Bridget P. Keenan et al. Journal for ImmunoTherapy of Cancer
- Tackling hepatocellular carcinoma with individual or combinatorial immunotherapy approaches
- (2019) Maria Tagliamonte et al. CANCER LETTERS
- Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial
- (2019) Richard S. Finn et al. JOURNAL OF CLINICAL ONCOLOGY
- Tumor-infiltrating Treg, MDSC, and IDO expression associated with outcomes of neoadjuvant chemotherapy of breast cancer
- (2018) Fangxuan Li et al. CANCER BIOLOGY & THERAPY
- How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions
- (2018) Annika M. Bruger et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Keratin 19 Expression in Hepatocellular Carcinoma Is Regulated by Fibroblast-Derived HGF via a MET-ERK1/2-AP1 and SP1 Axis
- (2018) Hyungjin Rhee et al. CANCER RESEARCH
- NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control
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- Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification
- (2018) Yutaka Kurebayashi et al. HEPATOLOGY
- Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment
- (2018) Jingying Zhang et al. HEPATOLOGY
- Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial
- (2018) Masatoshi Kudo et al. LANCET
- Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial
- (2018) Andrew X Zhu et al. LANCET ONCOLOGY
- High number of PD-1 positive intratumoural lymphocytes predicts survival benefit of cytokine-induced killer cells for hepatocellular carcinoma patients
- (2018) Boyang Chang et al. LIVER INTERNATIONAL
- Development of GPC3-Specific Chimeric Antigen Receptor-Engineered Natural Killer Cells for the Treatment of Hepatocellular Carcinoma
- (2018) Min Yu et al. MOLECULAR THERAPY
- A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments
- (2018) Kevin C. Barry et al. NATURE MEDICINE
- Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges
- (2018) Dai Fukumura et al. Nature Reviews Clinical Oncology
- Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa
- (2018) Kabir A. Khan et al. Nature Reviews Clinical Oncology
- Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity
- (2018) Shishir Shetty et al. Nature Reviews Gastroenterology & Hepatology
- Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma
- (2018) Ghassan K. Abou-Alfa et al. NEW ENGLAND JOURNAL OF MEDICINE
- Macrophages: The Road Less Traveled, Changing Anticancer Therapy
- (2018) Jennifer L. Guerriero TRENDS IN MOLECULAR MEDICINE
- Crosstalk between hepatic tumor cells and macrophages via Wnt/β-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors
- (2018) Yang Yang et al. Cell Death & Disease
- Conditional survival of patients with hepatocellular carcinoma: results from the Surveillance, Epidemiology, and End Results registry
- (2018) Guoqing Zhang et al. Expert Review of Gastroenterology & Hepatology
- γδ T cells in liver diseases
- (2018) Xuefu Wang et al. Frontiers of Medicine
- Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease
- (2018) Lin Jia et al. Molecular Metabolism
- Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations
- (2018) Judith A. Seidel et al. Frontiers in Oncology
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Immune-related adverse events from combination immunotherapy in cancer patients: A comprehensive meta-analysis of randomized controlled trials
- (2018) Bo Zhang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Molecular therapies and precision medicine for hepatocellular carcinoma
- (2018) Josep M. Llovet et al. Nature Reviews Clinical Oncology
- Natural Killer Cells in Liver Disease and Hepatocellular Carcinoma and the NK Cell-Based Immunotherapy
- (2018) Pingyi Liu et al. Journal of Immunology Research
- Combination of radiation and interleukin 12 eradicates large orthotopic hepatocellular carcinoma through immunomodulation of tumor microenvironment
- (2018) Chia-Jen Wu et al. OncoImmunology
- Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors
- (2018) Daniel Y. Wang et al. JAMA Oncology
- Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next Generation Sequencing for Matching Patients to Targeted and Immune Therapies
- (2018) James J Harding et al. CLINICAL CANCER RESEARCH
- Targeted and Immune-Based Therapies for Hepatocellular Carcinoma
- (2018) Tim F. Greten et al. GASTROENTEROLOGY
- Tremelimumab in combination with microwave ablation in patients with refractory biliary tract cancer
- (2018) Changqing Xie et al. HEPATOLOGY
- Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts
- (2018) Yuan Zhou et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Cancer-associated fibroblasts promote the stemness of CD24+ liver cells via paracrine signaling
- (2018) Yawen Li et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Thermodynamics of helix formation in small peptides of varying length in vacuo, in implicit solvent, and in explicit solvent
- (2018) Xiaohui Wang et al. JOURNAL OF MOLECULAR MODELING
- Prognostic value of tumor-infiltrating lymphocytes in hepatocellular carcinoma
- (2018) Wei Ding et al. MEDICINE
- Comprehensive molecular and immunological characterization of hepatocellular carcinoma
- (2018) Shu Shimada et al. EBioMedicine
- Genetic Features of Aflatoxin-Associated Hepatocellular Carcinoma
- (2017) Weilong Zhang et al. GASTROENTEROLOGY
- Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features
- (2017) Daniela Sia et al. GASTROENTEROLOGY
- Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy
- (2017) Jingying Zhou et al. GUT
- Neutrophils in Homeostasis, Immunity, and Cancer
- (2017) José Ángel Nicolás-Ávila et al. IMMUNITY
- Programmed Cell Death 1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) in Viral Hepatitis
- (2017) Hyosun Cho et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ARID2 modulates DNA damage response in human hepatocellular carcinoma cells
- (2017) Atsushi Oba et al. JOURNAL OF HEPATOLOGY
- Tremelimumab in combination with ablation in patients with advanced hepatocellular carcinoma
- (2017) Austin G. Duffy et al. JOURNAL OF HEPATOLOGY
- Neutrophils as active regulators of the immune system in the tumor microenvironment
- (2017) Merav E. Shaul et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial
- (2017) Jordi Bruix et al. LANCET
- Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial
- (2017) Anthony B El-Khoueiry et al. LANCET
- Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses
- (2017) Valerie Chew et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
- (2017) Dung T. Le et al. SCIENCE
- Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
- (2017) David Kung-Chun Chiu et al. Nature Communications
- Neutrophil-to-lymphocyte ratio predicts survival in European patients with hepatocellular carcinoma administered sorafenib
- (2017) Alberto Lué et al. Oncotarget
- SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis
- (2017) Vaishaali Natarajan et al. Biomed Research International
- Anti-GPC3-CAR T Cells Suppress the Growth of Tumor Cells in Patient-Derived Xenografts of Hepatocellular Carcinoma
- (2017) Zhiwu Jiang et al. Frontiers in Immunology
- Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment
- (2017) Janna Michaeli et al. OncoImmunology
- T Cell-Activating Mesenchymal Stem Cells as a Biotherapeutic for HCC
- (2017) Arpad Szoor et al. Molecular Therapy-Oncolytics
- A Natural CCR2 Antagonist Relieves Tumor-associated Macrophage-mediated Immunosuppression to Produce a Therapeutic Effect for Liver Cancer
- (2017) Wenbo Yao et al. EBioMedicine
- NKT cell subsets as key participants in liver physiology and pathology
- (2016) Keya Bandyopadhyay et al. Cellular & Molecular Immunology
- Liver immunology and its role in inflammation and homeostasis
- (2016) Mark W Robinson et al. Cellular & Molecular Immunology
- Role of the Microenvironment in Liver Metastasis: From Pre- to Prometastatic Niches
- (2016) P. Brodt CLINICAL CANCER RESEARCH
- Atezolizumab: First Global Approval
- (2016) Anthony Markham DRUGS
- Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib
- (2016) Shao-Lai Zhou et al. GASTROENTEROLOGY
- Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26
- (2016) David Kung-Chun Chiu et al. HEPATOLOGY
- Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration
- (2016) Daniel A. Patten et al. HEPATOLOGY
- A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice
- (2016) Mei Yee Koh et al. HEPATOLOGY
- Immunology in the liver — from homeostasis to disease
- (2016) Felix Heymann et al. Nature Reviews Gastroenterology & Hepatology
- Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells
- (2016) Y Deng et al. ONCOGENE
- Specific CD8+T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis
- (2016) Elia Moreno-Cubero et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis
- (2015) Anne Bertrand et al. BMC Medicine
- Liver natural killer cells: subsets and roles in liver immunity
- (2015) Hui Peng et al. Cellular & Molecular Immunology
- Adjuvant Immunotherapy With Autologous Cytokine-Induced Killer Cells for Hepatocellular Carcinoma
- (2015) Joon Hyeok Lee et al. GASTROENTEROLOGY
- Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma
- (2015) Xiaoguang Li et al. GUT
- Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages
- (2015) Wenjiang Yan et al. GUT
- Type IIFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human
- (2015) Lisa Andzinski et al. INTERNATIONAL JOURNAL OF CANCER
- Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient
- (2015) Waseem Qasim et al. JOURNAL OF HEPATOLOGY
- The yin and yang of evasion and immune activation in HCC
- (2015) Oxana V. Makarova-Rusher et al. JOURNAL OF HEPATOLOGY
- Liver-infiltrating CD8+lymphocytes as prognostic factor for tumour recurrence in hepatitis C virus-related hepatocellular carcinoma
- (2015) Muhammad Ramzan et al. LIVER INTERNATIONAL
- Immunological landscape and immunotherapy of hepatocellular carcinoma
- (2015) Jesús Prieto et al. Nature Reviews Gastroenterology & Hepatology
- Hepatocellular Carcinoma with β-Catenin Mutation: Imaging and Pathologic Characteristics
- (2015) Azusa Kitao et al. RADIOLOGY
- Adipocytokines and hepatic fibrosis
- (2015) Neeraj K. Saxena et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy
- (2015) W. Peng et al. Cancer Discovery
- Changing Hepatocellular Carcinoma Incidence and Liver Cancer Mortality Rates in the United States
- (2014) Sean F Altekruse et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Expression of Fas/FasL in CD8+T and CD3+Foxp3+Treg Cells - Relationship with Apoptosis of Circulating CD8+T Cells in Hepatocellular Carcinoma Patients
- (2014) Cun-Li Guo et al. Asian Pacific Journal of Cancer Prevention
- Pharmacodynamic change in plasma angiogenic proteins: a dose-escalation phase 1 study of the multi-kinase inhibitor lenvatinib
- (2014) Noriyuki Koyama et al. BMC CANCER
- NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma
- (2014) Cheng Sun et al. Cellular & Molecular Immunology
- Tumor-Associated Macrophages: From Mechanisms to Therapy
- (2014) Roy Noy et al. IMMUNITY
- A killer choice for cancer immunotherapy
- (2014) Tobi L. Schmidt et al. IMMUNOLOGIC RESEARCH
- Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
- (2014) Gregory T Motz et al. NATURE MEDICINE
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- (2014) Li Li et al. PLoS One
- Tim-3 expression on peripheral monocytes and CD3+CD16/CD56+natural killer-like T cells in patients with chronic hepatitis B
- (2014) Y.-H. Rong et al. TISSUE ANTIGENS
- Changes in plasma vascular endothelial growth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma
- (2013) Kaoru Tsuchiya et al. CANCER
- Clinical significance of macrophage heterogeneity in human malignant tumors
- (2013) Yoshihiro Komohara et al. CANCER SCIENCE
- Human CD14+CTLA-4+regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma
- (2013) Yanmei Han et al. HEPATOLOGY
- Oncology Meets Immunology: The Cancer-Immunity Cycle
- (2013) Daniel S. Chen et al. IMMUNITY
- Analysis of cytotoxic T lymphocytes from a patient with hepatocellular carcinoma who showed a clinical response to vaccination with a glypican-3-derived peptide
- (2013) YOSHITAKA TADA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
- (2013) Bruno Sangro et al. JOURNAL OF HEPATOLOGY
- Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma
- (2013) Tamar Kapanadze et al. JOURNAL OF HEPATOLOGY
- Regulatory T Cell Infiltration Predicts Outcome Following Resection of Colorectal Cancer Liver Metastases
- (2012) Steven C. Katz et al. ANNALS OF SURGICAL ONCOLOGY
- A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma
- (2012) Tim F Greten et al. BMC CANCER
- Serum Insulin-Like Growth Factor-1 Levels Predict Outcomes of Patients with Advanced Hepatocellular Carcinoma Receiving Antiangiogenic Therapy
- (2012) Y.-Y. Shao et al. CLINICAL CANCER RESEARCH
- Natural killer p46Highexpression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis
- (2012) Benjamin Krämer et al. HEPATOLOGY
- Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma
- (2012) Shao-Lai Zhou et al. HEPATOLOGY
- Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma
- (2012) Hang Li et al. HEPATOLOGY
- Natural killer cells in liver disease
- (2012) Zhigang Tian et al. HEPATOLOGY
- Sorafenib reduces hepatic infiltrated regulatory T cells in hepatocellular carcinoma patients by suppressing TGF-beta signal
- (2012) Quanrongzi Wang et al. JOURNAL OF SURGICAL ONCOLOGY
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
- (2011) Tuanjie Li et al. CANCER LETTERS
- Immune Dysfunction and Infections in Patients With Cirrhosis
- (2011) Alexander R. Bonnel et al. Clinical Gastroenterology and Hepatology
- Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma
- (2011) Valerie Chew et al. GUT
- Foxp3+ regulatory T cells are associated with the natural history of chronic hepatitis B and poor prognosis of hepatocellular carcinoma
- (2011) Fengmei Wang et al. LIVER INTERNATIONAL
- Selective Recruitment of Regulatory T Cell through CCR6-CCL20 in Hepatocellular Carcinoma Fosters Tumor Progression and Predicts Poor Prognosis
- (2011) Kang-Jie Chen et al. PLoS One
- Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion
- (2011) R. D. Schreiber et al. SCIENCE
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- Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells
- (2010) V. Dardalhon et al. JOURNAL OF IMMUNOLOGY
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cancer/testis (CT) antigens: Potential targets for immunotherapy
- (2009) Otavia L. Caballero et al. CANCER SCIENCE
- Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor
- (2009) Bastian Hoechst et al. HEPATOLOGY
- Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells
- (2009) Dong-Ming Kuang et al. HEPATOLOGY
- Human Liver Dendritic Cells Promote T Cell Hyporesponsiveness
- (2009) Z. M. Bamboat et al. JOURNAL OF IMMUNOLOGY
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- (2008) Ogyi Park et al. HEPATOLOGY
- Potent antitumor effect of TRAIL mediated by a novel adeno-associated viral vector targeting to telomerase activity for human hepatocellular carcinoma
- (2008) Yigang Wang et al. JOURNAL OF GENE MEDICINE
- Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
- (2008) Ann-Lii Cheng et al. LANCET ONCOLOGY
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
- The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity
- (2007) Kjetil Elvevold et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Abrogation of the Antifibrotic Effects of Natural Killer Cells/Interferon-γ Contributes to Alcohol Acceleration of Liver Fibrosis
- (2007) Won–Il Jeong et al. GASTROENTEROLOGY
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