Dendritic Cell and T Cell Crosstalk in Liver Fibrogenesis and Hepatocarcinogenesis: Implications for Prevention and Therapy of Liver Cancer

Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses

(2020) Kerry L. Hilligan et al.   Cellular & Molecular Immunology

The innate immune cells in cirrhosis

(2020) Christine Bernsmeier et al.   JOURNAL OF HEPATOLOGY

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

(2020) Natascha Roehlen et al.   Cells

T Cells in Fibrosis and Fibrotic Diseases

(2020) Mengjuan Zhang et al.   Frontiers in Immunology

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

(2019) Sema Kurtulus et al.   IMMUNITY

Phase 1 Trial With the Cell-Based Immune Primer Ilixadencel, Alone, and Combined With Sorafenib, in Advanced Hepatocellular Carcinoma

(2019) Magnus Rizell et al.   Frontiers in Oncology

Treatment Strategies for Hepatocellular Carcinoma – a Multidisciplinary Approach

(2019) Isabella Lurje et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell–Dependent Control of Senescence

(2019) Jana C. Mossanen et al.   GASTROENTEROLOGY

Nivolumab (NIVO) + ipilimumab (IPI) combination therapy in patients (pts) with advanced hepatocellular carcinoma (aHCC): Results from CheckMate 040.

(2019) Thomas Yau et al.   JOURNAL OF CLINICAL ONCOLOGY

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

(2019) Linda Hammerich et al.   NATURE MEDICINE

Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysis

(2019) Thomas Yau et al.   JOURNAL OF HEPATOLOGY

Immunotherapy for hepatocellular carcinoma: Current and future

(2019) Michael P Johnston et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE)

(2019) M. Moehler et al.   OncoImmunology

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

(2019) Charles-Antoine Dutertre et al.   IMMUNITY

From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma

(2019) Yaojie Fu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

(2019) Catrin Tauber et al.   Oncotarget

CX3CR1 Mediates the Development of Monocyte-Derived Dendritic Cells during Hepatic Inflammation

(2019) Salvatore Sutti et al.   Cells

Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming

(2019) Alexandre P. Bénéchet et al.   NATURE

MHC-II neoantigens shape tumour immunity and response to immunotherapy

(2019) Elise Alspach et al.   NATURE

Adaptive immunity: an emerging player in the progression of NAFLD

(2019) Salvatore Sutti et al.   Nature Reviews Gastroenterology & Hepatology

Combination anti–CTLA-4 plus anti–PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies

(2019) Spencer C. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Responses in the Liver

(2018) Paul Kubes et al.   Annual Review of Immunology

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma

(2018) Yusheng Cheng et al.   Cell Death & Disease

Effect of dendritic cell–based immunotherapy on hepatocellular carcinoma: A systematic review and meta-analysis

(2018) CONG CHEN et al.   CYTOTHERAPY

The Etiology, Diagnosis and Prevention of Liver Cirrhosis

(2018) Johannes Wiegand et al.   Deutsches Arzteblatt International

Intrahepatic Cross-Presentation and Hepatocellular Antigen Presentation Play Distinct Roles in the Induction of HBV-Specific CD8+ T Cell Responses

(2018) Yasuhiro Murata et al.   JOURNAL OF VIROLOGY

Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas

(2017) Guoying Zhou et al.   GASTROENTEROLOGY

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

(2017) Daniela Sia et al.   GASTROENTEROLOGY

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

(2017) Filippo Veglia et al.   Nature Communications

Immune Regulation of Intrahepatic Regulatory T Cells in Fibrotic Livers of Mice

(2017) Xiaohui Zhang et al.   MEDICAL SCIENCE MONITOR

Abstract 4908: Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells

(2016) Alfonso R. Sánchez-Paulete et al.   CANCER RESEARCH

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

(2016) L.-Y. Ye et al.   CANCER RESEARCH

Presentation of hepatocellular antigens

(2016) Arash Grakoui et al.   Cellular & Molecular Immunology

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis

(2016) Richard L. Gieseck et al.   IMMUNITY

Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort

(2016) Laura Q.M. Chow et al.   JOURNAL OF CLINICAL ONCOLOGY

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Persistence of cirrhosis is maintained by intrahepatic regulatory T cells that inhibit fibrosis resolution by regulating the balance of tissue inhibitors of metalloproteinases and matrix metalloproteinases

(2016) Xiaohui Zhang et al.   Translational Research

Experimental models of liver fibrosis

(2015) Sara Crespo Yanguas et al.   ARCHIVES OF TOXICOLOGY

Immunosurveillance of the Liver by Intravascular Effector CD8 + T Cells

(2015) Luca G. Guidotti et al.   CELL

CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis

(2015) Salvatore Sutti et al.   CLINICAL SCIENCE

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

(2015) Rikke B. Holmgaard et al.   Cell Reports

Investigating Evolutionary Conservation of Dendritic Cell Subset Identity and Functions

(2015) Thien-Phong Vu Manh et al.   Frontiers in Immunology

Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors

(2015) Alexander Pedroza-Gonzalez et al.   OncoImmunology

Hepatocellular carcinoma epidemiology

(2014) Cristina Bosetti et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

(2014) Josef Ehling et al.   GUT

Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy

(2014) Yuichiroh Umemoto et al.   JOURNAL OF GASTROENTEROLOGY

Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance

(2014) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer

(2014) W. Cao et al.   JOURNAL OF IMMUNOLOGY

Dendritic cells regulate angiogenesis associated with liver fibrogenesis

(2013) Sandra M. Blois et al.   ANGIOGENESIS

From NAFLD to NASH to fibrosis to HCC: Role of dendritic cell populations in the liver

(2013) Frank Tacke et al.   HEPATOLOGY

Human CD14+CTLA-4+regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma

(2013) Yanmei Han et al.   HEPATOLOGY

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Immunodominance and functional alterations of tumor-associated antigen-specific CD8+T-cell responses in hepatocellular carcinoma

(2013) Tobias Flecken et al.   HEPATOLOGY

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

(2013) Elodie Segura et al.   IMMUNITY

Inactivation of tumor-specific CD8+ CTLs by tumor-infiltrating tolerogenic dendritic cells

(2013) Hirotomo Harimoto et al.   IMMUNOLOGY AND CELL BIOLOGY

Dendritic cells in liver injury and fibrosis: Shortcomings and promises

(2013) Veronika Lukacs-Kornek et al.   JOURNAL OF HEPATOLOGY

Defective thymopoiesis and poor peripheral homeostatic replenishment of T-helper cells cause T-cell lymphopenia in cirrhosis

(2013) Margaret Lario et al.   JOURNAL OF HEPATOLOGY

Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis

(2013) A. Wehr et al.   JOURNAL OF IMMUNOLOGY

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

(2013) Jeong Heo et al.   NATURE MEDICINE

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Immature, Semi-Mature, and Fully Mature Dendritic Cells: Toward a DC-Cancer Cells Interface That Augments Anticancer Immunity

(2013) Aleksandra M. Dudek et al.   Frontiers in Immunology

Natural killer and natural killer T cells in liver fibrosis

(2012) Bin Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells

(2012) John J. Engelhardt et al.   CANCER CELL

Dendritic Cell Populations With Different Concentrations of Lipid Regulate Tolerance and Immunity in Mouse and Human Liver

(2012) Junaid Ibrahim et al.   GASTROENTEROLOGY

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer

(2012) Alexander Pedroza-Gonzalez et al.   HEPATOLOGY

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

(2012) Hang Li et al.   HEPATOLOGY

Radiation Therapy to Convert the Tumor Into an In Situ Vaccine

(2012) Silvia C. Formenti et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Significance of the Balance between Regulatory T (Treg) and T Helper 17 (Th17) Cells during Hepatitis B Virus Related Liver Fibrosis

(2012) Jing Li et al.   PLoS One

Treatment of Hepatocellular Carcinoma: A Systematic Review

(2012) Shibo Lin et al.   Liver Cancer

Myeloid-derived suppressor cells impair the quality of dendritic cell vaccines

(2011) I. Poschke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

An immune-active tumor microenvironment favors clinical response to ipilimumab

(2011) Rui-Ru Ji et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression

(2011) Jingjing Jiao et al.   HEPATOLOGY

Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-Positive B-cell population

(2011) Hiroyoshi Doi et al.   HEPATOLOGY

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

Selective Recruitment of Regulatory T Cell through CCR6-CCL20 in Hepatocellular Carcinoma Fosters Tumor Progression and Predicts Poor Prognosis

(2011) Kang-Jie Chen et al.   PLoS One

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas

(2010) Cheolho Cheong et al.   CELL

Role of IL-17 and Th17 Cells in Liver Diseases

(2010) Linda Hammerich et al.   Clinical & Developmental Immunology

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Interferon- -triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells

(2009) B. Jurgens et al.   BLOOD

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver

(2009) Ekaterina Breous et al.   HEPATOLOGY

In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-α

(2009) Michael K. Connolly et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Liver Dendritic Cells Promote T Cell Hyporesponsiveness

(2009) Z. M. Bamboat et al.   JOURNAL OF IMMUNOLOGY

Inhibition of major histocompatibility complex Class I antigen presentation by hepatitis C virus core protein in myeloid dendritic cells

(2009) James O'Beirne et al.   VIROLOGY

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

The interleukin-17 pathway is involved in human alcoholic liver disease

(2008) Arnaud Lemmers et al.   HEPATOLOGY

Innate immunity and alcoholic liver fibrosis

(2008) Won-Il Jeong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

(2008) Ann-Lii Cheng et al.   LANCET ONCOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE