How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions

Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor–Mediated Natural Killer Cell Function

(2018) Andrew Stiff et al.   CLINICAL CANCER RESEARCH

Myeloid-derived suppressor cells—a new therapeutic target to overcome resistance to cancer immunotherapy

(2017) Jason A. Chesney et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

(2017) Paul E. Clavijo et al.   Oncotarget

Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma

(2017) Yago Pico de Coana et al.   Oncotarget

Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment

(2017) Michel Eisenblaetter et al.   Theranostics

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

(2016) Susanna Mandruzzato et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hepatitis C Virus–Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1

(2016) Celeste C. Goh et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells in Psoriasis Are an Expanded Population Exhibiting Diverse T-Cell–Suppressor Mechanisms

(2016) Lauren Y. Cao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice

(2016) K. Moses et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Arginase-1–dependent promotion of T H 17 differentiation and disease progression by MDSCs in systemic lupus erythematosus

(2016) Hao Wu et al.   Science Translational Medicine

Human neutrophils: Their role in cancer and relation to myeloid-derived suppressor cells

(2016) Katrin Moses et al.   SEMINARS IN IMMUNOLOGY

Comparative Study of the Immunoregulatory Capacity of In Vitro Generated Tolerogenic Dendritic Cells, Suppressor Macrophages, and Myeloid-Derived Suppressor Cells

(2016) Laura Carretero-Iglesia et al.   TRANSPLANTATION

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

99mTc-labelled anti-CD11b SPECT/CT imaging allows detection of plaque destabilization tightly linked to inflammation

(2016) Guobing Liu et al.   Scientific Reports

Phase I/II Study of Metastatic Melanoma Patients Treated with Nivolumab Who Had Progressed after Ipilimumab

(2016) J. Weber et al.   Cancer Immunology Research

Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients

(2016) Salman M. Toor et al.   Frontiers in Immunology

Monocytic myeloid-derived suppressor cells from females, but not males, alleviate CVB3-induced myocarditis by increasing regulatory and CD4+IL-10+ T cells

(2016) Nan Su et al.   Scientific Reports

Pathogenic Fungi Regulate Immunity by Inducing Neutrophilic Myeloid-Derived Suppressor Cells

(2015) Nikolaus Rieber et al.   Cell Host & Microbe

Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression

(2015) Laura Pinton et al.   Oncotarget

Lung-Residing Myeloid-derived Suppressors Display Dual Functionality in Murine Pulmonary Tuberculosis

(2014) Julia K. Knaul et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of Tumor-Derived Prostaglandin-E2 Blocks the Induction of Myeloid-Derived Suppressor Cells and Recovers Natural Killer Cell Activity

(2014) Y. Mao et al.   CLINICAL CANCER RESEARCH

Myeloid-derived suppressor cell functionality and interaction withLeishmania majorparasites differ in C57BL/6 and BALB/c mice

(2014) Maximilian Schmid et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF- 1

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2014) J.-I. Youn et al.   JOURNAL OF IMMUNOLOGY

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

Rescue of Notch-1 Signaling in Antigen-Specific CD8+ T Cells Overcomes Tumor-Induced T-cell Suppression and Enhances Immunotherapy in Cancer

(2014) R. A. Sierra et al.   Cancer Immunology Research

Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways

(2013) Patrick L. Raber et al.   INTERNATIONAL JOURNAL OF CANCER

Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer

(2013) J. Yu et al.   JOURNAL OF IMMUNOLOGY

Arginase-1 mRNA expression correlates with myeloid-derived suppressor cell levels in peripheral blood of NSCLC patients

(2013) Marlies E. Heuvers et al.   LUNG CANCER

Myeloid derived suppressor cells – a new therapeutic target in the treatment of cancer

(2013) Robert Wesolowski et al.   Journal for ImmunoTherapy of Cancer

Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology

(2012) Claudia A. Dumitru et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells

(2012) Ariane Luyckx et al.   CLINICAL IMMUNOLOGY

Immune Suppression: The Hallmark of Myeloid Derived Suppressor Cells

(2012) Lydia A Haile et al.   IMMUNOLOGICAL INVESTIGATIONS

Myeloid-Derived Suppressor Cells and anti-tumor T cells: a complex relationship

(2012) Ngozi R. Monu et al.   IMMUNOLOGICAL INVESTIGATIONS

Granulocytic myeloid-derived suppressor cells are cryosensitive and their frequency does not correlate with serum concentrations of colony-stimulating factors in head and neck cancer

(2012) Sokratis Trellakis et al.   Innate Immunity

The danger theory: 20 years later

(2012) Thomas Pradeu et al.   Frontiers in Immunology

Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells

(2011) N. Obermajer et al.   BLOOD

Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

(2011) Je-In Youn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

(2010) S. Gregori et al.   BLOOD

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell-Dependent Antitumor Immunity

(2010) J. Vincent et al.   CANCER RESEARCH

Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

(2010) S. Nagaraj et al.   CLINICAL CANCER RESEARCH

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells

(2010) M. G. Lechner et al.   JOURNAL OF IMMUNOLOGY

Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties

(2010) Sven Brandau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

(2009) Paulo C. Rodriguez et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Population alterations of l-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14−/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer

(2009) Chien-Ying Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Myeloid-Derived Suppressor Cells Down-Regulate L-Selectin Expression on CD4+ and CD8+ T Cells

(2009) E. M. Hanson et al.   JOURNAL OF IMMUNOLOGY

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY