The Role of Sinusoidal Endothelial Cells in the Axis of Inflammation and Cancer Within the Liver

Novel endothelial LECT2/Tie1 signaling in liver fibrosis

(2020) Tingting Su et al.   HEPATOLOGY

Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses

(2020) Cristina I. Øie et al.   Scientific Reports

Cell-in-Cell Structures in the Liver: A Tale of Four E’s

(2020) Scott P. Davies et al.   Frontiers in Immunology

LSEC Fenestrae Are Preserved Despite Pro-inflammatory Phenotype of Liver Sinusoidal Endothelial Cells in Mice on High Fat Diet

(2019) Edyta Kus et al.   Frontiers in Physiology

Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis

(2019) Xiang Yu et al.   Nature Communications

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway

(2019) Sun Ah Nam et al.   Cell Death & Disease

Novel Targets in the Immune Microenvironment of the Hepatic Sinusoids for Treating Liver Diseases

(2019) Daniel Patten et al.   SEMINARS IN LIVER DISEASE

Role of liver sinusoidal endothelial cells in nonalcoholic fatty liver disease

(2019) Adel Hammoutene et al.   JOURNAL OF HEPATOLOGY

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

(2019) Moira B. Hilscher et al.   GASTROENTEROLOGY

BMP 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting from hepatic fibrosis

(2019) Agnès Desroches‐Castan et al.   HEPATOLOGY

Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cells

(2019) Le Wang et al.   EBioMedicine

Liver sinusoidal endothelial cells (LSECs) modifications in patients with chronic hepatitis C

(2019) Andrea Baiocchini et al.   Scientific Reports

LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis

(2019) Meng Xu et al.   CELL

Cellular and functional loss of liver endothelial cells correlates with poor hepatocyte regeneration in acute-on-chronic liver failure

(2019) Smriti Shubham et al.   Hepatology International

Liver Tropism in Cancer: The Hepatic Metastatic Niche

(2019) Ainhoa Mielgo et al.   Cold Spring Harbor Perspectives in Medicine

Delta-like ligand 4/DLL4 regulates the capillarization of liver sinusoidal endothelial cell and liver fibrogenesis

(2019) Liuying Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A defect in endothelial autophagy occurs in patients with nonalcoholic steatohepatitis and promotes inflammation and fibrosis

(2019) Adel Hammoutene et al.   JOURNAL OF HEPATOLOGY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

MKL1 promotes endothelial-to-mesenchymal transition and liver fibrosis by activating TWIST1 transcription

(2019) Zilong Li et al.   Cell Death & Disease

Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses

(2019) Aitor Benedicto et al.   Scientific Reports

Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated

(2019) Kaisa Auvinen et al.   Scientific Reports

Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process

(2019) Scott P. Davies et al.   Cell Reports

Fuzhenghuayu Decoction ameliorates hepatic fibrosis by attenuating experimental sinusoidal capillarization and liver angiogenesis

(2019) Hong-liang Liu et al.   Scientific Reports

Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice

(2018) Juan-Li Duan et al.   HEPATOLOGY

SCARF1: a multifaceted, yet largely understudied, scavenger receptor

(2018) Daniel A. Patten   INFLAMMATION RESEARCH

Targeting liver sinusoidal endothelial cells with miR-20a-loaded nanoparticles reduces murine colon cancer metastasis to the liver

(2018) Joana Marquez et al.   INTERNATIONAL JOURNAL OF CANCER

Characterization of Pattern Recognition Receptor Expression and Functionality in Liver Primary Cells and Derived Cell Lines

(2018) Suzanne Faure-Dupuy et al.   Journal of Innate Immunity

Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

(2018) Masatoshi Kudo et al.   LANCET

Matrix metalloproteinase functions in hepatic injury and fibrosis

(2018) Martin Roderfeld   MATRIX BIOLOGY

LSECs express functional NOD1 receptors: A role for NOD1 in LSEC maturation-induced T cell immunity in vitro

(2018) Shunmei Huang et al.   MOLECULAR IMMUNOLOGY

Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

(2018) Shishir Shetty et al.   Nature Reviews Gastroenterology & Hepatology

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

Liver vascular anatomy: a refresher

(2018) Rishi Philip Mathew et al.   Abdominal Radiology

Effects of aging on liver microcirculatory function and sinusoidal phenotype

(2018) Raquel Maeso-Díaz et al.   AGING CELL

Angiopoietin-2 promotes pathological angiogenesis and is a novel therapeutic target in murine non-alcoholic fatty liver disease

(2018) Sander Lefere et al.   HEPATOLOGY

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Autophagy in FOXD1 stroma-derived cells regulates renal fibrosis through TGF-β and NLRP3 inflammasome pathway

(2018) Sun Ah Nam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatic endothelial Notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling

(2018) Sebastian A Wohlfeil et al.   CANCER RESEARCH

Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury

(2018) Maria Ruart et al.   JOURNAL OF HEPATOLOGY

Substance P Promotes Liver Sinusoidal Endothelium-Mediated Hepatic Regeneration by NO/HGF Regulation

(2018) Jiyuan Piao et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Endothelial fatty liver binding protein 4: a new targetable mediator in hepatocellular carcinoma related to metabolic syndrome

(2018) Samira Laouirem et al.   ONCOGENE

Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer

(2018) Joanne Marie O’Rourke et al.   WORLD JOURNAL OF GASTROENTEROLOGY

More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking

(2018) Daniel A. Patten et al.   Frontiers in Immunology

Tetramethylpyrazine attenuates sinusoidal angiogenesis via inhibition of hedgehog signaling in liver fibrosis

(2017) Shifeng Zhao et al.   IUBMB LIFE

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis

(2017) Cyrill Géraud et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel roles of DC-SIGNR in colon cancer cell adhesion, migration, invasion, and liver metastasis

(2017) Heya Na et al.   Journal of Hematology & Oncology

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2

(2017) Michaela Wittlich et al.   JOURNAL OF HEPATOLOGY

Global trends and predictions in hepatocellular carcinoma mortality

(2017) Paola Bertuccio et al.   JOURNAL OF HEPATOLOGY

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

Activation of the CXCR4 chemokine receptor enhances biological functions associated with B16 melanoma liver metastasis

(2017) Mayela Mendt et al.   MELANOMA RESEARCH

Tumor regulation of the tissue environment in the liver

(2017) Tobias Eggert et al.   PHARMACOLOGY & THERAPEUTICS

Liver Sinusoidal Endothelial Cell: An Update

(2017) Ana Maretti-Mira et al.   SEMINARS IN LIVER DISEASE

RIP3 attenuates the pancreatic damage induced by deletion of ATG7

(2017) Xiaodong Zhou et al.   Cell Death & Disease

Role of liver ICAM-1 in metastasis

(2017) Aitor Benedicto et al.   Oncology Letters

Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis

(2017) Neil P. Dufton et al.   Nature Communications

SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis

(2017) Vaishaali Natarajan et al.   Biomed Research International

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Mouse Liver Sinusoidal Endothelium Eliminates HIV-Like Particles from Blood at a Rate of 100 Million per Minute by a Second-Order Kinetic Process

(2017) Jessica M. Mates et al.   Frontiers in Immunology

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015

(2017) et al.   JAMA Oncology

Tyrosine kinase inhibitor BIBF1120 ameliorates inflammation, angiogenesis and fibrosis in CCl4-induced liver fibrogenesis mouse model

(2017) Büsra Öztürk Akcora et al.   Scientific Reports

SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress

(2017) Daniel A. Patten et al.   Scientific Reports

VEGF-sdf1 recruitment of CXCR7+ bone marrow progenitors of liver sinusoidal endothelial cells promotes rat liver regeneration

(2016) Laurie D. DeLeve et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

(2016) Man J. Livingston et al.   Autophagy

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

(2016) L.-Y. Ye et al.   CANCER RESEARCH

Immunological functions of liver sinusoidal endothelial cells

(2016) Percy A Knolle et al.   Cellular & Molecular Immunology

Role of the Microenvironment in Liver Metastasis: From Pre- to Prometastatic Niches

(2016) P. Brodt   CLINICAL CANCER RESEARCH

Liver metastases: Microenvironments and ex-vivo models

(2016) Amanda M Clark et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration

(2016) Daniel A. Patten et al.   HEPATOLOGY

Rationally combining anti-VEGF therapy with checkpoint inhibitors in hepatocellular carcinoma

(2016) Tai Hato et al.   Immunotherapy

Human liver-resident CD56bright/CD16neg NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways

(2016) Kelly Hudspeth et al.   JOURNAL OF AUTOIMMUNITY

Sinusoidal communication in liver fibrosis and regeneration

(2016) Giusi Marrone et al.   JOURNAL OF HEPATOLOGY

Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein

(2016) Zhili Yao et al.   JOURNAL OF IMMUNOLOGY

Fetal liver endothelium regulates the seeding of tissue-resident macrophages

(2016) Pia Rantakari et al.   NATURE

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Plasmalemma vesicle-associated protein: A crucial component of vascular homeostasis

(2016) Ling Guo et al.   Experimental and Therapeutic Medicine

On the origin of myeloid-derived suppressor cells

(2016) Camilla Rydberg Millrud et al.   Oncotarget

Liver sinusoidal endothelial cells induce tolerance of autoreactive CD4+ recent thymic emigrants

(2016) Xi Xu et al.   Scientific Reports

Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36

(2016) Shiguo Li et al.   Open Biology

Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

(2016) Sonsoles Piera-Velazquez et al.   Journal of Clinical Medicine

CXCR6 marks a novel subset of T-betloEomeshi natural killer cells residing in human liver

(2016) Kerstin A. Stegmann et al.   Scientific Reports

Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function

(2015) Andrew J. Ford et al.   Acta Biomaterialia

Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis

(2015) Sandra Cabrera et al.   Autophagy

Immunosurveillance of the Liver by Intravascular Effector CD8 + T Cells

(2015) Luca G. Guidotti et al.   CELL

CD147 promotes liver fibrosis progression via VEGF-A/VEGFR2 signalling-mediated cross-talk between hepatocytes and sinusoidal endothelial cells

(2015) Zhaoyong Yan et al.   CLINICAL SCIENCE

Hepatitis C Virus Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cells and Release of Exosomes, Which Inhibits Viral Replication

(2015) Silvia Giugliano et al.   GASTROENTEROLOGY

Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis

(2015) Chahrazade Kantari-Mimoun et al.   HEPATOLOGY

The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes

(2015) Pia Rantakari et al.   NATURE IMMUNOLOGY

Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts

(2015) S Ghavami et al.   Cell Death & Disease

Multimodal super-resolution optical microscopy visualizes the close connection between membrane and the cytoskeleton in liver sinusoidal endothelial cell fenestrations

(2015) Viola Mönkemöller et al.   Scientific Reports

Chemokine Transfer by Liver Sinusoidal Endothelial Cells Contributes to the Recruitment of CD4+ T Cells into the Murine Liver

(2015) Katrin Neumann et al.   PLoS One

Liver Sinusoidal Endothelial Cells Escape Senescence by Loss of p19ARF

(2015) Petra Koudelkova et al.   PLoS One

The landscape of metastatic progression patterns across major human cancers

(2015) Jan Budczies et al.   Oncotarget

Plasmalemmal Vesicle Associated Protein (PLVAP) as a therapeutic target for treatment of hepatocellular carcinoma

(2014) Yun-Hsin Wang et al.   BMC CANCER

Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial–mesenchymal transition

(2014) Juanjuan Ou et al.   CARCINOGENESIS

Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis

(2014) M. Karikoski et al.   CLINICAL CANCER RESEARCH

Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice

(2014) Liu Yang et al.   GASTROENTEROLOGY

KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins

(2014) Giusi Marrone et al.   GUT

Update on implications and mechanisms of angiogenesis in liver fibrosis

(2014) Zili Zhang et al.   HEPATOLOGY RESEARCH

The Essential Autophagy GeneATG7Modulates Organ Fibrosis via Regulation of Endothelial-to-Mesenchymal Transition

(2014) Krishna K. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells

(2014) Feng Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis

(2014) Chris J. Weston et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells

(2014) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

Neovascularization and oxidative stress in the progression of non-alcoholic steatohepatitis

(2014) Mitsuteru Kitade et al.   Molecular Medicine Reports

Formation of Fenestrae in Murine Liver Sinusoids Depends on Plasmalemma Vesicle-Associated Protein and Is Required for Lipoprotein Passage

(2014) Leonie Herrnberger et al.   PLoS One

IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell Function

(2014) Jan P. Böttcher et al.   Cell Reports

Expression and Role of ICAM-1 in the Occurrence and Development of Hepatocellular Carcinoma

(2013) Xi-Wen Zhu et al.   Asian Pacific Journal of Cancer Prevention

The Multifaceted Role of the Microenvironment in Liver Metastasis: Biology and Clinical Implications

(2013) G. G. Van den Eynden et al.   CANCER RESEARCH

Paracrine signals from liver sinusoidal endothelium regulate hepatitis C virus replication

(2013) Ian A. Rowe et al.   HEPATOLOGY

Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models

(2013) Stephanie Coulon et al.   HEPATOLOGY

Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

(2013) Chi-Kuan Chen et al.   HEPATOLOGY

Liver sinusoidal endothelial cells and liver regeneration

(2013) Laurie D. DeLeve   JOURNAL OF CLINICAL INVESTIGATION

Combination of sorafenib and angiotensin-II receptor blocker attenuates preneoplastic lesion development in a non-diabetic rat model of steatohepatitis

(2013) Hitoshi Yoshiji et al.   JOURNAL OF GASTROENTEROLOGY

TLR1/2 Ligand-Stimulated Mouse Liver Endothelial Cells Secrete IL-12 and Trigger CD8+ T Cell Immunity In Vitro

(2013) J. Liu et al.   JOURNAL OF IMMUNOLOGY

Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival

(2013) Cyrill Géraud et al.   LIVER INTERNATIONAL

Soluble ICAM-1 levels in small-cell lung cancer: prognostic value for survival and predictive significance for response during chemotherapy

(2013) Elias A. Kotteas et al.   MEDICAL ONCOLOGY

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Simvastatin Ameliorates Liver Fibrosis via Mediating Nitric Oxide Synthase in Rats with Non-Alcoholic Steatohepatitis-Related Liver Fibrosis

(2013) Wei Wang et al.   PLoS One

Extracellular matrix rigidity controls podosome induction in microvascular endothelial cells

(2012) Amélie Juin et al.   BIOLOGY OF THE CELL

The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition

(2012) Radu V. Stan et al.   DEVELOPMENTAL CELL

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Disruption of Notch1 Induces Vascular Remodeling, Intussusceptive Angiogenesis, and Angiosarcomas in Livers of Mice

(2012) Michael T. Dill et al.   GASTROENTEROLOGY

Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver

(2012) Yunfei Zuo et al.   GUT

Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation

(2012) Guanhua Xie et al.   GUT

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice

(2012) Bastian Höchst et al.   HEPATOLOGY

Recruitment mechanisms of primary and malignant B cells to the human liver

(2012) Shishir Shetty et al.   HEPATOLOGY

Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice

(2012) Leonie Herrnberger et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis

(2012) Yosui Tamaki et al.   JOURNAL OF GASTROENTEROLOGY

The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial–stellate cell deactivation induced by statins

(2012) Giusi Marrone et al.   JOURNAL OF HEPATOLOGY

Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease

(2012) Sorina Georgiana Boaru et al.   Journal of Inflammation-London

The mannose receptor

(2012) Luisa Martinez-Pomares   JOURNAL OF LEUKOCYTE BIOLOGY

Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis

(2012) Daniel H Madsen et al.   JOURNAL OF PATHOLOGY

Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture

(2012) Sven Francque et al.   LABORATORY INVESTIGATION

Regulation of antigen transport into the cytosol for cross-presentation by ubiquitination of the mannose receptor

(2012) Matthias Zehner et al.   MOLECULAR IMMUNOLOGY

The mobilization, recruitment and contribution of bone marrow-derived endothelial progenitor cells to the tumor neovascularization occur at an early stage and throughout the entire process of hepatocellular carcinoma growth

(2012) HAITAO ZHU et al.   ONCOLOGY REPORTS

Sinusoidal Endothelial Dysfunction Precedes Inflammation and Fibrosis in a Model of NAFLD

(2012) Marcos Pasarín et al.   PLoS One

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

(2011) Abby L. Olsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Endothelial NO/cGMP/VASP Signaling Attenuates Kupffer Cell Activation and Hepatic Insulin Resistance Induced by High-Fat Feeding

(2011) Sanshiro Tateya et al.   DIABETES

Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

(2011) Guanhua Xie et al.   GASTROENTEROLOGY

Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 Mediates the Transmigration of Regulatory T Cells across Human Hepatic Sinusoidal Endothelium

(2011) Shishir Shetty et al.   JOURNAL OF IMMUNOLOGY

Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18

(2011) Clarisa Salado et al.   Journal of Translational Medicine

Hepatocyte entry leads to degradation of autoreactive CD8 T cells

(2011) V. Benseler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Rapid and Efficient Clearance of Blood-borne Virus by Liver Sinusoidal Endothelium

(2011) Latha P. Ganesan et al.   PLoS Pathogens

Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins

(2010) Ruomei Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Role of Chemokines in the Recruitment of Lymphocytes to the Liver

(2010) Ye H. Oo et al.   DIGESTIVE DISEASES

Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver

(2010) J. Gracia-Sancho et al.   GUT

CX3CR1 and vascular adhesion protein-1-dependent recruitment of CD16+ monocytes across human liver sinusoidal endothelium

(2010) Alexander I. Aspinall et al.   HEPATOLOGY

Colon carcinoma cell interaction with liver sinusoidal endothelium inhibits organ-specific antitumor immunity through interleukin-1-induced mannose receptor in mice

(2010) Beatriz Arteta et al.   HEPATOLOGY

Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity

(2010) Evaggelia Liaskou et al.   HEPATOLOGY

Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells

(2010) A. Schurich et al.   JOURNAL OF IMMUNOLOGY

Angiogenesis in chronic liver disease and its complications

(2010) Stephanie Coulon et al.   LIVER INTERNATIONAL

Vascular endothelial growth factor B controls endothelial fatty acid uptake

(2010) Carolina E. Hagberg et al.   NATURE

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE

Hypoxia, angiogenesis and liver fibrogenesis in the progression of chronic liver diseases

(2010) Claudia Paternostro   WORLD JOURNAL OF GASTROENTEROLOGY

The prototype endothelial marker PAL-E is a leukocyte trafficking molecule

(2009) J. Keuschnigg et al.   BLOOD

Targeting Matrix Metalloproteinases in Inflammatory Conditions

(2009) A. Clutterbuck et al.   CURRENT DRUG TARGETS

Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease

(2009) Kerry-Lee Milner et al.   HEPATOLOGY

Influence of the mannose receptor in host immune responses

(2009) Umut Gazi et al.   IMMUNOBIOLOGY

Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific

(2009) Jun Wu et al.   IMMUNOLOGY

Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor

(2009) Michael K. Connolly et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Three-dimensional organization of fenestrae labyrinths in liver sinusoidal endothelial cells

(2009) Filip Braet et al.   LIVER INTERNATIONAL

Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium

(2009) Bård Smedsrød et al.   LIVER INTERNATIONAL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Crosstalk between angiogenesis, cytokeratin-18, and insulinresistance in the progression of non-alcoholic steatohepatitis

(2009) Mitsuteru Kitade et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mechanisms by which E-Selectin Regulates Diapedesis of Colon Cancer Cells under Flow Conditions

(2008) P.-L. Tremblay et al.   CANCER RESEARCH

Impaired function of dendritic cells translocating the liver sinusoids: A veto effect contributing to intrahepatic tolerance?

(2008) Patrick Bertolino   EUROPEAN JOURNAL OF IMMUNOLOGY

Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells

(2008) Frank A. Schildberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis

(2008) Kojiro Taura et al.   GASTROENTEROLOGY

Liver Cell–Derived Microparticles Activate Hedgehog Signaling and Alter Gene Expression in Hepatic Endothelial Cells

(2008) Rafal P. Witek et al.   GASTROENTEROLOGY

Liver sinusoidal endothelial cells depend on mannose receptor-mediated recruitment of lysosomal enzymes for normal degradation capacity

(2008) Kjetil Elvevold et al.   HEPATOLOGY

Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines

(2008) Arnhild Schrage et al.   HEPATOLOGY

Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence

(2008) Laurie D. DeLeve et al.   HEPATOLOGY

E-selectin regulates gene expression in metastatic colorectal carcinoma cells and enhances HMGB1 release

(2008) Tegest Aychek et al.   INTERNATIONAL JOURNAL OF CANCER

Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms

(2008) Olga Barreiro et al.   JOURNAL OF CELL BIOLOGY

Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication

(2008) Ruth Broering et al.   JOURNAL OF HEPATOLOGY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lymphocyte recruitment to the liver: Molecular insights into the pathogenesis of liver injury and hepatitis

(2008) Shishir Shetty et al.   TOXICOLOGY

The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity

(2007) Kjetil Elvevold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY