Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages

Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation

(2013) Chih-Peng Chang et al.   Autophagy

Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages

(2013) Jiao Peng et al.   CANCER LETTERS

T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response

(2013) X. Yang et al.   JOURNAL OF IMMUNOLOGY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Tim-3 Expression Defines Regulatory T Cells in Human Tumors

(2013) Jing Yan et al.   PLoS One

Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands

(2013) Valerie Chew et al.   OncoImmunology

Interleukin-6 signaling pathway in targeted therapy for cancer

(2012) Yuqi Guo et al.   CANCER TREATMENT REVIEWS

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

(2012) Hang Li et al.   HEPATOLOGY

The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages

(2012) Daria Capece et al.   Biomed Research International

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Nuclear Factor- B and Tumor-Associated Macrophages

(2010) A. Mancino et al.   CLINICAL CANCER RESEARCH

Interleukin-6 in bone metastasis and cancer progression

(2010) Tasnim Ara et al.   EUROPEAN JOURNAL OF CANCER

T-Cell Immunoglobulin Mucin-3 Determines Severity of Liver Ischemia/Reperfusion Injury in Mice in a TLR4-Dependent Manner

(2010) Yoichiro Uchida et al.   GASTROENTEROLOGY

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocellular Carcinoma: Epidemiology, Surveillance, and Diagnosis

(2010) Morris Sherman   SEMINARS IN LIVER DISEASE

Transforming growth factor beta (TGF-β) and inflammation in cancer

(2009) Brian Bierie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients

(2009) Jia Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Human Pregnancy Up-Regulates Tim-3 in Innate Immune Cells for Systemic Immunity

(2009) Jie Zhao et al.   JOURNAL OF IMMUNOLOGY

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

TGFβ in Cancer

(2008) Joan Massagué   CELL

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE