From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma

Adoptive cell transfer therapy for hepatocellular carcinoma

(2019) Renyu Zhang et al.   Frontiers of Medicine

Fibroblast Growth Factor Receptor 4 Targeting in Cancer: New Insights into Mechanisms and Therapeutic Strategies

(2019) Liwei Lang et al.   Cells

Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade

(2019) Ying Zhu et al.   GUT

Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy

(2019) Anthony Tanoto Tan et al.   GASTROENTEROLOGY

Management of adverse events associated with tyrosine kinase inhibitors: Improving outcomes for patients with hepatocellular carcinoma

(2019) Lorenza Rimassa et al.   CANCER TREATMENT REVIEWS

Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma

(2019) Man Liu et al.   GUT

RIP 3 deficiency recruits myeloid‐derived suppressor cells to hepatocellular carcinoma through the CXCL 1‐ CXCR 2 axis

(2019) Yi‐Ming Li et al.   HEPATOLOGY

A Positive Feedback Loop Between Cancer Stem‐Like Cells and Tumor‐Associated Neutrophils Controls Hepatocellular Carcinoma Progression

(2019) Shao‐Lai Zhou et al.   HEPATOLOGY

4‐1BB Delineates Distinct Activation Status of Exhausted Tumor‐Infiltrating CD8 + T cells in Hepatocellular Carcinoma

(2019) Hyung‐Don Kim et al.   HEPATOLOGY

Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysis

(2019) Thomas Yau et al.   JOURNAL OF HEPATOLOGY

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

Neutrophil-lymphocyte ratio kinetics in patients with advanced solid tumours on phase I trials of PD-1/PD-L1 inhibitors

(2018) Malaka Ameratunga et al.   EUROPEAN JOURNAL OF CANCER

Immune checkpoint blockade in advanced hepatocellular carcinoma: an update and critical review of ongoing clinical trials

(2018) James J Harding   Future Oncology

Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment

(2018) Jingying Zhang et al.   HEPATOLOGY

Correlation between serum galectin-9 levels and liver fibrosis

(2018) Koji Fujita et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial

(2018) Andrew X Zhu et al.   LANCET ONCOLOGY

High number of PD-1 positive intratumoural lymphocytes predicts survival benefit of cytokine-induced killer cells for hepatocellular carcinoma patients

(2018) Boyang Chang et al.   LIVER INTERNATIONAL

Development of GPC3-Specific Chimeric Antigen Receptor-Engineered Natural Killer Cells for the Treatment of Hepatocellular Carcinoma

(2018) Min Yu et al.   MOLECULAR THERAPY

CCRK is a novel signalling hub exploitable in cancer immunotherapy

(2018) Myth T. Mok et al.   PHARMACOLOGY & THERAPEUTICS

Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development

(2018) Yun-Chieh Sung et al.   Theranostics

Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

(2018) Joo Sang Lee et al.   CELL

Inhibition of Cyclin-dependent Kinase 5 - a Novel Strategy to Improve Sorafenib Response in HCC Therapy

(2018) Maximilian A. Ardelt et al.   HEPATOLOGY

CCL15 recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma

(2018) Long-Zi Liu et al.   HEPATOLOGY

Combination of radiation and interleukin 12 eradicates large orthotopic hepatocellular carcinoma through immunomodulation of tumor microenvironment

(2018) Chia-Jen Wu et al.   OncoImmunology

Programmed cell death protein-1 (PD-1)/programmed death-ligand-1 (PD-L1) axis in hepatocellular carcinoma: prognostic and therapeutic perspectives

(2018) T. Mocan et al.   Clinical & Translational Oncology

Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas

(2017) Guoying Zhou et al.   GASTROENTEROLOGY

Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy

(2017) Jingying Zhou et al.   GUT

Neutrophils in Homeostasis, Immunity, and Cancer

(2017) José Ángel Nicolás-Ávila et al.   IMMUNITY

Endoplasmic reticulum stress induced LOX-1+  CD15+ polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma

(2017) Jiang Nan et al.   IMMUNOLOGY

Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models

(2017) Zhen Lu et al.   JOURNAL OF HEPATOLOGY

Tremelimumab in combination with ablation in patients with advanced hepatocellular carcinoma

(2017) Austin G. Duffy et al.   JOURNAL OF HEPATOLOGY

Combination therapy strategies for improving PD-1 blockade efficacy: a new era in cancer immunotherapy

(2017) P. S. Chowdhury et al.   JOURNAL OF INTERNAL MEDICINE

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

Immune Checkpoint Inhibition in Hepatocellular Carcinoma: Basics and Ongoing Clinical Trials

(2017) Masatoshi Kudo   ONCOLOGY

Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses

(2017) Valerie Chew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

(2017) David Kung-Chun Chiu et al.   Nature Communications

The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion

(2017) Runqiu Jiang et al.   Nature Communications

Tumor-Derived α-Fetoprotein Directly Drives Human Natural Killer–Cell Activation and Subsequent Cell Death

(2017) Lazar Vujanovic et al.   Cancer Immunology Research

Current immunotherapeutic strategies in hepatocellular carcinoma: recent advances and future directions

(2017) Hwi Young Kim et al.   Therapeutic Advances in Gastroenterology

Colony-stimulating factor-1-induced AIF1 expression in tumor-associated macrophages enhances the progression of hepatocellular carcinoma

(2017) Hao Cai et al.   OncoImmunology

Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment

(2017) Janna Michaeli et al.   OncoImmunology

T Cell-Activating Mesenchymal Stem Cells as a Biotherapeutic for HCC

(2017) Arpad Szoor et al.   Molecular Therapy-Oncolytics

Neutrophil lymphocyte ratio and duration of prior anti-angiogenic therapy as biomarkers in metastatic RCC receiving immune checkpoint inhibitor therapy

(2017) Ghayathri Jeyakumar et al.   Journal for ImmunoTherapy of Cancer

Overexpression of interleukin-35 associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection

(2016) Yi-Peng Fu et al.   BRITISH JOURNAL OF CANCER

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

(2016) L.-Y. Ye et al.   CANCER RESEARCH

Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

(2016) Shao-Lai Zhou et al.   GASTROENTEROLOGY

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

(2016) Julien Bollard et al.   GUT

Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26

(2016) David Kung-Chun Chiu et al.   HEPATOLOGY

Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humansin vitro

(2016) Quan Rao et al.   HEPATOLOGY

A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice

(2016) Mei Yee Koh et al.   HEPATOLOGY

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells

(2016) Y Deng et al.   ONCOGENE

Specific CD8+T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis

(2016) Elia Moreno-Cubero et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma

(2016) Fang-Zhu Ouyang et al.   Nature Communications

Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer

(2016) Li Ren et al.   Oncotarget

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

(2016) J-t Cheng et al.   Oncogenesis

Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor

(2016) Xuemei Jiang et al.   Frontiers in Immunology

Impact of myeloid-derived suppressor cell on Kupffer cells from mouse livers with hepatocellular carcinoma

(2016) Stéphanie Lacotte et al.   OncoImmunology

Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10

(2016) Aditya Ambade et al.   OncoImmunology

A phase I/IIa study of adjuvant immunotherapy with tumour antigen-pulsed dendritic cells in patients with hepatocellular carcinoma

(2015) Jeong-Hoon Lee et al.   BRITISH JOURNAL OF CANCER

Immunosurveillance of the Liver by Intravascular Effector CD8 + T Cells

(2015) Luca G. Guidotti et al.   CELL

Global Epidemiology of Hepatocellular Carcinoma

(2015) Katherine A. McGlynn et al.   Clinics in Liver Disease

Adjuvant Immunotherapy With Autologous Cytokine-Induced Killer Cells for Hepatocellular Carcinoma

(2015) Joon Hyeok Lee et al.   GASTROENTEROLOGY

Interleukin-8 Induces Expression of FOXC1 to Promote Transactivation of CXCR1 and CCL2 in Hepatocellular Carcinoma Cell Lines and Formation of Metastases in Mice

(2015) Wenjie Huang et al.   GASTROENTEROLOGY

Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

(2015) Xiaoguang Li et al.   GUT

Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages

(2015) Wenjiang Yan et al.   GUT

Type IIFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human

(2015) Lisa Andzinski et al.   INTERNATIONAL JOURNAL OF CANCER

Significant Roles of Regulatory T Cells and Myeloid Derived Suppressor Cells in Hepatitis B Virus Persistent Infection and Hepatitis B Virus-Related HCCs

(2015) Yasuteru Kondo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulatory CD4+ T cells modulate the interaction between NK cells and hepatic stellate cells by acting on either cell type

(2015) Bettina Langhans et al.   JOURNAL OF HEPATOLOGY

Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient

(2015) Waseem Qasim et al.   JOURNAL OF HEPATOLOGY

The yin and yang of evasion and immune activation in HCC

(2015) Oxana V. Makarova-Rusher et al.   JOURNAL OF HEPATOLOGY

Targeting cyclin dependent kinase 5 in hepatocellular carcinoma – A novel therapeutic approach

(2015) Sandra M. Ehrlich et al.   JOURNAL OF HEPATOLOGY

Immunological landscape and immunotherapy of hepatocellular carcinoma

(2015) Jesús Prieto et al.   Nature Reviews Gastroenterology & Hepatology

Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells

(2015) Chun-Hui Yuan et al.   Oncotarget

CD4+CD25+CD127low Regulatory T Cells Play Predominant Anti-Tumor Suppressive Role in Hepatitis B Virus-Associated Hepatocellular Carcinoma

(2015) Shreya Sharma et al.   Frontiers in Immunology

Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress

(2015) Meriem Hasmim et al.   Frontiers in Immunology

PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity

(2015) Tong Seng Lim et al.   OncoImmunology

Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition

(2015) Xiao-Xiang Rong et al.   OncoImmunology

Expression of Fas/FasL in CD8+T and CD3+Foxp3+Treg Cells - Relationship with Apoptosis of Circulating CD8+T Cells in Hepatocellular Carcinoma Patients

(2014) Cun-Li Guo et al.   Asian Pacific Journal of Cancer Prevention

NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma

(2014) Cheng Sun et al.   Cellular & Molecular Immunology

Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma

(2014) H. Gao et al.   CLINICAL CANCER RESEARCH

Dendritic cells and cancer immunotherapy

(2014) Kristen J Radford et al.   CURRENT OPINION IN IMMUNOLOGY

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

(2014) Shanshan Wan et al.   GASTROENTEROLOGY

Immune checkpoint blockade in hepatocellular carcinoma: Current progress and future directions

(2014) Tai Hato et al.   HEPATOLOGY

hIL-15 gene-modified human natural killer cells (NKL-IL15) augments the anti-human hepatocellular carcinoma effect in vivo

(2014) Wen Jiang et al.   IMMUNOBIOLOGY

A killer choice for cancer immunotherapy

(2014) Tobi L. Schmidt et al.   IMMUNOLOGIC RESEARCH

NY-ESO-1 specific antibody and cellular responses in melanoma patients primed with NY-ESO-1 protein in ISCOMATRIX and boosted with recombinant NY-ESO-1 fowlpox virus

(2014) Ji-Li Chen et al.   INTERNATIONAL JOURNAL OF CANCER

EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation

(2014) Hanane Lanaya et al.   NATURE CELL BIOLOGY

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

CXCL17 Expression Predicts Poor Prognosis and Correlates with Adverse Immune Infiltration in Hepatocellular Carcinoma

(2014) Li Li et al.   PLoS One

Virus associated malignancies: The role of viral hepatitis in hepatocellular carcinoma

(2014) Amir Shlomai et al.   SEMINARS IN CANCER BIOLOGY

Tim-3 expression on peripheral monocytes and CD3+CD16/CD56+natural killer-like T cells in patients with chronic hepatitis B

(2014) Y.-H. Rong et al.   TISSUE ANTIGENS

Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma

(2014) Bhavna Rani   WORLD JOURNAL OF GASTROENTEROLOGY

Oncolytic Viruses and Their Application to Cancer Immunotherapy

(2014) E. A. Chiocca et al.   Cancer Immunology Research

Preoperative Neutrophil-to-Lymphocyte Ratio Is a Predictor of Survival After Hepatectomy for Hepatocellular Carcinoma

(2013) Yohei Mano et al.   ANNALS OF SURGERY

The Efficacy of Cytokine-Induced Killer Cell Infusion as an Adjuvant Therapy for Postoperative Hepatocellular Carcinoma Patients

(2013) Ke Pan et al.   ANNALS OF SURGICAL ONCOLOGY

Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality

(2013) S. Kalathil et al.   CANCER RESEARCH

Human CD14+CTLA-4+regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma

(2013) Yanmei Han et al.   HEPATOLOGY

Epitope-optimized alpha-fetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma

(2013) Yuan Hong et al.   HEPATOLOGY

Immunodominance and functional alterations of tumor-associated antigen-specific CD8+T-cell responses in hepatocellular carcinoma

(2013) Tobias Flecken et al.   HEPATOLOGY

Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice

(2013) Yunching Chen et al.   HEPATOLOGY

Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

(2013) Dietmar M.W. Zaiss et al.   IMMUNITY

Potential therapeutic value of dendritic cells loaded with NY-ESO-1 protein for the immunotherapy of advanced hepatocellular carcinoma

(2013) YUQING CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Analysis of cytotoxic T lymphocytes from a patient with hepatocellular carcinoma who showed a clinical response to vaccination with a glypican-3-derived peptide

(2013) YOSHITAKA TADA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C

(2013) Bruno Sangro et al.   JOURNAL OF HEPATOLOGY

Intrahepatic IL-8 producing Foxp3+CD4+ regulatory T cells and fibrogenesis in chronic hepatitis C

(2013) Bettina Langhans et al.   JOURNAL OF HEPATOLOGY

Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma

(2013) Tamar Kapanadze et al.   JOURNAL OF HEPATOLOGY

Cytokine-induced Killer Cells in Combination With Transcatheter Arterial Chemoembolization and Radiofrequency Ablation for Hepatocellular Carcinoma Patients

(2013) Zhi-Mei Huang et al.   JOURNAL OF IMMUNOTHERAPY

Improving immunotherapy of hepatocellular carcinoma (HCC) using dendritic cells (DC) engineered to express IL-12in vivo

(2013) Annabelle Vogt et al.   LIVER INTERNATIONAL

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

(2013) Jeong Heo et al.   NATURE MEDICINE

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

(2012) B. G. Till et al.   BLOOD

A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma

(2012) Tim F Greten et al.   BMC CANCER

The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma

(2012) Juan Wu et al.   CANCER RESEARCH

Phase I Trial of a Glypican-3-Derived Peptide Vaccine for Advanced Hepatocellular Carcinoma: Immunologic Evidence and Potential for Improving Overall Survival

(2012) Y. Sawada et al.   CLINICAL CANCER RESEARCH

Tumor-Infiltrating FoxP3+ Tregs and CD8+ T Cells Affect the Prognosis of Hepatocellular Carcinoma Patients

(2012) Yong Huang et al.   DIGESTION

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

(2012) Hang Li et al.   HEPATOLOGY

Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions

(2012) Yan Wu et al.   HEPATOLOGY

Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma

(2012) FUJIMASA TADA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Immunotherapy by autologous dendritic cell vaccine in patients with advanced HCC

(2012) Mervat El Ansary et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection

(2012) Gaia Nebbia et al.   PLoS One

The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages

(2012) Daria Capece et al.   Biomed Research International

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

(2011) J. N. Kochenderfer et al.   BLOOD

Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO

(2011) Tuanjie Li et al.   CANCER LETTERS

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

(2011) S.-R. Woo et al.   CANCER RESEARCH

α-Fetoprotein impairs activation of natural killer cells by inhibiting the function of dendritic cells

(2011) M. Yamamoto et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence

(2011) Hiroteru Kamimura et al.   JOURNAL OF HEPATOLOGY

Sequential Therapy With JX-594, A Targeted Oncolytic Poxvirus, Followed by Sorafenib in Hepatocellular Carcinoma: Preclinical and Clinical Demonstration of Combination Efficacy

(2011) Jeong Heo et al.   MOLECULAR THERAPY

A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma

(2011) Tae-Ho Hwang et al.   MOLECULAR THERAPY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Selective Recruitment of Regulatory T Cell through CCR6-CCL20 in Hepatocellular Carcinoma Fosters Tumor Progression and Predicts Poor Prognosis

(2011) Kang-Jie Chen et al.   PLoS One

Hepatocellular carcinoma-specific immunotherapy with synthesized α1,3- galactosyl epitope-pulsed dendritic cells and cytokine-induced killer cells

(2011) Ying Qiu   WORLD JOURNAL OF GASTROENTEROLOGY

Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

(2010) Vincenzo Cerullo et al.   CANCER RESEARCH

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Amelioration of hepatic fibrosis by NK cell activation

(2010) N. Muhanna et al.   GUT

Apoptotic cells attenuate fulminant hepatitis by priming Kupffer cells to produce interleukin-10 through membrane-bound TGF-β

(2010) Minggang Zhang et al.   HEPATOLOGY

PD-1 and PD-L1 upregulation promotes CD8+ T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients

(2010) Feng Shi et al.   INTERNATIONAL JOURNAL OF CANCER

Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells

(2010) V. Dardalhon et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells in chronic hepatitis B patients affect the immunopathogenesis of hepatocellular carcinoma by suppressing the anti-tumour immune responses

(2010) H. H. Zhang et al.   JOURNAL OF VIRAL HEPATITIS

A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

(2010) John A. Mengshol et al.   PLoS One

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Cancer/testis (CT) antigens: Potential targets for immunotherapy

(2009) Otavia L. Caballero et al.   CANCER SCIENCE

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor

(2009) Bastian Hoechst et al.   HEPATOLOGY

Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells

(2009) Dong-Ming Kuang et al.   HEPATOLOGY

Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients

(2009) Jia Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of Cancer-Testis Antigens MAGE-A3/6 and NY-ESO-1 in Non-Small-Cell Lung Carcinomas and Their Relationship with Immune Cell Infiltration

(2009) Sang Hyun Kim et al.   LUNG

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma

(2008) Daniel H. Palmer et al.   HEPATOLOGY

Comprehensive analysis of the α-fetoprotein-specific CD8+ T cell responses in patients with hepatocellular carcinoma

(2008) Robert Thimme et al.   HEPATOLOGY

CD40ligand‐expressing dendritic cells induce regression of hepatocellular carcinoma by activating innate and acquired immunity in vivo

(2008) Maria A. Gonzalez‐Carmona et al.   HEPATOLOGY

Interleukin-12 improves cytotoxicity of natural killer cells via upregulated expression of NKG2D

(2008) Cai Zhang et al.   HUMAN IMMUNOLOGY

Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma

(2008) Ke Pan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Significant antitumor activity of oncolytic adenovirus expressing human interferon-β for hepatocellular carcinoma

(2008) Ling Feng He et al.   JOURNAL OF GENE MEDICINE

Potent antitumor effect of TRAIL mediated by a novel adeno-associated viral vector targeting to telomerase activity for human hepatocellular carcinoma

(2008) Yigang Wang et al.   JOURNAL OF GENE MEDICINE

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial

(2008) Byeong-Ho Park et al.   LANCET ONCOLOGY