NKT cell subsets as key participants in liver physiology and pathology

Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis

(2015) Sidsel Støy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Autoimmune hepatitis: an approach to disease understanding and management

(2015) Margaret Corrigan et al.   BRITISH MEDICAL BULLETIN

Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice

(2015) Igor Maricic et al.   HEPATOLOGY

The biliary epithelium presents antigens to and activates natural killer T cells

(2015) Elisabeth Schrumpf et al.   HEPATOLOGY

Oral ampicillin inhibits liver regeneration by breaking hepatic innate immune tolerance normally maintained by gut commensal bacteria

(2015) Xunyao Wu et al.   HEPATOLOGY

Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice

(2015) Kele Cui et al.   JOURNAL OF HEPATOLOGY

Genetics, diagnostics and therapeutic advances in NAFLD

(2015) Mary E. Rinella et al.   Nature Reviews Gastroenterology & Hepatology

Combination therapy: New hope for alcoholic hepatitis?

(2015) Bin Gao et al.   Clinics and Research in Hepatology and Gastroenterology

Type II NKT Cells in Inflammation, Autoimmunity, Microbial Immunity, and Cancer

(2015) Idania Marrero et al.   Frontiers in Immunology

Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation

(2014) S. Nair et al.   BLOOD

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Activation of invariant natural killer T cells impedes liver regeneration by way of both IFN-γ- and IL-4-dependent mechanisms

(2014) Shi Yin et al.   HEPATOLOGY

Different subsets of natural killer T cells may vary in their roles in health and disease

(2014) Vipin Kumar et al.   IMMUNOLOGY

Involvement of Secretory and Endosomal Compartments in Presentation of an Exogenous Self-Glycolipid to Type II NKT Cells

(2014) K. C. Roy et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Programmed Death-1/Programmed Death Ligand 1 Interaction Regulates the Induction and Maintenance of Invariant NKT Cell Anergy

(2014) W.-S. Chang et al.   JOURNAL OF IMMUNOLOGY

Recognition of Lysophosphatidylcholine by Type II NKT Cells and Protection from an Inflammatory Liver Disease

(2014) Igor Maricic et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cells and Anergic Type I NKT Cells Play a Crucial Role in Sulfatide-Mediated Immune Regulation in Experimental Autoimmune Encephalomyelitis

(2014) I. Maricic et al.   JOURNAL OF IMMUNOLOGY

Tuberous Sclerosis 1 Promotes Invariant NKT Cell Anergy and Inhibits Invariant NKT Cell-Mediated Antitumor Immunity

(2014) J. Wu et al.   JOURNAL OF IMMUNOLOGY

Natural Killer T cell obsession with self-antigens

(2013) Laurent Gapin et al.   CURRENT OPINION IN IMMUNOLOGY

Natural killer T (NKT) cells in autoimmune hepatitis

(2013) Jochen Mattner   CURRENT OPINION IN IMMUNOLOGY

Invariant NKT cell activation induces neutrophil accumulation and hepatitis: Opposite regulation by IL-4 and IFN-γ

(2013) Hua Wang et al.   HEPATOLOGY

Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: A critical role for E-selectin

(2013) Adeline Bertola et al.   HEPATOLOGY

NKT-cell subsets: Promoters and protectors in inflammatory liver disease

(2013) Vipin Kumar   JOURNAL OF HEPATOLOGY

Tim-3/Galectin-9 Regulate the Homeostasis of Hepatic NKT Cells in a Murine Model of Nonalcoholic Fatty Liver Disease

(2013) Z.-H. Tang et al.   JOURNAL OF IMMUNOLOGY

Activated Invariant NKT Cells Control Central Nervous System Autoimmunity in a Mechanism That Involves Myeloid-Derived Suppressor Cells

(2013) V. V. Parekh et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice

(2013) E. Hams et al.   JOURNAL OF IMMUNOLOGY

The role of invariant natural killer T cells in microbial immunity

(2013) Yuki Kinjo et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Cross-Activating Invariant NKT Cells and Kupffer Cells Suppress Cholestatic Liver Injury in a Mouse Model of Biliary Obstruction

(2013) Caroline C. Duwaerts et al.   PLoS One

Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs

(2013) R. V. V. Tatituri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of liver ischemia reperfusion injury: Insights from transgenic knockout models

(2013) Gourab Datta   WORLD JOURNAL OF GASTROENTEROLOGY

Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor

(2012) Jacinto López-Sagaseta et al.   EMBO JOURNAL

Identification of novel glycolipid ligands activating a sulfatide-reactive, CD1d-restricted, type II natural killer T lymphocyte

(2012) Sara Rhost et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

(2012) Wing-Kin Syn et al.   GUT

Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury

(2012) Brittany V. Martin-Murphy et al.   HEPATOLOGY

Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice

(2012) Marie Anson et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver regeneration

(2012) Nelson Fausto et al.   JOURNAL OF HEPATOLOGY

Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

(2012) Onisha Patel et al.   NATURE IMMUNOLOGY

Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens

(2012) Enrico Girardi et al.   NATURE IMMUNOLOGY

Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity

(2012) Sebastian Zeissig et al.   NATURE MEDICINE

NKT Cells Stimulated by Long Fatty Acyl Chain Sulfatides Significantly Reduces the Incidence of Type 1 Diabetes in Nonobese Diabetic Mice

(2012) Lakshmimathy Subramanian et al.   PLoS One

Immunomodulatory Type II Natural Killer T Lymphocytes in Health and Disease

(2012) S. Rhost et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The Unfolding Web of Innate Immune Dysregulation in Alcoholic Liver Injury

(2011) G. Szabo et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Role of NKT cells in autoimmune liver disease

(2011) Tania Santodomingo-Garzon et al.   AUTOIMMUNITY REVIEWS

The benefit of animal models for autoimmune hepatitis

(2011) Elmar Jaeckel et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

CXC chemokine signaling in the liver: Impact on repair and regeneration

(2011) Heather L. Van Sweringen et al.   HEPATOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Th17 cells and their associated cytokines in liver diseases

(2010) Fouad Lafdil et al.   Cellular & Molecular Immunology

Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches

(2010) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

Sulfatide-Mediated Activation of Type II Natural Killer T Cells Prevents Hepatic Ischemic Reperfusion Injury In Mice

(2010) Philomena Arrenberg et al.   GASTROENTEROLOGY

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3

(2010) Sung Hwan Ki et al.   HEPATOLOGY

Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion

(2010) Zubin M. Bamboat et al.   JOURNAL OF CLINICAL INVESTIGATION

Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis

(2010) Daniel Kreisel et al.   JOURNAL OF CLINICAL INVESTIGATION

Diverse Endogenous Antigens for Mouse NKT Cells: Self-Antigens That Are Not Glycosphingolipids

(2010) B. Pei et al.   JOURNAL OF IMMUNOLOGY

Raising the NKT cell family

(2010) Dale I Godfrey et al.   NATURE IMMUNOLOGY

An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

(2010) Woo-Yong Lee et al.   NATURE IMMUNOLOGY

Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a  -linked self-glycolipid

(2010) P. Arrenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alcoholic liver disease and the gut-liver axis

(2010) Gyongyi Szabo   WORLD JOURNAL OF GASTROENTEROLOGY

Liver Regeneration after Partial Hepatectomy

(2009) George K. Michalopoulos   AMERICAN JOURNAL OF PATHOLOGY

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-  and CXCR3 chemokines

(2009) K. L. Wallace et al.   BLOOD

Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease

(2009) Kazuto Tajiri et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Early kinetics of innate and adaptive immune responses during hepatitis B virus infection

(2009) P Fisicaro et al.   GUT

Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis

(2009) Michael Kremer et al.   HEPATOLOGY

Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 and Vβ7 Semi-invariant NKT T Cell Receptors

(2009) Daniel G. Pellicci et al.   IMMUNITY

PD-1/PD-L Blockade Prevents Anergy Induction and Enhances the Anti-Tumor Activities of Glycolipid-Activated Invariant NKT Cells

(2009) V. V. Parekh et al.   JOURNAL OF IMMUNOLOGY

Enrichment of Human CD4+ V 24/V 11 Invariant NKT Cells in Intrahepatic Malignant Tumors

(2009) G. Bricard et al.   JOURNAL OF IMMUNOLOGY

How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens

(2009) Manfred Brigl et al.   SEMINARS IN IMMUNOLOGY

The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease?

(2009) Luca Valenti et al.   Seminars in Immunopathology

Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer

(2008) D. H. Chang et al.   BLOOD

Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: Implications for posttransplant survival

(2008) Angela Shaulov et al.   EXPERIMENTAL HEMATOLOGY

Critical Role for CD1d-Restricted Invariant NKT Cells in Stimulating Intrahepatic CD8 T-Cell Responses to Liver Antigen

(2008) Dave Sprengers et al.   GASTROENTEROLOGY

Cellular and Molecular Mechanisms of Liver Injury

(2008) Harmeet Malhi et al.   GASTROENTEROLOGY

Invariant Natural Killer T Cells Suppress the Neutrophil Inflammatory Response in a Mouse Model of Cholestatic Liver Damage

(2008) Philip Wintermeyer et al.   GASTROENTEROLOGY

CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes

(2008) Li Ye et al.   HEPATOLOGY

Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride

(2008) Ogyi Park et al.   HEPATOLOGY

Hepatic IL-17 responses in human and murine primary biliary cirrhosis

(2008) Ruth Y.Z. Lan et al.   JOURNAL OF AUTOIMMUNITY

Cross-regulation between distinct natural killer T cell subsets influences immune response to self and foreign antigens

(2008) Philomena Arrenberg et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Innate immunity and alcoholic liver fibrosis

(2008) Won-Il Jeong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY