Natural Killer T Cells in Various Mouse Models of Hepatitis

Intestinal iNKT Cells Migrate to Liver and Contribute to Hepatocyte Apoptosis During Alcoholic Liver Disease

(2019) Kuei-Chuan Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hyperactivated peripheral invariant natural killer T cells correlate with the progression of HBV‐relative liver cirrhosis

(2019) Xin Wei et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Activation of hepatic iNKT2 cells by α-GalCer ameliorates hepatic steatosis induced by high-fat diet in C57BL/6J mice

(2019) Dongzhi Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Liver transplantation and alcoholic liver disease: History, controversies, and considerations

(2018) Claudio Augusto Marroni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

(2018) Mingzhu Yan et al.   Redox Biology

Autoimmune hepatitis

(2018) Giorgina Mieli-Vergani et al.   Nature Reviews Disease Primers

Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis

(2018) Igor Maricic et al.   JOURNAL OF IMMUNOLOGY

Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away?

(2017) William M. Lee   JOURNAL OF HEPATOLOGY

Pathology of non-alcoholic fatty liver disease

(2017) Pierre Bedossa   LIVER INTERNATIONAL

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients

(2017) Jijing Shi et al.   Scientific Reports

Suppression of Natural Killer Cell Activity by Regulatory NKT10 Cells Aggravates Alcoholic Hepatosteatosis

(2017) Kele Cui et al.   Frontiers in Immunology

NKT cell subsets as key participants in liver physiology and pathology

(2016) Keya Bandyopadhyay et al.   Cellular & Molecular Immunology

Drug-induced liver injury

(2016) D. Katarey et al.   CLINICAL MEDICINE

Pathogenesis of Alcoholic Liver Disease

(2016) Winston Dunn et al.   Clinics in Liver Disease

IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis

(2016) Jinling Huang et al.   JOURNAL OF IMMUNOLOGY

Enterogenous bacterial glycolipids are required for the generation of natural killer T cells mediated liver injury

(2016) Yingfeng Wei et al.   Scientific Reports

Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration

(2015) Stephanie Mathews et al.   Cellular & Molecular Immunology

Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame

(2015) Samar H. Ibrahim et al.   DIGESTIVE DISEASES AND SCIENCES

Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice

(2015) Igor Maricic et al.   HEPATOLOGY

Autoimmune hepatitis – Update 2015

(2015) Michael P. Manns et al.   JOURNAL OF HEPATOLOGY

Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice

(2015) Kele Cui et al.   JOURNAL OF HEPATOLOGY

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

The global burden of liver disease: The major impact of China

(2014) Fu-Sheng Wang et al.   HEPATOLOGY

Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells

(2014) A.-L. Chelakkot-Govindalayathil et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hepatitis B virus infection

(2014) Christian Trépo et al.   LANCET

The role of intrahepatic CD3+/CD4−/CD8− double negative T (DN T) cells in enhanced acetaminophen toxicity

(2014) Yonas Getachew et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases

(2014) Jessica A Williams et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Natural killer T cells play a necessary role in modulating of immune-mediated liver injury by gut microbiota

(2014) Jianing Chen et al.   Scientific Reports

Opposing effects of prednisolone treatment on T/NKT cell- and hepatotoxin-mediated hepatitis in mice

(2013) Hyo-Jung Kwon et al.   HEPATOLOGY

Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis

(2013) A. Wehr et al.   JOURNAL OF IMMUNOLOGY

PD-1/PDL1 and CD28/CD80 pathways modulate natural killer T cell function to inhibit hepatitis B virus replication

(2013) X. F. Wang et al.   JOURNAL OF VIRAL HEPATITIS

Autoimmune hepatitis

(2013) Michael A Heneghan et al.   LANCET

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

(2013) Adeline Bertola et al.   Nature Protocols

Vα14iNKT cell deficiency prevents acetaminophen-induced acute liver failure by enhancing hepatic glutathione and altering APAP metabolism

(2012) Isaac Downs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NF-κB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses

(2012) Irene Locatelli et al.   CLINICAL SCIENCE

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase

(2012) Laura Gomez-Santos et al.   HEPATOLOGY

Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury

(2012) Brittany V. Martin-Murphy et al.   HEPATOLOGY

Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-γ production in mice

(2012) Jie Chen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

NKT cells—an early warning system for HBV infection

(2012) Dale I Godfrey et al.   NATURE MEDICINE

Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity

(2012) Sebastian Zeissig et al.   NATURE MEDICINE

Immune mechanisms of Concanavalin A model of autoimmune hepatitis

(2012) Hai-Xia Wang   WORLD JOURNAL OF GASTROENTEROLOGY

SOCS1 regulates type I/type II NKT cell balance by regulating IFN  signaling

(2011) M. Hashimoto et al.   INTERNATIONAL IMMUNOLOGY

Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection

(2011) Jun Li et al.   Virology Journal

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Accelerated liver fibrosis in hepatitis B virus transgenic mice: Involvement of natural killer T cells

(2010) Zixue Jin et al.   HEPATOLOGY

Guidelines for the diagnosis and management of alcoholic liver disease: Update 2010

(2010) You Ming LI et al.   Journal of Digestive Diseases

Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet

(2010) Takuya Miyagi et al.   JOURNAL OF GASTROENTEROLOGY

Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease

(2009) Kazuto Tajiri et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide

(2008) Mary Jane Masson et al.   HEPATOLOGY

Role of V 14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of V 14+ NKT cells promotes the breakage of CTL tolerance

(2008) H. Ito et al.   INTERNATIONAL IMMUNOLOGY

Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells

(2008) Xiong Ma et al.   JOURNAL OF HEPATOLOGY

Abrogation of the Antifibrotic Effects of Natural Killer Cells/Interferon-γ Contributes to Alcohol Acceleration of Liver Fibrosis

(2007) Won–Il Jeong et al.   GASTROENTEROLOGY