The Muscle-Brain Axis and Neurodegenerative Diseases: The Key Role of Mitochondria in Exercise-Induced Neuroprotection

Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers

(2021) Andre F. Batista et al.   Journal of Neuroinflammation

Exercised state of mind: A perspective on ageing, cerebral blood flow and cognition

(2021) Thomas D. Griffiths et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

(2021) Jennifer K. Dowling et al.   Nature Communications

Exercise and Fitness Neuroprotective Effects: Molecular, Brain Volume and Psychological Correlates and Their Mediating Role in Healthy Late-Middle-Aged Women and Men

(2021) Alba Castells-Sánchez et al.   Frontiers in Aging Neuroscience

Extracellular Vesicles and Exosomes: Insights From Exercise Science

(2021) Joshua P. Nederveen et al.   Frontiers in Physiology

Role of Interleukin-6 in Vascular Health and Disease

(2021) Paulina Villar-Fincheira et al.   Frontiers in Molecular Biosciences

Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

(2021) Mikael Flockhart et al.   Cell Metabolism

Exercise Is Muscle Mitochondrial Medicine

(2021) Ashley N. Oliveira et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Evaluation of a Strength-Training Program on Clinical Outcomes in Older Adults

(2021) Johannes Burtscher et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High-intensity exercise training — too much of a good thing?

(2021) John A. Hawley et al.   Nature Reviews Endocrinology

Adult Hippocampal Neurogenesis: One Lactate to Rule Them All

(2021) Raneen Nicola et al.   NEUROMOLECULAR MEDICINE

Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs

(2021) Kiran Todkar et al.   Nature Communications

Exercise Is Medicine…and the Dose Matters

(2021) Sean P. Langan et al.   Frontiers in Physiology

Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease

(2021) Chun Chen et al.   npj Parkinsons Disease

The central role of mitochondrial fitness on antiviral defenses: An advocacy for physical activity during the COVID-19 pandemic

(2021) Johannes Burtscher et al.   Redox Biology

The emerging role of skeletal muscle mitochondrial dynamics in exercise and ageing

(2020) Rafael A. Casuso et al.   AGEING RESEARCH REVIEWS

The role of extracellular vesicles in skeletal muscle and systematic adaptation to exercise

(2020) Ivan J. Vechetti et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

(2020) Yasmine J. Liu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake

(2020) FJ Larsen et al.   Acta Physiologica

Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases

(2020) Inês Marques-Aleixo et al.   ANTIOXIDANTS & REDOX SIGNALING

Exercise, redox system and neurodegenerative diseases

(2020) Helong Quan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men

(2020) Jonathan S. T. Woodhead et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial fragmentation enables localized signaling required for cell repair

(2020) Adam Horn et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial biogenesis: An update

(2020) Lucia‐Doina Popov   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease

(2020) Giacomo Monzio Compagnoni et al.   MOLECULAR NEUROBIOLOGY

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The roles of microRNA in redox metabolism and exercise-mediated adaptation

(2020) Ferenc Torma et al.   Journal of Sport and Health Science

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

(2020) Vivian Hook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases

(2020) Deqiang Han et al.   Stem Cells International

The Regulatory Role of IL-10 in Neurodegenerative Diseases

(2020) Chiara Porro et al.   Biomolecules

Exercise benefits on Alzheimer’s disease: State-of-the-science

(2020) Pedro L. Valenzuela et al.   AGEING RESEARCH REVIEWS

pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise

(2020) Anita Reddy et al.   CELL

The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass

(2020) Vanina Romanello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Indomethacin markedly blunts cerebral perfusion and reactivity, with little cognitive consequence in healthy young and older adults

(2020) L. N. Shoemaker et al.   JOURNAL OF PHYSIOLOGY-LONDON

Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: Evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy

(2020) Yingjie Chen et al.   NEUROPHARMACOLOGY

Astrocyte Signaling in the Neurovascular Unit After Central Nervous System Injury

(2019) Lena Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Decreased Serum Brain-Derived Neurotrophic Factor (BDNF) Levels in Patients with Alzheimer’s Disease (AD): A Systematic Review and Meta-Analysis

(2019) Ted Ng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met

(2019) Claire Emma McGregor et al.   Frontiers in Cellular Neuroscience

Exercise-Induced Myokines With Therapeutic Potential for Muscle Wasting

(2019) Rosanna Piccirillo   Frontiers in Physiology

Fibroblast growth factor 21 controls mitophagy and muscle mass

(2019) Lynette J. Oost et al.   Journal of Cachexia Sarcopenia and Muscle

A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases

(2019) Michael F. Young et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Physical activity and muscle–brain crosstalk

(2019) Bente Klarlund Pedersen   Nature Reviews Endocrinology

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

(2019) Lauretta El Hayek et al.   JOURNAL OF NEUROSCIENCE

MicroRNA Profile and Adaptive Response to Exercise Training: A Review

(2019) Daria Domańska-Senderowska et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics

(2019) Xin Li et al.   Oxidative Medicine and Cellular Longevity

FGF21 as Modulator of Metabolism in Health and Disease

(2019) Caterina Tezze et al.   Frontiers in Physiology

Fibroblast growth factor 21 ameliorates neurodegeneration in rat and cellular models of Alzheimer’s disease

(2019) Song Chen et al.   Redox Biology

Stay Fit, Stay Young: Mitochondria in Movement: The Role of Exercise in the New Mitochondrial Paradigm

(2019) Jesus R. Huertas et al.   Oxidative Medicine and Cellular Longevity

FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

(2019) Cristal M. Hill et al.   Cell Reports

Physical Exercise Induces Immunoregulation of TREG, M2, and pDCs in a Lung Allergic Inflammation Model

(2019) Paula Fernandes et al.   Frontiers in Immunology

Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

(2019) Saara Forsström et al.   Cell Metabolism

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility

(2019) Xiuying Yang et al.   Science Signaling

Mitochondrial Transfer Ameliorates Cognitive Deficits, Neuronal Loss, and Gliosis in Alzheimer’s Disease Mice

(2019) Keren Nitzan et al.   JOURNAL OF ALZHEIMERS DISEASE

The effects of moderate exercise and overtraining on learning and memory, hippocampal inflammatory cytokine levels, and brain oxidative stress markers in rats

(2019) Zahra Jahangiri et al.   Journal of Physiological Sciences

Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis

(2019) Lars Karlsson et al.   Scientific Reports

Effects of Resistance Exercise on Cerebral Redox Regulation and Cognition: An Interplay Between Muscle and Brain

(2019) Ricardo A. Pinho et al.   Antioxidants

Sensing the Environment: Extracellular Lactate Levels Control Adult Neurogenesis

(2019) Valentina Scandella et al.   Cell Stem Cell

Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis

(2019) Jun Wang et al.   Cell Stem Cell

Exercise and mitochondrial health

(2019) Jonathan M. Memme et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lifelong Endurance Exercise as a Countermeasure Against Age-Related V˙O2max Decline: Physiological Overview and Insights from Masters Athletes

(2019) Pedro L. Valenzuela et al.   SPORTS MEDICINE

Boxing for Parkinson's Disease: Has Implementation Accelerated Beyond Current Evidence?

(2019) Meg E. Morris et al.   Frontiers in Neurology

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

(2018) Mark P. Mattson et al.   Cell Metabolism

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

(2018) Martin Whitham et al.   Cell Metabolism

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

(2018) Luca Peruzzotti-Jametti et al.   Cell Stem Cell

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Circulating microRNA as Emerging Biomarkers of Exercise

(2018) Manuel Fernández-Sanjurjo et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Effects of interleukin-6 and IL-6/AMPK signaling pathway on mitochondrial biogenesis and astrocytes viability under experimental septic condition

(2018) Xiao-Lan Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Irisin Protects Heart Against Ischemia-Reperfusion Injury Through a SOD2-Dependent Mitochondria Mechanism

(2018) Zhen Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

FGF21 Protects the Blood–Brain Barrier by Upregulating PPARγ via FGFR1/β-klotho after Traumatic Brain Injury

(2018) Jun Chen et al.   JOURNAL OF NEUROTRAUMA

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Voluntary running enhances glymphatic influx in awake behaving, young mice

(2018) Stephanie von Holstein-Rathlou et al.   NEUROSCIENCE LETTERS

Principles of Exercise Prescription, and How They Influence Exercise-Induced Changes of Transcription Factors and Other Regulators of Mitochondrial Biogenesis

(2018) Cesare Granata et al.   SPORTS MEDICINE

Training-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle

(2018) Cesare Granata et al.   SPORTS MEDICINE

Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2

(2018) Jin Liu et al.   Frontiers in Molecular Neuroscience

Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

(2018) Patrick Z. Liu et al.   Frontiers in Neuroscience

OxInflammation: From Subclinical Condition to Pathological Biomarker

(2018) Giuseppe Valacchi et al.   Frontiers in Physiology

Distinct patterns of skeletal muscle mitochondria fusion, fission and mitophagy upon duration of exercise training

(2018) Yoan Arribat et al.   Acta Physiologica

Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging

(2018) David A. Hood et al.   Annual Review of Physiology

Humanin Signal for Alzheimer's Disease

(2018) Masaaki Matsuoka   JOURNAL OF ALZHEIMERS DISEASE

Selective vulnerability in neurodegenerative diseases

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors

(2018) Carmen Fiuza-Luces et al.   Nature Reviews Cardiology

Strength exercise weakens aerobic exercise-induced cognitive improvements in rats

(2018) Yongsheng Lan et al.   PLoS One

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Endocrine Crosstalk Between Skeletal Muscle and the Brain

(2018) Julien Delezie et al.   Frontiers in Neurology

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions

(2018) David J. Bishop et al.   PHYSIOLOGY

Mobilizing Parkinson’s Disease: The Future of Exercise

(2018) Terry Ellis et al.   Journal of Parkinsons Disease

The compelling link between physical activity and the body's defense system

(2018) David C. Nieman et al.   Journal of Sport and Health Science

The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment

(2018) Chiara Zucchella et al.   Frontiers in Neurology

Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

(2018) Jianbin Bi et al.   Redox Biology

Exercise effects on physiological function during aging

(2018) Zsolt Radak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1α dependent manner

(2017) Jens Frey Halling et al.   EXPERIMENTAL GERONTOLOGY

Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress

(2017) Mohamed Bouzid et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Intravenous administration of mitochondria for treating experimental Parkinson's disease

(2017) Xianxun Shi et al.   MITOCHONDRION

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

(2017) Ken Chen et al.   Science Translational Medicine

Nutrition and Training Influences on the Regulation of Mitochondrial Adenosine Diphosphate Sensitivity and Bioenergetics

(2017) Graham P. Holloway   SPORTS MEDICINE

Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys

(2017) Hui Peng et al.   Nature Communications

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

(2017) Cecilie Morland et al.   Nature Communications

Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction

(2017) Ai-Ling Cui et al.   Drug Design Development and Therapy

Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

(2017) Andrés Caicedo et al.   Stem Cells International

Extreme Mountain Ultra-Marathon Leads to Acute but Transient Increase in Cerebral Water Diffusivity and Plasma Biomarkers Levels Changes

(2017) Davide Zanchi et al.   Frontiers in Physiology

The Mitochondrial Basis of Aging and Age-Related Disorders

(2017) Sarika Srivastava   Genes

Can physical exercise in old age improve memory and hippocampal function?

(2016) Emrah Duzel et al.   BRAIN

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells

(2016) Ting-Hsiang Wu et al.   Cell Metabolism

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

(2016) Mojtaba Golpich et al.   CNS Neuroscience & Therapeutics

Maximal aerobic power and anaerobic capacity in cycling across the age spectrum in male master athletes

(2016) C. Capelli et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle

(2016) Cesare Granata et al.   FASEB JOURNAL

Mitohormesis in exercise training

(2016) Troy L. Merry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Voluntary exercise improves hypothalamic and metabolic function in obese mice

(2016) Brenton T Laing et al.   JOURNAL OF ENDOCRINOLOGY

Physiological adaptations to interval training and the role of exercise intensity

(2016) Martin J. MacInnis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

The ever-expanding myokinome: discovery challenges and therapeutic implications

(2016) Martin Whitham et al.   NATURE REVIEWS DRUG DISCOVERY

The potential of endurance exercise-derived exosomes to treat metabolic diseases

(2016) Adeel Safdar et al.   Nature Reviews Endocrinology

Exercise-stimulated glucose uptake — regulation and implications for glycaemic control

(2016) Lykke Sylow et al.   Nature Reviews Endocrinology

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Characteristics of Mitochondrial Transformation into Human Cells

(2016) E. E. Kesner et al.   Scientific Reports

Syndromic parkinsonism and dementia associated withOPA1missense mutations

(2015) Valerio Carelli et al.   ANNALS OF NEUROLOGY

The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo

(2015) Petra Sabine Eisele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

(2015) P. Darrell Neufer et al.   Cell Metabolism

Combined Training Enhances Skeletal Muscle Mitochondrial Oxidative Capacity Independent of Age

(2015) Brian A. Irving et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle

(2015) CRAIG PORTER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Endurance Training-Induced Increase in Circulating Irisin Levels Is Associated with Reduction of Abdominal Visceral Fat in Middle-Aged and Older Adults

(2015) Eri Miyamoto-Mikami et al.   PLoS One

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

Adult Neurogenesis in Neurodegenerative Diseases: Figure 1.

(2015) Beate Winner et al.   Cold Spring Harbor Perspectives in Biology

Trans-mitochondrial coordination of cristae at regulated membrane junctions

(2015) Martin Picard et al.   Nature Communications

Muscle Releases Alpha-Sarcoglycan Positive Extracellular Vesicles Carrying miRNAs in the Bloodstream

(2015) Michele Guescini et al.   PLoS One

All-cause and disease-specific mortality among male, former elite athletes: an average 50-year follow-up

(2014) Jyrki A Kettunen et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

Skeletal Muscle Mitochondria in the Elderly: Effects of Physical Fitness and Exercise Training

(2014) Nicholas T. Broskey et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transcellular degradation of axonal mitochondria

(2014) Chung-ha O. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immunomodulating role of exercise in metabolic disease

(2014) Graeme I. Lancaster et al.   TRENDS IN IMMUNOLOGY

Mitochondrial Aging and Age-Related Dysfunction of Mitochondria

(2014) Dimitry A. Chistiakov et al.   Biomed Research International

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

(2013) Maria Damiano et al.   HUMAN MOLECULAR GENETICS

Improvements in exercise performance with high-intensity interval training coincide with an increase in skeletal muscle mitochondrial content and function

(2013) Robert Acton Jacobs et al.   JOURNAL OF APPLIED PHYSIOLOGY

Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle

(2013) Martin Picard et al.   JOURNAL OF APPLIED PHYSIOLOGY

Differential regulation of Bdnf expression in cortical neurons by class-selective histone deacetylase inhibitors

(2013) Indrek Koppel et al.   NEUROPHARMACOLOGY

Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans

(2013) Kook Hwan Kim et al.   PLoS One

Humanin: a harbinger of mitochondrial-derived peptides?

(2013) Changhan Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria express enhanced quality as well as quantity in association with aerobic fitness across recreationally active individuals up to elite athletes

(2012) Robert A. Jacobs et al.   JOURNAL OF APPLIED PHYSIOLOGY

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Long-term exercise treatment reduces oxidative stress in the hippocampus of aging rats

(2012) K. Marosi et al.   NEUROSCIENCE

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

The MyomiR Network in Skeletal Muscle Plasticity

(2011) John J. McCarthy   EXERCISE AND SPORT SCIENCES REVIEWS

Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes

(2011) R. A. Jacobs et al.   JOURNAL OF APPLIED PHYSIOLOGY

Exercise training increases mitochondrial biogenesis in the brain

(2011) Jennifer L. Steiner et al.   JOURNAL OF APPLIED PHYSIOLOGY

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training

(2011) Aaron L. Baggish et al.   JOURNAL OF PHYSIOLOGY-LONDON

Physical Activity and Inflammation in a Multiethnic Cohort of Women

(2011) I-MIN LEE et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Does vigorous exercise have a neuroprotective effect in Parkinson disease?

(2011) J. E. Ahlskog   NEUROLOGY

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria and Huntington's Disease Pathogenesis

(2010) Susan E. Browne   Annals of the New York Academy of Sciences

MicroRNAs of the immune system

(2010) Jan Davidson-Moncada et al.   Annals of the New York Academy of Sciences

Regulation of mitochondrial biogenesis

(2010) François R. Jornayvaz et al.   Essays in Biochemistry

Mitochondrial gene expression in elite cyclists: effects of high-intensity interval exercise

(2010) Psilander Niklas et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Elevated blood lactate is associated with increased motor cortex excitability

(2010) Marinella Coco et al.   SOMATOSENSORY AND MOTOR RESEARCH

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of Mammalian microRNA Expression

(2010) Xiaoxiao Zhang et al.   Journal of Cardiovascular Translational Research

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

(2009) Stephen Y. Chan et al.   Cell Metabolism

MicroRNA control of muscle development and disease

(2009) Andrew H Williams et al.   CURRENT OPINION IN CELL BIOLOGY

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

(2009) V. B. Matthews et al.   DIABETOLOGIA

Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis

(2009) Johannes Fuss et al.   HIPPOCAMPUS

Exercise and Physical Activity for Older Adults

(2009) Wojtek J. Chodzko-Zajko et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Protective effects of [Gly14]-Humanin on β-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction

(2009) Hui Jin et al.   NEUROCHEMISTRY INTERNATIONAL

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcribe to Survive: Transcriptional Control of Antioxidant Defense Programs for Neuroprotection in Parkinson’s Disease

(2008) Joanne Clark et al.   ANTIOXIDANTS & REDOX SIGNALING

miR-21: a small multi-faceted RNA

(2008) Anna M. Krichevsky et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Human Interleukin-10 Gene Transfer Is Protective in a Rat Model of Parkinson's Disease

(2008) Louisa C Johnston et al.   MOLECULAR THERAPY

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS

Exercise, oxidative stress and hormesis

(2007) Zsolt Radak et al.   AGEING RESEARCH REVIEWS

Systemic and mitochondrial adaptive responses to moderate exercise in rodents

(2007) Alberto Boveris et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cerebral blood flow and metabolism during exercise: implications for fatigue

(2007) Neils H. Secher et al.   JOURNAL OF APPLIED PHYSIOLOGY

The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis

(2007) J.L. Trejo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE