High-intensity exercise training — too much of a good thing?

Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

(2021) Mikael Flockhart et al.   Cell Metabolism

Maximizing Cellular Adaptation to Endurance Exercise in Skeletal Muscle

(2018) John A. Hawley et al.   Cell Metabolism

Molecular Basis of Exercise-Induced Skeletal Muscle Mitochondrial Biogenesis: Historical Advances, Current Knowledge, and Future Challenges

(2017) Christopher G.R. Perry et al.   Cold Spring Harbor Perspectives in Medicine

Health Benefits of Exercise

(2017) Gregory N. Ruegsegger et al.   Cold Spring Harbor Perspectives in Medicine

Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle

(2016) Cesare Granata et al.   FASEB JOURNAL

Physiological adaptations to interval training and the role of exercise intensity

(2016) Martin J. MacInnis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers

(2010) Martin Picard et al.   AGING CELL