Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

A Thoroughly Validated Virtual Screening Strategy for Discovery of Novel HDAC3 Inhibitors

(2017) Huabin Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sanctioned UK Trial of Mitochondrial Transfer Nears

(2017) Jeff Lyon   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mitochondrial transplantation: From animal models to clinical use in humans

(2017) James D. McCully et al.   MITOCHONDRION

Mitochondrial Donation — Clearing the Final Regulatory Hurdle in the United Kingdom

(2017) Mary Herbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Strategies for Derisking Translational Processes for Biomedical Technologies

(2017) Mohamed Abou-El-Enein et al.   TRENDS IN BIOTECHNOLOGY

Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

(2017) Marie-Luce Vignais et al.   Stem Cells International

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children

(2016) A. Diot et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial resetting and metabolic reprogramming in induced pluripotent stem cells and mitochondrial disease modeling

(2016) Yi-Chao Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial Transfer from Astrocytes to Neurons following Ischemic Insult: Guilt by Association?

(2016) Michael V. Berridge et al.   Cell Metabolism

Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells

(2016) Ting-Hsiang Wu et al.   Cell Metabolism

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes

(2016) Mitsutoshi Yamada et al.   Cell Stem Cell

Transferring Xenogenic Mitochondria Provides Neural Protection against Ischemic Stress in Ischemic Rat Brains

(2016) Po-Jui Huang et al.   CELL TRANSPLANTATION

Intercellular mitochondrial transfer: bioenergetic crosstalk between cells

(2016) Pratik Sinha et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Extracellular vesicles and intercellular communication within the nervous system

(2016) Valentina Zappulli et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

(2016) Eunju Kang et al.   NATURE

Late acquisition of mitochondria by a host with chimaeric prokaryotic ancestry

(2016) Alexandros A. Pittis et al.   NATURE

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

(2016) Matthijs K. C. Hesselink et al.   Nature Reviews Endocrinology

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial Replacement Techniques — Implications for the Clinical Community

(2016) Marni J. Falk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Finding an ethical path forward for mitochondrial replacement

(2016) A. B. Claiborne et al.   SCIENCE

From the first human gene-editing to the birth of three-parent baby

(2016) Xiaoxue Zhang et al.   Science China-Life Sciences

Mitochondria in mesenchymal stem cell biology and cell therapy: From cellular differentiation to mitochondrial transfer

(2016) Yi-Chao Hsu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

(2016) Megan V. Jackson et al.   STEM CELLS

Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine–induced neurotoxicity

(2016) Jui-Chih Chang et al.   Translational Research

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial Replacement Techniques: Divergence in Global Policy

(2016) Johanna Schandera et al.   TRENDS IN GENETICS

Synthetic Biology in Cell and Organ Transplantation

(2016) Sean Stevens   Cold Spring Harbor Perspectives in Biology

Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila

(2016) Nikolay P. Kandul et al.   Nature Communications

Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells

(2016) Tanja Macheiner et al.   Scientific Reports

Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy

(2016) Giorgos K. Sakellariou et al.   Scientific Reports

Increased activity of mitochondrial uncoupling protein 2 improves stress resistance in cultured endothelial cells exposed in vitro to high glucose levels

(2015) Agnieszka Koziel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy

(2015) Kana Unuma et al.   Autophagy

Intercellular transfer of mitochondria

(2015) E. Y. Plotnikov et al.   BIOCHEMISTRY-MOSCOW

Social and ethical issues in mitochondrial donation: Fig. 1

(2015) Rebecca Dimond   BRITISH MEDICAL BULLETIN

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Adult Stem-Like Cells Exclude “Older” Mitochondria

(2015) Michael A. Teitell   Cell Metabolism

Recent Advances in Mesenchymal Stem Cell Immunomodulation: The Role of Microvesicles

(2015) Alessandra Fierabracci et al.   CELL TRANSPLANTATION

Role of mitochondria in apoptotic and necroptotic cell death in the developing brain

(2015) Claire Thornton et al.   CLINICA CHIMICA ACTA

Targeting autophagy and mitophagy for mitochondrial diseases treatment

(2015) Marina Villanueva Paz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mitochondrial disorders: Challenges in diagnosis & treatment

(2015) Kumarasamy Thangaraj et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation

(2015) Felipe K. Teixeira et al.   NATURE CELL BIOLOGY

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Mitochondrial replacement therapy in reproductive medicine

(2015) Don P. Wolf et al.   TRENDS IN MOLECULAR MEDICINE

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function

(2015) Andrés Caicedo et al.   Scientific Reports

Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming

(2015) Peter J. Quesenberry et al.   Stem Cell Research & Therapy

Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function

(2015) C. A. Pacak et al.   Biology Open

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

(2014) L. H. Boudreau et al.   BLOOD

Microvesicles and exosomes for intracardiac communication

(2014) Joost P.G. Sluijter et al.   CARDIOVASCULAR RESEARCH

Induction of entosis by epithelial cadherin expression

(2014) Qiang Sun et al.   CELL RESEARCH

The regulation of mitochondrial dynamics

(2014) Suzanne Hoppins   CURRENT OPINION IN CELL BIOLOGY

Endosymbiotic theory for organelle origins

(2014) Verena Zimorski et al.   CURRENT OPINION IN MICROBIOLOGY

Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy

(2014) Tanveer Ahmad et al.   EMBO JOURNAL

Three-parent in vitro fertilization: gene replacement for the prevention of inherited mitochondrial diseases

(2014) Paula Amato et al.   FERTILITY AND STERILITY

Internalization of isolated functional mitochondria: involvement of macropinocytosis

(2014) Tomoya Kitani et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Systemic combined melatonin-mitochondria treatment improves acute respiratory distress syndrome in the rat

(2014) Cheuk Kwan Sun et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial DNA disease and developmental implications for reproductive strategies

(2014) Joerg Patrick Burgstaller et al.   MOLECULAR HUMAN REPRODUCTION

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Belonging to a network—microRNAs, extracellular vesicles, and the glioblastoma microenvironment

(2014) Jakub Godlewski et al.   NEURO-ONCOLOGY

Transcellular degradation of axonal mitochondria

(2014) Chung-ha O. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals

(2014) A Maeda et al.   Cell Death & Disease

The Challenges of Mitochondrial Replacement

(2014) Patrick F. Chinnery et al.   PLoS Genetics

Evidence for Mito-Nuclear and Sex-Linked Reproductive Barriers between the Hybrid Italian Sparrow and Its Parent Species

(2014) Cassandra N. Trier et al.   PLoS Genetics

Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury

(2013) Akihiro Masuzawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The mitochondrial H+-ATP synthase and the lipogenic switch

(2013) Alejandro Vazquez-Martin et al.   CELL CYCLE

Mitochondrial Regulation in Pluripotent Stem Cells

(2013) Xiuling Xu et al.   Cell Metabolism

Stem cells in retinal regeneration: past, present and future

(2013) C. M. Ramsden et al.   DEVELOPMENT

Human embryonic stem cell applications for retinal degenerations

(2013) Joseph Reynolds et al.   EXPERIMENTAL EYE RESEARCH

Strikingly Bacteria-Like and Gene-Rich Mitochondrial Genomes throughout Jakobid Protists

(2013) Gertraud Burger et al.   Genome Biology and Evolution

Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation

(2013) Ying Dai et al.   HUMAN MOLECULAR GENETICS

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Myo10 is a key regulator of TNT formation in neuronal cells

(2013) K. Gousset et al.   JOURNAL OF CELL SCIENCE

Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

(2013) Michal Bohdanowicz et al.   PHYSIOLOGICAL REVIEWS

When Cells Become Organelle Donors

(2013) Robert S. Rogers et al.   PHYSIOLOGY

The ethics of creating children with three genetic parents

(2013) Françoise Baylis   REPRODUCTIVE BIOMEDICINE ONLINE

Mitochondrial Replacement, Evolution, and the Clinic

(2013) K. Reinhardt et al.   SCIENCE

Isolated Mitochondria Infusion Mitigates Ischemia-Reperfusion Injury of the Liver in Rats

(2013) Han-Chen Lin et al.   SHOCK

Apoptosome Structure, Assembly, and Procaspase Activation

(2013) Shujun Yuan et al.   STRUCTURE

Mitochondrial disorders: aetiologies, models systems, and candidate therapies

(2013) G. Jane Farrar et al.   TRENDS IN GENETICS

An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila

(2013) Colin D. Meiklejohn et al.   PLoS Genetics

Mitochondria organelle transplantation: introduction of normal epithelial mitochondria into human cancer cells inhibits proliferation and increases drug sensitivity

(2012) R. L. Elliott et al.   BREAST CANCER RESEARCH AND TREATMENT

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

(2012) Clifford D.L. Folmes et al.   Cell Stem Cell

A molecular view on signal transduction by the apoptosome

(2012) Thomas F. Reubold et al.   CELLULAR SIGNALLING

Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

(2012) Changjin Lee et al.   CIRCULATION

Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy

(2012) Donald G. Phinney   JOURNAL OF CELLULAR BIOCHEMISTRY

Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery

(2012) Helerin Margus et al.   MOLECULAR THERAPY

Towards germline gene therapy of inherited mitochondrial diseases

(2012) Masahito Tachibana et al.   NATURE

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery

(2012) Jui-Chih Chang et al.   NEUROSIGNALS

An Ethanol Extract of Artemisia iwayomogi Activates PPARδ Leading to Activation of Fatty Acid Oxidation in Skeletal Muscle

(2012) Si Young Cho et al.   PLoS One

Tunneling-nanotube direction determination in neurons and astrocytes

(2012) X Sun et al.   Cell Death & Disease

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

Mitochondrial Structure and Function Are Disrupted by Standard Isolation Methods

(2011) Martin Picard et al.   PLoS One

Intercellular Communication by Exchange of Cytoplasmic Material via Tunneling Nano-Tube Like Structures in Primary Human Renal Epithelial Cells

(2011) Sophie Domhan et al.   PLoS One

Therapy for mitochondrial disorders: Little proof, high research activity, some promise

(2011) Anu Suomalainen   Seminars in Fetal & Neonatal Medicine

Diabetes, insulin, and development of acute lung injury

(2010) Shyoko Honiden et al.   CRITICAL CARE MEDICINE

Xenomitochondrial mice: Investigation into mitochondrial compensatory mechanisms

(2010) M.V. Cannon et al.   MITOCHONDRION

Growth Factor erv1-like Modulates Drp1 to Preserve Mitochondrial Dynamics and Function in Mouse Embryonic Stem Cells

(2010) Lance R. Todd et al.   MOLECULAR BIOLOGY OF THE CELL

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

(2010) Lyndsey Craven et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Structure of an Apoptosome-Procaspase-9 CARD Complex

(2010) Shujun Yuan et al.   STRUCTURE

Preparation of Highly Coupled Rat Heart Mitochondria

(2010) Irina Gostimskaya et al.   Jove-Journal of Visualized Experiments

Isolation of functional pure mitochondria by superparamagnetic microbeads

(2009) Hue-Tran Hornig-Do et al.   ANALYTICAL BIOCHEMISTRY

Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells

(2009) Nickolay V. Bukoreshtliev et al.   FEBS LETTERS

Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Sue/g

(2009) Regina Rabl et al.   JOURNAL OF CELL BIOLOGY

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Microinjection of serum-starved mitochondria derived from somatic cells affects parthenogenetic development of bovine and murine oocytes

(2009) Kumiko Takeda et al.   MITOCHONDRION

Mitochondrial gene replacement in primate offspring and embryonic stem cells

(2009) Masahito Tachibana et al.   NATURE

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

The Relationship Between Pluripotency and Mitochondrial DNA Proliferation During Early Embryo Development and Embryonic Stem Cell Differentiation

(2009) J. M. Facucho-Oliveira et al.   Stem Cell Reviews and Reports

Pathogenic Mitochondrial DNA Mutations Are Common in the General Population

(2008) Hannah R. Elliott et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Injection of isolated mitochondria during early reperfusion for cardioprotection

(2008) James D. McCully et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial involvement in psychiatric disorders

(2008) Ling Shao et al.   ANNALS OF MEDICINE

Novel mechanism of elimination of malfunctioning mitochondria (mitoptosis): Formation of mitoptotic bodies and extrusion of mitochondrial material from the cell

(2008) Konstantin G. Lyamzaev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

Mitochondrial Extrusion through the Cytoplasmic Vacuoles during Cell Death

(2008) Akihito Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cognitive decline as a manifestation of mitochondrial disorders (mitochondrial dementia)

(2008) Josef Finsterer   JOURNAL OF THE NEUROLOGICAL SCIENCES

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

Prevalence of mitochondrial DNA disease in adults

(2007) Andrew M. Schaefer et al.   ANNALS OF NEUROLOGY