The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met

Optogenetically enhanced axon regeneration: motor versus sensory neuron-specific stimulation

(2018) Patricia J. Ward et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior

(2018) Joanna I. Giza et al.   NEURON

Evaluation of apoptotic pathways in dorsal root ganglion neurons following peripheral nerve injury

(2018) Rebecca Wiberg et al.   NEUROREPORT

Physical Exercise Improves Peripheral BDNF Levels and Cognitive Functions in Mild Cognitive Impairment Elderly with Different BDNF Val66Met Genotypes

(2018) Carla Manuela Crispim Nascimento et al.   JOURNAL OF ALZHEIMERS DISEASE

BDNF Binds Its Pro-Peptide with High Affinity and the Common Val66Met Polymorphism Attenuates the Interaction

(2017) Koichi Uegaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Motoneuron activity is required for enhancements in functional recovery after peripheral nerve injury in exercised female mice

(2017) Poonam B. Jaiswal et al.   JOURNAL OF NEUROSCIENCE RESEARCH

High-Intensity Locomotor Exercise Increases Brain-Derived Neurotrophic Factor in Individuals with Incomplete Spinal Cord Injury

(2017) Kristan A. Leech et al.   JOURNAL OF NEUROTRAUMA

The influence of high intensity exercise and the Val66Met polymorphism on circulating BDNF and locomotor learning

(2017) Erin E. Helm et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The role of cAMP and its downstream targets in neurite growth in the adult nervous system

(2017) Nicholas J. Batty et al.   NEUROSCIENCE LETTERS

Actin Waves: Origin of Cell Polarization and Migration?

(2017) Naoyuki Inagaki et al.   TRENDS IN CELL BIOLOGY

Differential Expression of Sox11 and Bdnf mRNA Isoforms in the Injured and Regenerating Nervous Systems

(2017) Felix L. Struebing et al.   Frontiers in Molecular Neuroscience

Comparison of trophic factors' expression between paralyzed and recovering muscles after facial nerve injury. A quantitative analysis in time course

(2016) Maria Grosheva et al.   EXPERIMENTAL NEUROLOGY

Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice

(2016) Alessandro Ieraci et al.   NEUROPSYCHOPHARMACOLOGY

Electrical Stimulation to Enhance Axon Regeneration After Peripheral Nerve Injuries in Animal Models and Humans

(2016) Tessa Gordon   Neurotherapeutics

Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism

(2016) José R. Lemos et al.   PHYSIOLOGICAL GENOMICS

Optically-Induced Neuronal Activity Is Sufficient to Promote Functional Motor Axon Regeneration In Vivo

(2016) Patricia J. Ward et al.   PLoS One

Electrical stimulation enhances sensory recovery: A randomized controlled trial

(2015) Joshua N. Wong et al.   ANNALS OF NEUROLOGY

Strategies to promote peripheral nerve regeneration: electrical stimulation and/or exercise

(2015) Tessa Gordon et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pathways Mediating Activity-Induced Enhancement of Recovery From Peripheral Nerve Injury

(2015) Manning J. Sabatier et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Brief electrical stimulation improves nerve regeneration after delayed repair in Sprague Dawley rats

(2015) Kate Elzinga et al.   EXPERIMENTAL NEUROLOGY

Expression and Dendritic Trafficking of BDNF-6 Splice Variant are Impaired in Knock-In Mice Carrying Human BDNF Val66Met Polymorphism

(2015) Alessandra Mallei et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Delaying the onset of treadmill exercise following peripheral nerve injury has different effects on axon regeneration and motoneuron synaptic plasticity

(2015) Jaclyn Brandt et al.   JOURNAL OF NEUROPHYSIOLOGY

A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

(2015) Kristin L. Szuhany et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy

(2015) M Notaras et al.   MOLECULAR PSYCHIATRY

Optogenetic control of nerve growth

(2015) Seongjun Park et al.   Scientific Reports

Neuronal BDNF Signaling Is Necessary for the Effects of Treadmill Exercise on Synaptic Stripping of Axotomized Motoneurons

(2015) Joey Krakowiak et al.   NEURAL PLASTICITY

Dendritic targeting of short and long 3′ UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins

(2015) Annalisa Vicario et al.   Frontiers in Molecular Neuroscience

miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF

(2014) Kärt Varendi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell intrinsic control of axon regeneration

(2014) F. M. Mar et al.   EMBO REPORTS

Pharmacological Profile of Brain-derived Neurotrophic Factor (BDNF) Splice Variant Translation Using a Novel Drug Screening Assay

(2014) Valentina Vaghi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Adaptive Role for BDNF Val66Met Polymorphism in Motor Recovery in Chronic Stroke

(2014) L. Qin et al.   JOURNAL OF NEUROSCIENCE

Normal Distribution of VGLUT1 Synapses on Spinal Motoneuron Dendrites and Their Reorganization after Nerve Injury

(2014) T. M. Rotterman et al.   JOURNAL OF NEUROSCIENCE

Peripheral Nerve Injury Modulates Neurotrophin Signaling in the Peripheral and Central Nervous System

(2014) Mette Richner et al.   MOLECULAR NEUROBIOLOGY

Exercise, Neurotrophins, and Axon Regeneration in the PNS

(2014) Arthur W. English et al.   PHYSIOLOGY

Treadmill Exercise Induced Functional Recovery after Peripheral Nerve Repair Is Associated with Increased Levels of Neurotrophic Factors

(2014) Jae-Sung Park et al.   PLoS One

The Effects of Exercise on Synaptic Stripping Require Androgen Receptor Signaling

(2014) Caiyue Liu et al.   PLoS One

Enhancement of peripheral nerve regeneration due to treadmill training and electrical stimulation is dependent on androgen receptor signaling

(2013) Nicholas J. Thompson et al.   Developmental Neurobiology

Electrical stimulation accelerates nerve regeneration and functional recovery in delayed peripheral nerve injury in rats

(2013) Jinghui Huang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Schwann cell phenotype is regulated by axon modality and central–peripheral location, and persists in vitro

(2013) T.M. Brushart et al.   EXPERIMENTAL NEUROLOGY

Effects of treadmill training on functional recovery following peripheral nerve injury in rats

(2013) Tiffany Boeltz et al.   JOURNAL OF NEUROPHYSIOLOGY

PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons

(2013) K. J. Christie et al.   JOURNAL OF NEUROSCIENCE

Brain-Derived Neurotrophic Factor Induces Matrix Metalloproteinase 9 Expression in Neurons via the Serum Response Factor/c-Fos Pathway

(2013) B. Kuzniewska et al.   MOLECULAR AND CELLULAR BIOLOGY

HuD Promotes BDNF Expression in Brain Neurons via Selective Stabilization of the BDNF Long 3′UTR mRNA

(2013) Megan Allen et al.   PLoS One

Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves

(2013) A. W. English et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrical Stimulation of Schwann Cells Promotes Sustained Increases in Neurite Outgrowth

(2013) Abigail N Koppes et al.   TISSUE ENGINEERING PART A

Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

(2013) Agustin Anastasia et al.   Nature Communications

Effect of skilled and unskilled training on nerve regeneration and functional recovery

(2012) A.S. Pagnussat et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons

(2012) Sandra Dieni et al.   JOURNAL OF CELL BIOLOGY

Cooperative Roles of BDNF Expression in Neurons and Schwann Cells Are Modulated by Exercise to Facilitate Nerve Regeneration

(2012) J. C. Wilhelm et al.   JOURNAL OF NEUROSCIENCE

Sox11 modulates brain-derived neurotrophic factor expression in an exon promoter-specific manner

(2012) Kathleen M. Salerno et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve

(2012) Eileen M. Foecking et al.   JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT

Physical Exercise and Antidepressants Enhance BDNF Targeting in Hippocampal CA3 Dendrites: Further Evidence of a Spatial Code for BDNF Splice Variants

(2012) Gabriele Baj et al.   NEUROPSYCHOPHARMACOLOGY

p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity

(2012) Carlos F. Ibáñez et al.   TRENDS IN NEUROSCIENCES

Enhancing recovery from peripheral nerve injury using treadmill training

(2011) Arthur W. English et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Effects of activity-dependent strategies on regeneration and plasticity after peripheral nerve injuries

(2011) Esther Udina et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex

(2011) Rong-Jian Liu et al.   BIOLOGICAL PSYCHIATRY

Sex differences in the effectiveness of treadmill training in enhancing axon regeneration in injured peripheral nerves

(2011) Kylene Wood et al.   Developmental Neurobiology

Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. I. Loss of VGLUT1/IA synapses on motoneurons

(2011) Francisco J. Alvarez et al.   JOURNAL OF NEUROPHYSIOLOGY

The Role of the Met66 Brain-Derived Neurotrophic Factor Allele in the Recovery of Executive Functioning after Combat-Related Traumatic Brain Injury

(2011) F. Krueger et al.   JOURNAL OF NEUROSCIENCE

Axonal Localization of Transgene mRNA in Mature PNS and CNS Neurons

(2011) D. E. Willis et al.   JOURNAL OF NEUROSCIENCE

Accelerated axon outgrowth, guidance, and target reinnervation across nerve transection gaps following a brief electrical stimulation paradigm

(2011) Bhagat Singh et al.   JOURNAL OF NEUROSURGERY

Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat

(2011) Esther Udina et al.   MUSCLE & NERVE

BDNF Polymorphism Predicts General Intelligence after Penetrating Traumatic Brain Injury

(2011) Elham Rostami et al.   PLoS One

Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments

(2011) G. Baj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

(2011) K. Deinhardt et al.   Science Signaling

The formation of actin waves during regeneration after axonal lesion is enhanced by BDNF

(2011) Francesco Difato et al.   Scientific Reports

Swimming Exercise in the Acute or Late Phase after Sciatic Nerve Crush Accelerates Nerve Regeneration

(2011) Rosana Macher Teodori et al.   NEURAL PLASTICITY

Schwann cell p75NTR prevents spontaneous sensory reinnervation of the adult spinal cord

(2010) Angela L. M. Scott et al.   BRAIN

Electrical Activity Suppresses Axon Growth through Cav1.2 Channels in Adult Primary Sensory Neurons

(2010) Joana Enes et al.   CURRENT BIOLOGY

Blood BDNF concentrations reflect brain-tissue BDNF levels across species

(2010) Anders B. Klein et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

(2010) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of the 3′-untranslated region of the brain-derived neurotrophic factor gene in activity-dependent mRNA stabilization

(2010) Mamoru Fukuchi et al.   JOURNAL OF NEUROCHEMISTRY

Calcium and Cyclic AMP Promote Axonal Regeneration in Caenorhabditis elegans and Require DLK-1 Kinase

(2010) A. Ghosh-Roy et al.   JOURNAL OF NEUROSCIENCE

Detection of brain-derived neurotrophic factor (BDNF) in rat blood and brain preparations using ELISA: Pitfalls and solutions

(2010) Betina Elfving et al.   JOURNAL OF NEUROSCIENCE METHODS

Short-term low-frequency electrical stimulation enhanced remyelination of injured peripheral nerves by inducing the promyelination effect of brain-derived neurotrophic factor on Schwann cell polarization

(2010) Lidan Wan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Combinatorial treatments enhance recovery following facial nerve crush

(2010) Nijee Sharma et al.   LARYNGOSCOPE

Differential expression and regulation of brain-derived neurotrophic factor (BDNF) mRNA isoforms in androgen-sensitive motoneurons of the rat lumbar spinal cord

(2010) Erich N. Ottem et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Short- but not long-lasting treadmill running reduces allodynia and improves functional recovery after peripheral nerve injury

(2010) S. Cobianchi et al.   NEUROSCIENCE

Recovery of whisking function after manual stimulation of denervated vibrissal muscles requires brain-derived neurotrophic factor and its receptor tyrosine kinase B

(2010) J. Söhnchen et al.   NEUROSCIENCE

Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF)

(2010) A. G. Lau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth cone-like waves transport actin and promote axonogenesis and neurite branching

(2009) Kevin C. Flynn et al.   Developmental Neurobiology

Androgen Regulates Brain-Derived Neurotrophic Factor in Spinal Motoneurons and Their Target Musculature

(2009) Tom Verhovshek et al.   ENDOCRINOLOGY

Electrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury

(2009) Elena Asensio-Pinilla et al.   EXPERIMENTAL NEUROLOGY

Electrical stimulation and testosterone differentially enhance expression of regeneration-associated genes

(2009) Nijee Sharma et al.   EXPERIMENTAL NEUROLOGY

Rolipram-induced elevation of cAMP or chondroitinase ABC breakdown of inhibitory proteoglycans in the extracellular matrix promotes peripheral nerve regeneration

(2009) E. Udina et al.   EXPERIMENTAL NEUROLOGY

Brief post-surgical electrical stimulation accelerates axon regeneration and muscle reinnervation without affecting the functional measures in carpal tunnel syndrome patients

(2009) Tessa Gordon et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective actions of androgens on motoneurons

(2009) Keith N. Fargo et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Pro-BDNF–induced synaptic depression and retraction at developing neuromuscular synapses

(2009) Feng Yang et al.   JOURNAL OF CELL BIOLOGY

Treadmill training enhances axon regeneration in injured mouse peripheral nerves without increased loss of topographic specificity

(2009) Arthur W. English et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Cleavage of proBDNF to BDNF by a Tolloid-Like Metalloproteinase Is Required for Acquisition of In Vitro Eyeblink Classical Conditioning

(2009) J. Keifer et al.   JOURNAL OF NEUROSCIENCE

Complementary Actions of BDNF and Neurotrophin-3 on the Firing Patterns and Synaptic Composition of Motoneurons

(2009) M. A. D.-L. de Carrizosa et al.   JOURNAL OF NEUROSCIENCE

ERK1/2-Mediated Schwann Cell Proliferation in the Regenerating Sciatic Nerve by Treadmill Training

(2009) Tae Beom Seo et al.   JOURNAL OF NEUROTRAUMA

Peripheral Nerve Injuries: An International Survey of Current Treatments and Future Perspectives

(2009) Thomas Scholz et al.   JOURNAL OF RECONSTRUCTIVE MICROSURGERY

Activity-Dependent Dendritic Release of BDNF and Biological Consequences

(2009) Nicola Kuczewski et al.   MOLECULAR NEUROBIOLOGY

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

ACCELERATING AXON GROWTH TO OVERCOME LIMITATIONS IN FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY

(2009) Tessa Gordon et al.   NEUROSURGERY

Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

(2009) G. Nagappan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation

(2009) C. Chiaruttini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex

(2009) K. Sakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Translin/Trax RNA binding complex: Clues to function in the nervous system

(2008) Zhi Li et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

Treadmill training promotes axon regeneration in injured peripheral nerves

(2008) Manning J. Sabatier et al.   EXPERIMENTAL NEUROLOGY

Immediate electrical stimulation enhances regeneration and reinnervation and modulates spinal plastic changes after sciatic nerve injury and repair

(2008) Meritxell Vivó et al.   EXPERIMENTAL NEUROLOGY

A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex

(2008) Nikolaos Mellios et al.   HUMAN MOLECULAR GENETICS

Deletion of p75NTR impairs regeneration of peripheral nerves in mice

(2008) Xing-Yun Song et al.   LIFE SCIENCES

Manual stimulation of the orbicularis oculi muscle improves eyelid closure after facial nerve injury in adult rats

(2008) Anna Bischoff et al.   MUSCLE & NERVE

A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition

(2008) Elizabeth J. Hong et al.   NEURON

Accelerating functional recovery after rat facial nerve injury: Effects of gonadal steroids and electrical stimulation

(2008) Laura E. T. Hetzler et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Electrical stimulation facilitates rat facial nerve recovery from a crush injury

(2008) Devyani Lal et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Correlated waves of actin filaments and PIP3inDictyosteliumcells

(2008) Yukako Asano et al.   CELL MOTILITY AND THE CYTOSKELETON

BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae

(2007) C. Chiaruttini et al.   MOLECULAR AND CELLULAR NEUROSCIENCE