Physical activity and muscle–brain crosstalk

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

(2018) Leandro Z. Agudelo et al.   Cell Metabolism

Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control

(2018) Louise Lang Lehrskov et al.   Cell Metabolism

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

(2018) Martin Whitham et al.   Cell Metabolism

Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

(2018) Pernille Hojman et al.   Cell Metabolism

A brief primer on the mediational role of BDNF in the exercise-memory link

(2018) Paul D. Loprinzi et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

Experimental effects of acute exercise duration and exercise recovery on mood state

(2018) Elizabeth A. Crush et al.   JOURNAL OF AFFECTIVE DISORDERS

Blocking of BDNF-TrkB signaling inhibits the promotion effect of neurological function recovery after treadmill training in rats with spinal cord injury

(2018) Xiangzhe Li et al.   SPINAL CORD

Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle

(2018) Malcolm Eaton et al.   Journal of Sport and Health Science

Association of Efficacy of Resistance Exercise Training With Depressive Symptoms

(2018) Brett R. Gordon et al.   JAMA Psychiatry

Age-related loss of VGLUT1 excitatory, but not VGAT inhibitory, immunoreactive terminals on motor neurons in spinal cords of old sarcopenic male mice

(2018) Vidya S. Krishnan et al.   BIOGERONTOLOGY

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms

(2017) Frank W. Booth et al.   PHYSIOLOGICAL REVIEWS

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans -Signaling

(2017) Katharina Timper et al.   Cell Reports

On the Run for Hippocampal Plasticity

(2017) C’iana Cooper et al.   Cold Spring Harbor Perspectives in Medicine

Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise

(2017) Adeel Safdar et al.   Cold Spring Harbor Perspectives in Medicine

Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations

(2017) Christoph Hoffmann et al.   Cold Spring Harbor Perspectives in Medicine

Role of muscle IL-6 in gender-specific metabolism in mice

(2017) Amalia Molinero et al.   PLoS One

Systemic Nutrient and Stress Signaling via Myokines and Myometabolites

(2016) Mamta Rai et al.   Annual Review of Physiology

Can physical exercise in old age improve memory and hippocampal function?

(2016) Emrah Duzel et al.   BRAIN

How Body Affects Brain

(2016) Wendy A. Suzuki   Cell Metabolism

FGF21 Regulates Sweet and Alcohol Preference

(2016) Saswata Talukdar et al.   Cell Metabolism

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution

(2016) Line Pedersen et al.   Cell Metabolism

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver

(2016) Stephanie von Holstein-Rathlou et al.   Cell Metabolism

Skeletal muscle as a gene regulatory endocrine organ

(2016) Kristian Karstoft et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats

(2016) Piangkwan Sa-nguanmoo et al.   HORMONES AND BEHAVIOR

Exercise-Induced Secretion of FGF21 and Follistatin Are Blocked by Pancreatic Clamp and Impaired in Type 2 Diabetes

(2016) Jakob Schiøler Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice

(2016) Vidya S. Krishnan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Physical Activity and Alzheimer Disease: A Protective Association

(2016) Alejandro Santos-Lozano et al.   MAYO CLINIC PROCEEDINGS

The potential of endurance exercise-derived exosomes to treat metabolic diseases

(2016) Adeel Safdar et al.   Nature Reviews Endocrinology

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice

(2016) Zoe White et al.   Skeletal Muscle

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

(2015) Svenia Schnyder et al.   BONE

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

(2015) Mark P. Jedrychowski et al.   Cell Metabolism

Adult neurogenic and antidepressant effects of adiponectin: a potential replacement for exercise?

(2015) Ang Li et al.   CNS & Neurological Disorders-Drug Targets

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015) Theo Vos et al.   LANCET

Appetite control and energy balance: impact of exercise

(2015) J. E. Blundell et al.   Obesity Reviews

Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

(2015) B. K. Pedersen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Versatile functions for IL-6 in metabolism and cancer

(2015) Jan Mauer et al.   TRENDS IN IMMUNOLOGY

Irisin – a myth rather than an exercise-inducible myokine

(2015) Elke Albrecht et al.   Scientific Reports

Leisure Time Physical Activity and Mortality

(2015) Hannah Arem et al.   JAMA Internal Medicine

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

(2014) Leandro Z. Agudelo et al.   CELL

FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting

(2014) Q. Liang et al.   DIABETES

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Exercise as an anti-inflammatory therapy for rheumatic diseases—myokine regulation

(2014) Fabiana B. Benatti et al.   Nature Reviews Rheumatology

Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

(2014) S. Y. Yau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

Inter-relation between Interleukin (IL)-1, IL-6 and Body Fat Regulating Circuits of the Hypothalamic Arcuate Nucleus

(2013) E. Schéle et al.   JOURNAL OF NEUROENDOCRINOLOGY

Are skeletal muscleFNDC5gene expression and irisin release regulated by exercise and related to health?

(2013) Satu Pekkala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adipo-Myokines: Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise

(2013) Silja Raschke et al.   MEDIATORS OF INFLAMMATION

The role of hepatokines in metabolism

(2013) Norbert Stefan et al.   Nature Reviews Endocrinology

Differential regulation of Bdnf expression in cortical neurons by class-selective histone deacetylase inhibitors

(2013) Indrek Koppel et al.   NEUROPHARMACOLOGY

Lifelong Physical Activity Prevents Aging-Associated Insulin Resistance in Human Skeletal Muscle Myotubes via Increased Glucose Transporter Expression

(2013) Tipwadee Bunprajun et al.   PLoS One

Network beyond IDO in psychiatric disorders: Revisiting neurodegeneration hypothesis

(2013) Aye-Mu Myint et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease

(2012) Mark P. Mattson   Cell Metabolism

Epidemiology of depression and diabetes: A systematic review

(2012) Tapash Roy et al.   JOURNAL OF AFFECTIVE DISORDERS

Roles and Tissue Source of Adiponectin Involved in Lifestyle Modifications

(2012) Y. Dai et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Run for your life

(2012) Timothy Noakes et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Satellite Cells Derived from Obese Humans with Type 2 Diabetes and Differentiated into Myocytes In Vitro Exhibit Abnormal Response to IL-6

(2012) Camilla Scheele et al.   PLoS One

Exercise, brain, and cognition across the life span

(2011) Michelle W. Voss et al.   JOURNAL OF APPLIED PHYSIOLOGY

Interleukin-6 Regulates the Expression of Hypothalamic Neuropeptides Involved in Body Weight in a Gender-Dependent Way

(2011) R. M. Señarís et al.   JOURNAL OF NEUROENDOCRINOLOGY

Effect of Exercise on Cognitive Performance in Community-Dwelling Older Adults: Review of Intervention Trials and Recommendations for Public Health Practice and Research

(2011) Mark Snowden et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Running is the neurogenic and neurotrophic stimulus in environmental enrichment

(2011) T. Kobilo et al.   LEARNING & MEMORY

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

The kynurenine pathway in major depression: Haplotype analysis of three related functional candidate genes

(2011) Stephan Claes et al.   PSYCHIATRY RESEARCH

Obesity-associated insulin resistance in skeletal muscle: Role of lipid accumulation and physical inactivity

(2011) Kristin Eckardt et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Is physical activity a potential preventive factor for vascular dementia? A systematic review

(2010) Dag Aarsland et al.   AGING & MENTAL HEALTH

Hippocampal Plasticity in Response to Exercise in Schizophrenia

(2010) Frank-Gerald Pajonk et al.   ARCHIVES OF GENERAL PSYCHIATRY

Expression of functional GPR35 in human iNKT cells

(2010) Silvia Fallarini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity

(2010) Lorna C. Gleeson et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

(2010) V. B. Matthews et al.   DIABETOLOGIA

A Role for Myokines in Muscle-Bone Interactions

(2010) Mark W. Hamrick   EXERCISE AND SPORT SCIENCES REVIEWS

Dynamics of the Skeletal Muscle Secretome during Myoblast Differentiation

(2010) Jeanette Henningsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative analysis of the secretion of the MCP family of chemokines by muscle cells

(2010) Jeanette Henningsen et al.   Molecular BioSystems

PGC-1α-mediated adaptations in skeletal muscle

(2010) Jesper Olesen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials

(2010) Patrick J. Smith et al.   PSYCHOSOMATIC MEDICINE

Metabolic Signatures of Exercise in Human Plasma

(2010) G. D. Lewis et al.   Science Translational Medicine

Endurance training enhances BDNF release from the human brain

(2009) Thomas Seifert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat

(2009) Juan Hidalgo et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

(2009) V. B. Matthews et al.   DIABETOLOGIA

Evidence for a release of brain-derived neurotrophic factor from the brain during exercise

(2009) Peter Rasmussen et al.   EXPERIMENTAL PHYSIOLOGY

Interleukin-6 Gene Knockout Influences Energy Balance Regulating Peptides in the Hypothalamic Paraventricular and Supraoptic Nuclei

(2009) A. Benrick et al.   JOURNAL OF NEUROENDOCRINOLOGY

Should we screen for emotional distress in type 2 diabetes mellitus?

(2009) François Pouwer   Nature Reviews Endocrinology

Venlafaxine treatment stimulates expression of brain-derived neurotrophic factor protein in frontal cortex and inhibits long-term potentiation in hippocampus

(2009) J.D. Cooke et al.   NEUROSCIENCE

Cardiovascular fitness is associated with cognition in young adulthood

(2009) M. A. I. Aberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1 coactivators and skeletal muscle adaptations in health and disease

(2008) Zolt Arany   CURRENT OPINION IN GENETICS & DEVELOPMENT

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS