The Gut-Brain Axis in Inflammatory Bowel Disease—Current and Future Perspectives

Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

(2021) Samaneh K. Sarvestani et al.   Nature Communications

Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS

(2021) Gianfranco Natale et al.   Frontiers in Neuroscience

Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis

(2021) Tamara Pérez-Jeldres et al.   DRUGS

New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology

(2021) Maria D. Giraldez et al.   Nature Reviews Gastroenterology & Hepatology

Use of anti-TNF-α therapy in Crohn's disease is associated with increased incidence of multiple sclerosis

(2021) Jagannadha Avasarala et al.   Multiple Sclerosis and Related Disorders

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

(2020) Abigail Jarret et al.   CELL

Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches

(2020) Sungjin Min et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Modulation of sphingosine-1-phosphate in ulcerative colitis

(2020) Marjorie Argollo et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Pathway paradigms revealed from the genetics of inflammatory bowel disease

(2020) Daniel B. Graham et al.   NATURE

LRRK2 in Parkinson disease: challenges of clinical trials

(2020) Eduardo Tolosa et al.   Nature Reviews Neurology

Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells

(2020) Aditya Mithal et al.   Nature Communications

Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity

(2020) Anne-Laure Flamar et al.   IMMUNITY

Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility

(2020) Nick J. Spencer et al.   Nature Reviews Gastroenterology & Hepatology

Generation of intestinal organoids derived from human pluripotent stem cells for drug testing

(2020) Shinpei Yoshida et al.   Scientific Reports

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo

(2020) Yingchao Shi et al.   PLOS BIOLOGY

RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis

(2020) Erika Sugisawa et al.   CELL

Human CNS barrier-forming organoids with cerebrospinal fluid production

(2020) Laura Pellegrini et al.   SCIENCE

The Human and Mouse Enteric Nervous System at Single-Cell Resolution

(2020) Eugene Drokhlyansky et al.   CELL

Correction: Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22

(2020) Qihang Hou et al.   CELL DEATH AND DIFFERENTIATION

Gut microorganisms act together to exacerbate inflammation in spinal cords

(2020) Eiji Miyauchi et al.   NATURE

The gut microbiota–brain axis in behaviour and brain disorders

(2020) Livia H. Morais et al.   NATURE REVIEWS MICROBIOLOGY

Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity

(2020) Theresa L. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in Gastrointestinal Microbiome Composition in PD: A Pivotal Role of Covariates

(2020) Alexandra Cosma-Grigorov et al.   Frontiers in Neurology

Generation of Functional Human 3D Cortico-Motor Assembloids

(2020) Jimena Andersen et al.   CELL

Inflammatory Bowel Diseases (IBD) and the Microbiome—Searching the Crime Scene for Clues

(2020) Mirae Lee et al.   GASTROENTEROLOGY

Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis

(2020) Zuojia Chen et al.   IMMUNITY

Induced pluripotent stem cells in disease modelling and drug discovery

(2019) R. Grant Rowe et al.   NATURE REVIEWS GENETICS

Derivation of enteric neuron lineages from human pluripotent stem cells

(2019) Kevin Barber et al.   Nature Protocols

Persistent central inflammation and region specific cellular activation accompany depression- and anxiety-like behaviours during the resolution phase of experimental colitis

(2019) Elaine Dempsey et al.   BRAIN BEHAVIOR AND IMMUNITY

Parkinson’s disease and the gastrointestinal microbiome

(2019) Michal Lubomski et al.   JOURNAL OF NEUROLOGY

Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice

(2019) Yuki Kishimoto et al.   NEUROMOLECULAR MEDICINE

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

(2019) Nathalie Van Den Berge et al.   ACTA NEUROPATHOLOGICA

Vagal innervation of the stomach reassessed: brain−gut connectome uses smart terminals

(2019) Terry L. Powley et al.   Annals of the New York Academy of Sciences

What gastroenterologists and hepatologists should know about organoids in 2019

(2019) Claudia Günther et al.   DIGESTIVE AND LIVER DISEASE

Disease modelling in human organoids

(2019) Madeline A. Lancaster et al.   Disease Models & Mechanisms

Interferon lambda Promotes Paneth Cell Death via STAT1 Signaling in Mice and is Increased in Inflamed Ileal Tissues of Patients with Crohn’s Disease

(2019) Claudia Günther et al.   GASTROENTEROLOGY

Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

(2019) Diana Matheoud et al.   NATURE

Targeting immune cell circuits and trafficking in inflammatory bowel disease

(2019) Markus F. Neurath   NATURE IMMUNOLOGY

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

(2019) Vayu Maini Rekdal et al.   SCIENCE

Increasing Comparability and Utility of Gut Microbiome Studies in Parkinson’s Disease: A Systematic Review

(2019) Jeffrey M. Boertien et al.   Journal of Parkinsons Disease

TREM Receptors Connecting Bowel Inflammation to Neurodegenerative Disorders

(2019) Gianfranco Natale et al.   Cells

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure

(2019) Miriam Bittel et al.   Cell Death & Disease

Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn’s-Like Ileitis by Suppressing Thymocyte Maturation

(2019) Thangaraj Karuppuchamy et al.   INFLAMMATORY BOWEL DISEASES

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

(2019) Mike A Nalls et al.   LANCET NEUROLOGY

Host–microbiota interactions in inflammatory bowel disease

(2019) Markus F. Neurath   Nature Reviews Gastroenterology & Hepatology

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease

(2018) Annika Sommer et al.   Cell Stem Cell

Inflammatory bowel disease increases the risk of Parkinson’s disease: a Danish nationwide cohort study 1977–2014

(2018) Marie Villumsen et al.   GUT

Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defence against infection

(2018) Francesco Boccellato et al.   GUT

Inflammatory Bowel Disease and Parkinson’s Disease: A Nationwide Swedish Cohort Study

(2018) Petra Weimers et al.   INFLAMMATORY BOWEL DISEASES

Gut-selective integrin-targeted therapies for inflammatory bowel disease

(2018) Christopher A Lamb et al.   Journal of Crohns & Colitis

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis

(2018) Manuela Hefele et al.   Mucosal Immunology

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing

(2018) Shuai Gao et al.   NATURE CELL BIOLOGY

Anti–Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease

(2018) Inga Peter et al.   JAMA Neurology

The risk of Parkinson’s disease in inflammatory bowel disease: A systematic review and meta-analysis

(2018) Feng zhu et al.   DIGESTIVE AND LIVER DISEASE

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Cortical Inflammation is Increased in a DSS-Induced Colitis Mouse Model

(2018) Ying Han et al.   Neuroscience Bulletin

Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism

(2018) Michela Barichella et al.   MOVEMENT DISORDERS

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

(2017) Anna Heintz-Buschart et al.   MOVEMENT DISORDERS

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

The mucosal immune system: master regulator of bidirectional gut–brain communications

(2017) Nick Powell et al.   Nature Reviews Gastroenterology & Hepatology

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

(2017) Kerstin Berer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High frequency of intestinal T H 17 cells correlates with microbiota alterations and disease activity in multiple sclerosis

(2017) Ilaria Cosorich et al.   Science Advances

Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls

(2016) Helen Tremlett et al.   BMC Neurology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Development of the intrinsic and extrinsic innervation of the gut

(2016) Toshihiro Uesaka et al.   DEVELOPMENTAL BIOLOGY

Organoids: Modeling Development and the Stem Cell Niche in a Dish

(2016) Kai Kretzschmar et al.   DEVELOPMENTAL CELL

Gut microbiota in early pediatric multiple sclerosis: a case−control study

(2016) H. Tremlett et al.   EUROPEAN JOURNAL OF NEUROLOGY

Association Between Parkinsonʼs Disease and Inflammatory Bowel Disease

(2016) Jung-Chun Lin et al.   INFLAMMATORY BOWEL DISEASES

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance

(2016) Dena G. Hernandez et al.   JOURNAL OF NEUROCHEMISTRY

Multiple sclerosis and inflammatory bowel diseases: a systematic review and meta-analysis

(2016) Maria Kosmidou et al.   JOURNAL OF NEUROLOGY

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

(2016) Faranak Fattahi et al.   NATURE

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

The bowel and beyond: the enteric nervous system in neurological disorders

(2016) Meenakshi Rao et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals

(2016) Shahab A Shaffiey et al.   Regenerative Medicine

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis

(2016) Trisha Jenkins et al.   Nutrients

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

(2016) Jun Chen et al.   Scientific Reports

Functional Brain Imaging Reveals Rapid Blockade of Abdominal Pain Response Upon Anti-TNF Therapy in Crohn’s Disease

(2015) Andreas Hess et al.   GASTROENTEROLOGY

Food, Immunity, and the Microbiome

(2015) Herbert Tilg et al.   GASTROENTEROLOGY

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

(2015) Sina Bartfeld et al.   GASTROENTEROLOGY

Genetics of Inflammatory Bowel Diseases

(2015) Dermot P.B. McGovern et al.   GASTROENTEROLOGY

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Commensal bacteria direct selective cargo sorting to promote symbiosis

(2015) Qin Zhang et al.   NATURE IMMUNOLOGY

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

The Neuromodulation of the Intestinal Immune System and Its Relevance in Inflammatory Bowel Disease

(2015) Martina Di Giovangiulio et al.   Frontiers in Immunology

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Inflammatory bowel disease and demyelination: more than just a coincidence?

(2014) Aristeidis H Katsanos et al.   Expert Review of Clinical Immunology

Helicobacter pyloritargets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells

(2014) Lydia E Wroblewski et al.   GUT

Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays

(2014) Kelli L VanDussen et al.   GUT

Gut feelings about smoking and coffee in Parkinson's disease

(2014) Pascal Derkinderen et al.   MOVEMENT DISORDERS

Intestinal Barrier Dysfunction Develops at the Onset of Experimental Autoimmune Encephalomyelitis, and Can Be Induced by Adoptive Transfer of Auto-Reactive T Cells

(2014) Mehrnaz Nouri et al.   PLoS One

Epithelial Cell Shedding and Barrier Function

(2014) J. M. Williams et al.   VETERINARY PATHOLOGY

Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells

(2014) Ryan Forster et al.   Stem Cell Reports

Next-Generation Regenerative Medicine: Organogenesis from Stem Cells in 3D Culture

(2013) Yoshiki Sasai   Cell Stem Cell

Vedolizumab for the Treatment of IBD: A Selective Therapeutic Approach Targeting Pathogenic a4b7 Cells

(2013) Manol Jovani et al.   CURRENT DRUG TARGETS

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Vitamin B12 Deficiency

(2013) Sally P. Stabler   NEW ENGLAND JOURNAL OF MEDICINE

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

(2013) Caitriona M. Guinane et al.   Therapeutic Advances in Gastroenterology

Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics

(2013) Luca Pastorelli et al.   Frontiers in Immunology

Neurologic Complications in Patients with Inflammatory Bowel Disease

(2012) Siddharth Singh et al.   INFLAMMATORY BOWEL DISEASES

Multiple sclerosis and inflammatory bowel diseases: what we know and what we would need to know!

(2012) Mona M Alkhawajah et al.   Multiple Sclerosis Journal

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1 and Substance P Mediate Colitis in Mice

(2011) Matthias A. Engel et al.   GASTROENTEROLOGY

Hepatocyte turnover and regeneration: Virtually a virtuoso performance

(2011) Malcolm R. Alison et al.   HEPATOLOGY

Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis

(2011) Junji Umeno et al.   INFLAMMATORY BOWEL DISEASES

The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons

(2011) Matthias A. Engel et al.   JOURNAL OF GASTROENTEROLOGY

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Generating human intestinal tissue from pluripotent stem cells in vitro

(2011) Kyle W McCracken et al.   Nature Protocols

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

Role of sensory neurons in colitis: increasing evidence for a neuroimmune link in the gut

(2010) Matthias A. Engel et al.   INFLAMMATORY BOWEL DISEASES

Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease

(2010) Ruth F. Villarán et al.   JOURNAL OF NEUROCHEMISTRY

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vertebrate Endoderm Development and Organ Formation

(2009) Aaron M. Zorn et al.   Annual Review of Cell and Developmental Biology

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn disease

(2009) Ken Cadwell et al.   Autophagy

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS