Epithelial Cell Shedding and Barrier Function

Paneth cells

(2014) Johan H. van Es et al.   CURRENT BIOLOGY

Increased Gap Density Predicts Weakness of the Epithelial Barrier In Vivo by Confocal Laser Endomicroscopy in Indomethacin-Induced Enteropathy

(2014) Sha Shi et al.   DIGESTIVE DISEASES AND SCIENCES

Loss of Epithelial RelA Results in Deregulated Intestinal Proliferative/Apoptotic Homeostasis and Susceptibility to Inflammation

(2014) K. A. Steinbrecher et al.   JOURNAL OF IMMUNOLOGY

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

(2014) Laila Ritsma et al.   NATURE

A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide

(2013) J. M. Williams et al.   Disease Models & Mechanisms

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

(2013) Roosmarijn E. Vandenbroucke et al.   EMBO Molecular Medicine

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Long-term outcome of a third anti-TNF monoclonal antibody after the failure of two prior anti-TNFs in inflammatory bowel disease

(2012) P. S. A. Silva et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

(2012) Swaroop Pendyala et al.   GASTROENTEROLOGY

Proteasome Inhibition of Pathologic Shedding of Enterocytes to Defend Barrier Function Requires X-Linked Inhibitor of Apoptosis Protein and Nuclear Factor κB

(2012) Derek M. Foster et al.   GASTROENTEROLOGY

TLR3, TRIF, and Caspase 8 Determine Double-Stranded RNA-Induced Epithelial Cell Death and Survival In Vivo

(2012) C. S. McAllister et al.   JOURNAL OF IMMUNOLOGY

Shedding-induced gap formation contributes to gut barrier dysfunction in endotoxemia

(2012) Chieh-Wen Lai et al.   Journal of Trauma and Acute Care Surgery

Gut microbiota and gastrointestinal health: current concepts and future directions

(2012) Q. Aziz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells

(2011) Yanfang Guan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma

(2011) Chhinder Sodhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

(2011) Amanda M. Marchiando et al.   GASTROENTEROLOGY

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

(2011) R Kiesslich et al.   GUT

Intestinal epithelium is more susceptible to cytopathic injury and altered permeability than the lung epithelium in the context of acute sepsis

(2011) Mark W. Julian et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Transcytosis ofListeria monocytogenesacross the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin

(2011) Georgios Nikitas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

(2011) Monica Guma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

(2011) M. Roulis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF- -Induced Apoptosis and Proliferation by MAPKs

(2011) K. S. Lau et al.   Science Signaling

Mind The Gaps

(2010) Julia J. Liu et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Active deformation of apoptotic intestinal epithelial cells with adhesion-restricted polarity contributes to apoptotic clearance

(2010) Fengchao Wang et al.   LABORATORY INVESTIGATION

Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences

(2010) Brigitte Vollmar et al.   LANGENBECKS ARCHIVES OF SURGERY

SECOND HIT POST BURN INCREASED PROXIMAL GUT MUCOSA EPITHELIAL CELLS DAMAGE

(2009) Juquan Song et al.   SHOCK

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Life in the Gut Without Oxygen: Adaptive Mechanisms and Inflammatory Bowel Disease

(2008) Anthony T. Blikslager   GASTROENTEROLOGY

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse

(2008) M C Arrieta et al.   GUT

What role does intestinal permeability have in ibd pathogenesis?

(2008) Jon Meddings   INFLAMMATORY BOWEL DISEASES