The mucosal immune system: master regulator of bidirectional gut–brain communications

Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study

(2016) N. A. Koloski et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Colonic macrophage polarization in homeostasis, inflammation, and cancer

(2016) Raymond A. Isidro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Alternative Macrophage Activation Is Increased in Asthma

(2016) Pierre-Olivier Girodet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

(2016) A. Houlden et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

(2016) Ilana Gabanyi et al.   CELL

Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus

(2016) Pauline Luczynski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Histamine Receptor H1–Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

(2016) Mira M. Wouters et al.   GASTROENTEROLOGY

Leukocyte Trafficking to the Small Intestine and Colon

(2016) Aida Habtezion et al.   GASTROENTEROLOGY

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

(2016) Sales Ibiza et al.   NATURE

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

(2016) Suzanne M Bal et al.   NATURE IMMUNOLOGY

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Prevalence of mood and anxiety disorder in self reported irritable bowel syndrome (IBS). An epidemiological population based study of women

(2016) Arnstein Mykletun et al.   BMC GASTROENTEROLOGY

Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome

(2015) B. P. Chumpitazi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Evidence for Neuronal and Structural Changes in Submucous Ganglia of Patients With Functional Dyspepsia

(2015) Carla Cirillo et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis

(2015) Mira M Wouters et al.   GUT

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury

(2015) Sang-Uk Seo et al.   IMMUNITY

Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system

(2015) Panagiotis S. Kabouridis et al.   JOURNAL OF CLINICAL INVESTIGATION

The gut connectome: making sense of what you eat

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Norepinephrine Controls Effector T Cell Differentiation through β2-Adrenergic Receptor–Mediated Inhibition of NF-κB and AP-1 in Dendritic Cells

(2015) Maisa Carla Takenaka et al.   JOURNAL OF IMMUNOLOGY

The unusual suspects—innate lymphoid cells as novel therapeutic targets in IBD

(2015) Rimma Goldberg et al.   Nature Reviews Gastroenterology & Hepatology

Altered brain responses in subjects with irritable bowel syndrome during cued and uncued pain expectation

(2015) J.-Y. Hong et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Increased serum levels of lipopolysaccharide and antiflagellin antibodies in patients with diarrhea-predominant irritable bowel syndrome

(2015) A. Dlugosz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Functional Dyspepsia

(2015) Nicholas J. Talley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Catecholaminergic Gene Polymorphisms Are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome

(2015) Alexa Orand et al.   PLoS One

Molecular assessment of differences in the duodenal microbiome in subjects with irritable bowel syndrome

(2015) Evangelos Giamarellos-Bourboulis et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Assessing Cognitive behavioural Therapy in Irritable Bowel (ACTIB): protocol for a randomised controlled trial of clinical-effectiveness and cost-effectiveness of therapist delivered cognitive behavioural therapy and web-based self-management in irritable bowel syndrome in adults

(2015) Hazel Everitt et al.   BMJ Open

Factors associated with thiopurine non-adherence in patients with inflammatory bowel disease

(2015) J. R. Goodhand et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Maladjustment to Academic Life and Employment Anxiety in University Students with Irritable Bowel Syndrome

(2015) Jun Tayama et al.   PLoS One

The Lifetime Prevalence of Anxiety Disorders Among Patients with Irritable Bowel Syndrome

(2015) Magdalena Grzesiak et al.   Advances in Clinical and Experimental Medicine

Macrophage subsets and microglia in multiple sclerosis

(2014) Jeroen F. J. Bogie et al.   ACTA NEUROPATHOLOGICA

Editorial: probiotics and IBS - where are we now?

(2014) C. Moran et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Increased prevalence of autoimmune diseases in functional gastrointestinal disorders: case-control study of 23 471 primary care patients

(2014) A. C. Ford et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders

(2014) Z. Mujagic et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Altered faecal and mucosal microbial composition in post-infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress

(2014) J. Sundin et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effect of Antidepressants and Psychological Therapies, Including Hypnotherapy, in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis

(2014) Alexander C Ford et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota

(2014) Jeffrey D Galley et al.   BMC MICROBIOLOGY

Neuropeptide Y induces potent migration of human immature dendritic cells and promotes a Th2 polarization

(2014) Brigitta Buttari et al.   FASEB JOURNAL

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

(2014) Aleksandar D. Kostic et al.   GASTROENTEROLOGY

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts

(2014) Weronica E Ek et al.   GUT

IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice

(2014) Dong Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The impact of psychiatric and extraintestinal comorbidity on quality of life and bowel symptom burden in functional GI disorders

(2014) J. Vu et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Is fecal microbiota transplantation (FMT) an effective treatment for patients with functional gastrointestinal disorders (FGID)?

(2014) D. M. Pinn et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Cytokine imbalance in irritable bowel syndrome: a systematic review and meta-analysis

(2014) M. Bashashati et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Neural circuitry of abdominal pain-related fear learning and reinstatement in irritable bowel syndrome

(2014) A. Icenhour et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

(2014) Y. Goto et al.   SCIENCE

Crosstalk between interleukin-6 and corticotropin-releasing factor modulate submucosal plexus activity and colonic secretion

(2013) Dervla O’Malley et al.   BRAIN BEHAVIOR AND IMMUNITY

A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome

(2013) Emma P. Halmos et al.   GASTROENTEROLOGY

Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia

(2013) Hanne Vanheel et al.   GUT

A decrease of the butyrate-producing speciesRoseburia hominisandFaecalibacterium prausnitziidefines dysbiosis in patients with ulcerative colitis

(2013) Kathleen Machiels et al.   GUT

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

(2013) Tim Vanuytsel et al.   GUT

Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10−/− Mice

(2013) E. M. Lennon et al.   INFLAMMATORY BOWEL DISEASES

Duodenal eosinophilia and early satiety in functional dyspepsia: Confirmation of a positive association in an Australian cohort

(2013) Marjorie M Walker et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Microbiota is essential for social development in the mouse

(2013) L Desbonnet et al.   MOLECULAR PSYCHIATRY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Intestinal microbiota influence the early postnatal development of the enteric nervous system

(2013) J. Collins et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Effects of Interleukin-6 on the Expression of Tight Junction Proteins in Isolated Cerebral Microvessels from Yearling and Adult Sheep

(2013) Susan S. Cohen et al.   NEUROIMMUNOMODULATION

Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications

(2013) J.C. Felger et al.   NEUROSCIENCE

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2013) Brian G. Feagan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

(2013) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The Irritable Bowel Syndrome Outcome Study (IBSOS): Rationale and design of a randomized, placebo-controlled trial with 12month follow up of self- versus clinician-administered CBT for moderate to severe irritable bowel syndrome

(2012) Jeffrey M. Lackner et al.   Contemporary Clinical Trials

Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα

(2012) Caroline Swan et al.   GUT

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier

(2012) Cristina Martínez et al.   GUT

The brain–gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study

(2012) N A Koloski et al.   GUT

The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells

(2012) Nick Powell et al.   IMMUNITY

Mood disorders in inflammatory bowel disease: Relation to diagnosis, disease activity, perceived stress, and other factors

(2012) J. R. Goodhand et al.   INFLAMMATORY BOWEL DISEASES

DIGESTIVE PHYSIOLOGY OF THE PIG SYMPOSIUM: Gut chemosensing and the regulation of nutrient absorption and energy supply1

(2012) O. J. Mace et al.   JOURNAL OF ANIMAL SCIENCE

Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells

(2012) M. A. Lopez-Ramirez et al.   JOURNAL OF IMMUNOLOGY

Vulnerability to somatic symptoms of depression during interferon-alpha therapy for hepatitis C: A 16-week prospective study

(2012) Jennifer M. Loftis et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patients

(2012) S. Buhner et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome

(2012) I. M. Carroll et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Type II-Activated Murine Macrophages Produce IL-4

(2012) Anne Camille La Flamme et al.   PLoS One

Small Bowel Homing T Cells Are Associated With Symptoms and Delayed Gastric Emptying in Functional Dyspepsia

(2011) Tobias Liebregts et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Stress and visceral pain: From animal models to clinical therapies

(2011) Muriel Larauche et al.   EXPERIMENTAL NEUROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Association of TNFSF15 polymorphism with irritable bowel syndrome

(2011) M. Zucchelli et al.   GUT

An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota

(2011) Ian B Jeffery et al.   GUT

Crohn disease–associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae

(2011) Benoit Chassaing et al.   JOURNAL OF CLINICAL INVESTIGATION

Dopamine Induces IL-6-Dependent IL-17 Production via D1-Like Receptor on CD4 Naive T Cells and D1-Like Receptor Antagonist SCH-23390 Inhibits Cartilage Destruction in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model

(2011) K. Nakano et al.   JOURNAL OF IMMUNOLOGY

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation

(2011) Mark Pimentel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications of eosinophilia in the normal duodenal biopsy - an association with allergy and functional dyspepsia

(2010) M. M. WALKER et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Migration of Eosinophils and CCR2-/CD68-Double Positive Cells Into the Duodenal Mucosa of Patients With Postinfectious Functional Dyspepsia

(2010) Seiji Futagami et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A Prospective Population-Based Study of Triggers of Symptomatic Flares in IBD

(2010) Charles N Bernstein et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

(2010) Michael T. Bailey et al.   BRAIN BEHAVIOR AND IMMUNITY

The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

(2010) H. Okada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Rapid Response to Cognitive Behavior Therapy Predicts Treatment Outcome in Patients With Irritable Bowel Syndrome

(2010) Jeffrey M. Lackner et al.   Clinical Gastroenterology and Hepatology

Prevalence of Uninvestigated Dyspepsia 8 Years After a Large Waterborne Outbreak of Bacterial Dysentery: A Cohort Study

(2010) Alexander C. Ford et al.   GASTROENTEROLOGY

Bacterial infection causes stress-induced memory dysfunction in mice

(2010) M. G. Gareau et al.   GUT

Stressor Exposure Disrupts Commensal Microbial Populations in the Intestines and Leads to Increased Colonization by Citrobacter rodentium

(2010) M. T. Bailey et al.   INFECTION AND IMMUNITY

Systemic toll-like receptor ligands modify B-cell responses in human inflammatory bowel disease

(2010) Marie McDonnell et al.   INFLAMMATORY BOWEL DISEASES

Anxiety and depression in patients with inflammatory bowel disease

(2010) Winfried Häuser et al.   INFLAMMATORY BOWEL DISEASES

Gastrointestinal eosinophils in health, disease and functional disorders

(2010) Nicholas Powell et al.   Nature Reviews Gastroenterology & Hepatology

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Functional Metagenomics: A High Throughput Screening Method to Decipher Microbiota-Driven NF-κB Modulation in the Human Gut

(2010) Omar Lakhdari et al.   PLoS One

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repeated psychological stress-induced alterations of visceral sensitivity and colonic motor functions in mice: Influence of surgery and postoperative single housing on visceromotor responses

(2010) Muriel Larauche et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Mucosal Immune Activation in Irritable Bowel Syndrome: Gender-Dependence and Association With Digestive Symptoms

(2009) Cesare Cremon et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Neural regulation of endocrine and autonomic stress responses

(2009) Yvonne M. Ulrich-Lai et al.   NATURE REVIEWS NEUROSCIENCE

Review article: probiotics and prebiotics in irritable bowel syndrome

(2008) R. SPILLER   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Significant psychological morbidity occurs in irritable bowel syndrome: a case-control study using a pharmacy reimbursement database

(2008) J. B. CANAVAN et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Irritable bowel syndrome and dyspepsia among women veterans: prevalence and association with psychological distress

(2008) L. S. SAVAS et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Enhanced Cholinergic-Mediated Increase in the Pro-Inflammatory Cytokine IL-6 in Irritable Bowel Syndrome: Role of Muscarinic Receptors

(2008) Timothy G. Dinan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Alterations in Mucosal Immunity Identified in the Colon of Patients With Irritable Bowel Syndrome

(2008) Jeroen Aerssens et al.   Clinical Gastroenterology and Hepatology

Bone-marrow-derived microglia: myth or reality?

(2008) Denis Soulet et al.   CURRENT OPINION IN PHARMACOLOGY

Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

(2008) A Akbar et al.   GUT

Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease

(2008) Noah P. Zimmerman et al.   INFLAMMATORY BOWEL DISEASES

Many cytokines are very useful therapeutic targets in disease

(2008) Marc Feldmann   JOURNAL OF CLINICAL INVESTIGATION

Innate Immunity to Pneumococcal Infection of the Central Nervous System Depends on Toll‐Like Receptor (TLR) 2 and TLR4

(2008) Matthias Klein et al.   JOURNAL OF INFECTIOUS DISEASES

Functional gastrointestinal disorders as a public health problem

(2008) n. j. talley   NEUROGASTROENTEROLOGY AND MOTILITY

Immune dysfunction in patients with functional gastrointestinal disorders

(2008) s. kindt et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosal cytokine imbalance in irritable bowel syndrome

(2008) John Macsharry et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE