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Title
LRRK2 in Parkinson disease: challenges of clinical trials
Authors
Keywords
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Journal
Nature Reviews Neurology
Volume 16, Issue 2, Pages 97-107
Publisher
Springer Science and Business Media LLC
Online
2020-01-24
DOI
10.1038/s41582-019-0301-2
References
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Note: Only part of the references are listed.- LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice
- (2019) Michael X. Henderson et al. Acta Neuropathologica Communications
- Caught in the act: LRRK2 in exosomes
- (2019) Shijie Wang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Synthesis and preliminary evaluation of [11C]GNE‐1023 as a novel potent PET probe for imaging leucine‐rich repeat kinase 2 (LRRK2) in Parkinson’s disease
- (2019) Zhen Chen et al. ChemMedChem
- The role of Rab GTPases in the pathobiology of Parkinson’ disease
- (2019) Luis Bonet-Ponce et al. CURRENT OPINION IN CELL BIOLOGY
- LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages
- (2018) Anetta Härtlova et al. EMBO JOURNAL
- Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease: Updated from Pathogenesis to Potential Therapeutic Target
- (2018) Jinhua Chen et al. EUROPEAN NEUROLOGY
- Selective α-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson’s Disease
- (2018) Diana Alarcón-Arís et al. MOLECULAR THERAPY
- Targeted Therapies for Parkinson's Disease: From Genetics to the Clinic
- (2018) S. Pablo Sardi et al. MOVEMENT DISORDERS
- Application of the Movement Disorder Society prodromal criteria in healthy G2019S -LRRK2 carriers
- (2018) Anat Mirelman et al. MOVEMENT DISORDERS
- Disease Modification in Parkinson's Disease: Current Approaches, Challenges, and Future Considerations
- (2018) Anthony E. Lang et al. MOVEMENT DISORDERS
- LRRK2 kinase in Parkinson's disease
- (2018) Dario R. Alessi et al. SCIENCE
- Progression in the LRRK2-Associated Parkinson Disease Population
- (2018) Rachel Saunders-Pullman et al. JAMA Neurology
- Genetic background and outcome of Deep Brain Stimulation in Parkinson's disease
- (2018) Mario Giorgio Rizzone et al. PARKINSONISM & RELATED DISORDERS
- The genetic landscape of Parkinson's disease
- (2018) A. Lunati et al. REVUE NEUROLOGIQUE
- LRRK2 activation in idiopathic Parkinson’s disease
- (2018) Roberto Di Maio et al. Science Translational Medicine
- Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson’s Disease
- (2018) Siddharth Arora et al. Journal of Parkinsons Disease
- Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease
- (2018) Guangwei Du et al. ANNALS OF NEUROLOGY
- The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease
- (2018) Noémie Cresto et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- New Frontiers in Parkinson's Disease: From Genetics to the Clinic
- (2018) Lamya S. Shihabuddin et al. JOURNAL OF NEUROSCIENCE
- Genotype-phenotype relations for the Parkinson's disease genes SNCA, LRRK2, VPS35: MDSGene systematic review
- (2018) Joanne Trinh et al. MOVEMENT DISORDERS
- Dermal Phospho-Alpha-Synuclein Deposition in Patients With Parkinson's Disease and Mutation of the Glucocerebrosidase Gene
- (2018) Kathrin Doppler et al. Frontiers in Neurology
- Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
- (2017) Andrew B. West EXPERIMENTAL NEUROLOGY
- Targeting LRRK2 in Parkinson’s disease: an update on recent developments
- (2017) Sharon L. Chan et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
- (2017) Dilan Athauda et al. LANCET
- Synthesis and In Vitro and In Vivo Evaluation of [3H]LRRK2-IN-1 as a Novel Radioligand for LRRK2
- (2017) Noeen Malik et al. MOLECULAR IMAGING AND BIOLOGY
- The prodromal phase of leucine-rich repeat kinase 2-associated Parkinson disease: Clinical and imaging Studies
- (2017) Claustre Pont-Sunyer et al. MOVEMENT DISORDERS
- Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry
- (2017) Annie J. Lee et al. MOVEMENT DISORDERS
- Clinical and neuropathological features of progressive supranuclear palsy in Leucine rich repeat kinase (LRRK2 ) G2019S mutation carriers
- (2017) Dolores Vilas et al. MOVEMENT DISORDERS
- A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
- (2017) Diana Chang et al. NATURE GENETICS
- Prospective clinical and DaT-SPECT imaging in premotor LRRK2 G2019S-associated Parkinson disease
- (2017) María Sierra et al. NEUROLOGY
- Simvastatin as a Potential Disease-Modifying Therapy for Patients with Parkinson’s Disease: Rationale for Clinical Trial, and Current Progress
- (2017) Camille B. Carroll et al. Journal of Parkinsons Disease
- Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
- (2017) Martin Steger et al. eLife
- LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
- (2017) Hien Tran Zhao et al. Molecular Therapy-Nucleic Acids
- Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease
- (2017) Antonio Martin-Bastida et al. Scientific Reports
- Challenges of modifying disease progression in prediagnostic Parkinson's disease
- (2016) David Salat et al. LANCET NEUROLOGY
- Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study
- (2016) Dolores Vilas et al. LANCET NEUROLOGY
- Nigral and striatal connectivity alterations in asymptomaticLRRK2mutation carriers: A magnetic resonance imaging study
- (2016) Dolores Vilas et al. MOVEMENT DISORDERS
- Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease
- (2016) Kyle B. Fraser et al. MOVEMENT DISORDERS
- Arm swing as a potential new prodromal marker of Parkinson's disease
- (2016) Anat Mirelman et al. MOVEMENT DISORDERS
- Motor and nonmotor heterogeneity of LRRK2 -related and idiopathic Parkinson's disease
- (2016) Connie Marras et al. MOVEMENT DISORDERS
- Challenges in detecting disease modification in Parkinson's disease clinical trials
- (2016) Dilan Athauda et al. PARKINSONISM & RELATED DISORDERS
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations
- (2015) K. Rudi et al. BIOSCIENCE REPORTS
- Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial
- (2015) LANCET NEUROLOGY
- Nigral anatomy and striatal denervation in genetic Parkinsonism: A family report
- (2015) Roberto Ceravolo et al. MOVEMENT DISORDERS
- DAT imaging and clinical biomarkers in relatives at genetic risk for LRRK2 R1441G Parkinson's disease
- (2015) Alberto Bergareche et al. MOVEMENT DISORDERS
- Nonmotor symptoms in healthy Ashkenazi Jewish carriers of the G2019S mutation in theLRRK2gene
- (2015) Anat Mirelman et al. MOVEMENT DISORDERS
- Sleep aspects on video-polysomnography in LRRK2 mutation carriers
- (2015) Mickael Ehrminger et al. MOVEMENT DISORDERS
- MDS research criteria for prodromal Parkinson's disease
- (2015) Daniela Berg et al. MOVEMENT DISORDERS
- Cognitive and behavioral symptoms in Parkinson's disease patients with the G2019S and R1441G mutations of the LRRK2 gene
- (2015) Johanne Hatteland Somme et al. PARKINSONISM & RELATED DISORDERS
- LRRK2 mutations in Parkinson disease; a sex effect or lack thereof? A meta-analysis
- (2015) Ziv Gan-Or et al. PARKINSONISM & RELATED DISORDERS
- Neuropsychological performance in LRRK2 G2019S carriers with Parkinson's disease
- (2015) Roy N. Alcalay et al. PARKINSONISM & RELATED DISORDERS
- Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
- (2015) Reina N. Fuji et al. Science Translational Medicine
- Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease
- (2015) Lorraine V. Kalia et al. JAMA Neurology
- Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers
- (2015) Claustre Pont-Sunyer et al. PLoS One
- Motor phenotype of LRRK2-associated Parkinson's disease: A tunisian longitudinal study
- (2014) Fatma Nabli et al. MOVEMENT DISORDERS
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- Imaging prodromal Parkinson disease: The Parkinson Associated Risk Syndrome Study
- (2014) D. Jennings et al. NEUROLOGY
- LRRK2 parkinsonism in Tunisia and Norway: A comparative analysis of disease penetrance
- (2014) F. Hentati et al. NEUROLOGY
- Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers
- (2014) R. C. Helmich et al. NEUROLOGY
- Submandibular gland needle biopsy for the diagnosis of Parkinson disease
- (2014) C. H. Adler et al. NEUROLOGY
- Nonmotor Symptoms in LRRK2 G2019S Associated Parkinson’s Disease
- (2014) Carles Gaig et al. PLoS One
- Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers
- (2013) Avner Thaler et al. CORTEX
- Parkinson disease phenotype in Ashkenazi jews with and withoutLRRK2G2019S mutations
- (2013) Roy N. Alcalay et al. MOVEMENT DISORDERS
- Clinical profiles of Parkinson's disease associated with common leucine-rich repeat kinase 2 and glucocerebrosidase genetic variants in Chinese individuals
- (2013) Chaodong Wang et al. NEUROBIOLOGY OF AGING
- Olfaction and imaging biomarkers in premotor LRRK2 G2019S-associated Parkinson disease
- (2013) M. Sierra et al. NEUROLOGY
- Leucine-Rich Repeat Kinase 2 for Beginners: Six Key Questions
- (2013) L. R. Kett et al. Cold Spring Harbor Perspectives in Medicine
- Meta-analysis of early nonmotor features and risk factors for Parkinson disease
- (2012) Alastair J. Noyce et al. ANNALS OF NEUROLOGY
- Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?
- (2012) Iakov N Rudenko et al. BMC Medicine
- Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism
- (2012) B. F. L. van Nuenen et al. BRAIN
- How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder
- (2012) R. B. Postuma et al. BRAIN
- MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein
- (2012) Hyun Jin Cho et al. HUMAN MOLECULAR GENETICS
- The neuropathology of genetic Parkinson's disease
- (2012) Markos Poulopoulos et al. MOVEMENT DISORDERS
- Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
- (2012) Z. Sheng et al. Science Translational Medicine
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
- (2011) Martin C. Herzig et al. HUMAN MOLECULAR GENETICS
- Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study
- (2011) Alex Iranzo et al. LANCET NEUROLOGY
- Milestones in PD genetics
- (2011) Thomas Gasser et al. MOVEMENT DISORDERS
- Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers
- (2011) Kathrin Brockmann et al. MOVEMENT DISORDERS
- Olfactory deficits and cardiac 123I-MIBG in Parkinson's disease related to the LRRK2 R1441G and G2019S mutations
- (2011) Javier Ruiz-Martínez et al. MOVEMENT DISORDERS
- Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers
- (2011) C. Marras et al. NEUROLOGY
- Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain)
- (2010) Javier Ruiz-Martínez et al. MOVEMENT DISORDERS
- Structural imaging in the presymptomatic stage of genetically determined parkinsonism
- (2010) Kathrin Reetz et al. NEUROBIOLOGY OF DISEASE
- Genetic Analysis of Pathways to Parkinson Disease
- (2010) John Hardy NEURON
- A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson's disease
- (2009) K. Nishioka et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- (2009) Wataru Satake et al. NATURE GENETICS
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- Diagnosis and the premotor phase of Parkinson disease
- (2009) E. Tolosa et al. NEUROLOGY
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- LRRK2 G2019S and R1441G mutations associated with Parkinson’s disease are common in the Basque Country, but relative prevalence is determined by ethnicity
- (2008) A. Gorostidi et al. NEUROGENETICS
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