Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Authors
Keywords
-
Journal
SCIENCE
Volume 364, Issue 6445, Pages eaau6323
Publisher
American Association for the Advancement of Science (AAAS)
Online
2019-06-14
DOI
10.1126/science.aau6323
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease
- (2019) Sebastiaan P. van Kessel et al. Nature Communications
- Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice
- (2019) Stefanie Dichtl et al. mBio
- Separating host and microbiome contributions to drug pharmacokinetics and toxicity
- (2019) Michael Zimmermann et al. SCIENCE
- OUP accepted manuscript
- (2018) BIOINFORMATICS
- Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins
- (2018) Nitzan Koppel et al. eLife
- Dietary trehalose enhances virulence of epidemic Clostridium difficile
- (2018) J. Collins et al. NATURE
- Precision editing of the gut microbiota ameliorates colitis
- (2018) Wenhan Zhu et al. NATURE
- Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome
- (2017) Erin M. Hill-Burns et al. MOVEMENT DISORDERS
- The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder
- (2017) Anna Heintz-Buschart et al. MOVEMENT DISORDERS
- Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study
- (2017) Tomomi Minato et al. PLoS One
- Chemical transformation of xenobiotics by the human gut microbiota
- (2017) Nitzan Koppel et al. SCIENCE
- Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients
- (2017) J. R. Bedarf et al. Genome Medicine
- L-DOPA
- (2017) Oleh Hornykiewicz Journal of Parkinsons Disease
- Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men
- (2016) Kevin D Hall et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
- (2016) Timothy R. Sampson et al. CELL
- The Central Nervous System and the Gut Microbiome
- (2016) Gil Sharon et al. CELL
- The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism
- (2016) Peter Spanogiannopoulos et al. NATURE REVIEWS MICROBIOLOGY
- Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls
- (2016) Marcus M. Unger et al. PARKINSONISM & RELATED DISORDERS
- ggtree: anrpackage for visualization and annotation of phylogenetic trees with their covariates and other associated data
- (2016) Guangchuang Yu et al. Methods in Ecology and Evolution
- Rapid Detection and Quantification of Tyrosine Decarboxylase Gene (tdc) and Its Expression in Gram-Positive Bacteria Associated with Fermented Foods Using PCR-Based Methods
- (2016) SANDRA TORRIANI et al. JOURNAL OF FOOD PROTECTION
- Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding
- (2016) Haixia Zhu et al. Scientific Reports
- MetaQuery: a web server for rapid annotation and quantitative analysis of specific genes in the human gut microbiome
- (2015) Stephen Nayfach et al. BIOINFORMATICS
- Simultaneous generation of many RNA-seq libraries in a single reaction
- (2015) Alexander A Shishkin et al. NATURE METHODS
- Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide
- (2015) Kymberleigh A. Romano et al. mBio
- Characterization and Detection of a Widely Distributed Gene Cluster That Predicts Anaerobic Choline Utilization by Human Gut Bacteria
- (2015) Ana Martínez-del Campo et al. mBio
- Classics in Chemical Neuroscience: Levodopa
- (2014) A. Connor Whitfield et al. ACS Chemical Neuroscience
- Tyramine biosynthesis is transcriptionally induced at low pH and improves the fitness of Enterococcus faecalis in acidic environments
- (2014) Marta Perez et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Shifting the metallocentric molybdoenzyme paradigm: the importance of pyranopterin coordination
- (2014) Richard A. Rothery et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Heterologous Expression and Characterization of Tyrosine Decarboxylase from Enterococcus faecalis R612Z1 and Enterococcus faecium R615Z1
- (2014) FANG LIU et al. JOURNAL OF FOOD PROTECTION
- Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial
- (2014) PD MED Collaborative Group LANCET
- Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State
- (2014) Deanna M. Mudie et al. MOLECULAR PHARMACEUTICS
- Gut microbiota are related to Parkinson's disease and clinical phenotype
- (2014) Filip Scheperjans et al. MOVEMENT DISORDERS
- Eradication of Helicobacter pylori Infection Improves Levodopa Action, Clinical Symptoms and Quality of Life in Patients with Parkinson's Disease
- (2014) Hasriza Hashim et al. PLoS One
- The role of small intestinal bacterial overgrowth in Parkinson's disease
- (2013) Alfonso Fasano et al. MOVEMENT DISORDERS
- The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
- (2013) Yang Liao et al. NUCLEIC ACIDS RESEARCH
- Polymorphic Cytochrome P450 Enzymes (CYPs) and Their Role in Personalized Therapy
- (2013) Sarah C. Preissner et al. PLoS One
- Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta
- (2013) H. J. Haiser et al. SCIENCE
- Development of Quantitative PCR Assays Targeting the 16S rRNA Genes of Enterococcus spp. and Their Application to the Identification of Enterococcus Species in Environmental Samples
- (2012) Hodon Ryu et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- Is the production of the biogenic amines tyramine and putrescine a species-level trait in enterococci?
- (2011) Victor Ladero et al. FOOD MICROBIOLOGY
- Molecular insights into the pathogenicity of variants associated with the aromatic amino acid decarboxylase deficiency
- (2011) Riccardo Montioli et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
- (2010) D. J. Sweeny et al. DRUG METABOLISM AND DISPOSITION
- QIIME allows analysis of high-throughput community sequencing data
- (2010) J Gregory Caporaso et al. NATURE METHODS
- Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
- (2010) B. D. Wallace et al. SCIENCE
- trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses
- (2009) S. Capella-Gutierrez et al. BIOINFORMATICS
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
- (2009) M. N. Price et al. MOLECULAR BIOLOGY AND EVOLUTION
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now