Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice

Inflammatory bowel disease increases the risk of Parkinson’s disease: a Danish nationwide cohort study 1977–2014

(2018) Marie Villumsen et al.   GUT

Acute inflammation downregulates alpha-synuclein expression in enteric neurons

(2018) Alice Prigent et al.   JOURNAL OF NEUROCHEMISTRY

Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signalling

(2017) François Reichardt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Vagotomy and Parkinson disease

(2017) Bojing Liu et al.   NEUROLOGY

Amyloid imaging: Past, present and future perspectives

(2016) Victor L. Villemagne   AGEING RESEARCH REVIEWS

Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients

(2016) Morten Gersel Stokholm et al.   ANNALS OF NEUROLOGY

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Vagal neurocircuitry and its influence on gastric motility

(2016) R. Alberto Travagli et al.   Nature Reviews Gastroenterology & Hepatology

Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology

(2016) K. Del Tredici et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?

(2016) Abid Oueslati   Journal of Parkinsons Disease

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

Constipation preceding Parkinson's disease: a systematic review and meta-analysis

(2015) Kerala L Adams-Carr et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

(2015) Lisa Klingelhoefer et al.   Nature Reviews Neurology

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson’s disease

(2015) M.D. Sconce et al.   NEUROSCIENCE

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Irritable bowel syndrome correlates with increased risk of Parkinson’s disease in Taiwan

(2014) Shih-Wei Lai et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice

(2014) Carola Rotermund et al.   JOURNAL OF NEUROCHEMISTRY

Early and Persistent Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice

(2014) Anna Bencsik et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Caudo-rostral brain spreading of α-synuclein through vagal connections

(2013) Ayse Ulusoy et al.   EMBO Molecular Medicine

The genetics and neuropathology of Parkinson’s disease

(2012) Henry Houlden et al.   ACTA NEUROPATHOLOGICA

Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease

(2012) Mark P. Mattson   Cell Metabolism

Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein

(2012) Kathleen J. Griffioen et al.   NEUROBIOLOGY OF AGING

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

(2012) Penelope J. Hallett et al.   NEUROBIOLOGY OF DISEASE

Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system

(2012) Ali Reza Noorian et al.   NEUROBIOLOGY OF DISEASE

Colonic inflammation in Parkinson's disease

(2012) David Devos et al.   NEUROBIOLOGY OF DISEASE

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2011) Hui-Ming Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

When Does Parkinson Disease Start?

(2010) Rodolfo Savica et al.   ARCHIVES OF NEUROLOGY

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV  -Synucleinopathy

(2009) C. Y. Chung et al.   JOURNAL OF NEUROSCIENCE

Striatal Neuroinflammation Promotes Parkinsonism in Rats

(2009) Dong-Young Choi et al.   PLoS One

Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?

(2008) R.J. Phillips et al.   NEUROSCIENCE

Neuroinflammation in Parkinson's Disease: Is there sufficient evidence for mechanism-based interventional therapy?

(2007) Malu et al.   Frontiers in Bioscience-Landmark