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Title
CDK9 keeps RNA polymerase II on track
Authors
Keywords
-
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-06-19
DOI
10.1007/s00018-021-03878-8
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- (2021) Stephin J. Vervoort et al. CELL
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- (2020) Schuyler Lee et al. eLife
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- (2020) Ryan D. Martin et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2020) Yuki Aoi et al. MOLECULAR CELL
- Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression
- (2020) Yi Lu et al. NATURE CELL BIOLOGY
- Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
- (2020) Megan J. Bywater et al. Nature Communications
- ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation
- (2020) Chenghao Guo et al. Science Advances
- CDK13 cooperates with CDK12 to control global RNA polymerase II processivity
- (2020) Zheng Fan et al. Science Advances
- CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation
- (2020) Michael Tellier et al. NUCLEIC ACIDS RESEARCH
- Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination
- (2020) Kai-Lieh Huang et al. MOLECULAR CELL
- Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
- (2020) Pabitra K. Parua et al. Nature Communications
- Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
- (2020) Hai Zheng et al. SCIENCE
- P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress
- (2019) Andrii Bugai et al. MOLECULAR CELL
- Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation
- (2019) Leighton Core et al. GENES & DEVELOPMENT
- Selective kinase inhibition shows that Bur1 (Cdk9) phosphorylates the Rpb1 linker in vivo
- (2019) Yujin Chun et al. MOLECULAR AND CELLULAR BIOLOGY
- RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control
- (2019) Xianju Bi et al. MOLECULAR CELL
- HiChIRP reveals RNA-associated chromosome conformation
- (2019) Maxwell R. Mumbach et al. NATURE METHODS
- CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes
- (2019) Anil Paul Chirackal Manavalan et al. EMBO REPORTS
- Paf1C regulates RNA polymerase II progression by modulating elongation rate
- (2019) Liming Hou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
- (2019) Malgorzata Krajewska et al. Nature Communications
- A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing
- (2019) Theophilus T. Tettey et al. Cell Reports
- Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease
- (2019) Yongzhan Sun et al. Science Advances
- The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing
- (2019) Jean-Pierre Etchegaray et al. MOLECULAR CELL
- Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
- (2019) Yang Eric Guo et al. NATURE
- Organization and regulation of gene transcription
- (2019) Patrick Cramer NATURE
- Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb
- (2019) Joshua E Mayfield et al. eLife
- Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer
- (2019) Victor Quereda et al. CANCER CELL
- CDK12 Activity-Dependent Phosphorylation Events in Human Cells
- (2019) Bartlomiej Bartkowiak et al. Biomolecules
- The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes
- (2019) Nathan D. Elrod et al. MOLECULAR CELL
- Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a “Sitting Duck Torpedo” Mechanism
- (2019) Michael A. Cortazar et al. MOLECULAR CELL
- Analog-sensitive cell line identifies cellular substrates of CDK9
- (2019) Tim-Michael Decker et al. Oncotarget
- Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation
- (2018) Johanna Fitz et al. EMBO JOURNAL
- CDK9‐mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery
- (2018) Prisca Brauns‐Schubert et al. EMBO REPORTS
- Widespread transcriptional pausing and elongation control at enhancers
- (2018) Telmo Henriques et al. GENES & DEVELOPMENT
- Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7
- (2018) Catherine D. Eichhorn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Imaging dynamic and selective low-complexity domain interactions that control gene transcription
- (2018) Shasha Chong et al. SCIENCE
- Coactivator condensation at super-enhancers links phase separation and gene control
- (2018) Benjamin R. Sabari et al. SCIENCE
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- (2018) Won-Ki Cho et al. SCIENCE
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- (2018) Gregory T. Booth et al. Nature Communications
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- (2018) Tyler B Faust et al. eLife
- Dynamic turnover of paused Pol II complexes at human promoters
- (2018) Benjamin Erickson et al. GENES & DEVELOPMENT
- CDK12: an emerging therapeutic target for cancer
- (2018) Goldie Y L Lui et al. JOURNAL OF CLINICAL PATHOLOGY
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- (2018) Pabitra K. Parua et al. NATURE
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- (2018) Huasong Lu et al. NATURE
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- (2018) Seychelle M. Vos et al. NATURE
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- (2018) Seychelle M. Vos et al. NATURE
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- (2018) Marc Boehning et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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- (2018) Yuan Yang et al. Nature Chemical Biology
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- (2017) Arnaud R. Krebs et al. MOLECULAR CELL
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- (2017) Ameet Shetty et al. MOLECULAR CELL
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- (2017) Georg E. Winter et al. MOLECULAR CELL
- Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
- (2017) Calla M Olson et al. Nature Chemical Biology
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- (2017) Wanqing Shao et al. NATURE GENETICS
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- (2017) Lydia Herzel et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2017) Carrie Bernecky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Nuclear speckles: molecular organization, biological function and role in disease
- (2017) Lukasz Galganski et al. NUCLEIC ACIDS RESEARCH
- Structure of the complete elongation complex of RNA polymerase II with basal factors
- (2017) Haruhiko Ehara et al. SCIENCE
- PAF1 regulation of promoter-proximal pause release via enhancer activation
- (2017) Fei Xavier Chen et al. SCIENCE
- Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation
- (2017) S. Branden Van Oss et al. TRENDS IN BIOCHEMICAL SCIENCES
- Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
- (2017) Matthieu D. Lavigne et al. Nature Communications
- Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp
- (2017) Carrie Bernecky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription
- (2017) Matthew A Sdano et al. eLife
- CDK9-dependent RNA polymerase II pausing controls transcription initiation
- (2017) Saskia Gressel et al. eLife
- P-TEFb goes viral
- (2016) Justyna Zaborowska et al. BIOESSAYS
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- (2016) Miriam Sansó et al. GENES & DEVELOPMENT
- KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II
- (2016) Ryan P. McNamara et al. MOLECULAR CELL
- Heptad-Specific Phosphorylation of RNA Polymerase II CTD
- (2016) Roland Schüller et al. MOLECULAR CELL
- Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II
- (2016) Hyunsuk Suh et al. MOLECULAR CELL
- Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
- (2016) Tinghu Zhang et al. Nature Chemical Biology
- The pol II CTD: new twists in the tail
- (2016) Justyna Zaborowska et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- 7SK-BAF axis controls pervasive transcription at enhancers
- (2016) Ryan A Flynn et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb
- (2016) Alexandre J. C. Quaresma et al. NUCLEIC ACIDS RESEARCH
- mRNA capping: biological functions and applications
- (2016) Anand Ramanathan et al. NUCLEIC ACIDS RESEARCH
- Gdown1 Associates Efficiently with RNA Polymerase II after Promoter Clearance and Displaces TFIIF during Transcript Elongation
- (2016) Elizabeth DeLaney et al. PLoS One
- An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb
- (2016) Lydia Kobbi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle
- (2016) Sarah Schulz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The point of no return: The poly(A)-associated elongation checkpoint
- (2016) Michael Tellier et al. RNA Biology
- 7SKiing on chromatin: Move globally, act locally
- (2016) Iván D'Orso RNA Biology
- Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut
- (2016) N. J. Proudfoot SCIENCE
- Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation
- (2016) B. A. Gibson et al. SCIENCE
- The pol II CTD: new twists in the tail
- (2016) Justyna Zaborowska et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- 7SK-BAF axis controls pervasive transcription at enhancers
- (2016) Ryan A Flynn et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA
- (2016) Matthew S. Stratton et al. Cell Reports
- Structural and Functional Analysis of the Cdk13/Cyclin K Complex
- (2016) Ann Katrin Greifenberg et al. Cell Reports
- Architecture and RNA binding of the human negative elongation factor
- (2016) Seychelle M Vos et al. eLife
- Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas
- (2015) Bartlomiej Bartkowiak et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II
- (2015) Fei Xavier Chen et al. CELL
- Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide
- (2015) Fei Chen et al. GENES & DEVELOPMENT
- CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart
- (2015) G. Matrone et al. JOURNAL OF CELL SCIENCE
- HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist
- (2015) S G T Devaraj et al. LEUKEMIA
- Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing
- (2015) Kaiwei Liang et al. MOLECULAR AND CELLULAR BIOLOGY
- Molecular Basis of Transcription-Coupled Pre-mRNA Capping
- (2015) Fuensanta W. Martinez-Rucobo et al. MOLECULAR CELL
- Pausing of RNA Polymerase II Regulates Mammalian Developmental Potential through Control of Signaling Networks
- (2015) Lucy H. Williams et al. MOLECULAR CELL
- CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II–transcribed genes
- (2015) Clélia Laitem et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression
- (2015) Uri R. Mbonye et al. PROTEOMICS
- RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II
- (2015) M. Yu et al. SCIENCE
- CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II–transcribed genes
- (2015) Clélia Laitem et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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- (2014) Marco Saponaro et al. CELL
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- (2014) M. S. Buckley et al. GENES & DEVELOPMENT
- 3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells
- (2014) L. Davidson et al. GENES & DEVELOPMENT
- Histone variants: dynamic punctuation in transcription
- (2014) C. M. Weber et al. GENES & DEVELOPMENT
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- (2014) Pingyang Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2014) Bartlomiej Bartkowiak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2014) Tristan T. Eifler et al. MOLECULAR AND CELLULAR BIOLOGY
- Integrator Regulates Transcriptional Initiation and Pause Release following Activation
- (2014) Alessandro Gardini et al. MOLECULAR CELL
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- (2014) Nicholas Kwiatkowski et al. NATURE
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- (2014) Eliezer Calo et al. NATURE
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- (2014) Leighton J Core et al. NATURE GENETICS
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- (2014) David L. Bentley NATURE REVIEWS GENETICS
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- (2014) Tomohiko Kanno et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7
- (2014) Amelie Schreieck et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation
- (2014) Friederike Itzen et al. NUCLEIC ACIDS RESEARCH
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- (2014) Sheila S. Teves et al. TRENDS IN BIOCHEMICAL SCIENCES
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- (2014) Christian A. Bösken et al. Nature Communications
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- (2014) M. Gabay et al. Cold Spring Harbor Perspectives in Medicine
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- (2014) John M. Pagano et al. PLoS Genetics
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- (2014) Vincent Vanoosthuyse et al. PLoS Genetics
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- (2014) Xiaodan Ji et al. eLife
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- (2014) Iris Jonkers et al. eLife
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- (2013) Thomas Gonatopoulos-Pournatzis et al. BIOCHEMICAL JOURNAL
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- (2013) Jakob Lovén et al. CELL
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- (2013) Mounia Lagha et al. CELL
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- (2013) Wen Liu et al. CELL
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- (2013) Priti Anand et al. CELL
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- (2013) Xiong Ji et al. CELL
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- (2013) Asen Bagashev et al. CELL CYCLE
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- (2013) Argyris Papantonis et al. CHEMICAL REVIEWS
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- (2013) S. Lim et al. DEVELOPMENT
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- (2013) Kamaleldin E. Elagib et al. DEVELOPMENTAL CELL
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- (2013) A. Ghamari et al. GENES & DEVELOPMENT
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- (2013) L. Muniz et al. NUCLEIC ACIDS RESEARCH
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- (2011) David M Suter et al. CURRENT OPINION IN CELL BIOLOGY
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- (2011) N. He et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2010) Siobhan K. O'Brien et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclin-dependent Kinase-9 Is a Component of the p300/GATA4 Complex Required for Phenylephrine-induced Hypertrophy in Cardiomyocytes
- (2010) Yoichi Sunagawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes
- (2010) Eugene C. Dow et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression
- (2010) Kannanganattu V. Prasanth et al. MOLECULAR BIOLOGY OF THE CELL
- HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription
- (2010) Nanhai He et al. MOLECULAR CELL
- AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia
- (2010) Chengqi Lin et al. MOLECULAR CELL
- HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP
- (2010) Bijan Sobhian et al. MOLECULAR CELL
- CDK9 Regulates AR Promoter Selectivity and Cell Growth through Serine 81 Phosphorylation
- (2010) Vicki Gordon et al. MOLECULAR ENDOCRINOLOGY
- Crystal structure of HIV-1 Tat complexed with human P-TEFb
- (2010) Tahir H. Tahirov et al. NATURE
- Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain
- (2010) Bradley M Lunde et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
- (2010) Iván D'Orso et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Uniform transitions of the general RNA polymerase II transcription complex
- (2010) Andreas Mayer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK
- (2010) Brian J. Krueger et al. PLoS One
- P-TEFb stimulates transcription elongation and pre-mRNA splicing through multilateral mechanisms
- (2010) Tina Lenasi et al. RNA Biology
- Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat
- (2010) Lisa Muniz et al. PLoS Pathogens
- Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells
- (2009) Sungyoo Cho et al. EMBO JOURNAL
- Spt6 enhances the elongation rate of RNA polymerase II in vivo
- (2009) M Behfar Ardehali et al. EMBO JOURNAL
- DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation
- (2009) Y. Chen et al. GENES & DEVELOPMENT
- Pharmacological targeting of CDK9 in cardiac hypertrophy
- (2009) Vladimír Kryštof et al. MEDICINAL RESEARCH REVIEWS
- Cyclin T2 Is Essential for Mouse Embryogenesis
- (2009) J. Kohoutek et al. MOLECULAR AND CELLULAR BIOLOGY
- TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II
- (2009) K. Glover-Cutter et al. MOLECULAR AND CELLULAR BIOLOGY
- Phosphorylation of the Transcription Elongation Factor Spt5 by Yeast Bur1 Kinase Stimulates Recruitment of the PAF Complex
- (2009) Y. Liu et al. MOLECULAR AND CELLULAR BIOLOGY
- Chromatin Structure Is Implicated in "Late" Elongation Checkpoints on the U2 snRNA and -Actin Genes
- (2009) S. Egloff et al. MOLECULAR AND CELLULAR BIOLOGY
- Progression through the RNA Polymerase II CTD Cycle
- (2009) Stephen Buratowski MOLECULAR CELL
- Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling
- (2009) K. Adelman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development
- (2009) M. Barboric et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synchronous and Stochastic Patterns of Gene Activation in theDrosophilaEmbryo
- (2009) Alistair N. Boettiger et al. SCIENCE
- The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
- (2008) Sonja Baumli et al. EMBO JOURNAL
- PP2B and PP1 cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling
- (2008) R. Chen et al. GENES & DEVELOPMENT
- NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly
- (2008) D. A. Gilchrist et al. GENES & DEVELOPMENT
- Gene expression in early stage cervical cancer
- (2008) Petra Biewenga et al. GYNECOLOGIC ONCOLOGY
- Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop
- (2008) Yan Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cdk9‐55: A new player in muscle regeneration
- (2008) Cristina Giacinti et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The Positive Transcription Elongation Factor b Is an Essential Cofactor for the Activation of Transcription by Myocyte Enhancer Factor 2
- (2008) Masanori Nojima et al. JOURNAL OF MOLECULAR BIOLOGY
- A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis
- (2008) Nanhai He et al. MOLECULAR CELL
- Cyclin-dependent kinases and cell-cycle transitions: does one fit all?
- (2008) Helfrid Hochegger et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated
- (2008) B. J. Krueger et al. NUCLEIC ACIDS RESEARCH
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