CDK9: A key player in cancer and other diseases

Antitumor action of CDK inhibitor LS-007 as a single agent and in combination with ABT-199 against human acute leukemia cells

(2016) Shao Xie et al.   ACTA PHARMACOLOGICA SINICA

P-TEFb goes viral

(2016) Justyna Zaborowska et al.   BIOESSAYS

Overview of CDK9 as a target in cancer research

(2016) Fatima Morales et al.   CELL CYCLE

The positive transcriptional elongation factor (P-TEFb) is required for neural crest specification

(2016) Victoria L. Hatch et al.   DEVELOPMENTAL BIOLOGY

Targeting CDK9: a promising therapeutic opportunity in prostate cancer

(2016) Muhammed H Rahaman et al.   ENDOCRINE-RELATED CANCER

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

(2016) Miriam Sansó et al.   GENES & DEVELOPMENT

Heptad-Specific Phosphorylation of RNA Polymerase II CTD

(2016) Roland Schüller et al.   MOLECULAR CELL

The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition

(2016) Thomas K. Albert et al.   PLoS One

P-TEFb Kinase Activity Is Essential for Global Transcription, Resumption of Meiosis and Embryonic Genome Activation in Pig

(2016) Reza K. Oqani et al.   PLoS One

Functional Analysis of GATA4 Complex, a Cardiac Hypertrophy-response Transcriptional Factor, Using a Proteomics Approach

(2016) Yoichi Sunagawa et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancer

(2016) Sandeep Rajput et al.   Oncotarget

Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites

(2016) Robert J. Allaway et al.   Oncotarget

CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression

(2016) Partha Mitra et al.   Oncotarget

On the way of revealing coactivator complexes cross-talk during transcriptional activation

(2016) Aleksey N. Krasnov et al.   Cell and Bioscience

Heat Shock Factor 1 Mediates Latent HIV Reactivation

(2016) Xiao-Yan Pan et al.   Scientific Reports

A new model for post-integration latency in macroglial cells to study HIV-1 reservoirs of the brain

(2015) Martha Schneider et al.   AIDS

The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription

(2015) Temesgen D. Fufa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer

(2015) Erik S Knudsen et al.   CELL CYCLE

The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cells

(2015) KATJA STORCH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart

(2015) G. Matrone et al.   JOURNAL OF CELL SCIENCE

Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription

(2015) Huasong Lu et al.   NUCLEIC ACIDS RESEARCH

Serum cyclin-dependent kinase 9 is a potential biomarker of atherosclerotic inflammation

(2015) Yeming Han et al.   Oncotarget

Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma

(2015) L Lefèvre et al.   Oncogenesis

GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy

(2015) Minzhen He et al.   PLoS One

Comparative drug screening in NUT midline carcinoma

(2014) A H Beesley et al.   BRITISH JOURNAL OF CANCER

MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9

(2014) Ling Wang et al.   FEBS LETTERS

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

(2014) Chun-Hao Huang et al.   GENES & DEVELOPMENT

A Novel CDK9 Inhibitor Shows Potent Antitumor Efficacy in Preclinical Hematologic Tumor Models

(2014) T. Yin et al.   MOLECULAR CANCER THERAPEUTICS

Cap-binding complex (CBC)

(2013) Thomas Gonatopoulos-Pournatzis et al.   BIOCHEMICAL JOURNAL

Cyclin dependent kinase-9 mediated transcriptional de-regulation of cMYC as a critical determinant of endocrine-therapy resistance in breast cancers

(2013) Surojeet Sengupta et al.   BREAST CANCER RESEARCH AND TREATMENT

Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1

(2013) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

Synthesis, structure–activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents

(2013) Hao Shao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

(2013) V. Proserpio et al.   GENES & DEVELOPMENT

In vivo live imaging of RNA polymerase II transcription factories in primary cells

(2013) A. Ghamari et al.   GENES & DEVELOPMENT

Roles of p53 in Herpes Simplex Virus 1 Replication

(2013) Y. Maruzuru et al.   JOURNAL OF VIROLOGY

CDK9-Dependent Transcriptional Elongation in the Innate Interferon-Stimulated Gene Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells

(2013) B. Tian et al.   JOURNAL OF VIROLOGY

Adenovirus L-E1A Activates Transcription through Mediator Complex-Dependent Recruitment of the Super Elongation Complex

(2013) S. Vijayalingam et al.   JOURNAL OF VIROLOGY

Structural visualization of key steps in human transcription initiation

(2013) Yuan He et al.   NATURE

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

(2013) Kuang-Lei Tsai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Phase 2 Trial of Flavopiridol (Alvocidib) and Cisplatin in Platin-Resistant Ovarian and Primary Peritoneal Carcinoma: MC0261

(2012) Keith C. Bible et al.   GYNECOLOGIC ONCOLOGY

The super elongation complex (SEC) family in transcriptional control

(2012) Zhuojuan Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Herpes Simplex Virus 1 ICP22 Inhibits the Transcription of Viral Gene Promoters by Binding to and Blocking the Recruitment of P-TEFb

(2012) Lei Guo et al.   PLoS One

CDK2 Regulates HIV-1 Transcription by Phosphorylation of CDK9 on Serine 90

(2012) Denitra Breuer et al.   Retrovirology

Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition

(2012) Nadine Czudnochowski et al.   Nature Communications

Ser-634 and Ser-636 of Kaposi’s Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites

(2012) Wan-Hua Tsai et al.   Frontiers in Microbiology

Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms

(2011) Gabriella Esposito et al.   BIOCHEMICAL JOURNAL

Expression analysis and molecular targeting of cyclin-dependent kinases in advanced melanoma

(2011) Christopher Abdullah et al.   CELL CYCLE

Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation

(2011) Siobhan K. O'Brien et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cyclin-dependent kinase inhibitor, P276-00 induces apoptosis in multiple myeloma cells by inhibition of Cdk9-T1 and RNA polymerase II-dependent transcription

(2011) Sonal M. Manohar et al.   LEUKEMIA RESEARCH

Hexim-1 modulates androgen receptor and the TGF-β signaling during the progression of prostate cancer

(2011) Eduardo J. Mascareno et al.   PROSTATE

55K isoform of CDK9 associates with Ku70 and is involved in DNA repair

(2010) Hongbing Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pausing of RNA Polymerase II Disrupts DNA-Specified Nucleosome Organization to Enable Precise Gene Regulation

(2010) Daniel A. Gilchrist et al.   CELL

Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases

(2010) Gaetano Romano et al.   CELL CYCLE

Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8)

(2010) Li-li Li et al.   CELLULAR MICROBIOLOGY

Berberine regulates peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in diabetic adipocytes

(2010) Jiyin Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia

(2010) Sara C. Monroe et al.   EXPERIMENTAL HEMATOLOGY

Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cellular RNA Polymerase II

(2010) J. Zhang et al.   JOURNAL OF VIROLOGY

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

(2010) Chengqi Lin et al.   MOLECULAR CELL

CDK9 Regulates AR Promoter Selectivity and Cell Growth through Serine 81 Phosphorylation

(2010) Vicki Gordon et al.   MOLECULAR ENDOCRINOLOGY

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3′ end processing through p21, NPAT and CDK9

(2010) J Pirngruber et al.   ONCOGENE

Regulation of Hox Gene Activity by Transcriptional Elongation in Drosophila

(2009) Vivek S. Chopra et al.   CURRENT BIOLOGY

CDK9/cyclin complexes modulate endoderm induction by direct interaction with Mix.3/mixer

(2009) Haiqing Zhu et al.   DEVELOPMENTAL DYNAMICS

Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia

(2009) Dorothee Mueller et al.   PLOS BIOLOGY

Regulation of transcription by the Epstein–Barr virus nuclear antigen EBNA 2

(2008) Richard D. Palermo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors

(2008) Subhra Mohapatra et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cdk9‐55: A new player in muscle regeneration

(2008) Cristina Giacinti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cdk9/Cyclin T1 complex: A key player during the activation/differentiation process of normal lymphoid B cells

(2008) Giulia De Falco et al.   JOURNAL OF CELLULAR PHYSIOLOGY