Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
Authors
Keywords
-
Journal
Nature Chemical Biology
Volume 12, Issue 10, Pages 876-884
Publisher
Springer Nature
Online
2016-08-29
DOI
10.1038/nchembio.2166
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Structural and Functional Analysis of the Cdk13/Cyclin K Complex
- (2016) Ann Katrin Greifenberg et al. Cell Reports
- Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas
- (2015) Bartlomiej Bartkowiak et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing
- (2015) Kaiwei Liang et al. MOLECULAR AND CELLULAR BIOLOGY
- Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex
- (2015) Kingsley M. Ekumi et al. NUCLEIC ACIDS RESEARCH
- Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor
- (2014) Camilla L. Christensen et al. CANCER CELL
- CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer
- (2014) Edmond Chipumuro et al. CELL
- 3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells
- (2014) L. Davidson et al. GENES & DEVELOPMENT
- Expression, Purification, and Identification of Associated Proteins of the Full-length hCDK12/CyclinK Complex
- (2014) Bartlomiej Bartkowiak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors
- (2014) Poorval M. Joshi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclin-Dependent Kinase 12 Increases 3′ End Processing of Growth Factor-Induced c-FOS Transcripts
- (2014) Tristan T. Eifler et al. MOLECULAR AND CELLULAR BIOLOGY
- Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
- (2014) Nicholas Kwiatkowski et al. NATURE
- An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
- (2014) M. R. Mansour et al. SCIENCE
- The structure and substrate specificity of human Cdk12/Cyclin K
- (2014) Christian A. Bösken et al. Nature Communications
- RNA Polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation
- (2014) Elizabeth A Bowman et al. Nucleus
- How good are my data and what is the resolution?
- (2013) Philip R. Evans et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
- (2013) I. Bajrami et al. CANCER RESEARCH
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- (2013) Jakob Lovén et al. CELL
- Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
- (2013) Warren A. Whyte et al. CELL
- RefSeq: an update on mammalian reference sequences
- (2013) Kim D. Pruitt et al. NUCLEIC ACIDS RESEARCH
- A DNA Damage Response System Associated with the phosphoCTD of Elongating RNA Polymerase II
- (2013) Tiffany Sabin Winsor et al. PLoS One
- Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia
- (2012) Takaomi Sanda et al. CANCER CELL
- Revisiting Global Gene Expression Analysis
- (2012) Jakob Lovén et al. CELL
- Transcriptional Amplification in Tumor Cells with Elevated c-Myc
- (2012) Charles Y. Lin et al. CELL
- Discovery of Potent and Selective Covalent Inhibitors of JNK
- (2012) Tinghu Zhang et al. CHEMISTRY & BIOLOGY
- Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
- (2012) Stéphane Larochelle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition
- (2012) Nadine Czudnochowski et al. Nature Communications
- REFMAC5 for the refinement of macromolecular crystal structures
- (2011) Garib N. Murshudov et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Overview of theCCP4 suite and current developments
- (2011) Martyn D. Winn et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases
- (2011) Matthew P. Patricelli et al. CHEMISTRY & BIOLOGY
- The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
- (2011) D. Blazek et al. GENES & DEVELOPMENT
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1
- (2010) B. Bartkowiak et al. GENES & DEVELOPMENT
- The carboxy terminal domain of RNA polymerase II and alternative splicing
- (2010) Manuel J. Muñoz et al. TRENDS IN BIOCHEMICAL SCIENCES
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Improved Electrospray Ionization Efficiency Compensates for Diminished Chromatographic Resolution and Enables Proteomics Analysis of Tyrosine Signaling in Embryonic Stem Cells
- (2009) Scott B. Ficarro et al. ANALYTICAL CHEMISTRY
- Progression through the RNA Polymerase II CTD Cycle
- (2009) Stephen Buratowski MOLECULAR CELL
- Defining mechanisms that regulate RNA polymerase II transcription in vivo
- (2009) Nicholas J. Fuda et al. NATURE
- mzAPI: a new strategy for efficiently sharing mass spectrometry data
- (2009) Manor Askenazi et al. NATURE METHODS
- Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
- (2009) Ben Langmead et al. GENOME BIOLOGY
- Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
- (2008) Da Wei Huang et al. NUCLEIC ACIDS RESEARCH
- Yeast Screens Identify the RNA Polymerase II CTD and SPT5 as Relevant Targets of BRCA1 Interaction
- (2008) Craig B. Bennett et al. PLoS One
- High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
- (2008) S. Rottenberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now