Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
Authors
Keywords
-
Journal
SCIENCE
Volume 370, Issue 6520, Pages eabb5872
Publisher
American Association for the Advancement of Science (AAAS)
Online
2020-11-27
DOI
10.1126/science.abb5872
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Structure of an active human histone pre-mRNA 3′-end processing machinery
- (2020) Yadong Sun et al. SCIENCE
- Integrator is a key component of human telomerase RNA biogenesis
- (2019) M. P. Rubtsova et al. Scientific Reports
- The Integrator complex cleaves nascent mRNAs to attenuate transcription
- (2019) Deirdre C. Tatomer et al. GENES & DEVELOPMENT
- Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
- (2019) Dorothee Liebschner et al. Acta Crystallographica Section D-Structural Biology
- Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis
- (2019) Akihide Yoshimi et al. NATURE
- The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes
- (2019) Nathan D. Elrod et al. MOLECULAR CELL
- Structural Insights into the Human Pre-mRNA 3′-End Processing Machinery
- (2019) Yixiao Zhang et al. MOLECULAR CELL
- Protein phosphatases at the nuclear envelope
- (2018) Raquel Sales Gil et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Therapeutic targeting of PP2A
- (2018) Caitlin M. O’Connor et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Born to run: control of transcription elongation by RNA polymerase II
- (2018) Fei Xavier Chen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module
- (2018) Todd R Albrecht et al. NUCLEIC ACIDS RESEARCH
- Effects of stably incorporated iron on protein phosphatase-1 structure and activity
- (2018) Francesca Salvi et al. FEBS LETTERS
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs
- (2017) Jingyin Yue et al. GENES & DEVELOPMENT
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Addressing preferred specimen orientation in single-particle cryo-EM through tilting
- (2017) Yong Zi Tan et al. NATURE METHODS
- Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance
- (2017) Yixuan Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- Human mutations in integrator complex subunits link transcriptome integrity to brain development
- (2017) Renske Oegema et al. PLoS Genetics
- Integrator complex and transcription regulation: Recent findings and pathophysiology
- (2016) Monica Rienzo et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- PP2A as a master regulator of the cell cycle
- (2016) Nathan Wlodarchak et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution
- (2016) Thi Hoang Duong Nguyen et al. NATURE
- PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II
- (2015) Fei Xavier Chen et al. CELL
- The Integrator complex controls the termination of transcription at diverse classes of gene targets
- (2015) Jeffrey R Skaar et al. CELL RESEARCH
- All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase
- (2015) Jaya Sangodkar et al. FEBS Journal
- The host Integrator complex acts in transcription-independent maturation of herpesvirus microRNA 3′ ends
- (2015) Mingyi Xie et al. GENES & DEVELOPMENT
- Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide
- (2015) Fei Chen et al. GENES & DEVELOPMENT
- Integrator mediates the biogenesis of enhancer RNAs
- (2015) Fan Lai et al. NATURE
- EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
- (2015) Benjamin A Barad et al. NATURE METHODS
- Getting up to speed with transcription elongation by RNA polymerase II
- (2015) Iris Jonkers et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Integrator: surprisingly diverse functions in gene expression
- (2015) David Baillat et al. TRENDS IN BIOCHEMICAL SCIENCES
- Integrator Regulates Transcriptional Initiation and Pause Release following Activation
- (2014) Alessandro Gardini et al. MOLECULAR CELL
- Visualization of Subunit Interactions and Ternary Complexes of Protein Phosphatase 2A in Mammalian Cells
- (2014) Shu-Ting Mo et al. PLoS One
- Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes
- (2014) Bernd Stadelmayer et al. Nature Communications
- DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes
- (2014) Junichi Yamamoto et al. Nature Communications
- Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA
- (2014) Wendan Ren et al. Cell Reports
- Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome
- (2014) David A. Orlando et al. Cell Reports
- Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer
- (2013) Parthasarathy Seshacharyulu et al. CANCER LETTERS
- Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation
- (2013) Nathan Wlodarchak et al. CELL RESEARCH
- Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone
- (2013) Feng Guo et al. CELL RESEARCH
- Quantifying the local resolution of cryo-EM density maps
- (2013) Alp Kucukelbir et al. NATURE METHODS
- Scalable web services for the PSIPRED Protein Analysis Workbench
- (2013) Daniel W. A. Buchan et al. NUCLEIC ACIDS RESEARCH
- Structural Insights into the Recruitment of SMRT by the Corepressor SHARP under Phosphorylative Regulation
- (2013) Suzuka Mikami et al. STRUCTURE
- TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
- (2013) Daehwan Kim et al. GENOME BIOLOGY
- An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72
- (2012) K. Xiang et al. GENES & DEVELOPMENT
- The RNA polymerase II CTD coordinates transcription and RNA processing
- (2012) J.-P. Hsin et al. GENES & DEVELOPMENT
- Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
- (2012) Cole Trapnell et al. Nature Protocols
- An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation
- (2012) J. Chen et al. RNA
- Movies of Ice-Embedded Particles Enhance Resolution in Electron Cryo-Microscopy
- (2012) Melody G. Campbell et al. STRUCTURE
- A Primate Herpesvirus Uses the Integrator Complex to Generate Viral MicroRNAs
- (2011) Demián Cazalla et al. MOLECULAR CELL
- Ser7 Phosphorylation of the CTD Recruits the RPAP2 Ser5 Phosphatase to snRNA Genes
- (2011) Sylvain Egloff et al. MOLECULAR CELL
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Crystal structure of the human symplekin–Ssu72–CTD phosphopeptide complex
- (2010) Kehui Xiang et al. NATURE
- Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
- (2010) E. Kickstein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Serine/Threonine Phosphatases: Mechanism through Structure
- (2009) Yigong Shi CELL
- SOSS Complexes Participate in the Maintenance of Genomic Stability
- (2009) Jun Huang et al. MOLECULAR CELL
- Rtr1 Is a CTD Phosphatase that Regulates RNA Polymerase II during the Transition from Serine 5 to Serine 2 Phosphorylation
- (2009) Amber L. Mosley et al. MOLECULAR CELL
- Progression through the RNA Polymerase II CTD Cycle
- (2009) Stephen Buratowski MOLECULAR CELL
- Structure and Function of the PP2A-Shugoshin Interaction
- (2009) Zheng Xu et al. MOLECULAR CELL
- Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
- (2009) Ben Langmead et al. GENOME BIOLOGY
- Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation
- (2008) Yanhui Xu et al. MOLECULAR CELL
- Cracking the RNA polymerase II CTD code
- (2008) Sylvain Egloff et al. TRENDS IN GENETICS
- Multiple pathways regulated by the tumor suppressor PP2A in transformation
- (2008) Jukka Westermarck et al. TRENDS IN MOLECULAR MEDICINE
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now