Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence

Published 2018 View Full Article

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Title
Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence
Authors
Keywords
SPT6, H3K36me3, DNA replication stress, cellular senescence, R-loop, long non-coding RNA, eRNA, integrator complex, mNET-seq, mNuc-seq
Journal
MOLECULAR CELL
Volume 72, Issue 6, Pages 970-984.e7
Publisher
Elsevier BV
Online
2018-11-15
DOI
10.1016/j.molcel.2018.10.011

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