The pol II CTD: new twists in the tail

Distributive O-GlcNAcylation on the Highly Repetitive C-Terminal Domain of RNA Polymerase II

(2016) Lei Lu et al.   BIOCHEMISTRY

P-TEFb goes viral

(2016) Justyna Zaborowska et al.   BIOESSAYS

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

(2016) Miriam Sansó et al.   GENES & DEVELOPMENT

Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation

(2016) Shotaro Wani et al.   JOURNAL OF BIOCHEMISTRY

The RNA Polymerase II CTD: The Increasing Complexity of a Low-Complexity Protein Domain

(2016) Célia Jeronimo et al.   JOURNAL OF MOLECULAR BIOLOGY

Heptad-Specific Phosphorylation of RNA Polymerase II CTD

(2016) Roland Schüller et al.   MOLECULAR CELL

Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II

(2016) Hyunsuk Suh et al.   MOLECULAR CELL

Strand‐specific, high‐resolution mapping of modified RNA polymerase II

(2016) Laura Milligan et al.   Molecular Systems Biology

Transcription of lncRNAprt, clusteredprtRNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression ofpho1gene expression under phosphate-replete conditions in fission yeast

(2016) Debashree Chatterjee et al.   RNA

Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression

(2016) Corinna Hintermair et al.   Scientific Reports

Comprehensive RNA Polymerase II Interactomes Reveal Distinct and Varied Roles for Each Phospho-CTD Residue

(2016) Kevin M. Harlen et al.   Cell Reports

Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics

(2016) Zachary C. Poss et al.   Cell Reports

Structural and Functional Analysis of the Cdk13/Cyclin K Complex

(2016) Ann Katrin Greifenberg et al.   Cell Reports

Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas

(2015) Bartlomiej Bartkowiak et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Modifications of RNA polymerase II CTD: Connections to the histone code and cellular function

(2015) Rakesh Srivastava et al.   BIOTECHNOLOGY ADVANCES

Evolution of lysine acetylation in the RNA polymerase II C-terminal domain

(2015) Corinne N Simonti et al.   BMC EVOLUTIONARY BIOLOGY

Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing

(2015) Takayuki Nojima et al.   CELL

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II

(2015) Fei Xavier Chen et al.   CELL

CDK11 in TREX/THOC Regulates HIV mRNA 3′ End Processing

(2015) Vladimir Pak et al.   Cell Host & Microbe

Pcf11 orchestrates transcription termination pathways in yeast

(2015) Pawel Grzechnik et al.   GENES & DEVELOPMENT

Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing

(2015) Kaiwei Liang et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromatin-wide Profiling of DYRK1A Reveals a Role as a Gene-Specific RNA Polymerase II CTD Kinase

(2015) Chiara Di Vona et al.   MOLECULAR CELL

SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination

(2015) Dorothy Yanling Zhao et al.   NATURE

Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD

(2015) Mitsunori Koga et al.   NUCLEIC ACIDS RESEARCH

RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II

(2015) M. Yu et al.   SCIENCE

Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells

(2015) João D Dias et al.   eLife

3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells

(2014) L. Davidson et al.   GENES & DEVELOPMENT

Rtr1 Is a Dual Specificity Phosphatase That Dephosphorylates Tyr1 and Ser5 on the RNA Polymerase II CTD

(2014) Peter L. Hsu et al.   JOURNAL OF MOLECULAR BIOLOGY

Cyclin-Dependent Kinase 12 Increases 3′ End Processing of Growth Factor-Induced c-FOS Transcripts

(2014) Tristan T. Eifler et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone Deacetylases and Phosphorylated Polymerase II C-Terminal Domain Recruit Spt6 for Cotranscriptional Histone Reassembly

(2014) B. B. Burugula et al.   MOLECULAR AND CELLULAR BIOLOGY

A Splicing-Dependent Transcriptional Checkpoint Associated with Prespliceosome Formation

(2014) Keerthi T. Chathoth et al.   MOLECULAR CELL

RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation

(2014) Zuyao Ni et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7

(2014) Amelie Schreieck et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Threonine-4 of the budding yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling

(2014) E. Rosonina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure and substrate specificity of human Cdk12/Cyclin K

(2014) Christian A. Bösken et al.   Nature Communications

Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells

(2014) Nicolas Descostes et al.   eLife

Control of Transcriptional Elongation

(2013) Hojoong Kwak et al.   Annual Review of Genetics

O-GlcNAcylation at promoters, nutrient sensors, and transcriptional regulation

(2013) Brian A. Lewis   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

(2013) Matthew D. Galbraith et al.   CELL

The RNA Polymerase II Carboxy-Terminal Domain (CTD) Code

(2013) Dirk Eick et al.   CHEMICAL REVIEWS

Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline

(2013) E. A. Bowman et al.   DEVELOPMENT

In vivo live imaging of RNA polymerase II transcription factories in primary cells

(2013) A. Ghamari et al.   GENES & DEVELOPMENT

Acetylation of RNA Polymerase II Regulates Growth-Factor-Induced Gene Transcription in Mammalian Cells

(2013) Sebastian Schröder et al.   MOLECULAR CELL

Human snRNA genes use polyadenylation factors to promote efficient transcription termination

(2013) Dawn O’Reilly et al.   NUCLEIC ACIDS RESEARCH

Structural and Kinetic Analysis of Prolyl-isomerization/Phosphorylation Cross-Talk in the CTD Code

(2012) Mengmeng Zhang et al.   ACS Chemical Biology

Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function

(2012) Andrei Shchebet et al.   CELL CYCLE

Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation

(2012) Corinna Hintermair et al.   EMBO JOURNAL

Serine phosphorylation and proline isomerization in RNAP II CTD control recruitment of Nrd1

(2012) K. Kubicek et al.   GENES & DEVELOPMENT

Ssu72 Phosphatase-dependent Erasure of Phospho-Ser7 Marks on the RNA Polymerase II C-terminal Domain Is Essential for Viability and Transcription Termination

(2012) David W. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence of the Involvement ofO-GlcNAc-modified Human RNA Polymerase II CTD in Transcriptionin Vitroandin Vivo

(2012) Stella M. Ranuncolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Cyclin-Dependent Kinase 12/CrkRS with Cyclin K1 Is Required for the Phosphorylation of the C-Terminal Domain of RNA Polymerase II

(2012) S.- W. G. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

A Universal RNA Polymerase II CTD Cycle Is Orchestrated by Complex Interplays between Kinase, Phosphatase, and Isomerase Enzymes along Genes

(2012) Alain R. Bataille et al.   MOLECULAR CELL

BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

(2012) B. N. Devaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTD Tyrosine Phosphorylation Impairs Termination Factor Recruitment to RNA Polymerase II

(2012) A. Mayer et al.   SCIENCE

Updating the RNA polymerase CTD code: adding gene-specific layers

(2012) Sylvain Egloff et al.   TRENDS IN GENETICS

Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition

(2012) Nadine Czudnochowski et al.   Nature Communications

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

Ser7 Phosphorylation of the CTD Recruits the RPAP2 Ser5 Phosphatase to snRNA Genes

(2011) Sylvain Egloff et al.   MOLECULAR CELL

Nascent transcript sequencing visualizes transcription at nucleotide resolution

(2011) L. Stirling Churchman et al.   NATURE

Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription

(2011) Andres Clemente-Blanco et al.   NATURE CELL BIOLOGY

The C-Terminal Domain of RNA Polymerase II Is Modified by Site-Specific Methylation

(2011) R. J. Sims et al.   SCIENCE

RNAP II CTD Phosphorylated on Threonine-4 Is Required for Histone mRNA 3' End Processing

(2011) J.-P. Hsin et al.   SCIENCE

A Gene-Specific Requirement of RNA Polymerase II CTD Phosphorylation for Sexual Differentiation in S. pombe

(2010) Damien Coudreuse et al.   CURRENT BIOLOGY

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

(2010) B. Bartkowiak et al.   GENES & DEVELOPMENT

P-TEFb Kinase Complex Phosphorylates Histone H1 to Regulate Expression of Cellular and HIV-1 Genes

(2010) Siobhan K. O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cis-Proline-mediated Ser(P)5Dephosphorylation by the RNA Polymerase II C-terminal Domain Phosphatase Ssu72

(2010) Jon W. Werner-Allen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene-specific RNA polymerase II phosphorylation and the CTD code

(2010) Hyunmin Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chemical-genomic dissection of the CTD code

(2010) Joshua R Tietjen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Uniform transitions of the general RNA polymerase II transcription complex

(2010) Andreas Mayer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of the Yeast Rpb1 C-terminal Domain at Serines 2, 5, and 7

(2009) Minkyu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II

(2009) K. Glover-Cutter et al.   MOLECULAR AND CELLULAR BIOLOGY

Rtr1 Is a CTD Phosphatase that Regulates RNA Polymerase II during the Transition from Serine 5 to Serine 2 Phosphorylation

(2009) Amber L. Mosley et al.   MOLECULAR CELL

TFIIH Kinase Places Bivalent Marks on the Carboxy-Terminal Domain of RNA Polymerase II

(2009) Md. Sohail Akhtar et al.   MOLECULAR CELL

The multi-tasking P-TEFb complex

(2008) Vanessa Brès et al.   CURRENT OPINION IN CELL BIOLOGY

The Nrd1–Nab3–Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain

(2008) Lidia Vasiljeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY