P-TEFb goes viral

The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription

(2015) Temesgen D. Fufa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription

(2015) Huasong Lu et al.   NUCLEIC ACIDS RESEARCH

Widespread disruption of host transcription termination in HSV-1 infection

(2015) Andrzej J. Rutkowski et al.   Nature Communications

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells

(2015) Leonard Chavez et al.   PLoS Pathogens

Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4

(2014) Jianyou Gu et al.   CELL CYCLE

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

(2014) Makoto Yamamoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Coupling mRNA processing with transcription in time and space

(2014) David L. Bentley   NATURE REVIEWS GENETICS

Herpes Simplex Virus 1 (HSV-1) ICP22 Protein Directly Interacts with Cyclin-Dependent Kinase (CDK)9 to Inhibit RNA Polymerase II Transcription Elongation

(2014) Justyna Zaborowska et al.   PLoS One

Recent developments in anti-herpesvirus drugs

(2013) H. J. Field et al.   BRITISH MEDICAL BULLETIN

Viral–Host Interactions That Control HIV-1 Transcriptional Elongation

(2013) Huasong Lu et al.   CHEMICAL REVIEWS

The RNA Polymerase II Carboxy-Terminal Domain (CTD) Code

(2013) Dirk Eick et al.   CHEMICAL REVIEWS

Roles of p53 in Herpes Simplex Virus 1 Replication

(2013) Y. Maruzuru et al.   JOURNAL OF VIROLOGY

Adenovirus L-E1A Activates Transcription through Mediator Complex-Dependent Recruitment of the Super Elongation Complex

(2013) S. Vijayalingam et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 ICP22 but Not US1.5 Is Required for Efficient Acute Replication in Mice and VICE Domain Formation

(2013) H. H. Mostafa et al.   JOURNAL OF VIROLOGY

The Cyclin-Dependent Kinase Ortholog pUL97 of Human Cytomegalovirus Interacts with Cyclins

(2013) Laura Graf et al.   Viruses-Basel

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

Neonatal Herpes Simplex Virus Infection

(2012) THOMAS L. CHERPES et al.   CLINICAL OBSTETRICS AND GYNECOLOGY

Negative Elongation Factor-Mediated Suppression of RNA Polymerase II Elongation of Kaposi's Sarcoma-Associated Herpesvirus Lytic Gene Expression

(2012) Zsolt Toth et al.   JOURNAL OF VIROLOGY

HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold

(2012) S. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Updating the RNA polymerase CTD code: adding gene-specific layers

(2012) Sylvain Egloff et al.   TRENDS IN GENETICS

Ser-634 and Ser-636 of Kaposi’s Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites

(2012) Wan-Hua Tsai et al.   Frontiers in Microbiology

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children

(2011) Yi Wang et al.   JOURNAL OF CLINICAL VIROLOGY

Recruitment of cyclin-dependent kinase 9 to nuclear compartments during cytomegalovirus late replication: importance of an interaction between viral pUL69 and cyclin T1

(2011) S. Feichtinger et al.   JOURNAL OF GENERAL VIROLOGY

RNA Polymerase II Stalling Promotes Nucleosome Occlusion and pTEFb Recruitment to Drive Immortalization by Epstein-Barr Virus

(2011) Richard D. Palermo et al.   PLoS Pathogens

Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8)

(2010) Li-li Li et al.   CELLULAR MICROBIOLOGY

Differential Proteomics Based on18O Labeling to Determine the Cyclin Dependent Kinase 9 Interactome

(2010) Karel Bezstarosti et al.   JOURNAL OF PROTEOME RESEARCH

Human T-Lymphotropic Virus Type 1 Tax Protein Complexes with P-TEFb and Competes for Brd4 and 7SK snRNP/HEXIM1 Binding

(2010) W.-K. Cho et al.   JOURNAL OF VIROLOGY

Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cellular RNA Polymerase II

(2010) J. Zhang et al.   JOURNAL OF VIROLOGY

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

(2010) Nanhai He et al.   MOLECULAR CELL

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

(2010) Chengqi Lin et al.   MOLECULAR CELL

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

Pharmacodynamic Effects of Seliciclib, an Orally Administered Cell Cycle Modulator, in Undifferentiated Nasopharyngeal Cancer

(2009) W.-S. Hsieh et al.   CLINICAL CANCER RESEARCH

Cyclin-dependent Kinases Phosphorylate the Cytomegalovirus RNA Export Protein pUL69 and Modulate Its Nuclear Localization and Activity

(2009) Sabine Rechter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of cdk9 to the Immediate-Early Viral Transcriptosomes during Human Cytomegalovirus Infection Requires Efficient Binding to Cyclin T1, a Threshold Level of IE2 86, and Active Transcription

(2009) A. J. Kapasi et al.   JOURNAL OF VIROLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

(2009) M. Barboric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of transcription by the Epstein–Barr virus nuclear antigen EBNA 2

(2008) Richard D. Palermo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes

(2008) Andreas Markert et al.   EMBO REPORTS

Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop

(2008) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of cdk9 in the Optimization of Expression of the Genes Regulated by ICP22 of Herpes Simplex Virus 1

(2008) L. O. Durand et al.   JOURNAL OF VIROLOGY

Cracking the RNA polymerase II CTD code

(2008) Sylvain Egloff et al.   TRENDS IN GENETICS

CDK inhibitors in cancer therapy: what is next?

(2007) Marcos Malumbres et al.   TRENDS IN PHARMACOLOGICAL SCIENCES