Journal
RNA BIOLOGY
Volume 13, Issue 6, Pages 545-553Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2016.1181254
Keywords
KAP1/TRIM28; P-TEFb; RNA polymerase II; 7SK snRNP; transcription elongation
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Funding
- National Institute of Allergy and Infectious Diseases (NIAID) of the NIH [R01AI114362]
- Welch Foundation [I-1782]
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RNA polymerase II (Pol II) pausing at promoter-proximal regions is a highly regulated step in the transcription cycle. Pause release is facilitated by the P-TEFb kinase, which phosphorylates Pol II and negative elongation factors. Recent studies suggest that P-TEFb (as part of the inhibitory 7SK snRNP) is recruited to promoter-proximal regions through interaction with KAP1/TRIM28/TIF1 beta to facilitate 'on-site' kinase activation and transcription elongation. Here, I discuss features of this model and future challenges to further hone our understanding of transcriptional regulation including Pol II pausing and pause release.
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