The past, present, and future of breast cancer models for nanomedicine development

Breast tumor-on-chip models: From disease modeling to personalized drug screening

(2021) Bano Subia et al.   JOURNAL OF CONTROLLED RELEASE

Cancer‐on‐a‐Chip for Modeling Immune Checkpoint Inhibitor and Tumor Interactions

(2021) Xing Jiang et al.   Small

Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury

(2021) Sandra Tejedor et al.   Advanced Healthcare Materials

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Genetically Engineered Pigs to Study Cancer

(2020) Daniela Kalla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Orthotopic Implantation Achieves Better Engraftment and Faster Growth Than Subcutaneous Implantation in Breast Cancer Patient-Derived Xenografts

(2020) Maiko Okano et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The entry of nanoparticles into solid tumours

(2020) Shrey Sindhwani et al.   NATURE MATERIALS

Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

(2020) Kuan-Wei Huang et al.   Science Advances

Nanomedicine and cancer immunotherapy

(2020) Hai-jun Yu et al.   ACTA PHARMACOLOGICA SINICA

Best Practices for Preclinical In Vivo Testing of Cancer Nanomedicines

(2020) Danielle M. Valcourt et al.   Advanced Healthcare Materials

Challenges in nanomedicine clinical translation

(2020) Josbert M. Metselaar et al.   Drug Delivery and Translational Research

Nanoparticle interactions with immune cells dominate tumor retention and induce T cell–mediated tumor suppression in models of breast cancer

(2020) Preethi Korangath et al.   Science Advances

Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment

(2020) Jin Li et al.   Acta Pharmaceutica Sinica B

Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer

(2020) Mark Gray et al.   Frontiers in Oncology

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

(2020) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Translational considerations in nanomedicine: The oncology perspective

(2020) Alberto A. Gabizon et al.   ADVANCED DRUG DELIVERY REVIEWS

Mouse Tumor Models for Advanced Cancer Immunotherapy

(2020) Daria S. Chulpanova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ag/Au Bimetallic Nanoparticles Inhibit Tumor Growth and Prevent Metastasis in a Mouse Model

(2020) Hector Katifelis et al.   International Journal of Nanomedicine

Engineering peptide-targeted liposomal nanoparticles optimized for improved selectivity for HER2-positive breast cancer cells to achieve enhanced in vivo efficacy

(2020) Baksun Kim et al.   JOURNAL OF CONTROLLED RELEASE

The importance of spheroids in analyzing nanomedicine efficacy

(2020) Inês Mó et al.   Nanomedicine

A phase I dose-escalation and pharmacokinetic study of a micellar nanoparticle with entrapped docetaxel (CPC634) in patients with advanced solid tumours

(2020) Florence Atrafi et al.   JOURNAL OF CONTROLLED RELEASE

Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases

(2020) Masayuki Fujii et al.   NATURE MATERIALS

Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis

(2020) Lea Monteran et al.   Scientific Reports

Zebrafish as a preclinical in vivo screening model for nanomedicines

(2019) Sandro Sieber et al.   ADVANCED DRUG DELIVERY REVIEWS

Therapeutic impact of Nintedanib with paclitaxel and/or a PD-L1 antibody in preclinical models of orthotopic primary or metastatic triple negative breast cancer

(2019) Elaine Reguera-Nuñez et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis

(2019) Peng Guo et al.   Science Advances

Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness

(2019) Fei Peng et al.   Nature Nanotechnology

Clinical cancer nanomedicine

(2019) Joy Wolfram et al.   Nano Today

A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9-mediated somatic recombination

(2019) Noboru Ideno et al.   LABORATORY INVESTIGATION

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Characterization of Triple-Negative Breast Cancer Preclinical Models Provides Functional Evidence of Metastatic Progression

(2019) Juan J. Arroyo-Crespo et al.   INTERNATIONAL JOURNAL OF CANCER

Establishment and characterization of a patient-derived circulating lung tumor cell line in vitro and in vivo

(2019) Zujun Que et al.   Cancer Cell International

Combining Nanomedicine and Immunotherapy

(2019) Yang Shi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

(2019) Nathan D. Donahue et al.   ADVANCED DRUG DELIVERY REVIEWS

Intraductal Adaptation of the 4T1 Mouse Model of Breast Cancer Reveals Effects of the Epithelial Microenvironment on Tumor Progression and Metastasis

(2019) HUDA I. ATIYA et al.   ANTICANCER RESEARCH

Nanomedicines for Reactive Oxygen Species Mediated Approach: An Emerging Paradigm for Cancer Treatment

(2019) Seunglee Kwon et al.   ACCOUNTS OF CHEMICAL RESEARCH

The role of mouse tumour models in the discovery and development of anticancer drugs

(2019) Christopher R. Ireson et al.   BRITISH JOURNAL OF CANCER

Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S

(2019) Yaping Li et al.   International Journal of Nanomedicine

Alendronate-Modified Polymeric Micelles for the Treatment of Breast Cancer Bone Metastasis

(2019) Tong Liu et al.   MOLECULAR PHARMACEUTICS

Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and Cats

(2019) Moustafa R. K. Ali et al.   Cancers

Patient-Derived Xenograft Models of Breast Cancer and Their Application

(2019) Murayama et al.   Cells

Human Organoids: Tools for Understanding Biology and Treating Diseases

(2019) Frans Schutgens et al.   Annual Review of Pathology-Mechanisms of Disease

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge

(2019) Nedeljković et al.   Cells

Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial

(2019) Peter Schmid et al.   LANCET ONCOLOGY

Smart cancer nanomedicine

(2019) Roy van der Meel et al.   Nature Nanotechnology

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

(2019) Vaishali Aggarwal et al.   Biomolecules

Could 3D models of cancer enhance drug screening?

(2019) Virginia Brancato et al.   BIOMATERIALS

Grand challenges in nanomedicine

(2019) Lin-Ping Wu et al.   Materials Science & Engineering C-Materials for Biological Applications

T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression

(2018) Dana A. M. Mustafa et al.   ACTA NEUROPATHOLOGICA

Tumor targeting via EPR: Strategies to enhance patient responses

(2018) Susanne K. Golombek et al.   ADVANCED DRUG DELIVERY REVIEWS

Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid-Based Combination-Drug Conjugate

(2018) Juan J. Arroyo-Crespo et al.   ADVANCED FUNCTIONAL MATERIALS

A novel 3D breast-cancer-on-chip platform for therapeutic evaluation of drug delivery systems

(2018) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Humanized Mice as Unique Tools for Human-Specific Studies

(2018) Kylie Su Mei Yong et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer

(2018) Jasmine Miller-Kleinhenz et al.   BIOMATERIALS

Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins

(2018) Carrie J. Lovitt et al.   BMC CANCER

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Genetically engineered pigs as models for human disease

(2018) Carolin Perleberg et al.   Disease Models & Mechanisms

The theranostic efficiency of tumor-specific, pH-responsive, peptide-modified, liposome-containing paclitaxel and superparamagnetic iron oxide nanoparticles

(2018) Xiu-Chai Zheng et al.   International Journal of Nanomedicine

Co-delivery nanoparticle to overcome metastasis promoted by insufficient chemotherapy

(2018) Qing Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle transport pathways into tumors

(2018) S. M. Moghimi et al.   JOURNAL OF NANOPARTICLE RESEARCH

Translational gaps in animal models of human infusion reactions to nanomedicines

(2018) S Moein Moghimi et al.   Nanomedicine

Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles

(2018) Hongxu Lu et al.   Small

Zebrafish ( Danio rerio ) model as an early stage screening tool to study the biodistribution and toxicity profile of doxorubicin-loaded mixed micelles

(2018) María Natalia Calienni et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy

(2018) Shantanu Pradhan et al.   Scientific Reports

Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment

(2018) Juan J. Arroyo-Crespo et al.   BIOMATERIALS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Folate-receptor-targeted laser-activable poly(lactide-co-glycolic acid) nanoparticles loaded with paclitaxel/indocyanine green for photoacoustic/ultrasound imaging and chemo/photothermal therapy

(2018) Fengqiu Liu et al.   International Journal of Nanomedicine

Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery

(2018) Thinzar M Lwin et al.   JOURNAL OF SURGICAL ONCOLOGY

Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

(2018) Zhenzhen Wang et al.   Nature Communications

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

(2018) Ana S. Nunes et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention

(2018) Lewis A. Quayle et al.   CLINICAL & EXPERIMENTAL METASTASIS

Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions

(2018) Maryse Fiche et al.   JOURNAL OF PATHOLOGY

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

(2018) Parisa Foroozandeh et al.   Nanoscale Research Letters

Roadmap and strategy for overcoming infusion reactions to nanomedicines

(2018) Janos Szebeni et al.   Nature Nanotechnology

Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer

(2018) Gunter von Minckwitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mouse Models for Cancer Immunotherapy Research

(2018) Brian Olson et al.   Cancer Discovery

Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models

(2018) Xia Liu et al.   Cancer Discovery

3D Bioprinting of Breast Cancer Models for Drug Resistance Study

(2018) Ying Wang et al.   ACS Biomaterials-Science & Engineering

Atezolizumab Plus nab-Paclitaxel in the Treatment of Metastatic Triple-Negative Breast Cancer With 2-Year Survival Follow-up

(2018) Sylvia Adams et al.   JAMA Oncology

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

(2018) John P. A. Ioannidis et al.   Nature Biomedical Engineering

Risk Factors and Preventions of Breast Cancer

(2017) Yi-Sheng Sun et al.   International Journal of Biological Sciences

Nanomedicine applications in the treatment of breast cancer: current state of the art

(2017) Di Wu et al.   International Journal of Nanomedicine

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

(2017) Jing Zhang et al.   International Journal of Nanomedicine

Preclinical development of drug delivery systems for paclitaxel-based cancer chemotherapy

(2017) Feihu Wang et al.   JOURNAL OF CONTROLLED RELEASE

Advances in multicellular spheroids formation

(2017) X. Cui et al.   Journal of the Royal Society Interface

Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial

(2017) Véronique Diéras et al.   LANCET ONCOLOGY

Profiling the relationship between tumor-associated macrophages and pharmacokinetics of liposomal agents in preclinical murine models

(2017) Andrew T. Lucas et al.   Nanomedicine-Nanotechnology Biology and Medicine

Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines

(2017) Gianpiero Lazzari et al.   Polymer Chemistry

In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles

(2017) Altug Ozcelikkale et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Inbred or Outbred? Genetic Diversity in Laboratory Rodent Colonies

(2017) Thomas D. Brekke et al.   G3-Genes Genomes Genetics

Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping

(2017) Xiaofeng Dai et al.   Journal of Cancer

Nanoparticle Interactions with the Immune System: Clinical Implications for Liposome-Based Cancer Chemotherapy

(2017) Ninh M. La-Beck et al.   Frontiers in Immunology

The acidic tumor microenvironment: a target for smart cancer nano-theranostics

(2017) Liangzhu Feng et al.   National Science Review

A novel nanopolymer based tumor targeted delivery system for paclitaxel

(2017) A. T. Singh et al.   JOURNAL OF CLINICAL ONCOLOGY

PD-L1 Detection in Tumors Using [64Cu]Atezolizumab with PET

(2016) Wojciech G. Lesniak et al.   BIOCONJUGATE CHEMISTRY

Investigating the effect of tumor vascularization on magnetic targeting in vivo using retrospective design of experiment

(2016) Kuo-Ching Mei et al.   BIOMATERIALS

SWOG S0800 (NCI CDR0000636131): addition of bevacizumab to neoadjuvant nab-paclitaxel with dose-dense doxorubicin and cyclophosphamide improves pathologic complete response (pCR) rates in inflammatory or locally advanced breast cancer

(2016) Z. A. Nahleh et al.   BREAST CANCER RESEARCH AND TREATMENT

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

(2016) Lacey E. Dobrolecki et al.   CANCER AND METASTASIS REVIEWS

A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response

(2016) George Sflomos et al.   CANCER CELL

Relevant Physicochemical Descriptors of “Soft Nanomedicines” to Bypass Biological Barriers

(2016) Amaya Nino-Pariente et al.   CURRENT PHARMACEUTICAL DESIGN

Genetically engineered mouse models in oncology research and cancer medicine

(2016) Kelly Kersten et al.   EMBO Molecular Medicine

Nanoparticles for imaging and treatment of metastatic breast cancer

(2016) Qingxin Mu et al.   Expert Opinion on Drug Delivery

Treatment of natural mammary gland tumors in canines and felines using gold nanorods-assisted plasmonic photothermal therapy to induce tumor apoptosis

(2016) Mostafa A. El-Sayed et al.   International Journal of Nanomedicine

Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis

(2016) Rachel Eyre et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Common swine models of cardiovascular disease for research and training

(2016) Verónica Crisóstomo et al.   LAB ANIMAL

The cell fate: senescence or quiescence

(2016) Menderes Yusuf Terzi et al.   MOLECULAR BIOLOGY REPORTS

Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review

(2016) Giovana Calixto et al.   MOLECULES

Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer

(2016) Charles J. Bowerman et al.   NANO LETTERS

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

(2016) Saeid Zanganeh et al.   Nature Nanotechnology

Pigs as models of human cancers

(2016) Tatiana Flisikowska et al.   THERIOGENOLOGY

Current understanding of interactions between nanoparticles and the immune system

(2016) Marina A. Dobrovolskaia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dogs as a Model for Cancer

(2016) Heather L. Gardner et al.   Annual Review of Animal Biosciences

Engineered Swine Models of Cancer

(2016) Adrienne L. Watson et al.   Frontiers in Genetics

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Canine cancer immunotherapy studies: linking mouse and human

(2016) Jiwon S. Park et al.   Journal for ImmunoTherapy of Cancer

NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice

(2016) Madhavi Puchalapalli et al.   PLoS One

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

(2015) Hiroshi Maeda   ADVANCED DRUG DELIVERY REVIEWS

Complete regression of breast tumour with a single dose of docetaxel-entrapped core-cross-linked polymeric micelles

(2015) Qizhi Hu et al.   BIOMATERIALS

Recommendations for Benchmarking Preclinical Studies of Nanomedicines

(2015) C. M. Dawidczyk et al.   CANCER RESEARCH

A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs

(2015) C. Khanna et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Nanomedicine of anastrozole for breast cancer: Physicochemical evaluation, in vitro cytotoxicity on BT-549 and MCF-7 cell lines and preclinical study on rat model

(2015) Gopal Venkatesh Shavi et al.   LIFE SCIENCES

Pharmacologic Sensitivity of Paclitaxel to Its Delivery Vehicles Drives Distinct Clinical Outcomes of Paclitaxel Formulations

(2015) Yan Li et al.   MOLECULAR PHARMACEUTICS

3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation

(2015) Pallavi Sethi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Role of the Tumor Microenvironment in Breast Cancer

(2015) Savas D. Soysal et al.   PATHOBIOLOGY

Alternatives to animal testing: A review

(2015) Sonali K. Doke et al.   SAUDI PHARMACEUTICAL JOURNAL

A bladder cancer microenvironment simulation system based on a microfluidic co-culture model

(2015) Peng-fei Liu et al.   Oncotarget

A porcine model system of BRCA1 driven breast cancer

(2015) Howard Donninger et al.   Frontiers in Genetics

Dissecting the Molecular Mechanism of Apoptosis during Photothermal Therapy Using Gold Nanoprisms

(2014) Marta Pérez-Hernández et al.   ACS Nano

Drug discovery through stem cell-based organoid models

(2014) Adrian Ranga et al.   ADVANCED DRUG DELIVERY REVIEWS

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Nanoparticle toxicity assessment using an in vitro 3-D kidney organoid culture model

(2014) Anna I. Astashkina et al.   BIOMATERIALS

Effects of Tumor Microenvironment Heterogeneity on Nanoparticle Disposition and Efficacy in Breast Cancer Tumor Models

(2014) G. Song et al.   CLINICAL CANCER RESEARCH

Naturally Occurring Cancers in Dogs: Insights for Translational Genetics and Medicine

(2014) C. E. Alvarez   ILAR JOURNAL

State-of-the-art in design rules for drug delivery platforms: Lessons learned from FDA-approved nanomedicines

(2014) Charlene M. Dawidczyk et al.   JOURNAL OF CONTROLLED RELEASE

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

(2014) Sutapa Barua et al.   Nano Today

Animal models and therapeutic molecular targets of cancer: utility and limitations

(2014) Maria Cekanova et al.   Drug Design Development and Therapy

PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast Cancer

(2014) H. Wimberly et al.   Cancer Immunology Research

PD-L1 Expression in Triple-Negative Breast Cancer

(2014) E. A. Mittendorf et al.   Cancer Immunology Research

Assessment of Juvenile Pigs to Serve as Human Pediatric Surrogates for Preclinical Formulation Pharmacokinetic Testing

(2013) Wyatt J. Roth et al.   AAPS Journal

Nanomedicine therapeutic approaches to overcome cancer drug resistance

(2013) Janet L. Markman et al.   ADVANCED DRUG DELIVERY REVIEWS

Change in the microenvironment of breast cancer studied by FTIR imaging

(2013) S. Kumar et al.   ANALYST

Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response

(2013) Michel DuPage et al.   CURRENT OPINION IN IMMUNOLOGY

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

(2013) Stephen W. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Biodegradable polymeric micelle-encapsulated quercetin suppresses tumor growth and metastasis in both transgenic zebrafish and mouse models

(2013) Qinjie Wu et al.   Nanoscale

Tumour heterogeneity in the clinic

(2013) Philippe L. Bedard et al.   NATURE

Pharmacokinetics and Efficacy of PEGylated Liposomal Doxorubicin in an Intracranial Model of Breast Cancer

(2013) Carey K. Anders et al.   PLoS One

Evaluation of Nanoparticle Uptake in Co-culture Cancer Models

(2013) Elisabete C. Costa et al.   PLoS One

Blood vessel hyperpermeability and pathophysiology in human tumour xenograft models of breast cancer: a comparison of ectopic and orthotopic tumours

(2012) Karyn S Ho et al.   BMC CANCER

Liposomal paclitaxel formulations

(2012) Štěpán Koudelka et al.   JOURNAL OF CONTROLLED RELEASE

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zebrafish Models for Human Cancer

(2012) H. R. Shive   VETERINARY PATHOLOGY

VIP-targeted cytotoxic nanomedicine for breast cancer

(2012) Aparna Dagar et al.   Drug Delivery and Translational Research

A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer

(2011) Joaquim Calbo et al.   CANCER CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Adverse drug reaction profile of nanoparticle versus conventional formulation of paclitaxel: An observational study

(2011) Avijit Hazra et al.   INDIAN JOURNAL OF PHARMACOLOGY

Nanotherapeutics in angiogenesis: synthesis and in vivo assessment of drug efficacy and biocompatibility in zebrafish embryos

(2011) Jinping Cheng et al.   International Journal of Nanomedicine

Nanomedicine(s) under the Microscope

(2011) Ruth Duncan et al.   MOLECULAR PHARMACEUTICS

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

Dog models of naturally occurring cancer

(2011) Jennie L. Rowell et al.   TRENDS IN MOLECULAR MEDICINE

Pulsed Ultrasound Enhances Nanoparticle Penetration into Breast Cancer Spheroids

(2010) Stephanie J. Grainger et al.   MOLECULAR PHARMACEUTICS

Targeting nanoparticles to cancer

(2010) M. Wang et al.   PHARMACOLOGICAL RESEARCH

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

(2010) C.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase I pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol®-PM) in patients with solid tumors

(2009) W. T. Lim et al.   ANNALS OF ONCOLOGY

Effects of Branching Architecture and Linker on the Activity of Hyperbranched Polymer−Drug Conjugates

(2009) Omathanu Perumal et al.   BIOCONJUGATE CHEMISTRY

A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer

(2009) Theresa A. DiMeo et al.   CANCER RESEARCH

Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer

(2009) Seymour   INTERNATIONAL JOURNAL OF ONCOLOGY

N-methylnitrosourea Induced Breast Cancer in Rat, the Histopathology of the Resulting Tumours and its Drawbacks as a Model

(2009) M. Perše et al.   PATHOLOGY & ONCOLOGY RESEARCH

A clinical study on the premedication of paclitaxel liposome in the treatment of solid tumors

(2008) Qian Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Randomized Crossover Pharmacokinetic Study of Solvent-Based Paclitaxel and nab-Paclitaxel

(2008) E. R. Gardner et al.   CLINICAL CANCER RESEARCH

Implications of the Cancer Stem-Cell Hypothesis for Breast Cancer Prevention and Therapy

(2008) Madhuri Kakarala et al.   JOURNAL OF CLINICAL ONCOLOGY