Article
Chemistry, Multidisciplinary
Yu Zhang, Sheng Ma, Xinming Liu, Yudi Xu, Jiayu Zhao, Xinghui Si, Hongxiang Li, Zichao Huang, Zhenxin Wang, Zhaohui Tang, Wantong Song, Xuesi Chen
Summary: A programmable immune activation nanomedicine (PIAN) is reported in this study, which sequentially finishes multiple steps after intravenous injection and elicits robust antitumor immunity in situ. This innovative approach provides a new framework for designing programmable nanomedicine as an in situ cancer vaccine for cancer immunotherapy.
ADVANCED MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Yushu Wang, Bin Wang, Kao Li, Maosheng Wang, Haihua Xiao
Summary: The review summarizes the current state-of-art metallic nanomedicine for enhancing the efficacy of cancer immunotherapy. It points out that metal-based nanomedicine can reverse immune suppression, but there are still obstacles and challenges to be overcome.
MATERIALS TODAY ADVANCES
(2022)
Review
Chemistry, Multidisciplinary
Zerong Pei, Shuting Chen, Liqin Ding, Jingbo Liu, Xinyi Cui, Fengyun Li, Feng Qiu
Summary: This review analyzes the development trend, main authors, and research hotspots of nanomedicine in the field of cancer, revealing that despite China having more publications than the United States, the United States still dominates this field. Moreover, the study identifies cancer nanomedicine, tumor microenvironment, nanoparticles, prodrug, targeted nanomedicine, combination, and cancer immunotherapy as the current research hotspots.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Physical
Zhongyuan Guo, Audrey T. Zhu, Ronnie H. Fang, Liangfang Zhang
Summary: Phototherapy is a promising cancer treatment approach that utilizes light irradiation to induce local hyperthermia and reactive oxygen species production for eradicating cancer cells. Nanoparticles, with their small size and tunable properties, have been widely used as carriers to enhance the biocompatibility and tumor-targeted delivery of phototherapeutic agents. Recent developments have focused on using nanoparticle-based phototherapy to achieve durable and systemic antitumor responses through immune modulation.
Article
Chemistry, Multidisciplinary
Haijing Qu, Longmeng Li, Han Chen, Menghuan Tang, Wei Cheng, Tzu-yin Lin, Lingyan Li, Bin Li, Xiangdong Xue
Summary: In this study, researchers developed nanoparticles with strong photo/immune therapeutic effects by integrating a photosensitizer and a Toll-like receptor 7/8 agonist. These nanoparticles can directly inhibit tumor growth, promote the immune response, and reverse the suppressive tumor immune microenvironment. They have the potential to enhance the effectiveness of immunotherapy and phototherapy in cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Jing Liu, Si Si Liew, Jun Wang, Kanyi Pu
Summary: Cancer vaccines aim to stimulate tumor-specific immune responses while sparing normal tissues, with bioinspired materials and technologies playing a role in reshaping the field of cancer nanomedicine. By mimicking desirable properties in nature, bioinspired engineering of cancer vaccine delivery platforms can enhance therapeutic efficacy and safety profiles for clinical translation.
ADVANCED MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Shanshan Hou, Muhammad Hasnat, Ziwei Chen, Yinong Liu, Mirza Muhammad Faran Ashraf Baig, Fuhe Liu, Zelong Chen
Summary: This article outlines the applications of nanomedicine in cancer treatment, focusing on chemotherapy, gene therapy, and immunotherapy. Addressing common problems in these treatment modalities, the article discusses how nanomedicine can be combined with them, provides typical examples, and summarizes the advantages brought by the application of nanomedicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Yunfei Yi, Mian Yu, Wen Li, Dunwan Zhu, Lin Mei, Meitong Ou
Summary: The development of therapeutic cancer vaccines using nanotechnology has great potential in improving the limitations of current immunotherapies. Nanoparticles enhance vaccine stability and antigen recognition through their small size, while surface modifications allow targeted delivery. Nanocarriers with adjuvant effect also improve vaccine efficacy. Additionally, nanoparticle-mediated chemotherapy and radiotherapy induce the release of tumor antigens, simulating anti-tumor immune responses. These vaccine-like nanomedicines can effectively eliminate tumors and prevent recurrence and metastasis. This article presents recent advancements in nanoparticle-based antigen delivery for in situ anti-tumor vaccination and discusses the remaining opportunities and challenges for clinical translation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Instruments & Instrumentation
Isra Rana, Jaeeun Oh, Juwon Baig, Jeong Hyun Moon, Sejin Son, Jutaek Nam
Summary: The immune system can target and kill cancer cells, and nanocarriers offer a promising approach to enhance cancer immunotherapy by boosting immune activity and improving drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Mohammad Doroudian, Saba Zanganeh, Elham Abbasgholinejad, Seamas C. Donnelly
Summary: Lung cancer is a leading cause of cancer death globally. Nanoparticles have great potential and challenges in lung cancer immunotherapy, as they can precisely target and regulate immune responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Haiqin Liao, Chengcheng Niu
Summary: This article introduces the mechanisms by which cancer evades immunological surveillance and the CD47-SIRPα signaling pathway, as well as the applications of nanocarriers developed for this signaling pathway in anticancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Shreyas Mukherjee, Samrat Mukherjee, Mohammed A. S. Abourehab, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Dendrimers, as a novel drug delivery system, play an important role in cancer immunotherapy. They have various properties and functions, forming high-specificity bonds with different functional groups. However, the increasing toxicity of newer generations of dendrimers can be mitigated through the attachment of anionic or neutral ligand groups.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Engineering, Biomedical
Qiaofeng Li, Yu Chao, Bo Liu, Zhisheng Xiao, Zhijuan Yang, Yuzhe Wu, Zhuang Liu
Summary: This study developed pH-responsive lipid-coated calcium phosphate nanoparticles (LCP NPs) that co-loaded with disulfiram (DSF) and copper ions (Cu2+). The nanoparticles selectively accumulated in tumors and released DSF and Cu2+ in the acidic tumor microenvironment, inducing cytotoxicity and immunogenic cell death (ICD) of cancer cells. These findings demonstrate the potential of repurposing DSF as a new ICD inducer for improved tumor-responsive therapy and enhanced immune checkpoint blockade (ICB) therapy.
Article
Nanoscience & Nanotechnology
Shuxin Xu, Zikuan Gu, Haifeng Lu, Peixin Guan, Zhen Liu
Summary: By integrating molecular imprinting and nanotechnology, a novel nanocoordinator was designed and engineered for targeted remolding of tumor-associated macrophages (TAMs) to fully leverage the antitumor efficacy of macrophages by inducing a cascade effect. This study offers new TAM-targeted therapeutics that allow us to fully utilize the antitumor immune functions of macrophages without affecting normal tissues.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Yijing Zhang, Jingchao Li, Kanyi Pu
Summary: Nanomedicines with stimuli-responsive capabilities have shown potential in cancer treatment. However, traditional nanomedicines often cause severe side effects due to unintended drug retention in non-diseased tissues. Dual-and multi-responsive nanomedicines, which integrate different responsive components, provide a safer and more effective drug release mechanism, leading to improved therapeutic efficacy and reduced toxicity. This article summarizes recent advances in precision cancer therapy using dual-and multi-responsive nanomedicines and discusses their design strategies, working mechanisms, and applications in chemotherapy, phototherapy, and immunotherapy.
Article
Multidisciplinary Sciences
Leonard Kaps, Anne Huppertsberg, Niklas Choteschovsky, Adrian Klefenz, Feyza Durak, Babara Schroers, Mustafa Diken, Emma Eichler, Sebastian Rosigkeit, Sascha Schmitt, Christian Leps, Alicia Schulze, Friedrich Foerster, Ernesto Bockamp, Bruno G. De Geest, Kaloian Koynov, Hans-Joachim Raeder, Stefan Tenzer, Federico Marini, Detlef Schuppan, Lutz Nuhn
Summary: In this study, liver fibrosis progression was prevented by repolarizing M2-type macrophages towards a non-fibrotic phenotype using a pH-degradable nanogel carrier system. The nanogels efficiently delivered the drug alendronate to nonparenchymal cells of fibrotic livers, reprogramming profibrotic M2 into antifibrotic M1 macrophages and preventing liver fibrosis progression. This approach has potential implications for the treatment of diseases driven by M2-type macrophages, including cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Biomedical
Yutong Liu, Hui Li, Huajun Zhao, Yanyun Hao, Simon Van Herck, Zejun Xu, Guan Wang, Xiao Wang, Xinke Zhang, Xiaoyan Ge, Xia Li, Ailu Yang, Hongfei Chen, Jing Zou, Wentao Wang, Bruno G. De Geest, Zhiyue Zhang
Summary: This study reports a novel nanocomplex that can induce tumor antigen production, promote maturation of dendritic cells, and expansion of T cells through intratumoral injection and laser irradiation, showing potential for tumor suppression and therapeutic application in pre-operative and post-operative settings.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Yanyun Hao, Hui Li, Huajun Zhao, Yutong Liu, Xiaoyan Ge, Xia Li, Hongfei Chen, Ailu Yang, Jing Zou, Xue Li, Xuechun Sun, Xinke Zhang, Xiao Wang, Zepeng Li, Qilu Zhang, Hao Wu, Guan Wang, Jian Zhang, Bruno G. De Geest, Zhiyue Zhang
Summary: Intelligent nanovehicles accurately deliver drugs to tumor cells and dendritic cells, reducing tumor burden through immunogenic cell death and generating long-term immune protection.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Christian Czysch, Carolina Medina-Montano, Zifu Zhong, Alexander Fuchs, Judith Stickdorn, Pia Winterwerber, Sascha Schmitt, Kim Deswarte, Marco Raabe, Maximilian Scherger, Francis Combes, Jana De Vrieze, Sabah Kasmi, Niek N. Sandners, Stefan Lienenklaus, Kaloian Koynov, Hans-Joachim Raeder, Bart N. Lambrecht, Sunil A. David, Matthias Bros, Hansjorg Schild, Stephan Grabbe, Bruno G. De Geest, Lutz Nuhn
Summary: The development of controlled biodegradable materials is crucial for immunodrug delivery to achieve spatiotemporally controlled immune stimulation in lymph nodes. Polycarbonate nanogels, as degradable micellar carriers, have been developed to conjugate an immune agonist for immune cell control.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ting Wu, Tianqun Lang, Chao Zheng, Wenlu Yan, Yu Li, Runqi Zhu, Xin Huang, Huae Xu, Yaping Li, Qi Yin
Summary: In this study, a nanoparticle HDC-DM was prepared by coating red blood cell membrane onto a hybrid micelle consisting of prodrugs and an anti-metastasis agent. The combination of phototherapy, chemotherapy, and anti-metastatic therapy using HDC-DM showed promising results in treating TNBC, increasing drug concentration in tumors and promoting drug penetration and immunogenic cell death.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yun Zhu, Shunan Zhang, Yi Lai, Jiaxing Pan, Fangmin Chen, Tingting Wang, Fengyang Wang, Zhiai Xu, Wenjun Yang, Haijun Yu
Summary: This study presents a self-cooperative prodrug nanovesicle for highly tumor-specific chemoradiotherapy, which can target tumors efficiently and overcome immune evasion mechanisms.
Article
Chemistry, Physical
Yingjie Wang, Fangmin Chen, Huiling Zhou, Lujia Huang, Jiayi Ye, Xiaoying Liu, Weizhong Sheng, Weidong Gao, Haijun Yu, Feng Wang
Summary: This study reveals that a combination therapy of dihydroartemisinin (DHA) and RSL-3 can induce ferroptosis of pancreatic ductal adenocarcinoma (PDAC) tumor cells. Nanoparticles that can deliver DHA and RSL-3 are synthesized and shown to inhibit tumor growth effectively in mouse models. This study provides novel insights for the treatment of PDAC with ferroptosis-based immunotherapy.
Article
Engineering, Biomedical
Weiqi Wang, Qiwen Zhu, Yilan Jin, Jing Gao, Jianan Li, Xiaohua Zheng, Weidong Gao, Madiha Saeed, Weizhong Sheng, Haijun Yu
Summary: This study reports a self-immolated nanoadjuvant that enhances the effectiveness of cancer vaccination immunotherapy. The nanoadjuvants accumulate at the tumor site and release immune activators and photosensitizers in a specific manner. By activating immune cells and inducing immunogenic cell death of tumor cells, this nanoadjuvant effectively inhibits tumor growth and generates sustained immunological memory in a mouse model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Meike N. Leiske, Bruno G. De Geest, Richard Hoogenboom
Summary: Zwitterionic polymers interact with cells and exhibit cancer cell specificity. The polymer backbone chemistry plays a significant role in the cellular specificity of amino-acid-derived polyzwitterions. Differences in cellular association and specificity were observed among the different polymer backbones, highlighting the importance of the polymer backbone design for cell-specific polymers.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jiaxing Pan, Yi Lai, Shunan Zhang, Huijuan Zhang, Yiming Shan, Lujia Huang, Feng Wang, Haijun Yu, Leiming Xu, Zhiai Xu
Summary: The weak response of pancreatic cancer patients to immunotherapy is attributed to cancer-associated fibroblast-induced fibrosis and tumor cell-mediated T-cell exhaustion. A self-adaptive nanoregulator has been developed to intervene in tumor fibrosis and reverse T-cell exhaustion, providing a novel approach to enhance PDAC immunotherapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
S. Saravanan, Anashwara Babu, Ronald Merckx, Zifu Zhong, Mageshwari Anandan, Venkatramaiah Nutalapati, Bruno G. De Geest, Richard Hoogenboom, Valentin Victor Jerca, Samarendra Maji
Summary: Temperature is a crucial parameter in various applications, and it has significant effects on cellular activity and molecular processes. However, the use of anthrapyrazolone moiety as a fluorescent probe for temperature sensing has been neglected. In this study, polymeric thermometers were developed by investigating the fluorescence properties of different polymer compositions, showing promising potential for intracellular temperature measurements.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Polymer Science
Meike N. Leiske, Ronak Singha, Somdeb Jana, Bruno G. De Geest, Richard Hoogenboom
Summary: In the past two decades, research on thermoresponsive polymers based on tertiary amine groups has been extensive, especially in their application in the biomedical field due to their temperature-dependent phase transition that can be modulated by the pH value of the environment. In this study, methyl-ester-functionalised poly(2-alkyl-2-oxazoline)s (PAOx) were used as a versatile platform for the synthesis of tertiary-amine-functionalised PAOx via post-polymerisation amidation. The resulting polymers showed responsiveness to pH value and temperature, forming polymeric nanoparticles, which demonstrated potential in polymeric drug delivery and inhibiting the proliferation of breast cancer cells.
Article
Nanoscience & Nanotechnology
Huijuan Zhang, Jiaxing Pan, Tingting Wang, Yi Lai, Xiaoying Liu, Fangmin Chen, Leiming Xu, Xiongwei Qu, Xiuli Hu, Haijun Yu
Summary: This study reported a dual-responsive and biodegradable polypeptide nanoparticle for combinatory chemotherapy and photodynamic therapy of breast cancer. The nanoparticle could be activated in the acidic environment to release drugs, inducing apoptosis in tumor cells and effectively inhibiting tumor growth and metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yi Lai, Yijing Dang, Qian Sun, Jiaxing Pan, Haijun Yu, Wen Zhang, Zhiai Xu
Summary: A novel Fe3O4 nanoparticle-conjugated MGO-activatable NIR-II fluorescent probe with enhanced BBB penetration and brain accumulation capability through T7 peptide is reported in this study, which can be used for MGO detection in AD.
Meeting Abstract
Gastroenterology & Hepatology
Leonard Kaps, Anne Huppertsberg, Niklas Choteschovsky, Adrian Klefenz, Feyza Durak, Barbara Schoers, Mustafa Diken, Emma Eichler, Sebastian Rosigkeit, Sascha Schmitt, Christian Leps, Friedrich Foerster, Ernesto Bockamp, Bruno Degeest, Federico Marini, Kaloian Koynov, Stefan Tenzer, Detlef Schuppan, Lutz Nuhn
JOURNAL OF HEPATOLOGY
(2022)
