How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation
Authors
Keywords
-
Journal
Nature Biomedical Engineering
Volume 2, Issue 11, Pages 797-809
Publisher
Springer Nature America, Inc
Online
2018-10-30
DOI
10.1038/s41551-018-0314-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- iReceptor: A platform for querying and analyzing antibody/B-cell and T-cell receptor repertoire data across federated repositories
- (2018) Brian D. Corrie et al. IMMUNOLOGICAL REVIEWS
- The Proposal to Lower P Value Thresholds to .005
- (2018) John P. A. Ioannidis JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment
- (2017) Denes Szucs et al. Frontiers in Human Neuroscience
- Acknowledging and Overcoming Nonreproducibility in Basic and Preclinical Research
- (2017) John P. A. Ioannidis JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Novel immunotherapies for adult patients with B-lineage acute lymphoblastic leukemia
- (2017) Guoqing Wei et al. Journal of Hematology & Oncology
- Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data
- (2017) Justin Guinney et al. LANCET ONCOLOGY
- Reference Standards for Gene and Cell Therapy Products
- (2017) Boro Dropulić MOLECULAR THERAPY
- A long journey to reproducible results
- (2017) Gordon J. Lithgow et al. NATURE
- Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model
- (2017) Tetsuhiro Kikuchi et al. NATURE
- Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
- (2017) Florian T. Merkle et al. NATURE
- Reproducibility, sharing and progress in nanomaterial databases
- (2017) Alexander Tropsha et al. Nature Nanotechnology
- Chimeric antigen receptor T-cell therapies for lymphoma
- (2017) Jennifer N. Brudno et al. Nature Reviews Clinical Oncology
- Potential Pitfall of Pluripotent Stem Cells
- (2017) Alan Trounson NEW ENGLAND JOURNAL OF MEDICINE
- Evaluating optimal therapy robustness by virtual expansion of a sample population, with a case study in cancer immunotherapy
- (2017) Syndi Barish et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Preservation and stability of cell therapy products: recommendations from an expert workshop
- (2017) Glyn N Stacey et al. Regenerative Medicine
- Modeling continuous response variables using ordinal regression
- (2017) Qi Liu et al. STATISTICS IN MEDICINE
- Breaking Down the Barriers to Precision Cancer Nanomedicine
- (2017) Christina von Roemeling et al. TRENDS IN BIOTECHNOLOGY
- Can cancer researchers accurately judge whether preclinical reports will reproduce?
- (2017) Daniel Benjamin et al. PLOS BIOLOGY
- Empirical assessment of published effect sizes and power in the recent cognitive neuroscience and psychology literature
- (2017) Denes Szucs et al. PLOS BIOLOGY
- Making sense of replications
- (2017) Brian A Nosek et al. eLife
- Intrinsic Variability Present in Wharton’s Jelly Mesenchymal Stem Cells and T Cell Responses May Impact Cell Therapy
- (2017) Fernanda Vieira Paladino et al. Stem Cells International
- Lessons Learned from Pioneering Neural Stem Cell Studies
- (2017) Sally Temple et al. Stem Cell Reports
- The reproducibility of research and the misinterpretation of p -values
- (2017) David Colquhoun Royal Society Open Science
- The why, what, and how of the new FACT standards for immune effector cells
- (2017) Marcela V. Maus et al. Journal for ImmunoTherapy of Cancer
- Most Do, but Some Do Not: CD4+CD25− T Cells, but Not CD4+CD25+ Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR)
- (2017) Andreas Hombach et al. Cancers
- Designing nanomedicine for immuno-oncology
- (2017) Wen Jiang et al. Nature Biomedical Engineering
- A phase I study of weekly dosing of trastuzumab-DM1 (T-DM1) in patients (pts) with advanced HER2+ breast cancer (BC)
- (2017) S. N. Holden et al. JOURNAL OF CLINICAL ONCOLOGY
- Cost-Effectiveness Analysis of Abiraterone and Sipuleucel-T in Asymptomatic Metastatic Castration-Resistant Prostate Cancer
- (2017) Cynthia L. Gong et al. Journal of the National Comprehensive Cancer Network
- Luciferase Expression Allows Bioluminescence Imaging But Imposes Limitations on the Orthotopic Mouse (4T1) Model of Breast Cancer
- (2017) V. P. Baklaushev et al. Scientific Reports
- The ASA's Statement onp-Values: Context, Process, and Purpose
- (2016) Ronald L. Wasserstein et al. AMERICAN STATISTICIAN
- Toxicities of chimeric antigen receptor T cells: recognition and management
- (2016) Jennifer N. Brudno et al. BLOOD
- Modeling Development and Disease with Organoids
- (2016) Hans Clevers CELL
- Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease
- (2016) Rodolfo Gonzalez et al. CELL TRANSPLANTATION
- Defining quality attributes to enable measurement assurance for cell therapy products
- (2016) Sheng Lin-Gibson et al. CYTOTHERAPY
- Academic criteria for appointment, promotion and rewards in medical research: where's the evidence?
- (2016) David Moher et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations
- (2016) Sander Greenland et al. EUROPEAN JOURNAL OF EPIDEMIOLOGY
- Reproducibility: A tragedy of errors
- (2016) David B. Allison et al. NATURE
- Expanding antigen-specific regulatory networks to treat autoimmunity
- (2016) Xavier Clemente-Casares et al. NATURE
- 1,500 scientists lift the lid on reproducibility
- (2016) Monya Baker NATURE
- Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice
- (2016) Arturo J Vegas et al. NATURE MEDICINE
- Nanomedicine, meet autoimmune disease
- (2016) Caroline Barranco Nature Reviews Rheumatology
- Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14–15 September 2015
- (2016) David J Williams et al. Regenerative Medicine
- Enhancing reproducibility for computational methods
- (2016) V. Stodden et al. SCIENCE
- Origin of the U87MG glioma cell line: Good news and bad news
- (2016) Marie Allen et al. Science Translational Medicine
- Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic in 2016?
- (2016) Roger A. Barker et al. Journal of Parkinsons Disease
- Analysis of nanoparticle delivery to tumours
- (2016) Stefan Wilhelm et al. Nature Reviews Materials
- p-Curve and p-Hacking in Observational Research
- (2016) Stephan B. Bruns et al. PLoS One
- Sipuleucel-T (Provenge®)—Autopsy of an Innovative Paradigm Change in Cancer Treatment: Why a Single-Product Biotech Company Failed to Capitalize on its Breakthrough Invention
- (2015) Szymon Jarosławski et al. BIODRUGS
- Stem Cell Therapies in Clinical Trials: Progress and Challenges
- (2015) Alan Trounson et al. Cell Stem Cell
- Registered Reports: Realigning incentives in scientific publishing
- (2015) Christopher D. Chambers et al. CORTEX
- Principles of nanoparticle design for overcoming biological barriers to drug delivery
- (2015) Elvin Blanco et al. NATURE BIOTECHNOLOGY
- Organs-on-chips at the frontiers of drug discovery
- (2015) Eric W. Esch et al. NATURE REVIEWS DRUG DISCOVERY
- Sipuleucel-T for the Treatment of Metastatic Hormone-Relapsed Prostate Cancer: A NICE Single Technology Appraisal; An Evidence Review Group Perspective
- (2015) Emma L. Simpson et al. PHARMACOECONOMICS
- Increasing disparities between resource inputs and outcomes, as measured by certain health deliverables, in biomedical research
- (2015) Anthony Bowen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phacking in biology: An open secret: Fig. 1.
- (2015) Stavros D. Veresoglou PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Promoting an open research culture
- (2015) B. A. Nosek et al. SCIENCE
- Nanomedicine for Infectious Disease Applications: Innovation towards Broad-Spectrum Treatment of Viral Infections
- (2015) Joshua A. Jackman et al. Small
- Are manufacturers sharing data as promised?
- (2015) Evan Mayo-Wilson et al. BMJ-British Medical Journal
- The Economics of Reproducibility in Preclinical Research
- (2015) Leonard P. Freedman et al. PLOS BIOLOGY
- Concise Review: Manufacturing of Pancreatic Endoderm Cells for Clinical Trials in Type 1 Diabetes
- (2015) Thomas C. Schulz Stem Cells Translational Medicine
- Are manufacturers sharing data as promised?
- (2015) Evan Mayo-Wilson et al. BMJ-British Medical Journal
- “Mesenchymal” Stem Cells
- (2014) Paolo Bianco Annual Review of Cell and Developmental Biology
- Assessing Value in Biomedical Research
- (2014) John P. A. Ioannidis et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Increasing value and reducing waste in research design, conduct, and analysis
- (2014) John P A Ioannidis et al. LANCET
- Development and function of human innate immune cells in a humanized mouse model
- (2014) Anthony Rongvaux et al. NATURE BIOTECHNOLOGY
- Translational strategies and challenges in regenerative medicine
- (2014) Stefanie Dimmeler et al. NATURE MEDICINE
- Economic evaluation of therapeutic cancer vaccines and immunotherapy: A systematic review
- (2014) Daniel M Geynisman et al. Human Vaccines & Immunotherapeutics
- Distinguishing between Exploratory and Confirmatory Preclinical Research Will Improve Translation
- (2014) Jonathan Kimmelman et al. PLOS BIOLOGY
- Future of the Particle Replication in Nonwetting Templates (PRINT) Technology
- (2013) Jing Xu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Particle size distributions by transmission electron microscopy: an interlaboratory comparison case study
- (2013) Stephen B Rice et al. METROLOGIA
- Reproducibility: The risks of the replication drive
- (2013) Mina Bissell NATURE
- Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface
- (2013) Anna Salvati et al. Nature Nanotechnology
- Power failure: why small sample size undermines the reliability of neuroscience
- (2013) Katherine S. Button et al. NATURE REVIEWS NEUROSCIENCE
- Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles
- (2013) P. L. Rodriguez et al. SCIENCE
- A Concerted Appeal for International Cooperation in Preclinical Stroke Research
- (2013) Ulrich Dirnagl et al. STROKE
- Tumour-on-a-chip provides an optical window into nanoparticle tissue transport
- (2013) Alexandre Albanese et al. Nature Communications
- Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases
- (2013) Konstantinos K. Tsilidis et al. PLOS BIOLOGY
- Threats to Validity in the Design and Conduct of Preclinical Efficacy Studies: A Systematic Review of Guidelines for In Vivo Animal Experiments
- (2013) Valerie C. Henderson et al. PLOS MEDICINE
- The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
- (2012) Alexandre Albanese et al. Annual Review of Biomedical Engineering
- Quality really matters: the need to improve specimen quality in biomedical research
- (2012) Daniel Simeon-Dubach et al. JOURNAL OF PATHOLOGY
- Mass spectrometry imaging for drug distribution studies
- (2012) Brendan Prideaux et al. Journal of Proteomics
- Cell-line authentication: End the scandal of false cell lines
- (2012) John R. Masters NATURE
- Raise standards for preclinical cancer research
- (2012) C. Glenn Begley et al. NATURE
- Biomolecular coronas provide the biological identity of nanosized materials
- (2012) Marco P. Monopoli et al. Nature Nanotechnology
- Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer
- (2012) Sunil Verma et al. NEW ENGLAND JOURNAL OF MEDICINE
- What Is the Greatest Regulatory Challenge in the Translation of Biomaterials to the Clinic?
- (2012) G. D. Prestwich et al. Science Translational Medicine
- The Alpha Stem Cell Clinic: A Model for Evaluating and Delivering Stem Cell-Based Therapies
- (2012) Alan Trounson et al. Stem Cells Translational Medicine
- Statistical Design Considerations in Animal Studies Published Recently inCancer Research
- (2011) Kenneth R. Hess CANCER RESEARCH
- Replication and reproducibility in spinal cord injury research
- (2011) Oswald Steward et al. EXPERIMENTAL NEUROLOGY
- Application of plasma spectrometry for the analysis of engineered nanoparticles in suspensions and products
- (2011) Petra Krystek et al. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
- Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake
- (2011) Carl D. Walkey et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
- (2011) Sonja Kriks et al. NATURE
- Believe it or not: how much can we rely on published data on potential drug targets?
- (2011) Florian Prinz et al. NATURE REVIEWS DRUG DISCOVERY
- Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer
- (2010) Philip W. Kantoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Reconstituting Organ-Level Lung Functions on a Chip
- (2010) D. Huh et al. SCIENCE
- Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
- (2009) Celestia S. Higano et al. CANCER
- Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens
- (2009) Steven M. Pollard et al. Cell Stem Cell
- A catalogue of reporting guidelines for health research
- (2009) I. Simera et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Identification of the murine firefly luciferase-specific CD8 T-cell epitopes
- (2009) M P Limberis et al. GENE THERAPY
- How Many Scientists Fabricate and Falsify Research? A Systematic Review and Meta-Analysis of Survey Data
- (2009) Daniele Fanelli PLoS One
- Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals
- (2009) Carol Kilkenny et al. PLoS One
- Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate
- (2008) G. D. Lewis Phillips et al. CANCER RESEARCH
- Microfluidic Platform for Controlled Synthesis of Polymeric Nanoparticles
- (2008) Rohit Karnik et al. NANO LETTERS
- Nanoparticle-mediated cellular response is size-dependent
- (2008) Wen Jiang et al. Nature Nanotechnology
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now