The role of mouse tumour models in the discovery and development of anticancer drugs

Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

(2019) A. Capasso et al.   Journal for ImmunoTherapy of Cancer

A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9-mediated somatic recombination

(2019) Noboru Ideno et al.   LABORATORY INVESTIGATION

Establishment and characterization of a patient-derived circulating lung tumor cell line in vitro and in vivo

(2019) Zujun Que et al.   Cancer Cell International

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

(2018) Samra Turajlic et al.   CELL

A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression

(2018) Arianna Fumagalli et al.   Nature Protocols

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling

(2018) Barbara Oldrini et al.   Nature Communications

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

(2018) Kristiaan J. Lenos et al.   NATURE CELL BIOLOGY

The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care

(2018) John G. Clohessy et al.   Frontiers in Oncology

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

A framework for the development of effective anti-metastatic agents

(2018) Robin L. Anderson et al.   Nature Reviews Clinical Oncology

A systematic review of the validity of patient derived xenograft (PDX) models: the implications for translational research and personalised medicine

(2018) Anne T. Collins et al.   PeerJ

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

(2017) Kevin P O'Rourke et al.   NATURE BIOTECHNOLOGY

Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression

(2017) Taeyoung Koo et al.   NUCLEIC ACIDS RESEARCH

Experimental animal modeling for immuno-oncology

(2017) Qi-Xiang Li et al.   PHARMACOLOGY & THERAPEUTICS

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma

(2017) Clemens Krepler et al.   Cell Reports

Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

(2016) Suzanne I.S. Mosely et al.   Cancer Immunology Research

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges

(2015) Chi-Ping Day et al.   CELL

GEMMs as preclinical models for testing pancreatic cancer therapies

(2015) Aarthi Gopinathan et al.   Disease Models & Mechanisms

Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer

(2015) C. N. Johnstone et al.   Disease Models & Mechanisms

Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma

(2015) M. R. Girotti et al.   Cancer Discovery

Cancer metastases: challenges and opportunities

(2015) Xiangming Guan   Acta Pharmaceutica Sinica B

Strategies for modern biomarker and drug development in oncology

(2014) Alan D Smith et al.   Journal of Hematology & Oncology

Long-Term Engraftment and Expansion of Tumor-Derived Memory T Cells Following the Implantation of Non-Disrupted Pieces of Human Lung Tumor into NOD-scid IL2R null Mice

(2014) M. R. Simpson-Abelson et al.   JOURNAL OF IMMUNOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Lymph node-independent liver metastasis in a model of metastatic colorectal cancer

(2014) Ida B. Enquist et al.   Nature Communications

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study

(2014) Mariam Jamal-Hanjani et al.   PLOS BIOLOGY

A Model of Postsurgical Advanced Metastatic Breast Cancer More Accurately Replicates the Clinical Efficacy of Antiangiogenic Drugs

(2013) E. Guerin et al.   CANCER RESEARCH

Phase I Study of Vismodegib in Children with Recurrent or Refractory Medulloblastoma: A Pediatric Brain Tumor Consortium Study

(2013) A. Gajjar et al.   CLINICAL CANCER RESEARCH

How can attrition rates be reduced in cancer drug discovery?

(2013) Lucas Moreno et al.   Expert Opinion on Drug Discovery

Versatile and enhanced tumour modelling in mice via somatic cell transduction

(2013) Esther Rodriguez et al.   JOURNAL OF PATHOLOGY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity

(2012) Timothy S. Fisher et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Molecular networks that regulate cancer metastasis

(2012) Daniela Spano et al.   SEMINARS IN CANCER BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Pharmacokinetic-Pharmacodynamic Analysis of Vismodegib in Preclinical Models of Mutational and Ligand-Dependent Hedgehog Pathway Activation

(2011) H. Wong et al.   CLINICAL CANCER RESEARCH

Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2nullIl2rγnull mouse model: A multivariable optimization approach

(2011) Julie Lang et al.   CLINICAL IMMUNOLOGY

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

A Molecularly Annotated Platform of Patient-Derived Xenografts ("Xenopatients") Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

(2011) A. Bertotti et al.   Cancer Discovery

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

(2010) Mallika Singh et al.   NATURE BIOTECHNOLOGY

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The use of xenograft models for the selection of cancer treatments with the EGFR as an example

(2007) Teresa Troiani et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY